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| 1 | Serum Bcl-2 concentrations in overweight-obese subjects with nonalcoholic fatty liver disease显示文摘AIM: To shed some light on the relationship between anti-apoptotic serum Bcl-2 concentrations and metabolic status, anthropometric parameters, inflammation indices, and non-alcoholic fatty liver disease severity were investigated in 43 young individuals with fatty liver (FL)and 41 with nonalcoholic steatohepatitis (NASH).METHODS: Circulating levels of Bcl-2 were detected in 84 patients with ultrasono graphic findings of 'bright liver' and/or hyper-transaminasemia of unknown origin and/or increase in γ-glutamyl-transpeptidase (γ-GT)strictly in the absence of other acute or chronic liver disease, whose age was not advanced, who gave consent to liver biopsy and were then divided on the basis of the histological results into two groups (43 with FL and 41 with NASH). Twenty lean subjects, apparently healthy and young, were chosen as controls.RESULTS: Serum Bcl-2 concentrations were significantly higher in the FL group than in the NASH group. Insulin resistance and γ-GT activity were significantly higher in NASH subjects. Apoptotic hepatocytes were significantly more numerous in NASH patients. NASH patients presented with larger spleens and augmented C-reactive protein (CRP) concentrations than healthy subjects. Steatosis grade at histology was similar in both NASH and FL populations. The number of apoptotic cells was significantly related to anti-apoptotic Bcl-2 protein values in FL patients. Bcl-2 serum levels positively correlated to body mass index (BMI) values (P ≤ 0.0001) but not to age of the population. Triglycerides/HDL ratio correlated well to waist circumference in males (P = 0.0008).γ-GT activity was associated with homeostatic metabolic assessment (HOMA) (P = 0.0003) and with serum ferritin (P = 0.02). Bcl-2 concentrations were not related to either spleen size or CRP values. NASH patients presented a weak negative correlation between lobular inflammation and Bcl-2 levels. A prediction by low values of serum Bcl-2 towards a greater presence of metaboli-cally unhealthy overweight/obese patients (MUOs) was evidenced. HOMA, BMI and uric acid, in that sequence,best predicted serum Bcl-2 concentrations.CONCLUSION: MUOs could be detected by Bcl-2 levels.By favoring the life span of hepatocytes, and enhancing triglyceride formation, the anti-apoptotic process inhibits free fatty acids toxicity in FL. | Giovanni Tarantino Francesco Scopacasa Annamaria Colao Domenico Capone Marianna Tarantino Ernesto Grimaldi Silvia Savastano | 2011 | World Journal of Gastroenterology2011，17，48： | 10 |
| 2 | Expression pattern analysis of odorant-binding proteins in the pea aphid Acyrthosiphon pisum显示文摘有气味的东西绑定蛋白质(OBP ) 是在昆虫的可溶的蛋白质调停化学感应。在以前的研究,我们调查了蚜虫采用检测警报 pheromone (E)-β-farnesene 的分子的机制,我们发现这和在结构上的识别联系了分子被 OBP3 和 OBP7 调停。这里,我们证明 5 的微分表达式模式选择了 OBP (OBP1, OBP3, OBP6, OBP7, OBP8 ) 在成年人的不同身体部分并且在 5 发展中间形态的获得的表现量的 RT-PCR 和 immunolocalization 实验包括 winged 和 unwinged morphs,豌豆蚜虫 Acyrthosiphon pisum。结果提供允许我们在在 OBP 和他们的通常认为的功能的微分表示之间的关系上推测的一幅全面图画。在 antennal sensilla 的 OBP3, OBP6,和 OBP7 的表达式为这些蛋白质建议一个化学感应的函数,而在所有中间形态的 OBP8 的经常的表达式水平能建议一个保存角色。而且, OBP1 和 OBP3 也在 nonsensory 机关被表示。蚜虫,特别地天线,腿, mouthparts,和 cornicles 尾的不同身体部分上的 sensilla 的轻、扫描的电子显微镜学研究,完成提供一个指南便于印射 OBP 表示侧面的这研究。 | Filomena De Biasio Lea Riviello Daniele Bruno Annalisa Grimaldi Terenzio Congiu Yu Feng Sun Patrizia Falabella | 2015 | Insect Science2015，22，2： | 7 |
| 3 | Displacement Trends of Slow-moving Landslides: Classification and Forecasting显示文摘A framework is proposed to characterize and forecast the displacement trends of slow-moving landslides, defined as the reactivation stage of phenomena in rocks or fine-grained soils, with movements localized along one or several existing shear surfaces. The framework is developed based on a thorough analysis of the scientific literature and with reference to significant reported case studies for which a consistent dataset of continuous displacement measurements is available. Three distinct trends of movement are defined to characterize the kinematic behavior of the active stages of slow-moving landslides in a velocity-time plot: a linear trend-type I, which is appropriate for stationary phenomena; a convex shaped trend-type II, which is associated with rapid increases in pore water pressure due to rainfall, followed by a slow decrease in the groundwater level with time; and a concave shaped trend-type III, which denotes a non-stationary process related to the presence of new boundary conditions such as those associated with the development of a newly formed local slip surface that connects with the main existing slip surface. Within the proposed framework, a model is developed to forecast future displacements for active stages of trend-type II based on displacement measurements at the beginning of the stage. The proposed model is validated by application to two case studies. | CASCINI Leonardo CALVELLO Michele GRIMALDI Giuseppe Maria | 2014 | Journal of Mountain Science2014，11，3： | 7 |
| 4 | Novel epigenetic-based therapies useful in cardiovascular medicine显示文摘Epigenetic modifications include DNA methylation, his-tone modifications, and micro RNA. Gene alterations have been found to be associated with cardiovascular diseases, and epigenetic mechanisms are continuously being studied to find new useful strategies for the clinical management of afflicted patients. Numerous cardiovascular disorders are characterized by the abnormal methylation of Cp G islands and so specific drugs that could inhibit DNA methyltransferase directly or by reducing its gene expression(e.g., hydralazine and procainamide) are currently under investigation. The anti-proliferative and anti-inflammatory properties of histone deacetylase inhibitors and their cardio-protective effects have been confirmed in preclinical studies. Furthermore, the regulation of the expression of micro RNA targets through pharmacological tools is still under development. Indeed, large controlled trials are required to establish whether current possible candidate antisense micro RNAs could offer better therapeutic benefits in clinical practice. Here, we updated therapeutic properties, side effects, and feasibility of eme-rging epigenetic-based strategies in cardiovascular diseases by highlighting specific problematic issues that still affect the development of large scale novel therapeutic protocols. | Claudio Napoli Vincenzo Grimaldi Maria Rosaria De Pascale Linda Sommese Teresa Infante Andrea Soricelli | 2016 | World Journal of Cardiology2016，8，2： | 5 |
| 5 | AME证据系列001--转化医学协会:脓毒症诊断和早期识别的临床实践指南显示文摘脓毒症是一种由感染引起的异质性疾病,感染触发了一系列复杂的局部或者全身的免疫炎症反应,引起多器官功能衰竭,发病率和病死率显著升高。由于至今仍然没有诊断脓毒症的金标准,所以脓毒症的临床诊断仍是一个难题。因此,脓毒症的临床诊断需要不断改变来满足临床和研究的要求。然而,尽管有许多新型的生物标记和筛选工具去预测脓毒症发生的风险,但是这些措施的诊断价值和有效性不足以让人满意,并且没有充分的证据去建议临床使用这些新技术。因此,脓毒症的临床诊断标准需要定期更新去适应不断产生的新证据。这篇综述旨在呈现当前脓毒症的诊断和早期识别方面的最新研究证据。临床运用不同的诊断方法的推荐意见依赖于推荐、评价、发展和评估分级体系(Grades of Recommendation Assessment,Development and Evaluation,GRADE),因为大部分的研究是观察性研究,并没有对这些方法进行可靠评估,采用的是两步推理方法。未来需要更多研究来确认或者反驳某一特殊的指标检测,同时应该直接采用相关病人的结果数据。 | Zhongheng Zhang Nathan J.Smischney Haibo Zhang Sven Van Poucke Panagiotis Tsirigotis Jordi Rello Patrick M.Honore Win Sen Kuan Juliet June Ray Jiancang Zhou You Shang Yuetian Yu Christian Jung Chiara Robba Fabio Silvio Taccone Pietro Caironi David Grimaldi Stefan Hofer George Dimopoulos Marc Leone Sang-Bum Hong Mabrouk Bahloul Laurent Argaud Won Young Kim Herbert D.Spapen Jose Rodolfo Rocco 张建成(译) 尚游(译) 钟鸣(校) | 2016 | 临床与病理杂志2016，36，10： | 5 |
| 6 | Sampling Variability of Liver Biopsy in Nonalcoholic Fatty Liver Disease显示文摘 | Vlad Ratziu Frédéric Charlotte Agnès Heurtier Sophie Gombert Philippe Giral Eric Bruckert André Grimaldi Frédérique Capron Thierry Poynard | 2005 | Gastroenterology2005，，7： | 4 |
| 7 | Computed tomographic colonography in subjects with positive faecal occult blood test refusing optical colonoscopy显示文摘 | Lapo Sali Grazia Grazzini Leonardo Ventura Massimo Falchini Alessandra Borgheresi Guido Castiglione Michele Grimaldi Nicola Ianniciello Beatrice Mallardi Marco Zappa Mario Mascalchi | 2012 | Digestive and Liver Disease2012，，： | 3 |
| 8 | Long-term outcome of pancreatic function following oncological surgery in children:Institutional experience and review of the literature显示文摘BACKGROUND Pancreatic neoplasms are uncommon in children and in most cases they are benign or have low malignant potential.Pancreatoblastoma and solid pseudopapillary tumor are the most frequent types in early and late childhood,respectively.Complete resection,although burdened by severe complications,is the only curative treatment for these diseases.Pancreatic surgery may result in impaired exocrine and endocrine pancreatic function.However,limited data are available on the long-term pediatric pancreatic function following surgical resection.AIM To investigate endocrine and exocrine pancreatic function and growth after oncological pancreatic surgery in a pediatric series.METHODS A retrospective analysis of all pediatric patients who underwent surgery for pancreatic neoplasm in our Institution from January 31,2002 to the present was performed.Endocrine and exocrine insufficiency,auxological and fat-soluble vitamin status(A,D,E and clotting tests)were assessed at diagnosis and at every follow-up visit.Exocrine insufficiency was defined as steatorrhea with fecal elastase-1<200μg/g stool,while endocrine insufficiency was identified as onset of Diabetes or Impaired Glucose Tolerance.Growth was evaluated based on body mass index(BMI)z-score trend.RESULTS Sixteen patients(12 girls and 4 boys,mean age 10.7±5.3 years),were included.Nine patients(56%)had a neoplasm in the pancreatic head,4 in the body/tail,2 in the tail and 1 in the body.Histological findings were as follows:Solid pseudopapillary tumor in 10 patients(62.5%),insulinoma in 2 patients,neuroendocrine tumor in 2 patients and acinar cell carcinoma in 2 patients.The most frequent surgery was pancreaticoduodenectomy(50%).Exocrine failure occurred in 4 patients(25%)and endocrine failure in 2 patients(12.5%).Exocrine insufficiency occurred early(within 6 mo after surgery)and endocrine insufficiency later(8 and 10 years after surgery).Mean BMI z-score was 0.36±1.1 at diagnosis and 0.27±0.95 at the last assessment.Vitamin D was insufficient(<30 ng/mL)in 8 of the 16 patients during the follow-up period.Vitamins A,E and clotting test were into the normal ranges in all patients.CONCLUSION Careful and long-term monitoring should follow any pancreatic surgery,to recognize and promptly treat exocrine and endocrine pancreatic insufficiency,which can occur after surgery. | Giulia Bolasco Teresa Capriati Chiara Grimaldi Lidia Monti Maria Debora De Pasquale Ippolita Patrizia Patera Marco Spada Giuseppe Maggiore Antonella Diamanti | 2021 | World Journal of Clinical Cases2021，9，25： | 2 |
| 9 | Three-dimensional modelling of tunnel excavation and lining显示文摘 | G Galli A Grimaldi A Leonardi | 2004 | Computers and Geotechnics2004，，3： | 2 |
| 10 | Epigenetic Reprogramming in Atherosclerosis显示文摘 | Vincenzo Grimaldi Maria Teresa Vietri Concetta Schiano Antonietta Picascia Maria Rosaria De Pascale Carmela Fiorito Amelia Casamassimi Claudio Napoli | 2015 | Current Atherosclerosis Reports2015，，2： | 2 |
| 11 | Business incubators and new venture creation: An assessment of incubating models显示文摘 | Grimaldi R and Grandi A | 2005 | Technovation2005，25，2： | 1 |
| 12 | Anandamide inhibits adhesion and migration of breast cancer cells显示文摘 | Grimaldi C Pisanti S Laezza C | 2006 | Exp Cell Res2006，312，4： | 1 |
| 13 | Effect of chemical interesterification on physicochemical properties and industrial applications of c anola oil and fully hydrogenated cottonseed oil blends 显示文摘 | RIBEIRO A P B BASSO R C GRIMALDI R | 2009 | Journal of Food Lipids2009，16，3： | 1 |
| 14 | 显示文摘 | Sartore A Grimaldi E Guaschino S | 2003 | Am J Obstet Gynecol2003，189，3： | 1 |
| 15 | Sex hormone and SLE: influencing the fate of autoreactive B cells 显示文摘 | Solal JF Jeganathan V Grimaldi CM | 2006 | Curr Top Microbiol Immunol2006，305，： | 1 |
| 16 | Spontaneous osteoclast formation from peripheral blood mononuclear cells in postmenopausal osteoporosis显示文摘 | Damelio P Grimaldi A Pescarmona GP et at | 2005 | FASEB J2005，19，3： | 1 |
| 17 | The Complete Genome Sequence of Lactobacillus bulgaricus Reveals Exten- sive and Ongoing Reductive Evolution 显示文摘 | VAN D E GUCHTE M PENAUD S GRIMALDI C | 2006 | Proceedings of the Na- tional Academy of Sciences of the United States of America2006，103，： | 1 |
| 18 | The role of carbon dioxide therapy in the treatment of chronic wounds 显示文摘 | Brandi C Grimaldi L Nisi G | 2010 | In Vivo2010，24，2： | 1 |
| 19 | 30 years af- ter Bayh-Dole: Reassessing academic entrepreneur- ship显示文摘 | Grimaldi R Kenney M Siegel D | 2011 | Research Policy2011，40，8： | 1 |
| 20 | Peroxisome proliferator-activated recep- tors as sensors of fatty acids and derivatives显示文摘 | GRIMALDI P A | 2007 | Cell Mol Life Sci2007，64，1920： | 1 |
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