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| 1 | FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis显示文摘 | Xu Zhao Ying Yang Bao-Fa Sun Yue Shi Xin Yang Wen Xiao Ya-Juan Hao Xiao-Li Ping Yu-Sheng Chen Wen-Jia Wang Kang-Xuan Jin Xing Wang Chun-Min Huang Yu Fu Xiao-Meng Ge Shu-Hui Song Hyun Seok Jeong Hiroyuki Yanagisawa Yamei Niu Gui-Fang Jia Wei Wu Wei-Min Tong Akimitsu Okamoto Chuan He Jannie M Rendtlew Danielsen Xiu-Jie Wang Yun-Gui Yang | 2014 | Cell Research2014，24，12： | 109 |
| 2 | Immune mechanisms of Concanavalin A model of autoimmune hepatitis显示文摘As a chronic inflammatory disease of the liver,the pathogenic mechanisms of autoimmune hepatitis (AIH) have not yet been elucidated,with prognosis and diagnosis remaining unsatisfied.Currently the only viable treatments of AIH are immunosuppressant application and liver transplantation.It is considered that lack of good animal AIH models is the main reason for the shortage of a simple and efficient cure.The Concanavalin A (Con A) model is a typical and well established model for investigating T-cell and macrophage dependent liver injury in mice,which closely mimics the pathogenesis mechanisms and pathological changes of patients,and is regarded as the best experimental model for AIH research so far.In this paper we eluci-dated the pathogenic mechanisms of AIH and the evolution of relative animal models.We go on to further focus on Con A-induced liver injury from the point of immunological mechanisms and the change of cytokine levels.Finally,we manifested the clinical significance of the AIH animal models and the challenges they would meet during their future development. | Hai-Xia Wang Man Liu Shun-Yan Weng Jing-Jing Li Chao Xie Hong-Lin He Wen Guan Yun-Sheng Yuan Jin Gao | 2012 | World Journal of Gastroenterology2012，18，2： | 52 |
| 3 | Deep Learning for Wireless Physical Layer: Opportunities and Challenges显示文摘Machine learning(ML) has been widely applied to the upper layers of wireless communication systems for various purposes, such as deployment of cognitive radio and communication network. However, its application to the physical layer is hampered by sophisticated channel environments and limited learning ability of conventional ML algorithms. Deep learning(DL) has been recently applied for many fields, such as computer vision and natural language processing, given its expressive capacity and convenient optimization capability. The potential application of DL to the physical layer has also been increasingly recognized because of the new features for future communications, such as complex scenarios with unknown channel models, high speed and accurate processing requirements; these features challenge conventional communication theories. This paper presents a comprehensive overview of the emerging studies on DL-based physical layer processing, including leveraging DL to redesign a module of the conventional communication system(for modulation recognition, channel decoding, and detection) and replace the communication system with a radically new architecture based on an autoencoder. These DL-based methods show promising performance improvements but have certain limitations, such as lack of solid analytical tools and use of architectures that are specifically designed for communication and implementation research, thereby motivating future research in this field. | Tianqi Wang Chao-Kai Wen Hanqing Wang Feifei Gao Tao Jiang Shi Jin | 2017 | China Communications2017，14，11： | 51 |
| 4 | Indicators of prognosis after liver transplantation in Chinese hepatocellular carcinoma patients显示文摘AIM: To identify prognostic factors of patients with hepatocellular carcinoma (HCC), who were treated by orthotopic liver transplantation (OLT). METHODS: From January 2000 to October 2006, 165 patients with HCC underwent OLT. Various clinicopathological risk factors for actuarial and recurrence-free survival were identified using the Kaplan-Meier method with the log-rank test. The Cox proportional hazards model was used to identify independently predictive factors for actuarial and recurrence-free survival, which were used to propose new selection criteria. We compared the outcome of the subgroup patients meeting different criteria. Survival analysis was performed using the Kaplan-Meier method with the log-rank test. RESULTS: The median follow-up was 13.0 mo (2.8-69.5 mo). Overall, 1-, 2-, 3-and 5-year actuarial survival was 73.3%, 45.6%, 35.4% and 32.1%, respectively. One-, 2-, 3-and 5-year overall recurrencefree survival was 67.0%, 44.3%, 34.5% and 34.5%, respectively. In univariate analysis, number of tumors, total tumor size, lobar distribution, differentiation, macrovascular invasion, microvascular invasion, capsulationof the tumor, and lymph node metastasis were found to be associated significantly with actuarial and tumor-free survival. By means of using the multivariate Cox proportional hazards model, total tumor size and macrovas-cular invasion were found to be independent predictors of actuarial and tumor-free survival. When the selection criteria were expanded into the proposed criteria, there was no significant difference in 1-, 2-, 3-and 5-year actuarial and tumor-free survival of the 49 patients who met the proposed criteria (97.6%, 82.8%, 82.8% and 82.8%, and 90.7%, 82.8%, 68.8% and 68.8%, respectively) compared with that of patients who met the Milan or University of California, San Francisco (UCSF) criteria. CONCLUSION: Macrovascular invasion and total tumor diameter are the strongest prognostic factors. The proposed criteria do not adversely affect the outcome of liver transplantation for HCC, compared with the Milan or UCSF criteria. | Jin Li Lu-Nan Yan Jan Yang Zhe-Yu Chen Bo Li Yong Zeng Tian-Fu Wen Ji-Chun Zhao Wen-Tao Wang Jia-Yin Yang Ming-Qing Xu Yu-Kui Ma | 2009 | World Journal of Gastroenterology2009，15，33： | 37 |
| 5 | Summary of Report on Cardiovascular Diseases in China,2012显示文摘The prevalence of cardiovascular diseases(CVDs)is associated with the socioeconomic prosperity,lifestyle changes,accelerated process of ageing and urbanization.The prevalence of CVDs is continuously increasing in China and will remain an upward trend in the next 10 years.CVDs are the leading cause of death for Chinese in both urban area and rural area. | WANG Wen HU Sheng Shou KONG Ling Zhi GAO Run Lin ZHU Man Lu WANG Yong Jun WU Zhao Su CHEN Wei Wei YANG Jin Gang MALi Yuan LIU Ming Bo For the editorial board | 2014 | Biomedical and Environmental Sciences2014，27，7： | 31 |
| 6 | Broadband diffusion of terahertz waves by multi-bit coding metasurfaces显示文摘The terahertz region is a special region of the electromagnetic spectrum that incorporates the advantages of both microwaves and infrared light waves.In the past decade,metamaterials with effective medium parameters or gradient phases have been studied to control terahertz waves and realize functional devices.Here,we present a new approach to manipulate terahertz waves by using coding metasurfaces that are composed of digital coding elements.We propose a general coding unit based on a Minkowski closed-loop particle that is capable of generating 1-bit coding(with two phase states of 0 and 180°),2-bit coding(with four phase states of 0,90°,180°,and 270°),and multi-bit coding elements in the terahertz frequencies by using different geometric scales.We show that multi-bit coding metasurfaces have strong abilities to control terahertz waves by designing-specific coding sequences.As an application,we demonstrate a new scattering strategy of terahertz waves—broadband and wide-angle diffusion—using a 2-bit coding metasurface with a special coding design and verify it by both numerical simulations and experiments.The presented method opens a new route to reducing the scattering of terahertz waves. | Li-Hua Gao Qiang Cheng Jing Yang Shao-Jie Ma Jie Zhao Shuo Liu Hai-Bing Chen Qiong He Wei-Xiang Jiang Hui-Feng Ma Qi-Ye Wen Lan-Ju Liang Biao-Bing Jin Wei-Wei Liu Lei Zhou Jian-Quan Yao Pei-Heng Wu Tie-Jun Cui | 2015 | Light(Science & Applications)2015，4，1： | 31 |
| 7 | Hepatic venous outflow reconstruction in adult right lobe living donor liver transplantation without middle hepatic vein显示文摘背景重建困难、挑战性在没有中间的肝的静脉(MHV ) 的成年正确脑叶生活施主肝移植(LDLT ) 的肝的静脉的流出。门静脉和静脉的流出阻塞的过多的灌注将导致接枝的尖锐拥挤,最终导致主要 nonfunction。尽管各种各样的重建模式在许多国家被探索了,当前没有清楚的一致。在这研究,我们描述一种技术没有 MHV.Methods A ,用正确脑叶接枝在 LDLT 与劣等的静脉 cava ( IVC )在流出吻合阻止接枝的“ chocking ”回顾的分析从没有 MHV ,用正确脑叶接枝经历 LDLT 的 55 个接受者在临床的数据上被进行或肝的静脉的流出的重建。施主的恰好肝的静脉(RHV ) 与接受者 IVC 的三角形的开始被吻合;劣等的恰好肝的静脉(IRHV ) 足够大,直接被吻合到 IVC。大 saphenous 静脉(GSV ) 被用于重要 MHV tributaries.Results 的重建没有死亡发生在任何施主。55 个接受者,复杂并发症发生在 6,包括 hepaticvein 苛评(1 个盒子) , small-for-size 症候群(1 ) ,肝的动脉血栓(1 ) ,肠的流血(1 ) ,胆汁漏(1 )(1 ) ,左 subphrenic 脓肿和肺的感染。三个病人的一个总数死了,从 small-for-size 症候群的并且二从多重系统机关 failure.Conclusions,多重洞的垂直吻合与肝的静脉流出被重建。这种技术减轻生活施主的外科的风险,保证优秀静脉的排水,并且阻止脉管的 thromboses 和主要 nonfunction。 | WU Hong YANG Jia-yin YAN Lü-nan LI Bo ZENG Yong WEN Tian-fu ZHAO Ji-chun WANG Wen-tao XU Ming-qing LU Qiang CHEN Zhe-yu MA Yu-kui LI Jin | 2007 | Chinese Medical Journal2007，，11： | 27 |
| 8 | Taxus chinensis ameliorates diabetic nephropathy through down-regulating TGF-β1/Smad pathway显示文摘Diabetic nephropathy(DN) is one of the common microvascular complications of diabetes mellitus. Renal fibrosis is closely related to the deterioration of renal function. The present study aimed to investigate protective effect of Taxus chinensis on high-fat diet/streptozotocin-induced DN in rats and explore the underlying mechanism of action. The rat DN model was established via feeding high fat diet for 4 weeks and subsequently injecting streptozotocin(30 mg·kg^(-1) body weight) intraperitoneally. The rats with blood glucose levels higher than 16.8 mmol·L^(-1) were selected for experiments. The DN rats were treated with Taxus chinensis orally(0.32, 0.64, and 1.28 g·kg^(-1)) once a day for 8 weeks. Taxus chinensis significantly improved the renal damage, which was indicated by the decreases in 24-h urinary albumin excretion rate, blood serum creatinine, and blood urea nitrogen. Histopathological examination confirmed the protective effect of Taxus chinensis. The thickness of glomerular basement membrane was reduced, and proliferation of mesangial cells and podocytes cells and increase in mesangial matrix were attenuated. Further experiments showed that Taxus chinensis treatment down-regulated the expression of TGF-β1 and α-SMA, inhibited phosphorylation of Smad2 and Smad3. These results demonstrated that Taxus chinensis alleviated renal injuries in DN rats, which may be associated with suppressing TGF-β1/Smad signaling pathway. | WENG Hong-Bo HAN Wen-Ke XIONG Yan-Wen JIN Zhou-Hui LAN Zhen LIU Cheng ZHANG Xue-Mei PENG Wen | 2018 | Chinese Journal of Natural Medicines2018，16，2： | 28 |
| 9 | Telomerase activity in gastric cancer and its clinical implications显示文摘INTRODUCTIONThedevelopmentofcarcinomaresultsfrommultipleindependentgeneticchangesthatactivateprotooncogenesorinactivatetheac... | ZHAN Wen Hua, MA Jin Ping, PENG Jun Sheng, GAO Jing Song, CAI Shi Rong, WANG Jian Ping, ZHENG Zhang Qing and WANG Lei | 1999 | World Journal of Gastroenterology1999，5，4： | 25 |
| 10 | Direct generation of ES-like cells from unmodified mouse embryonic fibroblasts by Oct4/Sox2/Myc/KIf4显示文摘 | Dajiang Qin Wen Li Jin Zhang Duanqing Pei | 2007 | Cell Research2007，17，11： | 26 |
| 11 | U-Pb zircon geochronology and Hf isotope study of metamorphosed basic-ultrabasic rocks from metamorphic basement in southwestern Zhejiang:The response of the Cathaysia Block to Indosinian orogenic event显示文摘A combined study using LA-ICP-MS U-Pb dating, Hf isotopes, trace elements and the Ti-in-zircon geo-thermometer was carried out on zircons from the metamorphosed basic-ultrabasic rocks in the meta-morphic basement of the Cathaysia Block, southwestern Zhejiang Province. The formation and meta-morphic ages of the rocks from the metamorphic basement of the Cathaysia Block were determined based on zircon U-Pb geochronology. The age for the magmatic crystalline zircons from the protolith is about 1.85 Ga. The εHf(t) values of the older zircons were from ?7 to ?3, with two-stage model Hf ages (TDM2LC) of about 2.9 to 3.4 Ga, indicating that the source material was derived from anatexis and recy-cling of the Archean crust. The newly formed metamorphic zircons yielded U-Pb ages of 260―230 Ma. The metamorphic temperature calculated using the Ti-in-zircon geothermometer ranged from 610 to 720℃, consistent with the results from petrographic observations, indicating that the Cathaysia Block experienced an amphibolite facies metamorphism during the Indosinian. Results from this study pro-vided an important timeframe for the tectonic evolution in South China and the Southeast Asia during the Late Permian and Early Triassic times. | XIANG Hua ZHANG Li ZHOU HanWen ZHONG ZengQiu ZENG Wen LIU Rui JIN Song | 2008 | Science China Earth Sciences2008，51，6： | 24 |
| 12 | Paleoproterozoic reworking of ancient crust in the Cathaysia Block,South China:Evidence from zircon trace elements,U-Pb and Lu-Hf isotopes显示文摘A combined study of zircon LA-ICP-MS U-Pb dating, trace elements and Hf isotope was carried out for gneissic granite from the Sanzhishu area in Jingning, SW Zhejiang Province. Nearly all the zircons separated from the granite exhibited oscillatory zoning and high Th/U ratios (>0.1). The REE profile showed a pronounced positive Ce anomaly, negative Eu anomaly and an enrichment of HREE, which are typical characteristics of magmatic zircon. Thirteen concordant or nearly concordant analytical data yielded a weighted mean 207Pb/206Pb age of 1860±13 Ma (MSWD=0.084), representing the formation age of the granite. The magmatic zircons had negative εHf(t) values of -15.6 to -10.0 and two-stage Hf model ages of 3.1 to 3.4 Ga, indicating that the granites were formed by reworking of ancient crust. The major- and trace-element data indicate that the gneissic granites are metaluminous high-K calc-alkaline rocks and exhibit the same geochemical characteristics as aluminous A-type granites, implying the emplacement of the granite in a post-orogenic extensional tectonic setting. We conclude that the Pa-leoproterozoic crustal reworking event in the Cathaysia Block of South China marked the transition from assembly to break-up of the Columbia supercontinent. | LIU Rui ZHOU Han Wen ZHANG Li ZHONG ZengQiu ZENG Wen XIANG Hua JIN Song LU Xin Qian LI ChunZhong | 2009 | Chinese Science Bulletin2009，54，9： | 22 |
| 13 | Incidence and mortality rate of esophageal cancer has decreased during past 40 years in Hebei Province,China显示文摘Background:Hebei province is located in North of China with of approximately 6% of whole national population.It is known as a high-risk area for esophageal cancer in China and worldwide.The aim of our study was to estimate the esophageal cancer burden and trend in Hebei Province.Methods:Eight cancer registries in Hebei Province submitted cancer registry data to the Hebei Provincial Cancer Registry Center.All data were qualified and compiled for cancer statistics in 2011.The pooled data were stratified by gender and age group(0,1-4,5-9,10-14…80+).Incidence and mortality rates were age-standardized to World Segi's population standard and expressed per 100,000 persons.In addition,proportions and cumulative incidence/mortality rates for esophageal cancer were calculated.Esophageal cancer mortality data during the periods 1973-1975,1990-1992,and 2004-2005 were extracted from the national death surveys.Mortality and incidence rate data from Cixian and Shexian were obtained from population-based cancer registries in each county.Results:The estimated number of newly diagnosed esophageal cancer cases and deaths in 2011 in Hebei Province was 24,318 and 18,226,respectively.The crude incidence rate of esophageal cancer was 33.37/100,000(males,42.18/100,000 and females,24.31/100,000).The age-standardized rate by world standard population(ASRW) was 28.09/100,000,ranking third among all cancers.The esophageal cancer mortality rate was 25.01/100,000(males,31.40/100,000 and females,18.45/100,000),ranking third in deaths among all cancers.The mortality rates of esophageal cancer displayed a significant decreasing trend in Hebei Province from 1973-1975(ASRW =48.69/100,000) to 2004-2005(ASRW =28.02/100,000),with a decreased rate of 42.45%.In Cixian,the incidence of esophageal cancer decreased from 250.76/100,000 to 106.74/100,000 in males and from 153.86/100,000 to 75.41/100,000 in females,with annual percentage changes(APC) of 2.13 and 2.16,while the mortality rates declined with an APC of 2.46 for males and 3.10 for females from 1988 to 2011.In Shexian,the incidence rate decreased from 116.90/100,000 to 74.12/100,000 in males and from 46.98/100,000 to 40.64/100,000 in females,while the mortality rates declined,with an APC of 4.89 in males from 2003 to 2011.Conclusions:Although the incidence and mortality rates of esophageal cancer remain high,an obvious decreasing trend has been observed in Hebei Province,as well as in high-risk regions,such as Cixian and Shexian,over the past 40 years. | Yutong He Yan Wu Guohui Song Yongwei Li Di Liang Jing Jin Denggui Wen Baoen Shan | 2015 | Chinese Journal of Cancer Research2015，27，6： | 22 |
| 14 | Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1显示文摘Ferroptosis is a non-apoptotic regulated cell death caused by iron accumulation and subsequent lipid peroxidation.Currently,the therapeutic role of ferroptosis on cancer is gaining increasing interest.Baicalin an active component in Scutellaria baicalensis Georgi with anticancer potential various cancer types;however,the effects of baicalein on bladder cancer and the underlying molecular mechanisms remain largely unknown.In the study,we investigated the effect of baicalin on bladder cancer cells5637 and KU-19-19.As a result,we show baicalin exerted its anticancer activity by inducing apoptosis and cell death in bladder cancer cells.Subsequently,we for the first time demonstrate baicalin-induced ferroptotic cell death in vitro and in vivo,accompanied by reactive oxygen species(ROS) accumulation and intracellular chelate iron enrichment.The ferroptosis inhibitor deferoxamine but not necrostatin-1,chloroquine(CQ),N-acetyl-L-cysteine,L-glutathione reduced,or carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]-fluoromethylketone(Z-VAD-FMK) rescued baicalin-induced cell death,indicating ferroptosis contributed to baicalin-induced cell death.Mechanistically,we show that ferritin heavy chain1(FTH1) was a key determinant for baicalin-induced ferroptosis.Overexpression of FTH1 abrogated the anticancer effects of baicalin in both 5637 and KU19-19 cells.Taken together,our data for the first time suggest that the natural product baicalin exerts its anticancer activity by inducing FTH1-dependent ferroptosis,which will hopefully provide a prospective compound for bladder cancer treatment. | Na Kong Xiaying Chen Jiao Feng Ting Duan Shuiping Liu Xueni Sun Peng Chen Ting Pan Lili Yan Ting Jin Yu Xiang Quan Gao Chengyong Wen Weirui Ma Wencheng Liu Mingming Zhang Zuyi Yang Wengang Wang Ruonan Zhang Bi Chen Tian Xie Xinbing Sui Wei Tao | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 23 |
| 15 | Clinical and experimental study on regional administration of phosphorus32 glassmicrospheres in treating hepatic carcinoma显示文摘AIM To study the therapeutical effectiveness, dosage range and toxic adverse effects of domestic phosphorus 32 glass microsphere and evaluate its clinical significance. METHODS Ⅰ. Fifty two BALB/*!c tumor bearing male nude mice were allocated into treatment group( n =38) and control group( n =14). In the former group different doses of 32 P GMS were injected into the tumor mass, while in the latter 31 P GMS or no treatment was given. The experimental animals were sacrificed in batches, and then the tumors and their nearby tissues were examined by light and electron microscopy. Ⅱ. Through selective catheterization of hepatic artery, 32 P GMS was infused to 5 healthy domestic pigs in a dosage equivalent to the therapeutic dose for human being, and 31 P GMS was infused to another 5 healthy domestic pigs. Two pigs infused with contrast medium served as whole course blank controls. One pig from each group was surrendered to euthanasia at week 1, 4, 8 and 16 respectively. The ultrastructural histopath ological changes in liver tissues taken from different sites were evaluated semiquan titatively. Ⅲ. One hundred and twenty seven times of 32 P GMS intrahepatic artery interventional therapies were performed on 93 patients with hepatic carcinoma, including 79 cases of primary hepatic carcinoma and 14 cases of secondary hepatic carcinoma. 32 P GMS ( n =30), and group B, 32 P GMS and half dose of trans hepatic artery embolization (TAE) ( n =49) , and 18 patients with HCC by TAE only as control group C. Fourteen patients with secondary hepatic carcinoma were treated in the same way as group B or C. RESULTS Ⅰ. Comparing with the control group, the treatment group of tumor bearing nude mice attained the tumor inhibition rates of 59 7%-93 7% ( F =579 62, P <0 01) at 14*!d . At an absorbed dose of 7320Gy, the tumor cells were completely destroyed. When the absorbed doses ranged from 1830Gy to 3660Gy, most of the tumor cells showed the evidences of injury or necrosis, but there appeared some well differentiated tumor cells and enhanced effect of the autoimmunocytes. At an absorbed dose of 366Gy or less, some tumor cells still remained active proliferative ability. The definite anticancer effect appeared as early as 3d after intratumoral injection of 32 P GMS. Ⅱ. The cumulative amount of 32 P GMS in the target tissue after trans hepatic artery instillation attained more than 90% of the total dose administrated. Semiquantitative analysis of ultrastructral morphology in the experimental group showed no statistical difference between the nuclear abnormality (N abn ) and mitochondrial variability (M var ) at week 1 or 2, but revealed prominent difference (χ 2=6 70-9 68, P <0 01 , χ 2=65 09-115 09, P <0 001 ) as compared with those in the other groups. In the experimental group the N abn in tissues showed no significant difference between week 8 and week 16. No apparent changes were found in the stomach, spleen, kidney and lung tissues of the experimental pigs. Ⅲ. The therapeutical results of HCC patients in group A were closely approximated to those of group C, no hematological toxic side effects were noted, and the systemic reaction was mild. In some patients 2*!mos - 3*!mos after treatment some secondary foci appeared around the periphery of the primary lesion. In general better effectiveness was obtained in patients with small lesion. After analyzing by RIDIT method, the therapeutic result in group B was significantly better than that in group C, and secondary foci around the original lesion were rarely seen at 3*!mos after treatment. In group C the collateral circulation was reestablished along the periphery of primary foci and the secondary foci appeared more frequently, and required to undergo several courses of treatment. In group B, 4 cases of HCC were treated surgically as their mass decreased in size after 32 P GMS treatment. | LIU Lu, JIANG Zao, TENG Gao Jun, SONG Ji Zhi, ZHANG Dong Sheng, GUO Qing Ming, FANG Wen, HE Shi Cheng and GUO Jin He | 1999 | World Journal of Gastroenterology1999，5，6： | 21 |
| 16 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 17 | Caledonian reworking of Paleoproterozoic basement in the Cathaysia Block: Constraints from zircon U-Pb dating, Hf isotopes and trace elements显示文摘A combined study of zircon U-Pb dating, Hf isotopes and trace elements has been carried out for granodioritic neosomes of migmatites from the Tianjingping area in northwestern Fujian Province. Zircons are characterized by zoning, higher Th/U ratios (mostly ≥0.1), HREE enrichment, and positive Ce and negative Eu anomalies, and show features similar to magmatic or anatectic zircons. Apparent 206Pb/238U ages for the zircons are 447±2 Ma (95% conf., MSWD = 0.88), corresponding to a Caledonian event. εHf(t) values are ?13.3 to ?9.7, indicating a crustal source. Two-stage Hf model ages are 1.7 to 1.9 Ga, suggesting that protolith of the migmates was probably formed in the Paleoproterozoic. The granodioritic neosomes have the characteristics of peraluminous calc-alkaline granite, and their REE patterns and trace elements spidergrams show features of middle to upper crustal rocks. Together with previous studies, we conclude that the protolith of the Cathaysia basement in the Tianjingping area was likely formed in the middle-late Paleoproterozoic and experienced partial melting during the Caledonian period. The recognition of Caledonian reworking of the Paleoproterozoic basement in the Cathaysia Block provides a new insight into the tectonic evolution of the Cathaysia Block in the Caledonian pe- riod and the interaction between the Cathaysia Block and the Yangtze Block. | ZENG Wen ZHANG Li ZHOU HanWen ZHONG ZengQiu XIANG Hua LIU Rui JIN Song LU XinQian LI ChunZhong | 2008 | Chinese Science Bulletin2008，53，6： | 21 |
| 18 | DOG 1.0: illustrator of protein domain structures显示文摘 | Jian Ren Longping Wen Xinjiao Gao Changjiang Jin Yu Xue Xuebiao Yao | 2009 | Cell Research2009，19，2： | 20 |
| 19 | 钢轨波磨处高速轮轨滚动接触行为与波磨发展的模拟研究(英文)显示文摘研究目的:为求解钢轨(短波)波磨处的高速轮轨瞬态滚动接触建立有限元模型,研究影响高速钢轨波磨发展的重要因素。创新要点:1.求解不同牵引条件下轮轨间的瞬态法和切向滚动接触问题,并考虑真实轮轨几何和钢轨波磨,最高模拟速度达500 km/h;2.基于模拟结果,解释了中国高速线路上发现的钢轨波磨很快稳定下来的现象。研究方法:1.详细分析钢轨波磨处高速轮轨瞬态滚动接触的法、切向解以及由此导致的V-M等效应力和摩擦功沿轨面的波动;2.变化波磨波长、波深及重要滚动参数如速度和牵引系数等,研究它们对波磨处滚动接触行为的影响;3.对比上述有限元模型与传统多体动力模型在波磨处的法向轮轨力结果。重要结论:1.法、切向轮轨力及法、切向接触应力均随着波磨几何呈周期性波动,但相位略有差异,V-M等效应力和摩擦功的波动形式接近切向接触应力;2.牵引系数越大,波磨处V-M等效应力和摩擦功的波动范围越大;3.名义参数下,对于所研究高铁系统,波长为80 mm左右、速度为250–300 km/h时波磨的动态响应最大,这与现场观测相符;4.传统多体动力模型会高估钢轨波磨激励的法向轮轨力;5.钢轨波磨会逐渐稳定下来,通过速度越高进入稳定越快。 | Xin ZHAO Ze-feng WEN Heng-yu WANG Xue-song JIN Min-hao ZHU | 2014 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2014，15，12： | 20 |
| 20 | Experimental analysis of the mechanism of high-order polygonal wear of wheels of a high-speed train显示文摘目的:通过试验研究,对高速列车车轮多边形磨耗机理进行初步探究。创新点:以试验方法为基础,跟踪调查车轮多边形磨耗的发展规律,然后分别对轨道系统和车辆系统开展现场试验,对导致车轮发生多边形磨耗的因素进行排查,探明了车轮多边形磨耗的机理。方法:1.进行车轮多边形磨耗跟踪测试;2.进行轨道结构模态特性测试、钢轨波磨测试和轨道振动响应测试;3.进行转向架模态特性仿真研究、悬挂系统隔振特性测试以及车辆振动特性跟踪测试。结论:1.列车运行时,车轮受到周期性激励作用会发生多边形磨耗,且当激励波长整分车轮周长时,多边形磨耗发展迅速;2.作为主要激励源,轮轨接触表面出现的车轮偏心、钢轨表面不平顺、轨下支承不均匀、钢轨接头和道岔等激发了转向架系统在550~600 Hz频段内的模态耦合共振,从而导致了车轮多边形磨耗的产生;3.变速运行可以有效地控制车轮多边形磨耗的产生与发展。 | Yue WU Xing DU He-ji ZHANG Ze-feng WEN Xue-song JIN | 2017 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2017，18，8： | 20 |
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