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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Magnetically levitated/piezoelectric/triboelectric hybrid generator as a power supply for the temperature sensor显示文摘The combination of new intelligent materials and structure technology is becoming an effective way in energy havesting and self-powered sensing. In this work, we demonstrate a magnetically levitated/piezoelectric/triboelectric hybrid generator, which does not use complex structure and has high steady output performance. It includes three parts: magnetically levitated generator(MLG), piezoelectric generator(PNG), triboelectric nanogenerator(TENG). The peak power of each is 135 μW, 22 mW and3.6 mW, which are obtained at 1 MΩ, 10 kΩ and 1 kΩ, respectively. The hybrid generator can completely light up light-emitting diodes(LEDs) under the vibration frequency of 20 Hz and the vibration amplitude of 10 mm. It also can charge a 470 μF capacitor.On this basis, we have integrated the hybrid generaor as a power supply into a self-powered tempreature sensing system. The combination of three generators can not only broaden the operating range, but also increase the operating length and sensitivity.This work will extend the application of self-powered sensor in automatic production line and promote the development of industrial control technology. | ZHANG ZengXing HE Jian HAN JianQiang XU HongYan MU JiLiang WEN Tao WANG DaWei TIAN ZhuMei CHEN ZeTian XUE ChenYang | 2017 | Science China(Technological Sciences)2017，60，7： | 3 |
| 3 | Accelerating the discontinuous Galerkin method for seismic wave propagation simulations using multiple GPUs with CUDA and MPI显示文摘We have successfully ported an arbitrary highorder discontinuous Galerkin method for solving the threedimensional isotropic elastic wave equation on unstructured tetrahedral meshes to multiple Graphic Processing Units(GPUs)using the Compute Unified Device Architecture(CUDA)of NVIDIA and Message Passing Interface(MPI)and obtained a speedup factor of about 28.3 for the single-precision version of our codes and a speedup factor of about 14.9 for the double-precision version.The GPU used in the comparisons is NVIDIA Tesla C2070 Fermi,and the CPU used is Intel Xeon W5660.To effectively overlap inter-process communication with computation,we separate the elements on each subdomain into inner and outer elements and complete the computation on outer elements and fill the MPI buffer first.While the MPI messages travel across the network,the GPU performs computation on inner elements,and all other calculations that do not use information of outer elements from neighboring subdomains.A significant portion of the speedup also comes from a customized matrix–matrix multiplication kernel,which is used extensively throughout our program.Preliminary performance analysis on our parallel GPU codes shows favorable strong and weak scalabilities. | Dawei Mu Po Chen Liqiang Wang | 2013 | Earthquake Science2013，26，6： | 2 |
| 4 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 5 | Edge detection of wood image with rot based on BP neural network显示文摘 | Mu Hongbo Qi Dawei Zhang Mingming | 2013 | Journal of Convergence Information Technology2013，8，2： | 1 |
| 6 | Edge extraction of wood image with flaw based on BP neural network显示文摘 | Mu Hongbo Qi Dawei Zhang Mingming | 2013 | Journal of Convergence Information Technology2013，8，1： | 1 |
| 7 | Edge detection of wood image with rot based on gray transformation enhancement显示文摘 | Mu Hongbo Qi Dawei Zhang Mingming | 2012 | Advances in Information Sciences and Service Sciences2012，4，18： | 1 |
| 8 | Fgl2 deficiency causes neonatal death and cardiac dysfunction during embryonic and postnatal development in mice显示文摘 | Mu Junwu Qu Dawei Bartczak A | | 0，，01： | 1 |
| 9 | Single-cell RNA Sequencing Reveals Thoracolumbar Vertebra Heterogeneity and Rib-genesis in Pigs显示文摘Development of thoracolumbar vertebra(TLV)and rib primordium(RP)is a common evolutionary feature across vertebrates,although whole-organism analysis of the expression dynamics of TLV-and RP-related genes has been lacking.Here,we investigated the single-cell transcriptome landscape of thoracic vertebra(TV),lumbar vertebra(LV),and RP cells from a pig embryo at 27 days post-fertilization(dpf)and identified six cell types with distinct gene expression signatures.In-depth dissection of the gene expression dynamics and RNA velocity revealed a coupled process of osteogenesis and angiogenesis during TLV and RP development.Further analysis of cell type-specific and strand-specific expression uncovered the extremely high level of HOXA103′-UTR sequence specific to osteoblasts of LV cells,which may function as anti-HOXA10-antisense by counteracting the HOXA10-antisense effect to determine TLV transition.Thus,this work provides a valuable resource for understanding embryonic osteogenesis and angiogenesis underlying vertebrate TLV and RP development at the cell type-specific resolution,which serves as a comprehensive view on the transcriptional profile of animal embryo development. | Jianbo Li Ligang Wang Dawei Yu Junfeng Hao Longchao Zhang Adeniyi C.Adeola Bingyu Mao Yun Gao Shifang Wu Chunling Zhu Yongqing Zhang Jilong Ren Changgai Mu David M.Irwin Lixian Wang Tang Hai Haibing Xie Yaping Zhang | 2021 | Genomics, Proteomics & Bioinformatics2021，19，3： | 1 |
| 10 | The Hemodynamic Study on the Effects of Entry Tear and Coverage in Aortic Dissection显示文摘In this work,the hemodynamic effects of the type-A aortic dissection in different entry and covering entry tear positions were mainly studied.It provides a new method or idea in the field of the aortic dissection hemodynamics,and it is of profound significance to provide basic theoretical research on the development of aortic dissection in the aspect of clinical judgment.Two type-A aortic dissection models with different entry tear positions(Model 1:The entry tear was located at the entrance of the ascending aorta,Model 2:The entry tear was located at the starting position of the descending aorta)were reconstructed according to the computed tomography(CT)images of the patients.In our study,the thoracic aortic endovascular repair was simulated by covering the entry tear(Model 3).To clarify the hemodynamic effects of entry tear and coverage,the comparative study on the true lumen(TL)and false lumen(FL)blood flow patterns of three models were carried out numerically.The velocity vector,flow ratio,pressure,time-averaged wall shear stress(TAWSS)and relative residence time(RRT)were calculated to evaluate the hemodynamic changes.The results of this work indicated that(I)the velocity of entry tear at the aorta entrance was higher;(II)The helical development of the TL and FL might be related to the helical nature of aortic arch;(III)The blood flow which passing the FL of Model 1,Model 2 and Model 3 in one cardiac cycle were approximately 26.63%,13.39%and 1%,respectively;(IV)The difference in intima wall pressure of the TL and FL were showed a strong pulsation;(V)The TAWSS distribution in TL and FL were completely different(the TAWSS in TL intima>8 Pa,the TAWSS in FL intima<4 Pa).In brief,the aortic morphology and location of the entry tear were found to have a significant effect on the hemodynamics of the aortic dissection.In addition,the CFD method is used to obtain multi-dimensional hemodynamic information such as velocity field,pressure,TAWSS and RRT,which can help clinicians better understand the development of type-A aortic dissection and provide a theoretical basis for clinical treatment. | Zhenxia Mu Xiaofei Xue Minrui Fu Dawei Zhao Bin Gao Yu Chang | 2019 | Computer Modeling in Engineering & Sciences2019，，12： | 0 |
| 11 | Short-term effects of fire disturbance on CH4 emission from forested wetlands in the Xiaoxing’an Mountains, Northeast China显示文摘Using static chamber gas chromatography, we determined the seasonal dynamics, controlling factors, and distribution patterns of forest swamp CH4 levels and related environmental factors (temperature, water level) after fire disturbance in the Xiaoxing’an Mountains. The results showed the following: during the growing season, the annual CH4 emission distribution ranged from - 0.001 ± 0.012 to 22.373 ± 3.650 mg m^-2 h^-1;mild fire caused the swamp CH4 emission flux of tussock, shrub, Alnus sibirica and birch swamp to increase by 56.0–524.7%;at low water levels, temperature had a significant influence on the swamp type, and the correlation between the methane emission flux and temperature was significantly strengthened;after a fire disturbance, methane emissions from all types of marsh were highest in summer and second highest in autumn, with a weak absorption in spring;and along the water environment gradient of the transition zone, the CH4 emission flux presented a decreasing trend in its spatial distribution pattern. | Han Gu Wenyu Zheng Dawei Xu Changcheng Mu | 2019 | Journal of Forestry Research2019，30，3： | 0 |
| 12 | Emergence of hypervirulent Pseudomonas aeruginosa pathotypically armed with co-expressed T3SS effectors ExoS and ExoU显示文摘Pseudomonas aeruginosa is a significant pathogen mainly causing healthcare-associated infections(HAIs).Newly emerging high-risk clones of P.aeruginosa with elevated virulence profiles furtherly cause severe community-acquired infections(CAIs).Usually,it is not common for P.aeruginosa to co-carry exoU and exoS genes,encoding two type III secretion system(T3SS)effectors.The pathogenicity mechanism of exoS+/exoU+strains of P.aeruginosa remains unclear.Here,we provide detailed evidence for a subset of hypervirulent P.aeruginosa strains,which abundantly co-express and secrete the T3SS effectors ExoS and ExoU.The exoS+/exoU+P.aeruginosa strains were available to cause both HAIs and CAIs.The CAI-associated strains could elicit severe inflammation and hemorrhage,leading to higher death rates in a murine acute pneumonia model,and had great virulence potential in establishing chronic infections,demonstrating hypervirulence when compared to PAO1(exoS+/exoU-)and PA14(exoS-/exoU+).Both ExoS and ExoU were co-expressed and co-secreted in abundance in exoS+/exoU+strains.Their abundant protein secretion could boost exoS+/exoU+strains’potentials for cytotoxicity in vitro and pathogenicity in vivo.Genomic evidence indicates that exoU acquisition is likely mediated by horizontal gene transfer(HGT)of the pathogenicity island PAPI-2,while deletion of exoU was sufficient to mitigate virulence in the exoS+/exoU+strains.Furthermore,bioinformatics analysis showed that such exoS+/exoU+P.aeruginosa strains turned out to be widely distributed across the globe.Overall,the research provide detailed evidence for the high virulence and epidemicity of exoS+/exoU+strains of P.aeruginosa,highlighting an urgent need for surveillance against these high-risk hypervirulent strains. | Yuqin Song Yongqi Mu Nai-Kei Wong Zhuo Yue Juan Li Min Yuan Xiong Zhu Jinshu Hu Gang Zhang Dawei Wei Chao Wang Weihui Wu Fang Bai Jie Feng | 2023 | hLife2023，1，1： | 0 |
| 13 | Clinical Epidemiology,Illness Profiles,and the Implication of COVID-19 Before and After the Nationwide Omicron Outbreak During the Winter of 2022显示文摘China.In this study,we aimed to investigate the clinical characteristics and outcomes of patients with coronavirus disease 2019(COVID-19)in the Beijing region.Methods:In this retrospective study,we enrolled inpatients admitted for COVID-19 in the Fifth Medical Center of Chinese PLA General Hospital in Beijing between November 10,2022,and January 30,2023.Demographic and clinical features and treatment outcomeswere comprehensively analyzed.We used logistic regression and linear regression analyses to explore the risk factors associated with disease severity and time of nucleic acid conversion,respectively.Results:A total of 1010 hospitalized patients with COVID-19 were enrolled.The median age was 43.0 years(interquartile range,28.0–63.0),and patients aged<60 years and≥60 years comprised 71.2%and 28.8%of total included patients,respectively.The clinical classification of mild(74.6%,753/1010),moderate(21.0%,212/1010),severe(2.7%,27/1010),and unidentified(1.8%,18/1010)was separately recorded;1005 patients were discharged,and 5 patients died in the hospital.The outbreak of the emerging epidemic witnessed an evident increase in the proportion of moderate(42.9%vs.16.4%)and severe(10.3%vs.1.1%)cases after December 7,2022.Patients with a moderate/severe classification had higher levels of procalcitonin,IL-6,serum ferritin,C-reactive protein,lactic dehydrogenase,serum urea nitrogen,and D-dimer and lower counts of CD4+T,CD8+T,and B cells(all P<0.001).Multivariable regression analysis revealed that increased odds of disease severity were associated with the following factors:age≥60 years,IL-6>7 pg/mL,lactic dehydrogenase level>245 U/L,cough,and fever at admission.Age≥80 years and chronic lung diseasewere independent risk factors in the nonmild group in elderly patients.In addition,the duration for nucleic acid to turn negativewas approximately 5.0 d(interquartile range,3.0–7.0).Prolonged time of nucleic acid conversion was associated with age≥60 years,serum urea nitrogen level>8.2 mmol/L,neutrophil count>7×10^(9)/L,and the presence of a chronic lung disease or carcinoma.Finally,unvaccinated patients accounted for 37.3%of enrolled patients;children and the elder people accounted for approximately half of that.The univariable analysis found that booster doses reduced disease severity and shortened the time of nucleic acid conversion in elderly patients.Conclusions:The outbreak ofOmicron rapidly increased the number of patientswith COVID-19 in Beijing.In elderly patients,booster doses may reduce disease severity and shorten the time of nucleic acid conversion.Healthcare systems should be optimized before an emerging epidemic outbreak. | Yuming Guo Zhe Xu Wen-Xin Wang Cheng Zhen Jinhua Hu Jinsong Mu Chengcheng Ji Xin Yuan Ruonan Xu Lei Huang Lei Shi Fanping Meng Junliang Fu Shuangnan Zhou Siyu Wang Fengyi Li Bo Tu Dawei Zhang Huihuang Huang Yufeng Mao Wen Xu Chao Zhang Xiuying Mu Jun Zhao Bo Jin Haibin Su Yinying Lu Yongqian Cheng Dong Ji Shaoli You Jinghui Dong Changchun Liu Mengmeng Zhang Yuanyuan Li Tianjun Jiang Yonggang Li Fu-Sheng Wang | 2023 | Infectious Diseases & Immunity2023，3，4： | 0 |
| 14 | The Hemodynamic Study on the Effects of Entry Tear and Coverage in Aortic Dissection显示文摘Nowadays,cardiovascular disease has gradually become the number one killer of human health.The Stanford type-A aortic dissection is a relatively common cardiovascular disease with potential hazards.The disease is caused by a partialtearing of the aortic intima.Thoracic endovascular aortic repair(TEVAR)is one of the most effective treatment for type A aortic dissection and has been widely used clinically to achieve thrombosis and reduce pressure by covering the incision tear in the FL.However,the effect of entry tear location on type-A aortic dissection and the prognosis of TEVAR intervention are unclear.In this work,the hemodynamic effects of the type-A aortic dissection in different entry and covering entry tear position were mainly studied.It can provide a new method or idea in the field of the aortic dissection hemodynamics,which is of great significance to provide a basic theoretical research on the development of aortic dissection in the aspect of clinical judgment.Two type-A aortic dissection models with different entry tear positions(Model 1:the entry tear was located at the entrance of the ascending aorta,Model 2:the entry tear was located at the starting position of the descending aorta)were reconstructed according to the computed tomography(CT)images of the patients.In our study,the thoracic aortic endovascular repair was simulated by covering the entry tear(Model 3).Then,the semi-automatic adaptive technology HyperMeshl0.0(Altair HyperWorks,Troy,Ml,USA)mesh generator was used to generate the high-quality tetrahedral 3D mesh.To clarify the hemodynamic effects of entry tear and coverage in aortic blood flow pattern,the comparative study on the true lumen(TL)and false lumen(FL)blood flow patterns of three models were carried out numerically(the time-dependent pulsatile waveform of pressure boundary conditions used at the aortic inlet were consistent with Rapezzis’s work,time-dependent pulsatile waveform of velocity at the descending aorta outlet and the time-dependent pulsatile waveform of pressure at the brachiocephalic artery,left common carotid artery,and left subclavian artery were obtained from the work of Olufsenet et al).The velocity vector,flow ratio,pressure,time-average wall shear stress(TAWSS)and relative residence time(RRT)were calculated to evaluate the hemodynamic changes.The results of this work indicated that(Ⅰ)the velocity was higher at the entry tear in aorta entrance;(Ⅱ)the helical development of the TL and FL might be related to the helical nature of aortic arch;(Ⅲ)the blood flow which passing the FL of Model 1,Model 2 and Model 3 in one cardiac cycle were approximately 26.63%,13.39%and 1%,respectively;(Ⅳ)the difference in intima wall pressure among the TL and FL was found varied a lot and shown a strong pulsation;(Ⅴ)the TAWSS distribution in TL and FL were quite different(the TAWSS in TL intima>8 Pa,the TAWSS in FL intima<4 Pa).In brief,the aortic morphology and location of the entry tear were found to have a significant effect on the hemodynamic of the aortic dissection.What’s more,we found that the risk of the aortic rupture could be higher if the position of entry tear is closer to the ascending aorta.By covering the entry tear to simulate TEVAR,the pressure of FL was reduced,which could provide some help for the treatment of early retrograde type-A dissection. | Zhenxia Mu Xiaofei Xue Minrui Fu Dawei Zhao Bin Gao Yu Chang | 2019 | 医用生物力学2019，34，A01： | 0 |
| 15 | Leaf recognition using BP-RBF hybrid neural network显示文摘Plant recognition has great potential in forestry research and management.A new method combined back propagation neural network and radial basis function neural network to identify tree species using a few features and samples.The process was carried out in three steps:image pretreatment,feature extraction,and leaf recognition.In the image pretreatment processing,an image segmentation method based on hue,saturation and value color space and connected component labeling was presented,which can obtain the complete leaf image without veins and back-ground.The BP-RBF hybrid neural network was used to test the influence of shape and texture on species recogni-tion.The recognition accuracy of different classifiers was used to compare classification performance.The accuracy of the BP-RBF hybrid neural network using nine dimensional features was 96.2%,highest among all the classifiers. | Xin Yang Haiming Ni Jingkui Li Jialuo Lv Hongbo Mu Dawei Qi | 2022 | Journal of Forestry Research2022，33，2： | 0 |
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