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| 1 | NF-KB in immunobiology显示文摘 | Matthew S Hayden Sankar Ghosh | 2011 | Cell Research2011，21，2： | 101 |
| 2 | 应用IVE模型计算上海市机动车污染物排放显示文摘为了解上海市机动车污染现状,建立上海市机动车源排放清单,分别选择上海市中心城区、商业区和收入相对较低区域中的主干道、快速道和次干道3种共9条典型道路,开展机动车技术水平参数、比功率(VSP)分布状况、启动状况等测试,并在此基础上将InternationalVehicleEmission(IVE)模型本地化.调查结果表明,上海市区实际道路上轻型客车、出租车、公交巴士、卡车和摩托车(包含助动车)分别占道路总车流量的41.0%、30.8%、15.6%、6.9%和5.7%;从技术组成看,约85%的轻型客车和97%的出租车均安装有三元催化装置,约30%的公交巴士和90%的卡车没有达到欧I标准;机动车的VSP分布主要集中在-2.9~1.2kW·t-1.模式计算结果表明,2004年上海市机动车CO、VOC、NOx和PM排放量分别为57.06×104t、7.75×104t、9.20×104t和0.26×104t;20%的高排放车对总排放量的贡献占到25%~45%;启动过程中排放的CO、VOC和PM占总排放量的15%~25%,NOx仅占总排放量的4.5%. | 王海鲲 陈长虹 黄成 潘汉生 景启国 王冰研 戴懿 赵静 李莉 James Lents Matthew Barth Richard Nikkila 钱华 戴海夏 | 2006 | 环境科学学报2006，26，1： | 68 |
| 3 | Staging accuracy of esophageal cancer by endoscopic ultrasound:A meta-analysis and systematic review显示文摘AIM: To evaluate the accuracy of endoscopic ultrasound (EUS) in the staging of esophageal cancer. METHODS: Only EUS studies confirmed by surgery were selected. Articles were searched in Medline and Pubmed. Two reviewers independently searched and extracted data. Meta-analysis of the accuracy of EUS was analyzed by calculating pooled estimates of sensitivity, specificity, likelihood ratios, and diagnostic odds ratio. Pooling was conducted by both the Mantel-Haenszel method (fixed effects model) and DerSimonian Laird method (random effects model). The heterogeneity of studies was tested using Cochran’s Q test based upon inverse variance weights. RESULTS: Forty-nine studies (n = 2558) which met the inclusion criteria were included in this analysis. Pooled sensitivity and specificity of EUS to diagnose T1 was 81.6% (95% CI: 77.8-84.9) and 99.4% (95% CI: 99.0-99.7), respectively. To diagnose T4, EUS had a pooled sensitivity of 92.4% (95% CI: 89.2-95.0) and specificity of 97.4% (95% CI: 96.6-98.0). With Fine Needle Aspiration (FNA), sensitivity of EUS to diagnose N stage improved from 84.7% (95% CI: 82.9-86.4) to 96.7% (95% CI: 92.4-98.9). The P value for the χ2 test of heterogeneity for all pooled estimates was > 0.10. CONCLUSION: EUS has excellent sensitivity and specificity in accurately diagnosing the TN stage of esophageal cancer. EUS performs better with advanced (T4) than early (T1) disease. FNA substantially improves the sensitivity and specificity of EUS in evaluating N stage disease. EUS should be strongly considered for staging esophageal cancer. | Srinivas R Puli Jyotsna BK Reddy Matthew L Bechtold Daphne Antillon Jamal A Ibdah Mainor R Antillon | 2008 | World Journal of Gastroenterology2008，14，10： | 55 |
| 4 | 利用多模式对中国气温序列中不连续点的检测显示文摘发展了一种对元数据依赖程度较小的气候序列均一化思路,在缺乏元数据的基础上,采取3种不同的方法,对中国东南部地区年平均最高、最低气温序列进行了均一性检验;并对其中不连续的气温序列进行了订正。对比表明,订正后序列较订正前更为合理。在检验过程中发现,对于最低气温检验可以明显得出比最高气温更多的不连续点。为了进一步认识这个问题,对此进行了进一步分析,认为最低温度对变化更为敏感主要是由于其物理特征最低温度一般出现在夜间,夜间大气较为稳定,因此一些变化(如仪器,迁站)可能引起明显的不连续现象,而最高气温往往出现在白天,因此大气混合比较充分,空间的均一性要明显强于最低温度。另外,热岛现象、台站密度等因素均是影响气温序列均一化的因素。 | 李庆祥 Matthew J.Menne Claude N.Williams Jr Bomin Sun | 2005 | 气候与环境研究2005，10，4： | 41 |
| 5 | 重型柴油车实际道路排放与行驶工况的相关性研究显示文摘采用SEMTECH-D车载排放测试仪测量了东风柴油卡车在城市实际道路工况以及等速和加速工况下的油耗及污染物排放状况.测试结果显示,测试卡车实际道路综合百公里油耗为17.8L,NOx、CO和Hc排放因子分别为3.96、8.86和2.15g ·km^-1.其中主干道路况相对较差,油耗与排放因子较高,是所有测试道路平均水平的1.3-1.8倍左右.研究结果表明,重型车油耗及污染物排放与各行驶工况下的速度、加速度均密切相关,车辆在高速加速行驶状态下易产生高排放.车辆在30~50km·h^-1速度区间内等速行驶时。油耗与排放因子最为经济且环境友好.车辆在加速行驶时,油耗与NOx、CO排放因子可达到城市实际道路平均水平的2.0、2.2、1.4倍,急加速时达到2.8、2.1、14倍.应用比功率概念可准确描述车辆在各运行工况下的排放水平,但在重型车上缺乏实验依据,有待进一步研究. | 黄成 陈长虹 景启国 潘汉生 王海鲲 黄海英 李莉 赵静 戴懿 Matthew Barth Richard Nikkila | 2007 | 环境科学学报2007，27，2： | 41 |
| 6 | Oxidative stress and male reproductive health显示文摘有缺点的精子功能的主要原因之一是氧化应力,它不仅破坏精子 DNA 的正直而且在精子血浆膜由于蛋白质和类脂化合物的并行的损坏限制这些房间的使肥沃的潜力。如此的氧化压力的起源看起来包含精子线粒体,它有一个趋势作为一篇序言产生 superoxide 阴离子的高水平到进入内在的 apoptotic 串联。不幸地,这些房间有很小的能力因为他们仅仅在基础切除修理(BER ) 拥有第一酶,对如此的攻击作出回应小径, 8-oxoguanine glycosylase 1 (OGG1 ) 。后者成功地创造一个 abasic 地点,而是精子因为他们缺乏下游的蛋白质,不能进一步处理氧化损害(APE1, XRCC1 ) 需要完成修理过程。在第一个有丝分裂的部门的 S 阶段的开始以前继续 BER 小径是卵母细胞的责任。如果一个错误被卵母细胞在开发的这个阶段犯,一个变化将被创造那将在身体在每个房间被代表。如此的机制可以在在作为年龄的后果在他们的细菌线承受了氧化应力的男性的后代观察的童年癌症和另外的疾病解释增加,环境或生活方式因素。在男不孕病人的精子的氧化 DNA 损坏的高流行可以为在 vitro 构思的孩子的健康有含意并且在细菌线为对免费激进的产生的起源的当前的研究担任一位司机。 | Robert J Aitken Tegan B Smith Matthew S Jobling Mark A Baker Geoffry N De Iuliis | 2014 | Asian Journal of Andrology2014，16，1： | 48 |
| 7 | 冠状动脉钙化和CT血管造影与常规危险因素诊断和预测冠心病的对比研究显示文摘目的 对比冠状动脉钙化积分 (CCS)、电子束CT血管造影 (EBA)与常规冠心病危险因素诊断和预测冠心病 (一支以上冠状动脉狭窄率≥ 5 0 % )的价值。方法 10 7例患者同时行常规冠状动脉造影 (CAG)、电子束CT冠状动脉钙化 (非增强扫描 )和电子束CT血管造影 (增强扫描 ) ,以及常规冠心病危险因素分析。EBA采用静脉法单层心电门控增强扫描 ,诊断在断层和三维重建图像上完成。CCS采用Agatston方法完成。电子束CT及常规冠心病危险因素与CAG结果做双盲法对照研究。结果 本组冠心病患者和非冠心病患者分别为 6 5例 ( 6 0 7% )和 4 2例 ( 39 3% ) ,CCS在冠心病组和非冠心病组分别为 5 33 5± 6 0 6 5和 14 2 4± 2 93 6 (P <0 0 0 1)。年龄、体重指数、糖尿病和高胆固醇血症的发病率在冠心病组显著高于非冠心病组 (P <0 0 5 )。冠状动脉钙化阳性 (CCS >0 )诊断冠心病与EBA有相近的敏感性和阴性预测值 (P >0 0 5 )。EBA诊断非钙化性 (CCS =0 )或少量钙化(CCS <10 0 )冠状动脉节段狭窄的特异性和准确性高于CCS且差异有显著性 (P <0 0 1) ;但对于较多冠状动脉钙化病变 (CCS >10 0 )差异无显著性 (P >0 0 5 )。CCS和EBA诊断冠心病的敏感性和特异性分别为 79%和 73% (P >0 0 5 ) ,以及 6 6 %和 88% (P <0 | 吕滨 庄囡 戴汝平 蒋世良 Matthew J.Budoff | 2004 | 中华心血管病杂志2004，32，6： | 32 |
| 8 | How good is endoscopic ultrasound for TNM staging of gastric cancers? A meta-analysis and systematic review显示文摘AIM: To evaluate the accuracy of endoscopic ultrasound (EUS) for staging of gastric cancers. METHODS: Only EUS studies confirmed by surgery were selected. Only studies from which a 2 × 2 table could be constructed for true positive, false negative, false positive and true negative values were included. Articles were searched in Medline, Pubmed, Ovid journals, Cumulative index for nursing & allied health literature, International pharmaceutical abstracts, old Medline, Medline nonindexed citations, and Cochrane control trial registry. Two reviewers independently searched and extracted data. The differences were resolved by mutual agreement. 2 × 2 tables were constructed with the data extracted from each study. Meta-analysis for the accuracy of EUS was analyzed by calculating pooled estimates of sensitivity, specifi city, likelihood ratios, and diagnostic odds ratio. Pooling was conducted by both the Mantel-Haenszel method (fi xed effects model) and DerSimonian Laird method (random effects model). The heterogeneity of studies was tested using Cochran's Q test based upon inverse variance weights. RESULTS: Initial search identified 1620 reference articles and of these, 376 relevant articles were selected and reviewed. Twenty-two studies (n = 1896) which met the inclusion criteria were included in this analysis. Pooled sensitivity of T1 was 88.1% (95% CI: 84.5-91.1) and T2 was 82.3% (95% CI: 78.2-86.0). For T3, pooled sensitivity was 89.7% (95% CI: 87.1-92.0). T4 hada pooled sensitivity of 99.2% (95% CI: 97.1-99.9). For nodal staging, the pooled sensitivity for N1 was 58.2% (95% CI: 53.5-62.8) and N2 was 64.9% (95% CI: 60.8-68.8). Pooled sensitivity to diagnose distant metastasis was 73.2% (95% CI: 63.2-81.7). The P for chi-squared heterogeneity for all the pooled accuracy estimates was > 0.10. CONCLUSION: EUS results are more accurate with advanced disease than early disease. If EUS diagnoses advanced disease, such as T4 disease, the patient is 500 times more likely to have true anatomic stage of T4 disease. | Srinivas Reddy Puli Jyotsna Batapati Krishna Reddy Matthew L Bechtold Mainor R Antillon Jamal A Ibdah | 2008 | World Journal of Gastroenterology2008，14，25： | 33 |
| 9 | Current state of laparoscopic parastomal hernia repair:A meta-analysis显示文摘AIM:To evaluate the efficacy and safety of the laparoscopic approaches for parastomal hernia repair reported in the literature.METHODS:A systematic review of PubMed and MEDLINE databases was conducted using various combination of the following keywords:stoma repair,laparoscopic,parastomal,and hernia.Case reports,studies with less than 5 patients,and articles not written in English were excluded.Eligible studies were further scrutinized with the 2011 levels of evidence from the Oxford Centre for Evidence-Based Medicine.Two authors reviewed and analyzed each study.If there was any discrepancy between scores,the study in question was referred to another author.A meta-analysis was performed using both random and fixed-effect models.Publication bias was evaluated using Begg's funnel plot and Egger's regression test.The primary outcome analyzed was recurrence of parastomal hernia.Secondary outcomes were mesh infection,surgical site infection,obstruction requiring reoperation,death,and other complications.Studies were grouped by operative technique where indicated.Except for recurrence,most postoperative morbidities were reported for the overall cohort and not by approach so they were analyzed across approach.RESULTS:Fifteen articles with a total of 469 patients were deemed eligible for review.Most postoperative morbidities were reported for the overall cohort,and not by approach.The overall postoperative morbidity rate was 1.8%(95%CI:0.8-3.2),and there was no difference between techniques.The most common postoperative complication was surgical site infection,which was seen in 3.8%(95%CI:2.3-5.7).Infected mesh was observed in 1.7%(95%CI:0.7-3.1),and obstruction requiring reoperation also occurred in 1.7%(95%CI:0.7-3.0).Other complications such as ileus,pneumonia,or urinary tract infection were noted in16.6%(95%CI:11.9-22.1).Eighty-one recurrences were reported overall for a recurrence rate of 17.4%(95%CI:9.5-26.9).The recurrence rate was 10.2%(95%CI:3.9-19.0) for the modified laparoscopic Sugarbaker approach,whereas the recurrence rate was27.9%(95%CI:12.3-46.9) for the keyhole approach.There were no intraoperative mortalities reported and six mortalities during the postoperative course.CONCLUSION:Laparoscopic intraperitoneal mesh repair is safe and effective for treating parastomal hernia.A modified Sugarbaker approach appears to provide the best outcomes. | Francis J DeAsis Brittany Lapin Matthew E Gitelis Michael B Ujiki | 2015 | World Journal of Gastroenterology2015，21，28： | 34 |
| 10 | 国外天然气管道检测技术现状及启示显示文摘中国天然气管道即将进入事故高发的老龄化阶段,如何高效进行管道检测成为亟待解决的问题。为此,在调研大量论文、研究报告和企业信息的基础上,围绕天然气管道可视化检测、管壁金属损失检测、泄漏检测和在线监测技术,对国外已成熟应用而国内正处于起步阶段的天然气管道检测技术进行了全面介绍,分析了该技术在我国应用所面临的主要障碍,并从检测功能、技术适应性、技术改进等方面总结了检测技术的发展方向。结论认为:(1)国外天然气管道检测技术主要针对腐蚀坑、缺陷、剩余壁厚和泄漏,很多技术都以管道机器人为载体,配合其他技术理论及多种传感器行使技术功能,管道检测的技术和设备必将朝着综合检测(检测多种数据)的方向发展;(2)国外天然气管道的部分检测技术仅可应用于小口径管道,对于大口径管道则具有一定的局限性,提高检测设备的适应性是必然趋势;(3)国外天然气管道检测技术在我国应用的难点主要体现在目前国内尚未形成检测技术实施和验收的标准体系,很多检测数据需要人为解释且暂时缺乏相关的专业培训;(4)自动解读数据成为管道检测的一个新兴发展方向,届时机器可自动识别管道内缺陷、腐蚀状况等参数并提供可靠性较高的检测报告;(5)提高检测设备的续航能力、数据存储能力和远传能力是检测技术改进的发展方向;(6)管道检测技术配套完整性管理平台的研发,能够促进天然气管道的智能化管理。 | 卢泓方 吴晓南 Tom Iseley John Matthews 彭善碧 | 2018 | 天然气工业2018，38，2： | 32 |
| 11 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 12 | 贵阳市大气颗粒物(PM_(2.5))污染特征及气象参数的影响显示文摘运用连续颗粒物采样仪(URG Model 2000-01J)对贵阳市城区大气颗粒物PM2.5进行了连续3个月(9-11月)的采集与分析,探讨了PM2.5的浓度分布特征、气象条件的影响。结果显示,贵阳市大气颗粒物PM2.5的平均质量浓度为53±27μg/m^3,变化范围为3.7-186μg/m^3;初步推断大气颗粒物PM2.5的污染来源主要是燃料燃烧、生物质燃烧、汽车尾气等人为源;相对湿度、风速、风向、温度等气象条件是影响大气颗粒物浓度及分布的重要因素。 | 刘娜 冯新斌 Landis Matthew 陈卓 仇广乐 | 2014 | 地球与环境2014，42，3： | 29 |
| 13 | Acupuncture's Role in Solving the Opioid Epidemic: Evidence, Cost-Effectiveness, and Care Availability for Acupuncture as a Primary, Non-Pharmacologic Method for Pain Relief and Management-White Paper 2017显示文摘The United States(U.S.) is facing a national opioid epidemic, and medical systems are in need of nonpharmacologic strategies that can be employed to decrease the public's opioid dependence. Acupuncture has emerged as a powerful, evidence-based, safe, cost-effective, and available treatment modality suitable to meeting this need. Acupuncture has been shown to be effective for the management of numerous types of pain conditions, and mechanisms of action for acupuncture have been described and are understandable from biomedical, physiologic perspectives. Further, acupuncture's cost-effectiveness can dramatically decrease health care expenditures, both from the standpoint of treating acute pain and through avoiding addiction to opioids that requires costly care, destroys quality of life, and can lead to fatal overdose. Numerous federal regulatory agencies have advised or mandated that healthcare systems and providers offer non-pharmacologic treatment options for pain. Acupuncture stands out as the most evidence-based, immediately available choice to fulfil these calls. Acupuncture can safely, easily, and cost-effectively be incorporated into hospital settings as diverse as the emergency department, labor and delivery suites, andneonatal intensive care units to treat a variety of commonly seen pain conditions. Acupuncture is already being successful y and meaningfully utilized by the Veterans Administration and various branches of the U.S. Military, in some studies demonstrably decreasing the volume of opioids prescribed when included in care. | arthur yin fan david w.miller bonnie bolash matthew bauer john mcdonald sarah faggert hongjian he yong ming li amy matecki lindy camardella mel hopper koppelman jennifer a.m.stone lindsay meade john pang | 2017 | Journal of Integrative Medicine2017，15，6： | 29 |
| 14 | 地下水铀污染的原位微生物还原与固定:在美国能源部田纳西橡树岭放射物污染现场的试验显示文摘总结了美国斯坦福大学和橡树岭国家实验室等在美国能源部田纳西州橡树岭综合试验基地进行的铀污染原位微生物修复阶段性试验结果.本试验利用微生物以乙醇为电子供体还原地下水和沉积物中的六价铀为不溶解的四价铀,使之原位固定化.随后通过加入溶解氧和硝酸盐来试验微生物还原后的地下水层中还原固定态铀的稳定性.通过预处理和长期间隔注入乙醇溶液,地下水中铀浓度从40~60mg·L-1降至0.03mg·L-1以下,达到了美国环保署饮用水的标准.还原的四价铀主要以U(Ⅳ)-Fe复合物的形态存在.结果表明,固定化后的四价铀只有在厌氧条件下才是稳定的,溶解氧和硝酸盐侵入地下水层后会使固定化的四价铀重新氧化为溶解态的六价铀.在试验过程中,采用多种分子生物学方法检测了微生物种群的变化和与铀氧化还原反应有关的功能微生物.本研究表明,在维持试验系统无氧和无硝酸盐的条件下,通过添加乙醇为电子供体可有效地促进地下水中土著功能微生物的活性,从而实现铀的原位还原固定与稳定. | 吴唯民 Jack Carley David Watson 顾宝华 Scott Brooks Shelly D.Kelly Kenneth Kemner Joy D.van Nostrand 吴力游 许玫英 周集中 罗剑 Erick Cardenas 黄家琪 Matthew W.Fields Terence L.Marsh James M.Tiedje Stefan J.Green Joel E.Kostka Peter K.Kitanidis Philip M.Jardme CraigS.Criddle | 2011 | 环境科学学报2011，31，3： | 28 |
| 15 | 急性下呼吸道感染儿童的维生素D摄入显示文摘目的明确维生素D(Vit D)摄入是否与儿童急性下呼吸道感染(ALRI)相关。方法比较因毛细支气管炎或肺炎入院的5岁以下儿童和非配对、无呼吸道感染的同龄对照组儿童之间Vit D摄入的差别。197例儿童的看护人完成了问卷调查,内容包括人口统计变量、ALRI危险因素和饮食。评估ALRI与Vit D摄入及其他危险因素的相关性。结果 ALRI组儿童的平均Vit D摄入为每日48 IU/kg,对照组为每日60 IU/kg。当控制年龄、民族、社会经济地位、北部地区居住、母乳喂养、免疫接种和接触吸烟等因素时,Vit D每日摄入<80 IU/kg的儿童患ALRI的可能性比每日摄入≥80 IU/kg的儿童高4倍(OR=4.9;95%CI:1.5~16.4)。结论为了避免罹患ALRI等疾病,5岁以下儿童可能需要摄入比现在推荐量更高的Vit D剂量。因毛细支气管炎和肺炎是年幼儿童住院的最常见原因,增加Vit D的补充可能有重要的公共卫生保健意义。 | Karen S Leis J Dayre McNally Matthew R Montgomery Koravangattu Sankaran Chandima Karunanayake Alan M Rosenberg 马丽亚(译) | 2012 | 中国当代儿科杂志2012，14，1： | 25 |
| 16 | 指南2.0:为成功制定指南而系统研发的全面清单显示文摘背景虽然当前已有一些评估卫生保健指南可靠性的工具,但仍缺乏针对制定指南实际步骤的指导。针对指南制定者们所需考虑的相关资源和工具,我们系统研发了一份全面的条目清单,但这并不意味着每篇指南都需遵守该清单的所有条目。方法我们检索了国际指南制定机构的指南制定手册、指南的指南(主要是来自国际和国家机构以及专业学会的方法学报告),以及提供系统指导的最新文章。经过反复评价这些资料,尽可能全面地罗列和提取条目,并制定与指南有关的重要主题。通过反复讨论,我们对条目进行评价以去重和补漏,同时邀请指南制定专家对所增加的条目进行修改并提出建议。结果我们制定了一份包含18个主题、146个条目的清单,并建立了帮助指南制定者应用这些条目的网站。这些主题和条目涵盖了指南从规划、完成、实施和评估的全过程。最终的清单版本也包括了培训所需的资料以及应用这些条目时用到的方法学参考文献的链接。解释本清单将提供给指南制定者用作参考。仔细考虑清单中的条目将有助于指南的制定、实施和评估,我们也将会通过大众反馈来修订并持续更新清单。 | Holger J. Schunemann Wojtek Wiercioch Itziar Etxeandia Maicon Falavigna Nancy Santesso Reem Mustafa Matthew Ventresca Romina Brignardello-petersen] Kaja-Triin Laisaar Sergio Kowalski Tejan Baldeh Yuan Zhang Uiia Raid Ignacio Neumann Susan L. Norris Judith Thornton Robin Harbour Shaun Treweek Gordon Guyatt Pablo Alonso-Coello Marge Reinap Jan Brozek Andrew Oxman Elie A. Akl | 2014 | 中国循证医学杂志2014，14，9： | 26 |
| 17 | 智能网联汽车协同生态驾驶策略综述显示文摘为了跟踪近年来智能网联汽车(CAV)协同生态驾驶策略的研究进展,分析了车辆、驾驶行为、交通网络和社会这4类因素对CAV能耗的影响程度,以车辆、基础设施和旅行者为对象对目前CAV生态研究进行分类,重点分析了信号交叉口生态驶入与离开、生态协同自适应巡航控制、匝道合流区生态协同驾驶、生态协同换道轨迹规划和生态路由5种典型车辆协同生态驾驶应用场景的研究现状。分析结果表明:相比人类驾驶方式,在任何交通流量CAV 100%渗透率的条件下和低交通流量CAV部分渗透率的条件下,CAV油耗节省效果显著,最高可达63%,而具有部分智能化和网联化等级的CAV油耗可至少节省7%;现有研究较少考虑人机共驾情况下,驾驶人反应延迟和自动控制器传输延迟导致的轨迹跟踪偏离;现有研究将车车通信/车路通信假定为理想数据交互过程,未考虑通信拓扑、传输时延、通信失效与基站切换等因素对CAV生态协同驾驶策略的影响;现有研究较少探讨多车道、交叉口转向-直行共用车道和U型车道等交通场景,以及不同智能网联等级CAV与人类驾驶汽车、行人、自行车等共存的混合交通条件下的生态驾驶策略;受限于自动驾驶技术和基础设施尚未成熟和完善,真实交通场景下的测试验证工作尚未开展;车辆控制、车车通信、多车协同、混合交通流场景、半实物仿真测试和真实交通场景测试等方面将是CAV协同生态驾驶策略的进一步发展方向。 | 杨澜 赵祥模 吴国垣 徐志刚 MATTHEW Barth 惠飞 郝鹏 韩梦杰 赵周桥 房山 景首才 | 2020 | 交通运输工程学报2020，20，5： | 26 |
| 18 | A Single Active Trehalose-6-P Synthase (TPS) and a Family of Putative Regulatory TPS-Like Proteins in Arabidopsis显示文摘更高的植物典型地不在大数量生产 trehalose,但是他们的染色体序列揭示通常认为的 trehalose 新陈代谢酶的大家庭。在植物生长和开发的一个重要规章的角色也为新陈代谢的中间的 trehalose-6-P (T6P ) 正在出现。这里,我们在场 Arabidopsis trehalose 新陈代谢上的更改和为进一步详细的分析的一个资源。另外,我们提供 Arabidopsis 靠着可能在活跃地种纸巾完成特定的规章的功能的催化地不活跃的象 TPS 一样蛋白质的一个家庭编码单个 trehalose-6-P synthase (TPS ) 的证据。 | Lies Vandesteene Matthew Ramon Katrien Le Roy Patrick Van Dijck Filip Rolland | 2010 | Molecular Plant2010，3，2： | 22 |
| 19 | Colorectal cancer in inflammatory bowel disease:What is the real magnitude of the risk?显示文摘The association between inflammatory bowel disease(IBD) and colorectal cancer(CRC) has been recognised since 1925 and still accounts for 10%-15% of deaths in IBD.IBD-associated CRC(IBD-CRC) affects patients at a younger age than sporadic CRC.The prognosis for sporadic CRC and IBD-CRC is similar,with a 5-year survival of approximately 50%.Identifying at risk patients and implementing appropriate surveillance for these patients is central to managing the CRC risk in IBD.The increased risk of colorectal cancer in association with IBD is thought to be due to genetic and acquired factors.The link between inflammation and cancer is well recognised but the molecular biology,immune pathobiology and genetics of IBD-CRC are areas of much ongoing research.This review examines the literature relating to IBD-CRC,focusing on the incidence of IBD-CRC and examining potential risk factors including age at diagnosis,gender,duration and extent of colitis,severity of inflammation,family history of sporadic CRC and co-existent primary sclerosing cholangitis(PSC).Confirmed risk factors for IBD-CRC are duration,severity and extent of colitis,the presence of co-existent PSC and a family history of CRC.There is insufficient evidence currently to support an increased frequency of surveillance for patients diagnosed with IBD at a younger age.Evidence-based guidelines advise surveillance colonoscopy for patients with colitis 8 to 10 years after diagnosis,with the interval for further surveillance guided by risk factors(extent of disease,family history of CRC,post-inflammatory polyps,concomitant PSC,personal history of colonic dysplasia,colonic strictures).There is a move away from using random colonic biopsies towards targeted biopsies aimed at abnormal areas identified by newer colonoscopic techniques(narrow band imaging,chromoendoscopy,confocal microendoscopy). | Jessica K Dyson Matthew D Rutter | 2012 | World Journal of Gastroenterology2012，18，29： | 22 |
| 20 | A nomogram based on age, prostate-specific antigen level, prostate volume and digital rectal examination for predicting risk of prostate cancer显示文摘当适用于一个中国队时,为预言前列腺癌症的风险用另外的人口发展了的诺模图可以介绍相当大的偏爱。在现在的学习,我们寻求了为在一张中国人口预言积极起始的前列腺活体检视的概率开发一张诺模图。与完全的活体检视数据在过去的十年为前列腺癌症的察觉经历了 prostatic 活体检视的 535 个中国人的一个总数被包括。逐步的逻辑回归被用来决定积极起始的活体检视的独立预言者。变老,前列腺特定的抗原(PSA ) ,前列腺体积(PV ) ,数字直肠的考试(DRE ) 地位, %免费 PSA 和 transrectal 超声(TRUS ) 调查结果在分析被包括。一个诺模图模型被开发那基于这些独立预言者计算积极起始的前列腺活体检视的概率。一条操作接收装置的典型曲线被用来估计独自使用诺模图和 PSA 层次预言积极前列腺活体检视的精确性。为积极起始的前列腺活体检视的率是 41.7 %(223/535 ) 。过去常预言积极起始的前列腺活体检视的独立变量是很长时间, PSA, PV 和 DRE 地位。在为为独自一个的 PSA 和诺模图的积极起始的前列腺活体检视的操作接收装置的典型曲线下面的区域是 79.7 %并且 84.8 %分别地。我们的结果显示积极起始的前列腺活体检视的风险能用我们的诺模图在一张中国人口被预言到令人满意的水平。诺模图能被用来识别并且建议应该考虑前列腺活体检视的病人,最终在诊断前列腺癌症提高精确性。 | Ping Tang Hui Chen Matthew Uhlman Yu-Rong Lin Xiang-Rong Deng Bin Wang Wen-Jun Yang Ke-Ji Xie | 2013 | Asian Journal of Andrology2013，15，1： | 22 |
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