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| 1 | A review of oxygen reduction mechanisms for metal-free carbon-based electrocatalysts显示文摘The sluggish kinetics of Oxygen Reduction Reaction(ORR)at the cathode in proton exchange membrane fuel cells or metal-air batteries requires highly effective and stable electrocatalysts to boost the reaction.The low abundance and high price of Pt-based electrocatalysts hamper the widespread application of proton exchange membrane fuel cells and metal-air batteries.As promising alternatives,metal-free carbon materials,especially upon doping heteroatoms or creating defects demonstrated excellent ORR activity,which is as efficient as or even superior to commercial platinum on carbon.Significant progress on the development of advanced carbon materials as highly stable and durable catalysts has been achieved,but the catalytic mechanisms of these materials still remain undistinguished.In present review,we summarized the up-to-date progress in the studies of carbon materials,and emphasized on the combination of experiment and theory to clarify the underlying mechanisms of these materials.At last,we proposed the perspectives on the proper strategies of elucidating the mechanisms of carbon materials as electrocatalysts towards ORR. | Ruguang Ma Gaoxin Lin Yao Zhou Qian Liu Tao Zhang Guangcun Shan Minghui Yang Jiacheng Wang | 2019 | npj Computational Materials2019，，1： | 9 |
| 2 | Regulation of the inflammatory cycle by a controllable release hydrogel for eliminating postoperative inflammation after discectomy显示文摘Surgery is the final choice for most patients with intervertebral disc degeneration(IDD).Operation-caused trauma will cause inflammation in the intervertebral disc.Serious inflammation will cause tissue defects and induce tissue degeneration,IDD recurrence and the occurrence of other diseases.Therefore,we proposed a scheme to treat recurrence after discectomy by inhibiting inflammation with an aspirin(ASP)-loaded hydrogel to restore the mechanical stability of the spine and relieve local inflammation.ASP-liposomes(ASP-Lips)were incorporated into a photocrosslinkable gelatin-methacryloyl(GelMA)via mixing.This material can effectively alleviate inflammation by inhibiting the release of high mobility group box 1(HMGB1)from the nucleus to the cytoplasm.We further assessed the expression of inflammatory cytokines,such as interleukin 6(IL-6)and tumor necrosis factor-α(TNF-α),and degeneration-related factors,such as type II collagen(COL-2),Aggrecan,matrix metallopeptidases-3(MMP-3),MMP-13,a disintegrin and metalloproteinase with thrombospondin motifs-4(ADAMTS-4)and ADAMTS-5 in rat nucleus pulpous cells.The level of IDD was analyzed through H&E,safranin-O staining and immunohistochemistry in rabbit samples.In vitro,we found that ASP-Lip@GelMA treatment significantly decreased inflammatory cytokines,MMP-3 and-13,and ADAMTS-4 and-5 and up-regulated COL-2 and Aggrecan via the inhibited release of HMGB-1 from the nucleus.In vivo,ASP-Lip@GelMA can effectively inhibit inflammation of local tissue after disc surgery and fill local tissue defects.This composite hydrogel system is a promising way to treat the recurrence of IDD after surgery without persistent complications. | Yu Liu Jiacheng Du Peng Peng Ruoyu Cheng Jiayi Lin Congxin Xu Huilin Yang Wenguo Cui Haiqing Mao Yuling Li Dechun Geng | 2021 | Bioactive Materials2021，6，1： | 6 |
| 3 | Three-Phase Heterojunction NiMo-Based Nano-Needle for Water Splitting at Industrial Alkaline Condition显示文摘Constructing heterojunction is an effective strategy to develop high-performance non-preciousmetal-based catalysts for electrochemical water splitting(WS).Herein,we design and prepare an N-doped-carbon-encapsulated Ni/MoO_(2) nano-needle with three-phase heterojunction(Ni/MoO_(2)@CN)for accelerating the WS under industrial alkaline condition.Density functional theory calculations reveal that the electrons are redistributed at the three-phase heterojunction interface,which optimizes the adsorption energy of H-and O-containing intermediates to obtain the best ΔG_(H*) for hydrogen evolution reaction(HER)and decrease the ΔG value of ratedetermining step for oxygen evolution reaction(OER),thus enhancing the HER/OER catalytic activity.Electrochemical results confirm that Ni/MoO_(2)@CN exhibits good activity for HER(ƞ_(-10)=33 mV,ƞ_(-1000)=267 mV)and OER(ƞ_(10)=250 mV,ƞ_(1000)=420 mV).It shows a low potential of 1.86 V at 1000 mA cm^(−2) for WS in 6.0 M KOH solution at 60℃ and can steadily operate for 330 h.This good HER/OER performance can be attributed to the three-phase heterojunction with high intrinsic activity and the self-supporting nano-needle with more active sites,faster mass diffusion,and bubbles release.This work provides a unique idea for designing high efficiency catalytic materials for WS. | Guangfu Qian Jinli Chen Tianqi Yu Jiacheng Liu Lin Luo Shibin Yin | 2022 | Nano-Micro Letters2022，14，1： | 4 |
| 4 | 3D fully-enclosed triboelectric nanogenerator with bionic fish-like structure for harvesting hydrokinetic energy显示文摘The hydrokinetic energy of river current,as one of the essential and widespread renewable energies,is difficult to be harvested in low flow velocity and shallow water areas.In this work,a three-dimensional(3D)fully-enclosed triboelectric nanogenerator(FETENG)with bionic fish-like structure for harvesting hydrokinetic energy is reported,which is comprised of the triboelectric powergeneration unit,bionic fish-like structure and connection unit.Through the bionic structure,the FE-TENG realizes zero head power generation in shallow water with low flow velocity.What’s more,the effect of external excitations and bionic structures on the electrical performance are systematically studied in this work.The FE-TENG can generate peak power density of 7 and 0.36 W/m^(3)respectively under the simulated swing state with frequency of 1.25 Hz and simulated river current with flow velocity of 0.81 m/s.In practical applications,due to the 3D fully-enclosed design,the FE-TENG immersed in water for 35 days demonstrates excellent immersion durability with undiminished electrical performance.Therefore,the work proposes an efficient method realizing zero head power generation,and provides a good candidate for long-term service in the river current. | Zhaoxu Jing Jiacheng Zhang Jianlong Wang Mingkang Zhu Xinxian Wang Tinghai Cheng Jianyang Zhu Zhong Lin Wang | 2022 | Nano Research2022，15，6： | 3 |
| 5 | Gene duplication drove the loss of awn in sorghum.显示文摘Loss of the awn in some cereals including sorghum is a key transition during cereal domestication or improvement that has facilitated grain harvest and storage.The genetic basis for the loss of awn in sorghum during domestication or improvement remains unknown.Here,we identified a transcription factor gene awn1 encoding an ALOG domain,which is responsible for awn loss during sorghum domestication or improvement.awn1 arose from a gene duplication from chromosome 10 that translocated to chromosome 3,recruiting a new promoter from the neighbouring intergenic region filled with'noncoding DNA',and recreating the first exon and intron.The awn1 acquires high expr`ession after duplication and represses the elongation of awns in domesticated sorghum.Comparative mapping revealed a high collinearity at awn1 paralog locus on chromosome 10 across cereals and awn growth and development was successfully reactivated on the rice spikelet by inactivating rice awn1 orthologue.Further RNA-seq and DAP-seq revealed that as a transcription repressor,AWN1 directly bound to the motif in the regulatory regions from three MADS genes related to flower development and two genes DL and LKS2 for the development of awn,downregulated the expressions of these genes,and then repressed the elongation of awn.The preexistence of regulatory elements in the neighbouring intergenic region of awn1 before domestication signified that noncoding DNA may serve as a treasure trove for evolution during adaptation to a changing world.Our results supported that gene duplication can promptly drive the evolution of gene regulatory network. | Leina Zhou Can Zhu Xiaojian Fang Hangqin Liu Shuyang Zhong Yan Li Jiacheng Liu Yang Song Xing Jian Zhongwei Lin | 2021 | Molecular Plant2021，14，11： | 2 |
| 6 | NSC-640358 acts as RXRa ligand to promote TNFa-mediated apoptosis of cancer cell显示文摘 | Fan Chen Jiebo Chen Jiacheng Lin Anton V. Cheltsov Lin Xu Ya Chen Zhiping Zeng Liqun Chen Mingfeng Huang Mengjie Hu Xiaohong Ye YuqiZhou Guanghui Wang Ying su Long Zhang Fangfang Zhou Xiao-kun Zhang HU Zhou | 2015 | Protein & Cell2015，6，9： | 2 |
| 7 | A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1βand IL-6显示文摘Glycolytic metabolism enzymes have been implicated in the immunometabolism field through changes in metabolic status. PGK1 is a catalytic enzyme in the glycolytic pathway. Here, we set up a high-throughput screen platform to identify PGK1 inhibitors. DC-PGKI is an ATPcompetitive inhibitor of PGK1 with an affinity of Kd= 99.08 nmol/L. DC-PGKI stabilizes PGK1in vitro and in vivo, and suppresses both glycolytic activity and the kinase function of PGK1. In addition,DC-PGKI unveils that PGK1 regulates production of IL-1β and IL-6 in LPS-stimulated macrophages.Mechanistically, inhibition of PGK1 with DC-PGKI results in NRF2(nuclear factor-erythroid factor 2-related factor 2, NFE2L2) accumulation, then NRF2 translocates to the nucleus and binds to the proximity region of Il-1β and Il-6 genes, and inhibits LPS-induced expression of these genes. DC-PGKI ameliorates colitis in the dextran sulfate sodium(DSS)-induced colitis mouse model. These data support PGK1 as a regulator of macrophages and suggest potential utility of PGK1 inhibitors in the treatment of inflammatory bowel disease. | Liping Liao Wenzhen Dang Tingting Lin Jinghua Yu Tonghai Liu Wen Li Senhao Xiao Lei Feng Jing Huang Rong Fu Jiacheng Li Liping Liu Mingchen Wang Hongru Tao Hualiang Jiang Kaixian Chen Xingxing Diao Bing Zhou Xiaoyan Shen Cheng Luo | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 2 |
| 8 | Service Customized Space-Air-Ground Integrated Network for Immersive Media: Architecture, Key Technologies, and Prospects显示文摘The space-air-ground integrated network(SAGIN) is regarded as the key approach to realize global coverage in future network and it reaches broad access for various services. Being the new paradigm of service, immersive media(IM) has attracted users’ attention for its virtualization, but it poses challenges to network performance, e.g. bandwidth, rate, latency. However, the SAGIN has limitations in supporting IM services, such as 4 K/8 K video, virtual reality, and interactive games. In this paper, a novel service customized SAGIN architecture for IM applications(SAG-IM) is proposed, which achieves content interactive and real-time communication among terminal users. State-of-the-art research is investigated in detail to facilitate the combination of SAGIN and service customized technology, which provides endto-end differentiated services for users. Besides, the functional components of SAG-IM contain the infrastructure layer, perception layer, intelligence layer, and application layer, reaching the capabilities of intelligent management of the network. Moreover, to provide IM content with ultra-high-definition and high frame rate for the optimal user experience, the promising key technologies on intelligent routing and delivery are discussed. The performance evaluation shows the superiority of SAG-IM in supporting IM service.Finally, the prospects in practical application are high-lighted. | LinhuiWei Jiacheng Shuai Yu Liu YumeiWang Lin Zhang | 2022 | China Communications2022，19，1： | 1 |
| 9 | Extracellular matrix and its therapeutic potential for cancer treatment显示文摘The extracellular matrix(ECM)Is one of the major components of tumors that plays multiple crucial roles,including mechanical support,modulation of the microenvironment,and a source of signaling molecules.The quantity and cross-linking status of ECM components are major factors determining tissue stiffness.During tumorigenesis,the interplay between cancer cells and the tumor microenvironment(TME)often results in the stiffness of the ECM,leading to aberrant mechanotransduction and further malignant transformation.Therefore,a comprehensive understanding of ECM dysregulation in the TME would contribute to the discovery of promising therapeutic targets for cancer treatment.Herein,we summarized the knowledge concerning the following:(1)major ECM constituents and their functions in both normal and malignant conditions;(2)the interplay between cancer cells and the ECM in the TME;(3)key receptors for mechanotransduction and their alteration during carcinogenesis;and(4)the current therapeutic strategies targeting aberrant ECM for cancer treatment. | Jiacheng Huang Lele Zhang Dalong Wan Lin Zhou Shusen Zheng Shengzhang Lin Yiting Qiao | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 1 |
| 10 | G6:A web-based library for graph visualization显示文摘Authoring graph visualization poses great challenges to developers due to its high requirements on both domain knowledge and development skills.Although existing libraries and tools reduce the difficulty of generating graph visualization,there are still many challenges.We work closely with developers and formulate several design goals,then design and implement G6,a web-based library for graph visualization.It combines template-based configuration for high usability and flexible customization for high expressiveness.To enhance development efficiency,G6 proposes a range of optimizations,including state management and interaction modes.We demonstrate its capabilities through an extensive gallery,a quantitative performance evaluation,and an expert interview.G6 was first released in 2017 and has been iterated for 317 versions.It has served as a web-based library for thousands of applications and received 8312 stars on GitHub. | Yanyan Wang Zhanning Bai Zhifeng Lin Xiaoqing Dong Yingchaojie Feng Jiacheng Pan Wei Chen | 2021 | Visual Informatics2021，5，4： | 1 |
| 11 | Single-cell brain atlas of Parkinson's disease mouse model显示文摘Parkinson's disease(PD)is a neurodegenerative disease,leading to the impairment of movement execution.PD pathogenesis has been largely investigated,either limited to bulk transcriptomic levels or at certain cell types,which failed to capture the cellular heterogeneity and intrinsic interplays among distinct cell types.Here,we report the application of single-nucleus RNA-seq on midbrain,striatum,and cerebellum of theα-syn-A53 T mouse,a well-established PD mouse model,and matched controls,generating the first single cell transcriptomic atlas for the PD model mouse brain composed of 46,174 individual cells.Additionally,we comprehensively depicte the dysfunctions in PD pathology,covering the elevation of NF-k B activity,the alteration of ion channel components,the perturbation of protein homeostasis network,and the dysregulation of glutamatergic signaling.Notably,we identify a variety of cell types closely associated with PD risk genes.Taken together,our study provides valuable resources to systematically dissect the molecular mechanism of PD pathogenesis at the single-cell resolution,which facilitates the development of novel approaches for diagnosis and therapies against PD. | Jixing Zhong Gen Tang Jiacheng Zhu Weiying Wu Ge Li Xiumei Lin Langchao Liang Chaochao Chai Yuying Zeng Feiyue Wang Lihua Luo Jiankang Li Fang Chen Zhen Huang Xiuqing Zhang Yu Zhang Hongde Liu Xin Qiu Shengping Tang Dongsheng Chen | 2021 | Journal of Genetics and Genomics2021，48，4： | 1 |
| 12 | Preparation and Functional Design of Polyethyleneimine Reinforced Nanocellulose-based Aerogel显示文摘An aerogel electrode composed of conductive active materials based on nanocellulose aerogels can absorb more electrolytes,as well as enhance electron transport and ion diffusion channels.In the present study,aerogels with high strength were successfully prepared using 2,2,6,6-tetramethyl-1-piperidinyloxy free radical(TEMPO)-oxidized cellulose nanofibrils(CNF)as a raw material and polyethyleneimine(PEI)as a crosslinking agent.Simultaneously,functional electrode materials were prepared via self-assembly.Based on our findings,PEI can significantly improve the water and solvent solubility and enhance the wet strength and shape recovery ability of CNF aerogels.Meanwhile,the minimum density of the aerogel reached 0.0160 g/cm3,the maximum porosity was approximately 98.5%,and the maximum stress approximated 0.02 MPa.Furthermore,electrochemical tests revealed that after self-assembly of reduced graphene oxide(RGO)and polyaniline(PANI)solution,the mass specific capacitance of the functional composite aerogel was approximately 92 F/g and exhibited good chargedischarge performance. | Jiacheng Lin Tao Lin Xuefeng Yin Xue Cai Xiaoyao Wei Neng Zhang | 2022 | Paper And Biomaterials2022，7，1： | 1 |
| 13 | Software defined Internet of vehicles:architecture,challenges and solutions显示文摘IoV(Internet of Vehicles)is a promising paradigm to the future of automobiles,which will undoubtedly boost the automobile market as well as accelerate innovation in Internet services and applications.The concept of SD-IoV(Software Defined IoV)is presented,which is capable of improving resource utilization,service quality,and network optimization in the harsh vehicular network environments.First,A generalized SD-IoV architecture as an intuitive big picture is presented.Then,the major functions realized by SD-IoV are elabrated on to illustrate how the current challenges are resolved.As the key enablers of SD-IoV,three possible implementation methods of the wireless control path are described and compared.Finally,the challenges and existing solutions of SD-IoV are disuessed and open issues are pointed out so as to shed light on future research. | CHEN Jiacheng ZHOU Haibo ZHANG Ning YANG Peng GUI Lin SHEN Xuemin | 2016 | Journal of Communications and Information Networks2016，1，1： | 1 |
| 14 | Database-Assisted Dynamic Spectrum Access with QoS Guarantees:A Double-Phase Auction Approach显示文摘Since FCC's opening for white space(WS) utilization,database-assisted dynamic spectrum access(DSA) has become the de facto solution for the realization of dynamic spectrum sharing(DSS),due to its simplicity and compatibility with commercial off-the-shelf(COTS) devices.It is envisioned that such technology will strongly support the prosperous wireless multimedia networking(WMN) applications with satisfying QoS guarantees in the future.However,how to counter the time-frequency variant property when exploiting the WS spectrum for the provision of these services to secondary users(SUs) still remains a great challenge.In such context,a dynamic secondary access scheme for database-assisted spectrum sharing networks is proposed in this paper.In the beginning,the spectrum requirements of SUs for diverse services are modeled by considering the minimum required service data-rate and spectrum access duration.Afterwards,the spectrum demand evaluation and bidding policy are formulated based on the service classes of SUs.Furthermore,a doublephase(DP) spectrum allocation scheme,which consists of the initial resource allocation phase and resource allocation adjustment phase,is carefully designed for DSA.Finally,extensive simulations are conducted and the results demonstrate that our scheme can increase the spectrum trading revenue and adapt to varying service requirements. | ZHOU Haibo LIU Bo HOU Fen ZHANG Ning GUI Lin CHEN Jiacheng Xuemin(Sherman) Shen | 2015 | China Communications2015，12，1： | 1 |
| 15 | Crystallinity and thermal decomposition of dialdehyde celluloses from bacterial cellulose显示文摘 | Feng Yuhong Li Jiacheng Lin Qiang | 2007 | Key Engineering Materials2007，，： | 1 |
| 16 | Crystallinity and thermal decomposition of dialdehyde celluloses from bacterial cellulose显示文摘 | Feng Yuhong Li Jiacheng Lin Qiang | 2007 | Key Engineering Materials2007，，： | 1 |
| 17 | A novel small-molecule near-infrared II fluorescence probe for orthotopic osteosarcoma imaging显示文摘Osteosarcoma is the most common primary malignant tumor of bone,particularly among children and adolescents.Advances in imaging,surgical techniques,and implants have dramatically reduced the need for amputation in the past three decades.Recently,in vivo fluorescence imaging in the second near-infrared window(NIR-II,1,000–1,700 nm)shows impressive advantages of deeper tissue penetration and higher spatial resolution,which makes it a promising tool for the early diagnosis and post-operative observation of Osteosarcoma.To the best of our knowledge,this paper is the first time to develop a novel NIR-II fluorescence probe conjugated with an osteosarcoma targeted oligopeptide for molecular tumor imaging in a xenograft orthotopic osteosarcoma mouse model. | Jiacheng Lin Qianqian Li Xiaodong Zeng Ziyang Chen Qihang Ding Yang Li Hui Zhou Xianli Meng Deliang Chen Zixin Deng Xuechuan Hong Yuling Xiao | 2020 | Science China Chemistry2020，63，6： | 1 |
| 18 | Ion–Electron Coupling Enables Ionic Thermoelectric Material with New Operation Mode and High Energy Density显示文摘Ionic thermoelectrics(i-TE) possesses great potential in powering distributed electronics because it can generate thermopower up to tens of millivolts per Kelvin. However,as ions cannot enter external circuit, the utilization of i-TE is currently based on capacitive charge/discharge, which results in discontinuous working mode and low energy density. Here,we introduce an ion–electron thermoelectric synergistic(IETS)effect by utilizing an ion–electron conductor. Electrons/holes can drift under the electric field generated by thermodiffusion of ions, thus converting the ionic current into electrical current that can pass through the external circuit. Due to the IETS effect, i-TE is able to operate continuously for over 3000 min.Moreover, our i-TE exhibits a thermopower of 32.7 mV K^(-1) and an energy density of 553.9 J m^(-2), which is more than 6.9 times of the highest reported value. Consequently, direct powering of electronics is achieved with i-TE. This work provides a novel strategy for the design of high-performance i-TE materials. | Yongjie He Shaowei Li Rui Chen Xu Liu George Omololu Odunmbaku Wei Fang Xiaoxue Lin Zeping Ou Qianzhi Gou Jiacheng Wang Nabonswende Aida Nadege Ouedraogo Jing Li Meng Li Chen Li Yujie Zheng Shanshan Chen Yongli Zhou Kuan Sun | 2023 | Nano-Micro Letters2023，15，7： | 1 |
| 19 | A Novel Improved Bat Algorithm in UAV Path Planning显示文摘Path planning algorithm is the key point to UAV path planning scenario.Many traditional path planning methods still suffer from low convergence rate and insufficient robustness.In this paper,three main methods are contributed to solving these problems.First,the improved artificial potential field(APF)method is adopted to accelerate the convergence process of the bat’s position update.Second,the optimal success rate strategy is proposed to improve the adaptive inertia weight of bat algorithm.Third chaos strategy is proposed to avoid falling into a local optimum.Compared with standard APF and chaos strategy in UAV path planning scenarios,the improved algorithm CPFIBA(The improved artificial potential field method combined with chaotic bat algorithm,CPFIBA)significantly increases the success rate of finding suitable planning path and decrease the convergence time.Simulation results show that the proposed algorithm also has great robustness for processing with path planning problems.Meanwhile,it overcomes the shortcomings of the traditional meta-heuristic algorithms,as their convergence process is the potential to fall into a local optimum.From the simulation,we can see also obverse that the proposed CPFIBA provides better performance than BA and DEBA in problems of UAV path planning. | Na Lin Jiacheng Tang Xianwei Li Liang Zhao | 2019 | Computers, Materials & Continua2019，，7： | 0 |
| 20 | Tailoring impedance match and enhancing microwave absorption of Fe_3O_4/Bi_(24)Fe_2O_(39)/Bi hollow porous microrods by controlling their composition显示文摘A self-assembly/precipitate conversion/decomposition process was developed for the controllable synthesis of Fe_3O_4/Bi_(24)Fe_2O_(39)/Bi hollow porous microrods(HPMRs).The results demonstrated that the crystal size,component,and performances of HPMRs could be effectively modulated via changing Fe^(2+)/Bi^(3+)molar ratio(γ).Fe_3O_4/Bi_(24)Fe_2O_(39)/Bi HPMRs exhibited ferromagnetic behavior at room temperature.As Bi and Bi_(24)Fe_2O_(39)contents increased withγ,the saturation magnetization M_sand attenuation constantly decreased,whereas coercivity H_cand impedance matching ratio increased.Compounding Fe_3O_4with small quantities of Bi and Bi_(24)Fe_2O_(39)into HPMRs can significantly enhance microwave absorption.Fe_3O_4/Bi_(24)Fe_2O_(39)/Bi HPMRs formed atγ=1:0.25 exhibited the optimum microwave absorption performance.The minimum R_Lwas-47.3 dB at8.72 GHz,corresponding to 2.4 mm sample thickness.The absorption band with the reflection loss below-20 dB was up to 14.0 GHz for the absorber with a thickness of 1.4-8.0 mm.The results demonstrate that the introduction of electromagnetic transparent materials(Bi_(24)Fe_2O_(39)or Bi)can improve the microwave absorption performances of Fe_3O_4 composites owing to enhanced impedance matching rather than attenuation constant. | Lin Liu Na He Jiacheng Sun Panbing Hu Rujia He Jinxiu Cheng Weifu Tian Guoxiu Tong | 2018 | Progress in Natural Science:Materials International2018，28，5： | 0 |
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