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| 1 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 2 | NSC-640358 acts as RXRa ligand to promote TNFa-mediated apoptosis of cancer cell显示文摘 | Fan Chen Jiebo Chen Jiacheng Lin Anton V. Cheltsov Lin Xu Ya Chen Zhiping Zeng Liqun Chen Mingfeng Huang Mengjie Hu Xiaohong Ye YuqiZhou Guanghui Wang Ying su Long Zhang Fangfang Zhou Xiao-kun Zhang HU Zhou | 2015 | Protein & Cell2015，6，9： | 2 |
| 3 | Overexpression of OsSPL9 enhances accumulation of Cu in rice grain and improves its digestibility and metabolism显示文摘Copper(Cu)is an essential trace mineral element for all forms of life,and is an important structural component and co-factor for a variety of metalloenzymes(Pen^a et al.,1999;Bertinato and L'Abbe,2004).In humans,Cu deficiency is not common because of the ubiquitous occurrence of Cu and ease of gastrointestinal absorption(Zidar et al.,1977;Uauy et al.,1998).However,because of the low Cu content in most sources of feed,the use of Cu as a growth promoter to maximize animal production has been well documented in animal feeding(Braude,1945;Lu et al.,2010).Pre- | Mingfeng Tang Chuanshe Zhou Lu Meng Donghai Mao Can Peng Yuxing Zhu Daoyou Huang Zhiliang Tan Caiyan Chen Chengbing Liu Dechun Zhang | 2016 | Journal of Genetics and Genomics2016，43，11： | 2 |
| 4 | Nanoparticle-filled capillary electrophoresis for the separation of long DNA molecules in the presence of hydrodynamic and electrokinetic forces 显示文摘 | TSENG W L HUANG Mingfeng HUANG Yufen | 2005 | Electrophoresis2005，26，16： | 1 |
| 5 | Separation of dsDNA in the presence of electroosmotic flowunder discontinuous conditions显示文摘 | HUANG Mingfeng HSU C E TSENG W L | 2001 | Electrophoresis2001，22，： | 1 |
| 6 | Effects of Low-Dose Olanzapine on Duloxetine-Related Nausea and Vomiting for the Treatment of Major Depressive Disorder显示文摘 | Zhiyong Zhong Yunqing Zhang Hongying Han Zheping Huang Jihui Wang Mingfeng Chen Jinbei Zhang | 2014 | Journal of Clinical Psychopharmacology2014，，4： | 1 |
| 7 | Cold water stress attenuates dopaminergic neurotoxicity induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice显示文摘在现在的学习,我们在导致的 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP ) 在 dopaminergic 神经原上测试了冷水应力(CWS ) 的效果 Parkinson 是疾病(PD ) 老鼠模型,并且发现那个 CWS 预告的处理得到了更少的 MPTP neurotoxicity。理解位于这现象下面的分子的机制,我们在试验性的鼠标的 striatum 检测了热吃惊蛋白质 70 的表达式(Hsp70 ) ,并且发现那个 CWS 预告的处理能显著地在对待 MPTP 的鼠标增加 striatal Hsp70。与 Hsp70 的正式就职同时,而且, striatal -synuclein 的导致 MPTP 的增加在 CWS +对待 MPTP 的老鼠被禁止。CWS 预告的处理显著地也在 striatum 禁止了 anti-apoptotic 分子 Bcl-2 表示的减小并且在对待 MPTP 的老鼠的 substantia nigra 提高了 Bcl-2 抄写。一起拿,这些数据显示 Hsp70 可能是为对导致 MPTP 的 dopaminergic 毒性的 CWS 的 neuroprotective 效果的重要中介。 | Mingfeng Xia Minjuan Bian Qian Yu Jie Liu Yufang Huang Xueting Jin Shiduo Lu Mei Yu Fang Huang | 2011 | Acta Biochimica et Biophysica Sinica2011，43，6： | 1 |
| 8 | 本校近期发表IF≥4.0的SCI论文摘要(英文)——Genetic Variants on Chromosome 15q25 Associated with Lung Cancer Risk in Chinese Populations显示文摘 | Hu Zhibin Jin Guangfu Liang Jie Zhang Mingfeng Shen Hongbing Wu Chen Yu Dianke Huang Liming Tan Wen Lin Dongxin Guo Huan Wu Tangchun Qian Ji Lu Daru | 2009 | 南京医科大学学报(自然科学版)2009，29，9： | 1 |
| 9 | Economic growth and the environmental Kuznets curve in Taiwan 显示文摘 | HUANG Mingfeng Daigee Show | 1999 | Asimul- taneity Model Analysis1999，6，2： | 1 |
| 10 | Factors influencing the usage of 3G mobile services in Taiwan 显示文摘 | LIAO Chunhsiung TSOU Chunwang HUANG Mingfeng | 2007 | Online Information Review2007，31，6： | 1 |
| 11 | Peak factors of non‐Gaussian wind forces on a complex‐shaped tall building显示文摘 | Mingfeng Huang Wenjuan Lou Chun‐Man Chan Sheng Bao | 2013 | Struct Design Tall Spec Build2013，，14： | 1 |
| 12 | Improved separation of double-stranded DNA fragments by capillary electrophoresis using poly(ethylene oxide) solution containing colloids显示文摘 | HUANG Mingfeng HUANG Chinching CHANG Huantsung | 2003 | Electrophoresis2003，24，： | 1 |
| 13 | Separation of double-stranded DNA fragments by capillary electrophoresis: Impacts of poly(ethylene oxide), gold nanoparticles, ethidium bromide, and pH显示文摘 | CHIOU S H HUANG Mingfeng CHANG Huantsung | 2004 | Electrophoresis2004，25，14： | 1 |
| 14 | Characteristic studies of heat sources and performance analysis of free-cooling assisted air conditioning and ventilation systems for working faces of mineral mines显示文摘High temperature heat hazard at mineral mine becomes more and more serious as the increase of mining depth.Heat sources at working faces of mineral mines are complex and are of different characteristics,presenting new challenges for air conditioning systems.In this paper,heat sources at four types of working faces are summarized and their characteristics are investigated.Based on this,simplified equations,which are linear with length of working faces,are proposed to calculate heat dissipation rates.So that the main heat sources of different working faces can be found,and cooling load of air conditioning systems can be calculated.Then,considering main heat sources of coal mines,a typical working face is designed to investigate performances of different ventilation systems and air conditioning systems.Simulation results show that segmented ventilation systems(SC)and heat shield assisted centralized ventilation systems(CCHS)can realize much better temperature distributions at working faces.However,cooling load can be greatly reduced for CCHS,when untreated air is supplied to the coal seam side.Based on this,free cooling assisted air conditioning systems are designed,and annual average energy efficiency ratio(EERann)of the systems are investigated and compared between direct evaporate cooling and indirect evaporate cooling(IEC).For SC,as compared with scenarios without free-cooling,IEC can increase EERann by 15%-23%and 22%-32%under Benxi and Datong ambient conditions,respectively.Besides,to ensure high EERann,CCHS is preferred and it is essential to increase thermal insulation of air ducts. | Rang Tu Lijuan Huang Aibing Jin Mingfeng Zhang Xiao Hai | 2021 | Building Simulation2021，14，6： | 0 |
| 15 | Antisense oligonucleotide technology can be used to investigate a circular but not linear RNA-mediated function for its encoded gene locus显示文摘As a class of powerful molecular tool,antisense oligonucleotides(ASOs)are not only broadly used in protein and RNA biology,but also a highly selective therapeutic strategy for many diseases.Although the concept that ASO reagents only reduce expression of the targeted gene in a post-transcriptional manner has long been established,the effect and mechanism of ASO reagents on RNA polymerase II(Pol II)transcription are largely unknown.This raised question is particularly important for the appropriate use of ASOs and the valid interpretation of ASO-mediated experiments.In this study,our results show that linear RNA ASO attenuates transcription of nascent transcripts by inducing premature transcription termination which is combinatorially controlled by Integrator,exosome,and Rat1 in Drosophila.However,circular RNA(circRNA)ASO transfection does not affect transcription activity of the encoded gene.These data suggest that the ASO technique can be applied to study a circRNA-mediated but not linear RNA-mediated function for its encoded gene locus. | Zhenxing Song Ruirui Jia Mingfeng Tang Fei Xia Haiyang Xu Zhengguo Li Chuan Huang | 2021 | Science China(Life Sciences)2021，64，5： | 0 |
| 16 | A Method for Identification of Selenoprotein Genes in Archaeal Genomes显示文摘The genetic codon UGA has a dual function: serving as a terminator and encoding selenocysteine. However, most popular gene annotation programs only take it as a stop signal, resulting in misannotation or completely missing selenoprotein genes. We developed a computational method named Asec-Prediction that is specific for the prediction of archaeal selenoprotein genes. To evaluate its effectiveness, we first applied it to 14 archaeal genomes with previously known selenoprotein genes, and Asec-Prediction identified all reported selenoprotein genes without redundant results. When we applied it to 12 archaeal genomes that had not been researched for selenoprotein genes, Asec-Prediction detected a novel selenoprotein gene in Methanosarcina acetivorans. Further evidence was also collected to support that the predicted gene should be a real selenoprotein gene. The result shows that Asec-Prediction is effective for the prediction of archaeal selenoprotein genes. | Mingfeng Li Yanzhao Huang Yi Xiao | 2009 | Genomics, Proteomics & Bioinformatics2009，7，1： | 0 |
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