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| 1 | STING signaling activation inhibits HBV replication and attenuates the severity of liver injury and HBV-induced fibrosis显示文摘The covalently closed circular DNA(cccDNA)of HBV plays a crucial role in viral persistence and is also a risk factor for developing HBV-induced diseases,including liver fibrosis.Stimulator of interferon genes(STING),a master regulator of DNA-mediated innate immune activation,is a potential therapeutic target for viral infection and virus-related diseases.In this study,agonist-induced STING signaling activation in macrophages was revealed to inhibit cccDNA-mediated transcription and HBV replication via epigenetic modification in hepatocytes.Notably,STING activation could efficiently attenuate the severity of liver injury and fibrosis in a chronic recombinant cccDNA(rcccDNA)mouse model,which is a proven suitable research platform for HBV-induced fibrosis.Mechanistically,STING-activated autophagic flux could suppress macrophage inflammasome activation,leading to the amelioration of liver injury and HBV-induced fibrosis.Overall,the activation of STING signaling could inhibit HBV replication through epigenetic suppression of cccDNA and alleviate HBV-induced liver fibrosis through the suppression of macrophage inflammasome activation by activating autophagic flux in a chronic HBV mouse model.This study suggests that targeting the STING signaling pathway may be an important therapeutic strategy to protect against persistent HBV replication and HBV-induced fibrosis. | Yuqi Li Minjing He Ziyu Wang Zhiyun Duan Zhiwei Guo Ziteng Wang Ruijie Gong Tianhao Chu Jiabin Cai Bo Gao | 2022 | Cellular & Molecular Immunology2022，19，1： | 7 |
| 2 | 硬骨鱼类干扰素调节因子4,8,9,10基因比较显示文摘目的:为了阐明硬骨鱼类IRF4、IRF8、IRF0和IRF10在进化上的保守及分化。方法:从Ensembl和NCBI数据库下载基因的DNA和蛋白序列,绘制基因框架图,利用Mega5.0构建系统进化树,采用DNAStar计算蛋白相似率,利用Pfam软件分析保守结构域。结果:IRF8和IRFIO是相当保守的。各种硬骨鱼类中IRF8和IRF10基本一致。不同物种IRF8蛋白相似性最高(60%-87%),其次为IRF10(49~78%)。但IRF9和IRF4分化较大。硬骨鱼类有1—2个IRF9基因,1—3个IRF4基因。不同物种IRF4蛋白相似率为54—88%,IRF0更低(35—71%)。此外,在硬骨鱼类IRF9和IRF4蛋白上还发现有多种结构域。结论:硬骨鱼类IRF8和IRFIO非常保守,不同物种均含有8个外显子和7个内含子,蛋白相似性分别达到60%-87%和49。78%。IRF4和IRF0分化更大,不同物种基因数量从1变化到3,蛋白相似率低。 | 庹锐 许巧情 赵朝阳 万晶 袁汉文 李鹏 江涛 | 2013 | 生物技术2013，23，5： | 3 |
| 3 | 双重氧化酶与呼吸系统关系的研究进展显示文摘氧化应激是导致呼吸系统疾病的一个主要原因。近来越来越多的证据表明NADPH氧化酶在呼吸系统产生活性氧(ROS)过程中发挥重要作用。NADPH氧化酶体系现在已基本确定7种氧化酶(NOX)同源异构体,包括NOX1-5、DUOX1、DUOX2,两种组织亚基(p47phox、NOXO1),两种激活亚基(p67phox、NOXA1),以及两种双重氧化酶(DUOX)特定的成熟因素(DUOXA1和DUOXA2)-[1]。 | 黄云 黄文杰 | 2016 | 中国呼吸与危重监护杂志2016，15，1： | 0 |
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