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65篇 您的检索式：作者名="Roderfeld"

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	题名	作者	年代	出处	被引量
1	Innovative immunohistochemistry identifies MMP-9 expressing macrophages at the invasive front of murine HCC显示文摘AIM:To investigate the proteolytic contribution of tumor-associated macrophages(TAM)in tumor invasion,we analyzed whether TAM at the invasive front of small HCC in Abcb4-/--mice show an enhanced expression of MMP-9. METHODS:Liver cryosections of the hepatocellular carcinoma(HCC)invasive front from 12 mo old Abcb4-/--mice were stained for collagen typeⅠand MMP-9 using Alexa488 and Alexa568 labeled secondary antibodies.Afterwards,the Alexa568 dye was bleached and the macrophage marker F4/80 was visualized using Alexa568 labeled secondary antibodies.Finally, photographs of the invasive tumor front were digitally overlaid and analyzed. RESULTS:After complete bleaching of the primary dye,specific fluorescence staining of a third antigen, here F4/80,was successfully performed on the same histological section.With this method,we were able to identify conglomerates of matrix metalloproteinase (MMP-9)expressing macrophages within the tumor capsule of HCC. CONCLUSION:MMP-9 expressing macrophages are involved in matrix remodelling at the invasive tumor front of HCC.The described staining protocol provides a simple yet powerful extension of conventional immuno-histochemistry,facilitating visualization of at least three different antigens plus nuclei in one single histological section.	Martin Roderfeld Timo Rath Frank Lammert Christian Dierkes Jürgen Graf Elke Roeb	2010	World Journal of Hepatology2010，2，5：	6
2	Matrix metalloproteinase-13 is regulated by toll-like receptor-9 incolorectal cancer cells and mediates cellular migration显示文摘	Timo Rath Julia St?ckle Martin Roderfeld Annette Tschuschner Jürgen Graf Elke Roeb	2011	Oncology Letters2011，，3：	2
3	MMP-9 hemopexin domain hampers adhesion and migration of colorectal cancer cells显示文摘	Roderfeld M Wagner S	2007	Int J Oncol2007，30，4：	1
4	Matrix metalloproteinases in inflammatory bowel disease-from basic research to clinical significance显示文摘	Rath T Roderfeld M Graf J	2009	ZGastroenterol2009，47，8：	1
5	Inhibition of hepatic fibrogenesis by matrix metalloproteinase-9 mu- tants in mice显示文摘	Roderfeld M Weiskirchen R Wagner S	2006	FASEB J2006，20，3：	1
6	Bone marrow transplantation improves hepatic fibrosis in Abcb4-/-mice via Th1 response and matrix metalloproteinase activity显示文摘	Roderfeld M Rath T Pasupuleti S		0，，06：	1
7	Matrix metalloprotei- nase inflammatory bowel disease from basic research to clinical sig- nify cance显示文摘	RATH T RODERFELD M GRAF J	2009	Z Gastroenterol2009，47，8：	1
8	1 Matrixmetallop roteinases in inflamm a- tory bowel disease-from basic research to clinical significance显示文摘	Rath T Roderfeld M Graf J et a	2009	Zgas- troen tero2009，47，8：	1
9	Cytokine blockade inhibits hepatic tissue inhibitor of metalloproteinase - 1 expression and up - regulates matrix metalloproteinase - 9 in toxic liver injury 显示文摘	Roderfeld M Geier A Dietrich CG	2006	Liver Int2006，26，5：	1
10	Inhibition of he- patic fibrogenesis by matrix metalloproteinase-9 mutants in mice 显示文摘	Roderfeld M Weiskirchen R Wagner S	2006	FASEB J2006，20，3：	1
11	TIMP-1/-2 and transient elastography allow non invasive diagnosis of cystic fibrosis associated liver disease显示文摘	Timo Rath Katrin Menendez Menendez Marion Kügler Lisa Hage Christian Wenzel Richard Schulz Jürgen Graf Lutz N?hrlich Elke Roeb Martin Roderfeld	2012	Digestive and Liver Disease2012，，9：	1
12	MMP-9- hemopexin domain hampers adhesion and migration of colorectal cancer cells显示文摘	Burg-Roderfeld M Roderfeld M Wagner S	2007	Int J Oncol2007，30，4：	1
13	Matrix metalloproteinases in inflammatory bowel disease-from basic research to clinical significance显示文摘	Rath T Roderfeld M Graf J	2009	ZGastroenterol2009，47，8：	1
14	Expression of MMPs and TIMPs in liver fibrosis-a systematic review with special emphasis on anti-fibrotic strategies显示文摘	Hemmann S Graf J Roderfeld M	2007	J Hepatol2007，46，5：	1
15	Inhibition ofhepatic fibrogenesis by matrix metalloproteinase-9 mutants in mice显示文摘	Roderfeld M Weiskirchen R Wagner S	2006	FASEB J2006，20，3：	1
16	The impact of proteinase-induced matrix degradation on the release of VEGF from heparinized collagen matrices显示文摘	Yao C Roderfeld M Rath T	2006	Biomaterials2006，27，8：	1
17	Activation of hepatic stellate cells is associated with cytokine expression in thioacetamide-induced hepatic fibrosis in mice 显示文摘	Palacios RS Roderfeld M Hemmann S Rath T Atanasova S Tschu- schner A	2008	Lab Investigation2008，88，7：	1
18	Expression of MMPs and TIMPs in liver fibrosis-a systematic review with special emphasis on anti-fibrotic strategies 显示文摘	Hemmann S Graf J Roderfeld M	2007	J Hepatol2007，46，5：	1
19	Activation of hepatic stellate cells is associated with cytokine expression in thioac- etamide-induced hepatic fibrosis in mice 显示文摘	Salguero Palacios R Roderfeld M Hemmann S	2008	Lab Invest2008，88，：	1
20	Matrix metallproteinases in inflammatory bowel disease-fnm basic research to clinical significance 显示文摘	Rath T Roderfeld M Graf J	2009	Z Gastroenterol2009，47，8：	1

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