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| 1 | Effect of Liuweibuqi capsule, a Chinese patent medicine, on the JAK1/STAT3 pathway and MMP9/TIMP1 in a chronic obstructive pulmonary disease rat model显示文摘OBJECTIVE: To observe effect of Liuweibuqi Capsule, a Traditional Chinese Medicine(TCM), on the janus kinase(JAK)/signal transducer and activator of transcription(STAT) pathway and matrix metalloproteinases(MMPs) in a chronic obstructive pulmonary disease(COPD) rat model with lung deficiency in terms of TCM's pattern differentiation.METHODS: Rats were randomly divided into a normal group, model group, Liuweibuqi group, Jinshuibao group, and spleen aminopeptidase group(n=10). Aside from the normal group, all rats were ex-posed to smoke plus lipopolysaccharide tracheal instillation to establish the COPD model with lung deficiency. Models were established after 28 days and then the normal and model groups were given normal saline(0.09 g/kg), Liuweibuqi group was given Liuweibuqi capsule(0.35 g/kg), Jinshuibao group was given Jinshuibao capsules(0.495 g/kg), and the spleen group was given spleen aminopeptidase(0.33 mg/kg), once a day for 30 days. Changes in symptoms, signs, and lung histology were observed. Lung function was measured with a spirometer. Serum cytokines were detected using enzyme-linked immunosorbent assay, and changes in the JAK/STAT pathway, MMP-9, and MMPs inhibitor1(TIMP1) were detected by immunohistochemistry, RT-PCR, and western blotting, respectively.RESULTS: Compared with the normal group, lung tissue was damaged, and lung function was reduced in the model control group. Additionally, the levels of interleukin(IL)-1β, γ interferon(IFN-γ), and IL-6 were higher, while IL-4 and IL-10 were lower in the model control group than those in the normal group. The expressions of JAK1, STAT3, p-STAT3,and MMP-9 m RNA and protein in lung tissue were higher, and TIMP1 m RNA and protein was lower in the model group compared with the normal group.After treatment, compared with the model group,the expression of inflammatory cytokines was lower in each treatment group, and expressions of JAK/STAT pathway, MMPs were lower. Compared with the positive control groups, the Jinshuibao and spleen aminopeptidase groups, lung function was better, and JAK1, STAT3, and p-STAT3 protein were lower and TIMP1 was higher in the Liuweibuqi group.CONCLUSION: Liuweibuqi capsules can improve the symptoms of COPD possibly by regulating the expression of the JAK1/STAT3 pathway and MMP9/TIMP1. | Wang Chengyang Li Zegen Liu Xiangguo Peng Qinghe Li Fang Li Da Wang Chuanbo | 2015 | Journal of Traditional Chinese Medicine2015，35，1： | 23 |
| 2 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 3 | Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4显示文摘histone H3 离氨酸的 Dimethylations 9 和离氨酸 27 是与抄写压抑联系的重要 epigenetic 标记。这里,我们作为为这二个镇压标记特定的新奇 histone demethylase 识别了 KIAA1718 (KDM7A ) 。用老鼠胚胎的干细胞,我们证明那 KIAA1718 表情在神经区别的早阶段增加了。基因击倒堵住的神经区别和效果被野类型的人的基因,并且不由催化地不活跃的异种救。另外, KIAA1718 的 overexpression 加速了神经区别。我们提供 KDM7A 的支持 neural 区别效果通过 FGF4 的直接 transcriptional 激活被调停的证据,一个信号分子在神经区别含有。因此,我们的学习识别了通过 FGF4 调整神经区别的双特性的 histone demethylase。 | Chengyang Huang Yang Xiang Yanru Wang Xia Li Longyong Xu Ziqi Zhu Ting Zhang Qingqing Zhu Kejing Zhang Naihe Jing Charlie Degui Chen | 2010 | Cell Research2010，20，2： | 15 |
| 4 | NEECF: a project of nutrient enrichment experiments in China’s forests显示文摘Anthropogenic nitrogen(N)emissions to atmosphere have increased dramatically in China since 1980s,and this increase has aroused great concerns on its ecological impacts on terrestrial ecosystems.Previous studies have showed that terrestrial ecosystems in China are acting as a large carbon(C)sink,but its potential in the future remains largely uncertain.So far little work on the impacts of the N deposition on C sequestration in China’s terrestrial ecosystems has been assessed at a national scale.Aiming to assess and predict how ecological processes especially the C cycling respond to the increasing N deposition in China’s forests,recently researchers from Peking University and their partners have established a manipulation experimental network on the ecological effects of the N deposition:Nutrient Enrichment Experiments in China’s Forests Project(NEECF).The NEECF comprises 10 experiments at 7 sites located from north to south China,covering major zonal forest vegetation in eastern China from boreal forest in Greater Khingan Mountains to tropical forests in Hainan Island.This paper introduces the framework of the NEECF project and its potential policy implications. | Enzai Du Zhang Zhou Peng Li Xueyang Hu Yuecun Ma Wei Wang Chengyang Zheng Jianxiao Zhu Jin-Sheng He Jingyun Fang | 2013 | Journal of Plant Ecology2013，6，5： | 13 |
| 5 | Age,Genesis,and Tectonic Setting of the Mo-W Mineralized Dongshanwan Granite Porphyry from the Xilamulun Metallogenic Belt,NE China显示文摘The Xilamulun molybdenum polymetallic metallogenic belt in eastern Inner Mongolia forms one of the most important Mo metallogenic belts in northeastern China. The Dongshanwan porphyry Mo-W polymetallic deposit, in the northeastern part of the Xilamulun metallogenic belt, occurs along the periphery of a granite porphyry and consists of Mo-W-Ag sulfide and oxide disseminations and veinlets in hydrothermal assemblages. LA-ICP-MS zircon U-Pb dating of the Dongshanwan granite porphyry yields a crystallization age of 142.15± 0.91 Ma, whereas molybdenite Re-Os isotopic dating model ages are of 139.9–141.5 Ma and an isochron age is of 140.5± 3.2 Ma(MSWD=1.2). The age consistency indicates that the Dongshanwan deposit was a product of Early Cretaceous magmatism. The Dongshanwan granite porphyry is a high-alkali high-potassium intrusion and has high SiO_2(75.39 wt.%–76.15 wt.%), low Al_2O_3(12 wt.%–13 wt.%), Ba, Ti, P, and Sr contents, with negative Eu anomalies. The Y/Nb ratios are comparable to those of average continental crust and island arc basalts, corresponding to type-A2 granites. Our geochemical data indicate that the granite porphyry emplaced in an Early Cretaceous post-orogenic extensional environment following Mongol-Okhotsk oceanic subduction and subsequent continental collision. | Xuebing Zhang Keyong Wang Chengyang Wang Wen Li Qi YU Yicun Wang Jianfeng Li Duo Wan Guanghuan Huang | 2017 | Journal of Earth Science2017，28，3： | 4 |
| 6 | Subspace-based blind channel estimation for OFDM by exploiting virtual carriers 显示文摘 | Li Chengyang Roy S | 2003 | IEEE Trans Wireless Commun2003，2，1： | 1 |
| 7 | Structural Characteristics of Mesophase Spheres Prepared ftom Coal Tar Pitch Modified by Phenolic Resin显示文摘 | LI Tongqi LIU Xiujun WANG Chengyang | 2006 | Chinese Journal Chemical Engineering2006，14，5： | 1 |
| 8 | Preparation of mesophase-pitch-based carbon foams at low pressures显示文摘 | Wang Meixian Wang Chengyang Li Tongqi | 2008 | Carbon2008，46，1： | 1 |
| 9 | A subspace blind channel estimation method for OFDM systems without cyclic prefix 显示文摘 | Roy S Chengyang Li | 2002 | IEEE Trans on Wireless Communications2002，1，： | 1 |
| 10 | Characteristics of mesocarbon microbeads generated from a coal tar pitch with addition of micro-alumina powder显示文摘 | Li Tongqi Wang Chengyang Liu Xiujun | 2005 | Fuel Processing Technology2005，87，1： | 1 |
| 11 | Spherical hard carbon prepared from potato starch using as anode material for Li-ion batteries 显示文摘 | LI Wenbin CHEN Mingming WANG Chengyang | 2011 | Materials Letters2011，65，2324： | 1 |
| 12 | Study on the mechanism of droplet formation in T -junction mi- crochannel显示文摘 | Xiao - Bin Li Feng - ChenLi Juan - ChengYang | 2012 | Chemical Engineering Science2012，69，： | 1 |
| 13 | Subspace-based blind channel estimation for OFDM by exploiting virtual carriers显示文摘 | Li Chengyang Roy S | 2003 | IEEE Transactions on Wireless Communications2003，2，1： | 1 |
| 14 | A subspace blind channel estimation method for OFDM systems without cyclic prefix 显示文摘 | ROY S LI Chengyang | 2002 | IEEE Trans on Wireless Comm2002，1，4： | 1 |
| 15 | The effect of berberine in vitro on tight junctions in human Caco-2 intestinal epithelial cells显示文摘 | Lili Gu Ning Li Qiurong Li Qiang Zhang Chengyang Wang Weiming Zhu Jieshou Li | 2009 | Fitoterapia2009，，： | 1 |
| 16 | Application of SEM to detect the structure of mesocarbon microbeads显示文摘 | Li Tongqi Wang Chengyang Liu Xiujun | 2005 | Journal of Materials Science2005，40，8： | 1 |
| 17 | Distance regularized level set evolution and its application to image segmentation显示文摘 | Li Chunming Xu Chengyang Gui Changfeng | 2010 | IEEE Transactions on Image Processing2010，19，12： | 1 |
| 18 | Preparation of graphitic carbon foam using size-restriction method under atmospheric pressure显示文摘 | Li Tongqi Wang Chengyang An B X | | 0，，09： | 1 |
| 19 | Overexpression of Hepatocyte Nuclear Factor-4α Initiates Cell Cycle Entry, but Is not Sufficient to Promote β-Cell Expansion in Human Islets显示文摘 | Sebastian Rieck Jia Zhang Zhaoyu Li Chengyang Liu Ali Naji Karen K. Takane Nathalie M. Fiaschi-Taesch Andrew F. Stewart Jake A. Kushner Klaus H. Kaestner | 2012 | Molecular Endocrinology2012，，9： | 1 |
| 20 | Distance regularized level set evolution and its application to image segmentation显示文摘 | LI Chunming XU Chengyang GUI Changfeng | 2010 | IEEE Transactions on Image Processing2010，19，12： | 1 |
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