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| 1 | Comparison of inhaled milrinone, nitric oxide and prostacyclin in acute respiratory distress syndrome显示文摘AIM To evaluate the safety and efficacy of inhaled milrinone in acute respiratory distress syndrome(ARDS).METHODS Open-label prospective cross-over pilot study where fifteen adult patients with hypoxemic failure meeting standard ARDS criteria and monitored with a pulmonary artery catheter were recruited in an academic 24-bed medico-surgical intensive care unit. Random sequential administration of i NO(20 ppm) or nebulized epoprostenol(10 μg/mL) was done in all patients. Thereafter, inhaled milrinone(1 mg/mL) alone followed by inhaled milrinone in association with inhaled nitric oxide(iN O) was administered. A jet nebulization device synchronized with the mechanical ventilation was use to administrate the epoprostenol and the milrinone. Hemodynamic measurements and partial pressure of arterial oxygen(PaO_2) were recorded before and after each inhaled therapyadministration.RESULTS The majority of ARDS were of pulmonary cause(n = 13) and pneumonia(n = 7) was the leading underlying initial disease. Other pulmonary causes of ARDS were: Post cardiopulmonary bypass(n = 2), smoke inhalation injury(n = 1), thoracic trauma and pulmonary contusions(n = 2) and aspiration(n = 1). Two patients had an extra pulmonary cause of ARDS: A polytrauma patient and an intra-abdominal abscess Inhaled nitric oxide, epoprostenol, inhaled milrinone and the combination of inhaled milrinone and i NO had no impact on systemic hemodynamics. No significant adverse events related to study medications were observed. The median increase of PaO 2 from baseline was 8.8 mmH g [interquartile range(IQR) = 16.3], 6.0 mm Hg(IQR = 18.4), 6 mm Hg(IQR = 15.8) and 9.2 mm Hg(IQR = 20.2) respectively with i NO, epoprostenol, inhaled milrinone, and i NO added to milrinone. Only i NO and the combination of inhaled milrinone and i NO had a statistically significant effect on PaO 2. CONCLUSION When comparing the effects of inhaled NO, milrinone and epoprostenol, only NO significantly improved oxygenation. Inhaled milrinone appeared safe but failed to improve oxygenation in ARDS. | Martin Albert Daniel Corsilli David R Williamson Marc Brosseau Patrick Bellemare Stéphane Delisle Anne QN Nguyen France Varin | 2017 | World Journal of Critical Care Medicine2017，6，1： | 4 |
| 2 | IFNβ/TNFa synergism induces a non-canonical STAT2/IRF9-dependent pathway triggering a novel DUOX2 NADPH Oxidase-mediated airway antiviral response显示文摘 | Karin Fink Lvdie Martin Esperance Mukawera St&any Chartier Xavier De Deken Emmanuelle Brochiero Francoise Mi Nathalie Grandvaux | 2013 | Cell Research2013，23，5： | 3 |
| 3 | Dual Peroxisome Proliferator–Activated Receptor α/δ Agonist GFT505 Improves Hepatic and Peripheral Insulin Sensitivity in Abdominally Obese Subjects显示文摘 | Bertrand Cariou Rémy Hanf Stéphanie Lambert-Porcheron Yassine Za?r Valérie Sauvinet Benoit No?l Laurent Flet Hubert Vidal Bart Staels Martine Laville | 2013 | Diabetes Care2013，，10： | 2 |
| 4 | Matrix metalloproteinase-13 is regulated by toll-like receptor-9 incolorectal cancer cells and mediates cellular migration显示文摘 | Timo Rath Julia St?ckle Martin Roderfeld Annette Tschuschner Jürgen Graf Elke Roeb | 2011 | Oncology Letters2011，，3： | 2 |
| 5 | Co-occurrence of infantile epileptic seizures and childhood paroxysmal choreoathetosis in one family:clinical,EEG,and SPECT characterization of episodic events显示文摘 | Thiriaux A de St Martin A Vercueil L | 2002 | Mov Disord2002，79，1： | 1 |
| 6 | A histochemical study of iron,transferrin,and ferritin in Alzheimer’s diseased brains显示文摘 | Connor J R Menzies S L St Martin S M | 1992 | J Neurosci Res1992，31，1： | 1 |
| 7 | Engineering a mevalonate pathway in Escherichia coli for production of terpenoids 显示文摘 | Martin VJJ Pitera DJ Withers ST | 2003 | Nature Biotechnology2003，21，7： | 1 |
| 8 | Systematic review of out- comes after intersphincteric resection for low rectal cancer显示文摘 | Martin ST Heneghan HM Winter DC | 2012 | Br J Surg2012，99，5： | 1 |
| 9 | Systematic review of out- comes after intersphincteric resection for low rectal cancer 显示文摘 | Martin ST Heneghan HM Winter DC | 2012 | Br J Surg2012，99，5： | 1 |
| 10 | Winding down in a Qubic town:A case study of Schefferville显示文摘 | Bradbury J H St Martin I | 1983 | The Canadian Geographer1983，27，2： | 1 |
| 11 | Recommendations for the Management of Hepatitis C Virus Infection Among People Who Inject Drugs显示文摘 | Geert Robaeys Jason Grebely Stefan Mauss Philip Bruggmann Joseph Moussalli Andrea De Gottardi Tracy Swan Amber Arain Achim Kautz Heino St?ver Heiner Wedemeyer Martin Schaefer Lynn Taylor Markus Backmund Olav Dalgard Maria Prins Gregory J. Dore | 2013 | Clinical Infectious Diseases . 2013 (supp)2013，，： | 1 |
| 12 | Environmental applications of semiconductor photocatalysis 显示文摘 | Hoffmann MR Martin ST Choi W | 1995 | Chem Rev1995，，： | 1 |
| 13 | Molting cycle-dependent expression of CYP4C15, a cytochrome P450 enzyme putatively involved in ecdysteroidogenesis in the crayfish, Orconectes limosus显示文摘 | Santiago Aragon Stéphanie Claudinot Catherine Blais Martine Ma??bèche Chantal Dauphin-Villemant | 2002 | Insect Biochemistry and Molecular Biology2002，，2： | 1 |
| 14 | Imaging of hearing loss显示文摘 | St Martin M B Hirsch B E | 2008 | Otolaryngologic Clinics of North America2008，41，1： | 1 |
| 15 | Engineering a mevalonate pathway in Escherichia coli for production of terpenoids显示文摘 | Martin VJJ Pitera DJ Withers ST 2003 | 2003 | Nature Biotechnology2003，21，： | 1 |
| 16 | The potential of arsenic trioxide in the treatment of malignant diseae:past,present,and future显示文摘 | Andrew M E Martin ST Ronald BG | 2004 | Leukemia Research2004，28，： | 1 |
| 17 | Severe Pasteurella multocida infection in a patient on rituximab therapy for rheumatoid arthritis显示文摘 | Alban Rouil Stéfan Pollet Antoine Martin Pierre Tattevin Aleth Perdriger | 2012 | Joint Bone Spine2012，，： | 1 |
| 18 | Systematic review of out- comes afler intersphincteric resection for low rectal cancer 显示文摘 | Martin ST Heneghan HM Winter DC | 2012 | Br J Surg2012，99，5： | 1 |
| 19 | Impact of allogeneic haematopoietic stem cell transplantation in patients with abnl(17p) acute myeloid leukaemia显示文摘 | Brigitte Mohr Johannes Schetelig Kerstin Sch?fer‐Eckart Norbert Schmitz Mathias H?nel Wolf R?sler Norbert Frickhofen Hartmut Link Andreas Neubauer Ulrich Schuler Uwe Platzbecker Jan M. Middeke Gerhard Ehninger Martin Bornh?user Markus Schaich Friedrich St | 2013 | Br J Haematol2013，，： | 1 |
| 20 | Recommendations for the Management of Hepatitis C Virus Infection Among People Who Inject Drugs显示文摘 | Geert Robaeys Jason Grebely Stefan Mauss Philip Bruggmann Joseph Moussalli Andrea De Gottardi Tracy Swan Amber Arain Achim Kautz Heino St?ver Heiner Wedemeyer Martin Schaefer Lynn Taylor Markus Backmund Olav Dalgard Maria Prins Gregory J. Dore | 2013 | Clinical Infectious Diseases (suppl )2013，，2： | 1 |
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