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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Recent Progress in Studies of the Variabilities and Mechanisms of the East Asian Monsoon in a Changing Climate显示文摘Located in a monsoon domain,East Asia suffers devastating natural hazards induced by anomalous monsoon behaviors.East Asian monsoon(EAM)research has traditionally been a high priority for the Chinese climate community and is particularly challenging in a changing climate where the global mean temperature has been rising.Recent advances in studies of the variabilities and mechanisms of the EAM are reviewed in this paper,focusing on the interannual to interdecadal time scales.Some new results have been achieved in understanding the behaviors of the EAM,such as the evolution of the East Asian summer monsoon(EASM),including both its onset and withdrawal over the South China Sea,the changes in the northern boundary activity of the EASM,or the transitional climate zone in East Asia,and the cycle of the EASM and the East Asian winter monsoon and their linkages.In addition,understanding of the mechanism of the EAM variability has improved in several aspects,including the impacts of different types of ENSO on the EAM,the impacts from the Indian Ocean and Atlantic Ocean,and the roles of mid-to high-latitude processes.Finally,some scientific issues regarding our understanding of the EAM are proposed for future investigation. | Wen CHEN Lin WANG Juan FENG Zhiping WEN Tiaojiao MA Xiuqun YANG Chenghai WANG | 2019 | Advances in Atmospheric Sciences2019，36，9： | 13 |
| 3 | Intrinsic apoptotic pathway and G2/M cell cycle arrest involved in tubeimoside I-induced EC109 cell death显示文摘Objective: Squamous esophageal carcinoma is highly prevalent in developing countries, especially in China. Tu Bei Mu (TBM), a traditional folk medicine, has been used to treat esophageal squamous cell carcinoma (ESCC) for a long term. tubeimoside I (TBMS1) is the main component of TBM, exhibiting great anticancer potential. In this study, we investigated the mechanism of TBMS1 cytotoxic effect on EC109 cells. Methods: Comparative nuclear proteomic approach was applied in the current study and we identified several altered protein spots. Further biochemical studies were carried out to detect the mitochondrial membrane potential, cell cycle and corresponding proteins' expression and location. Results: Subcellular proteomic study in the nucleus from EC109 cells revealed that altered proteins were associated with mitochondrial function and cell proliferation. Further biochemical studies showed that TBMS1-induced molecular events were related to mitochondria-induced intrinsic apoptosis and P21-cyclin B1/cdc2 complex-related G2/M cell cycle arrest. Conclusions: Considering the conventional application of TBM in esophageal cancer, TBMS1 therefore may have a great potential as a chemotherapeutic drug candidate for ESCC. | Yang Xu Guanghui Wang Quancheng Chen Ting Lin Zhiping Zeng Qiang Luo Jie Liu Cuiling Sun | 2013 | Chinese Journal of Cancer Research2013，25，3： | 12 |
| 4 | Olivine-norite rock detected by the lunar rover Yutu-2 likely crystallized from the SPA-impact melt pool显示文摘Chang’E-4 landed in the South Pole-Aitken(SPA)basin,providing a unique chance to probe the composition of the lunar interior.Its landing site is located on ejecta strips in Von Karm´an crater that´possibly originate from the neighboring Finsen crater.A surface rock and the lunar regolith at 10 sites along the rover Yutu-2 track were measured by the onboard Visible and Near-Infrared Imaging Spectrometer in the first three lunar days of mission operations.In situ spectra of the regolith have peak band positions at 1 and 2μm,similar to the spectral data of Finsen ejecta from the Moon Mineralogy Mapper,which confirms that the regolith’s composition of the landing area is mostly similar to that of Finsen ejecta.The rock spectrum shows similar band peak positions,but stronger absorptions,suggesting relatively fresh exposure.The rock may consist of 38.1±5.4%low-Ca pyroxene,13.9±5.1%olivine and 48.0±3.1%plagioclase,referred to as olivine-norite.The plagioclase-abundant and olivine-poor modal composition of the rock is inconsistent with the origin of the mantle,but representative of the lunar lower crust.Alternatively,the rock crystallized from the impact-derived melt pool formed by the SPA-impact event via mixing the lunar crust and mantle materials.This scenario is consistent with fast-cooling thermal conditions of a shallow melt pool,indicated by the fine to medium-sized texture(<3 mm)of the rock and the SPA-impact melting model[Icarus 2012;220:730–43]. | Honglei Lin Zhiping He Wei Yang Yangting Lin Rui Xu Chi Zhang Meng-Hua Zhu Rui Chang Jinhai Zhang Chunlai Li Hongyu Lin Yang Liu Sheng Gou Yong Wei Sen Hu Changbin Xue Jianfeng Yang Jie Zhong Xiaohui Fu Weixing Wan Yongliao Zou | 2020 | National Science Review2020，7，5： | 9 |
| 5 | Geological characteristics and tectonic signifcance of unconformities in Mesoproterozoic successions in the northern margin of the North China Block显示文摘Several stratigraphic breaks and unconformities exist in the Mesoproterozoic successions in the northern margin of the North China Block.Geologic characters and spatial distributions of fve of these unconformities,which have resulted from different geological processes,have been studied.The unconformity beneath the Dahongyu Formation is interpreted as a breakup unconformity,representing the time of transition from continental rift to passive continental margin.The unconformities beneath the Gaoyuzhuang and the Yangzhuang formations are considered to be the consequence of regional eustatic fuctuations,leading to the exposure of highlands in passive margins during low sea-level stands and transgressive deposition on coastal regions during high sea-level stands.The unconformity atop the Tieling Formation might be caused by uplift due to contractional deformation in a back-arc setting,whereas the uplift after the deposition of the Xiamaling Formation might be attributed to a continental collision event.It is assumed that the occurrences of these unconformities in the Mesoproterozoic successions in the northern margin of the North China Block had a close bearing on the assemblage and breakup of the Columbia and Rodinia supercontinents. | Yongqiang Qu Jianguo Pan Shouxian Ma Zhiping Lei Lin Li Guoli Wu | 2014 | Geoscience Frontiers2014，5，1： | 7 |
| 6 | In-situ surface decoration of RuO_(2) nanoparticles by laser ablation for improved oxygen evolution reaction activity in both acid and alkali solutions显示文摘Improving the OER activity of noble metal-based materials is of profound importance to minimize the usage of noble metals and lower the cost.Here,we report considerable improvement on the catalytic activity of RuO_(2) particles for OER in both alkali and acid environments.The RuO_(2) nanoparticles were treated with a method of pulse laser ablation.Numerous Ru and RuO_(2) clusters were generated at the surface of RuO_(2) nanoparticles after the laser ablation,forming a lychee-shaped morphology.The larger pulse energy RuO_(2) nanoparticles are treated with,the better the OER activity can be.DFT calculations shows that the surface tension induced by the lychee-shaped morphology benefits the OER performance.Our best sample gives an overpotential of 172 mV(at 10 mA cm^(-2))and a Tafel slope of 53.5 mV dec^(-1) in KOH,while an overpotential of 219 mV and a Tafel slope of 44.9 mV dec^(-1) in H_(2)SO_(4),which are of topclass results.This work may inspire a new way to develop high-performance electrocatalysts for OER. | Zongpeng Wang Beibei Xiao Zhiping Lin Shijie Shen Aijiao Xu Zexin Du Yuchao Chen Wenwu Zhong | 2021 | Journal of Energy Chemistry2021，30，3： | 4 |
| 7 | Diode-pumped wavelength-switchable visible Pr^(3+):YLF laser and vortex laser around 670 nm显示文摘Here we developed a novel wavelength-switchable visible continuous-wave(CW)Pr^(3+):YLF laser around 670 nm.In single-wavelength laser operations,the maximum output powers of 2.60 W,1.26 W,and 0.21 W,the maximum slope efficiencies of 34.7%,27.3%,and 12.3%were achieved with good beam qualities(M^(2)<1.6)at 670.4 nm,674.2 nm,and 678.9 nm,respectively.Record-high output power(2.6 W)and record-high slope efficiency(34.7%)were achieved for the Pr^(3+):YLF laser operation at 670.4 nm.This is also the first demonstration of longer-wavelength peaks beyond 670 nm in the^(3)P_(1)→^(3)F_(3)transition of Pr^(3+):YLF.In multi-wavelength laser operations,the dual-wavelength lasings,including 670.1/674.8 nm,670.1/679.1 nm,and 675.0/679.4 nm,were obtained by fine adjustment of one/two etalons within the cavity.Furthermore,the triple-wavelength lasings,e.g.672.2/674.2/678.6 nm and 670.4/674.8/679.4 nm,were successfully demonstrated.Moreover,both the first-order vortex lasers(LG_(0)^(+1)and LG_(0)^(-1)modes)at 670.4 nm were obtained by off-axis pumping. | Xiuji Lin Qichen Feng Yao Zhu Shuaihao Ji Bo Xiao Huiying Xu Wensong Li Zhiping Cai | 2021 | Opto-Electronic Advances2021，4，4： | 4 |
| 8 | Three-dimensional image authentication using binarized images in double random phase integral imaging显示文摘We proposed a three-dimensional (3D) image authentication method using binarized phase images in double random phase integral imaging (Ini). Two-dimensional (2D) element images obtained from Ini are encoded using a double random phase encryption (DRPE) algorithm. Only part of the phase information is used in the proposed method rather than using all of the amplitude and phase information, which can make the final data sparse and beneficial to data compression, storage, and transmission. Experimental results verified the method and successfully proved the developed 3D authentication process using a nonlinear cross correlation method. | 宋维涛 程齐家 刘越 Yuanjin Zheng Zhiping Lin 王涌天 | 2019 | Chinese Optics Letters2019，17，5： | 2 |
| 9 | NSC-640358 acts as RXRa ligand to promote TNFa-mediated apoptosis of cancer cell显示文摘 | Fan Chen Jiebo Chen Jiacheng Lin Anton V. Cheltsov Lin Xu Ya Chen Zhiping Zeng Liqun Chen Mingfeng Huang Mengjie Hu Xiaohong Ye YuqiZhou Guanghui Wang Ying su Long Zhang Fangfang Zhou Xiao-kun Zhang HU Zhou | 2015 | Protein & Cell2015，6，9： | 2 |
| 10 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 11 | 显示文摘 | Lin Zhanru Yu Zhiping Hu Hanjie | 1999 | Prog in Nat Sci1999，9，10： | 1 |
| 12 | Quantum waveguide theory of a fractal structure显示文摘 | Lin Zhiping Hou Zhilin Liu Youyan | 2007 | Physics Letters A2007，365，3： | 1 |
| 13 | Selbadaptive evolutionary extreme learning machine 显示文摘 | Cao Jiuwen Lin Zhiping Huang Guangbin | 2012 | Neural Processing Letters2012，36，3： | 1 |
| 14 | 显示文摘 | Lin Zhanru Yu Zhiping Hu Hanjie | 1999 | Prog in Nate Sei1999，9，10： | 1 |
| 15 | Pollen-like self-supported FeIr alloy for improved hydrogen evolution reaction in acid electrolyte显示文摘Ir is recognized as efficient catalyst for hydrogen evolution reaction(HER).The high price,however,has hindered its application in the production of hydrogen.In this work,we prepared the self-supported FeIr alloy nanoparticles,taking advantage of solid-state synthesis method.The as-prepared FeIr alloy possesses a novel morphology of pollen,which is consist of smaller FeIr nanoparticles.DFT calculations reveal that the change of the free Gibbs for Ir is negative after the adsorption of active H,while it is positive for the case of Fe.Thus,the alloying of Fe and Ir not only effectively reduces the cost,but also can achieve more adequate adsorption of active H species.Benefitting from this,the as-prepared FeIr alloy nanoparticle exhibits superior HER performance with an overpotential of 19 m V at a current density of 10 m V/cm^(2)and a Tafel slope of 32 m V/dec,when tested in 0.5 M H_(2)SO_(4),better than pure Ir and Pt/C.This work paves the way to the exploration of efficient alloy electrocatalysts for HER. | Shengyu Ma Jun Deng Yaping Xu Weiying Tao Xiaoqi Wang Zhiping Lin Qinghua Zhang Lin Gu Wenwu Zhong | 2022 | Journal of Energy Chemistry2022，31，3： | 1 |
| 16 | Oxidative carbonylation of methanol to dimethyl carbonate over Cu (Ⅱ)-1,10-phenanthroline bromide complexes 显示文摘 | Du Zhiping Xiong Lihua Lin Zhikun Li Xuli Ding Yigang Wu Yuanxin | 2014 | Chinese Journal of Chemical Engineering2014，22，： | 1 |
| 17 | State-dependent vector hybrid linear and nonlinear ARMA modeling: Theory显示文摘 | Yuanjin Zheng Zhiping Lin David B. H. Tay | 2001 | Circuits Systems and Signal Processing2001，，5： | 1 |
| 18 | Minimax Phase Error Design of IIR Digital Filters with Prescribed Magnitude and Phase Responses显示文摘 | Lai Xiaoping Lin Zhiping | 2012 | IEEE Transactions on Signal Processing2012，60，2： | 1 |
| 19 | Recursive adaptive algorithms for fast and rapidly time-varying state 显示文摘 | ZHENG Yuanjin LIN Zhiping | 2003 | IEEE Transactions on Circuits and Systems Ⅱ-Analog and Digital Signal Processing2003，50，9： | 1 |
| 20 | Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease显示文摘 | Zhiping Li Shiqi Yang Huizhi Lin Jiawen Huang Paul A. Watkins Ann B. Moser Claudio DeSimone Xiao-yu Song Anna Mae Diehl | 2003 | Hepatology2003，，2： | 1 |
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