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| 1 | Hypoxia inducible factor(HIF) in the tumor microenvironment:friend or foe?显示文摘Hypoxia acts as an important regulator of physiological and pathological processes. Hypoxia inducible factors(HIFs) are the central players involved in the cellular adaptation to hypoxia and are regulated by oxygen sensing EGLN prolyl hydroxylases.Hypoxia affects many aspects of cellular growth through both redox effects and through the stabilization of HIFs. The HIF isoforms likely have differential effects on tumor growth via alteration of metabolism, growth, and self-renewal and are likely highly context-dependent. In some tumors such as renal cell carcinoma, the EGLN/HIF axis appears to drive tumorigenesis,while in many others HIF1 and HIF2 may actually have a tumor suppressive role. An emerging role of HIF biology is its effects on the tumor microenvironment. The EGLN/HIF axis plays a key role in regulating the function of the various components of the tumor microenvironment, which include cancer-associated fibroblasts, endothelial cells, immune cells, and the extracellular matrix(ECM). Here, we discuss hypoxia and the diverse roles of HIFs in the setting of tumorigenesis and the maintenance of the tumor microenvironment as well as possible future directions of the field. | Yanqing Huang Daniel Lin Cullen M.Taniguchi | 2017 | Science China(Life Sciences)2017，60，10： | 26 |
| 2 | 不同人工泪液对体外培养的人角结膜上皮细胞的毒性作用比较显示文摘干眼是泪液分泌量不足、泪膜稳定性受损所致的眼部疾病[1-2].流行病学研究表明,在世界范围内,干眼发病率很高,与老龄、妇女围绝经期、配戴隐形眼镜及自身免疫性疾病等有关[3-5],其中亚洲人群中发病率约为17% ~ 33% [6-9],而白种人发病率相对较低,约为7%~14.6%[3,10].目前,干眼最常用的治疗方法是眼表滴用人工泪液,由于干眼是慢性疾患,大部分患者需长期用药,因此其长期疗效和安全性值得关注.本研究比较了不同成分的人工泪液对体外培养的人角膜和结膜上皮细胞的毒性作用,以期为临床用药提供试验依据. | Malik Kahook Cullen T. Vogelson Usha Sivaprasad David A. Ammar | 2012 | 中华眼科杂志2012，48，2： | 11 |
| 3 | Acute drivers of neuroinflammation in traumatic brain injury显示文摘Neuroinflammation is initiated as a result of traumatic brain injury and can exacerbate evolving tissue pathology.Immune cells respond to acute signals from damaged cells,initiate neuroinflammation,and drive the pathological consequences over time.Importantly,the mechanism(s)of injury,the location of the immune cells within the brain,and the animal species all contribute to immune cell behavior following traumatic brain injury.Understanding the signals that initiate neuroinflammation and the context in which they appear may be critical for understanding immune cell contributions to pathology and regeneration.Within this paper,we review a number of factors that could affect immune cell behavior acutely following traumatic brain injury. | Kathryn L.Wofford David J.Loane D.Kacy Cullen | 2019 | Neural Regeneration Research2019，14，9： | 7 |
| 4 | Etiopathogenesis of primary sclerosing cholangitis显示文摘Primary sclerosing cholangitis(PSC) is a chronic cholestatic liver disease of unknown etiology but lymphocytic portal tract infiltration is suggestive of an immune-mediated basis for this disease.Associations with inflammatory bowel disease(IBD) especially ulcerative colitis(UC),and with particular autoimmune diseases,as well as the genetic associations further suggest PSC may be an immune-mediated disease.The immunogenetics of PSC have been the subject of active research and several HLA and non-HLA associated genes have been implicated in the development of the disease.Lymphocytes derived from the inflamed gut may enter the liver via the enterohepatic circulation to cause hepatic disease.PSC may be triggered in genetically susceptible individuals by infections or toxins entering the portal circulation through a permeable colon and hence evoking an abnormal immune response. | Roger Chapman Sue Cullen | 2008 | World Journal of Gastroenterology2008，14，21： | 6 |
| 5 | Natural orifice surgery: initial clinical experience显示文摘 | Santiago Horgan John P. Cullen Mark A. Talamini Yoav Mintz Alberto Ferreres Garth R. Jacobsen Bryan Sandler Julie Bosia Thomas Savides David W. Easter Michelle K. Savu Sonia L. Ramamoorthy Emily Whitcomb Sanjay Agarwal Emily Lukacz Guillermo Dominguez Ped | 2009 | Surgical Endoscopy2009，，7： | 5 |
| 6 | Restoring nervous system structure and function using tissue engineered living scaffolds显示文摘Neural tissue engineering is premised on the integration of engineered living tissue with the host nervous system to directly restore lost function or to augment regenerative capacity following nervous system injury or neurodegenerative disease.Disconnection of axon pathways – the long-distance fibers connecting specialized regions of the central nervous system or relaying peripheral signals – is a common feature of many neurological disorders and injury.However,functional axonal regeneration rarely occurs due to extreme distances to targets,absence of directed guidance,and the presence of inhibitory factors in the central nervous system,resulting in devastating effects on cognitive and sensorimotor function.To address this need,we are pursuing multiple strategies using tissue engineered 'living scaffolds',which are preformed three-dimensional constructs consisting of living neural cells in a defined,often anisotropic architecture.Living scaffolds are designed to restore function by serving as a living labeled pathway for targeted axonal regeneration – mimicking key developmental mechanisms– or by restoring lost neural circuitry via direct replacement of neurons and axonal tracts.We are currently utilizing preformed living scaffolds consisting of neuronal clusters spanned by long axonal tracts as regenerative bridges to facilitate long-distance axonal regeneration and for targeted neurosurgical reconstruction of local circuits in the brain.Although there are formidable challenges in preclinical and clinical advancement,these living tissue engineered constructs represent a promising strategy to facilitate nervous system repair and functional recovery. | Laura A.Struzyna James P.Harris Kritika S.Katiyar H.Isaac Chen D.Kacy Cullen | 2015 | Neural Regeneration Research2015，10，5： | 4 |
| 7 | The role of human papillomavirus in nongenital cancers显示文摘 | Dan P. Zandberg Ranjana Bhargava Simon Badin Kevin J. Cullen | 2012 | CA: A Cancer Journal for Clinicians2012，，1： | 3 |
| 8 | Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonuclease显示文摘 | Edward M. Kennedy Leda C. Bassit Henrik Mueller Anand V.R. Kornepati Hal P. Bogerd Ting Nie Payel Chatterjee Hassan Javanbakht Raymond F. Schinazi Bryan R. Cullen | 2014 | Virology2014，，： | 3 |
| 9 | 钢材轧机的绿色理念显示文摘就能源使用和碳足迹来说,炼铁和炼钢这类初级加工过程往往引起人们的极大关注。而轧制工序,虽然对能源需求很大,但钢铁企业在考虑自身的环境责任和节能机会时,却往往会将其忽略。初级加工过程相比于成品加工过程,能耗高,而且具有重要的影响。绿色轧制的关键主要在于收得率(和避免废品重熔),它就像能源的直接利用一样重要。以意大利阿维迪的全无头带钢生产(ESP)厂的设计和调试项目为案例,介绍现代化轧机如何为绿色钢铁工业做贡献。技术的有关特点包括近终形连铸和直接轧制及取消中间加热所带来的节能效果,传动和能量转换技术的进步,通过收得率最大化而实现节能的方案。还介绍了一些以绿色轧制为宗旨的重要的合作,包括与大学的合作,特别是剑桥大学的WellMet2050项目。作为结论,归纳了一般工业中使用钢铁的绿色原则,为设计打开重要思路。 | M Steeper G Hohenbichler R Shore F Loew J Allwood J Cullen | 2011 | 世界钢铁2011，11，1： | 2 |
| 10 | Plasma-electrified up-carbonization for low-carbon clean energy显示文摘Low-value,renewable,carbon-rich resources,with different biomass feedstocks and their derivatives as typical examples,represent virtually inexhaustive carbon sources and carbon-related energy on Earth.Upon conversion to higher-value forms(referred to as“up-carbonization”here),these abundant feedstocks provide viable opportunities for energy-rich fuels and sustainable platform chemicals production.However,many of the current methods for such up-carbonization still lack sufficient energy,cost,and material efficiency,which affect their economics and carbon-emissions footprint.With external electricity precisely delivered,discharge plasmas enable many stubborn reactions to occur under mild conditions,by creating locally intensified and highly reactive environments.This technology emerges as a novel,versatile technology platform for integrated or stand-alone conversion of carbon-rich resources.The plasma-based processes are compatible for integration with increasingly abundant and cost-effective renewable electricity,making the whole conversion carbon-neutral and further paving the plasma-electrified upcarbonization to be performance-,environment-,and economics-viable.Despite the chief interest in this emerging area,no review article brings together the state-of-the-art results from diverse disciplines and underlies basic mechanisms and chemistry underpinned.As such,this review aims to fill this gap and provide basic guidelines for future research and transformation,by providing an overview of the application of plasma techniques for carbon-rich resource conversion,with particular focus on the perspective of discharge plasmas,the fundamentals of why plasmas are particularly suited for upcarbonization,and featured examples of plasma-enabled resource valorization.With parallels drawn and specificity highlighted,we also discuss the technique shortcomings,current challenges,and research needs for future work. | Rusen Zhou Yadong Zhao Renwu Zhou Tianqi Zhang Patrick Cullen Yao Zheng Liming Dai Kostya(Ken)Ostrikov | 2023 | Carbon Energy2023，5，1： | 2 |
| 11 | Varicella zoster virus infection in inflammatory bowel disease显示文摘 | Garret Cullen Rachel P. Baden Adam S. Cheifetz | 2012 | Inflamm Bowel Dis2012，，12： | 2 |
| 12 | Durham污水处理厂提标改造--新增生污泥厌氧释磷和磷回收显示文摘Durham污水处理厂原采用典型的AAO工艺+强化化学除磷和砂滤,并于2002年研制了UFAT技术对初沉池污泥浓缩发酵,促进可挥发性脂肪酸的释放以利用其作为碳源强化生物脱氮除磷,减少外加除磷所需药剂量。为应对磷排放要求的提升,减少污泥厌氧消化系统中鸟粪石累积对管道、设备等的损害,同时降低消化液回流对主体工艺的氮、磷负荷,该厂进行了升级改造。2009年该厂新增Pearl~磷回收工艺生产基于鸟粪石成分的Crystal Green^(TM)化肥产品,并研发配套的WASSTRIP^(TM)工艺强化磷、镁的释放,以进一步减少鸟粪石在污泥系统中的产生和积累,使得污泥中约65%的磷得到固化利用,改善了生物除磷的效果、减少了后端强化化学除磷所需药剂量的40%,同时提高了消化污泥脱水率,据测算可在7年后收回投资成本并产生经济收益。 | 肖威中 Nate Cullen 陈涛 李军 | 2016 | 净水技术2016，35，6： | 2 |
| 13 | Pancreatic anastomotic leak after pancreaticoduodenectomy:incidence,significance,and management显示文摘 | Cullen JJ Sarr MG Ilstrup DM | 1994 | Am J Surg1994，168，： | 2 |
| 14 | 可持续性和澳大利亚水行业显示文摘可持续性和澳大利亚水行业SustainabilityandtheAustralianWaterIndustry￥PeterCullen(PeterCullen,DirectorofthecooperativeResearchCenterforFres... | Peter Cullen (Peter Cullen, Director of thecooperative Research Center for Freshwater Ecology at the University of Canberra, Australia.) | 1996 | 世界环境1996，，4： | 2 |
| 15 | Transcription and Processing of Human microRNA Precursors显示文摘 | Bryan R. Cullen | 2004 | Molecular Cell2004，，： | 2 |
| 16 | Simple Scoring Scheme for Calculating the Risk of Acute Coronary Events Based on the 10-Year Follow-Up of the Prospective Cardiovascular Münster (PROCAM) Study显示文摘 | Gerd Assmann Paul Cullen Helmut Schulte | 2002 | Circulation: Journal of the American Heart Association2002，，： | 2 |
| 17 | Supportive teacher talk:the importance of the F-move显示文摘 | R | 2002 | ELT Journal2002，562，： | 1 |
| 18 | Hyperglycemia and neurological outcome in patient with head injury显示文摘 | Winn HR Cullen BF | 1991 | Neurosurg1991，75，： | 1 |
| 19 | LipL21 is a novel surface-exposed lipoprotein of pathogenic Leptospira species显示文摘 | Haake DA Bulach DM | 2003 | Infect Immun2003，71，： | 1 |
| 20 | Safety and feasibility of cranictomy with duraplasty as the initial surgical intervention for severe traumatic brain injury显示文摘 | Coplin WM Cullen NK Policberla PN | 2001 | J Trauma2001，50，6： | 1 |
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