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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Hypoxia response element-directed expression of bFGF in dental pulp stem cells improve the hypoxic environment by targeting pericytes in SCI rats显示文摘Cell-based transplantation strategies possess great potential for spinal cord injury(SCI)repair.Basic fibroblast growth factor(bFGF)has been reported to have multiple neuro-promoting effects on developing and adult nervous system of mammals and considered a promising therapy for nerve injury following SCI.Human dental pulp stem cells(DPSCs)are abundant stem cells with low immune rejection,which can be considered for cell replacement therapy.The purpose of this study was to investigate the roles of DPSCs which express bFGF under the regulation of five hypoxia-responsive elements(5HRE)using an adeno-associated virus(AAV-5HRE-bFGF-DPSCs)in SCI repairing model.In this study,DPSCs were revealed to differentiate into CD13^(+)pericytes and up-regulate N-cadherin expression to promote the re-attachment of CD13^(+)pericytes to vascular endothelial cells.The re-attachment of CD13^(+)pericytes to vascular endothelial cells subsequently increased the flow rate of blood in microvessels via the contraction of protuberance.As a result,increased numbers of red blood cells carried more oxygen to the damaged area and the local hypoxia microenvironment in SCI was improved.Thus,this study represents a step forward towards the potential use of AAV-5HRE-bFGF-DPSCs in SCI treatment in clinic. | Sipin Zhu Yibo Ying Yan He Xingxing Zhong Jiahui Ye Zhiyang Huang Min Chen Qiuji Wu Yifan Zhang Ziyue Xiang Yurong Tu Weiyang Ying Jian Xiao Xiaokun Li Qingsong Ye Zhouguang Wang | 2021 | Bioactive Materials2021，6，8： | 2 |
| 3 | Chaotic response of cracked rotor supported on squeeze film damper and the routes to chaos显示文摘 | HE Erming REN Xingmin QIN Weiyang | | 0，，03： | 1 |
| 4 | A periodic DFT study on adsorption of small molecules(CH4,CO,H2O,H2S,NH3)on the WO3(001) surface-supported Au显示文摘Gas molecules(such as CH4,CO,H2O,H2S,NH_3)adsorption on the pure and Au-doped WO3(001)surface have been studied by Density functional theory calculations with generalized gradient approximation.Based on the the calculation of adsorption energy,we found the most stable adsorption site for gas molecules by comparing the adsorption energies of different gas molecules on the WO3(001)surface.We have also compared the adsorption energy of five different gas molecules on the WO3(001)surface,our calculation results show that when the five kinds of gases are adsorbed on the pure WO3(001)surface,the order of the surface adsorption energy is CO>H2S>CH4>H2O>NH3.And the results show that NH3 is the most easily adsorbed gas among the other four gases adsorbed on the surface of pure WO3(001)surface.We also calculated the five different gases on the Au-doped WO3(001)surface.The order of adsorption energy was found to be different from the previous calculation:CO>CH4>H2S>H2O>NH3.These results provide a new route for the potential applications of Au-doped WO3 in gas molecules adsorption. | Long Lin Jingtao Huang Weiyang Yu Chaozheng He Hualong Tao Yonghao Xu Linghao Zhu Pengtao Wang Zhanying Zhang | 2020 | Communications in Theoretical Physics2020，72，3： | 1 |
| 5 | Safety Risk Analysis of Large⁃scale Complex Project based on WBS⁃RBS and Interval Numbers显示文摘Safety risks are essential to the success or failure of the large⁃scale complex projects.In order to assess and evaluate the safety risks of the large⁃scale complex projects scientifically,a risk assessment method of work breakdown structure and risk breakdown structure(WBS⁃RBS)is proposed to identify the project risks.In this paper,interval numbers are used to evaluate the risk levels,weights are assigned automatically based on the complexity and risk degree of WBS to distinguish three types of nodes in WBS,and a risk assessment algorithm is designed to assess safety risk at all layers of the project.A case study is conducted to demonstrate how to apply the method.The results show the practicality,robustness and efficiency of our new method,which can be applied to different kinds of large⁃scale complex projects in reality. | JIANG Weiyang HE Xiaoliang DU Hejia | 2022 | International Journal of Plant Engineering and Management2022，27，3： | 1 |
| 6 | Survival after radical cystectomy for bladder cancer:Multicenter comparison between minimally invasive and open approaches显示文摘Objective:To investigate oncological outcomes in patients with bladder cancer who underwent minimally invasive radical cystectomy(MIRC)or open radical cystectomy(ORC).Methods:We identified patients with bladder cancer who underwent radical cystectomy(RC)in 13 centers of the Chinese Bladder Cancer Consortium(CBCC).Perioperative outcomes were compared between MIRC and ORC.The influence of surgical approaches on overall survival(OS)and cancer-specific survival(CSS)in the entire study group and subgroups classified according to pathologic stage or lymph node(LN)status was assessed with the log-rank test.Multivariable Cox proportional hazard models were used to evaluate the association among OS,CSS and risk factors of interest.Results:Of 2098 patients who underwent RC,1243 patients underwent MIRC(1087 laparoscopic RC and 156 robotic-assisted RC,respectively),while 855 patients underwent ORC.No significant differences were noted in positive surgical margin rate and 90-day postoperative mortality rate.MIRC was associated with less estimated blood loss,more LN yield,higher rate of neobladder diversion,longer operative time,and longer length of hospital stay.There was no significant difference in OS and CSS according to surgical approaches(pZ0.653,and 0.816,respectively).Subgroup analysis revealed that OS and CSS were not significantly different regardless of the status of extravesical involvement or LN involvement.Multivariable Cox regression analyses showed that the surgical approach was not a significant predictor of OS and CSS.Conclusions:Our study showed that MIRC was comparable to conventional ORC in terms of OS and CSS. | Weibin Xie Junming Bi Qiang Wei Ping Han Dongkui Song Lei Shi Dingwei Ye Yijun Shen Xin Gou Weiyang He Shaogang Wang Zheng Liu Jinhai Fan Kaijie Wu Zhiwen Chen Xiaozhou Zhou Chuize Kong Yang Liu Chunxiao Liu Abai Xu Baiye Jin Guanghou Fu Wei Xue Haige Chen Tiejun Pan Zhong Tu Tianxin Lin Jian Huang | 2020 | Asian Journal of Urology2020，7，3： | 1 |
| 7 | Mercury speciation and distribution in Aha Reservoir which was contaminated by coal mining activities in Guiyang, Guizhou, China显示文摘 | Xinbin Feng Weiyang Bai Lihai Shang Tianrong He Guangle Qiu Haiyu Yan | 2010 | Applied Geochemistry2010，，2： | 1 |
| 8 | Single-cell RNA Sequencing Reveals Sexually Dimorphic Transcriptome and Type 2 Diabetes Genes in Mouse Islet β Cells显示文摘Type 2 diabetes(T2D)is characterized by the malfunction of pancreaticβcells.Susceptibility and pathogenesis of T2D can be affected by multiple factors,including sex differences.However,the mechanisms underlying sex differences in T2D susceptibility and pathogenesis remain unclear.Using single-cell RNA sequencing(scRNA-seq),we demonstrate the presence of sexually dimorphic transcriptomes in mouseβcells.Using a high-fat diet-induced T2D mouse model,we identified sex-dependent T2D altered genes,suggesting sex-based differences in the pathological mechanisms of T2D.Furthermore,based on islet transplantation experiments,we found that compared to mice with sexmatched islet transplants,sex-mismatched islet transplants in healthy mice showed down-regulation of genes involved in the longevity regulating pathway ofβcells.Moreover,the diabetic mice with sex-mismatched islet transplants showed impaired glucose tolerance.These data suggest sexual dimorphism in T2D pathogenicity,indicating that sex should be considered when treating T2D.We hope that our findings could provide new insights for the development of precision medicine in T2D. | Gang Liu Yana Li Tengjiao Zhang Mushan Li Sheng Li Qing He Shuxin Liu Minglu Xu Tinghui Xiao Zhen Shao Weiyang Shi Weida Li | 2021 | Genomics, Proteomics & Bioinformatics2021，19，3： | 1 |
| 9 | CD97 negatively regulates the innate immune response against RNA viruses by promoting RNF125-mediated RIG-I degradation显示文摘The G protein-coupled receptor ADGRE5(CD97)binds to various metabolites that play crucial regulatory roles in metabolism.However,its function in the antiviral innate immune response remains to be determined.In this study,we report that CD97 inhibits virus-induced type-I interferon(IFN-I)release and enhances RNA virus replication in cells and mice.CD97 was identified as a new negative regulator of the innate immune receptor RIG-I,and RIG-1 degradation led to the suppression of the IFN-I signaling pathway.Furthermore,overexpression of CD97 promoted the ubiquitination of RIG-I,resulting in its degradation,but did not impact its mRNA expression.Mechanistically,CD97 upregulates RNF125 expression to induce RNF125-mediated RIG-I degradation via K48-linked ubiquitination at Lys181 after RNA virus infection.Most importantly,CD97-deficient mice are more resistant than wild-type mice to RNA virus infection.We also found that sanguinarine-mediated inhibition of CD97 effectively blocks VSV and SARS-CoV-2 replication.These findings elucidate a previously unknown mechanism through which CD97 negatively regulates RIG-I in the antiviral innate immune response and provide a molecular basis for the development of new therapeutic strategies and the design of targeted antiviral agents. | Huasong Chang Peili Hou Xuefeng Wang Aibiao Xiang Hao Wu Wenjing Qi Rukun Yang Xue Wang Xingyu Li Wenqi He Guimin Zhao Weiyang Sun Tiecheng Wang Daniel Chang He Hongmei Wang Yuwei Gao Hongbin He | 2023 | Cellular & Molecular Immunology2023，20，12： | 0 |
| 10 | The concentration and distribution of different mercury species in the water columns and sediment of Aha Lake显示文摘 | Weiyang BAI Xinbin FENG Xuewu FU Tianrong HE Guangle QIU | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
| 11 | Research of Personnel Operational Ability Evaluation of Large-scale Complex Equipment显示文摘The level of personnel operation ability determines the expected effectiveness of large-scale complex equipment. Firstly, this paper constructs the personnel operational ability evaluation index system and analyzes the data source of index. Secondly, the weight of index is determined and the fuzzy comprehensive evaluation model is proposed. Finally, results of instance analysis show that the evaluation model is feasible and effective. | JIANG Weiyang HE Xiaoliang ZHAO Manyun | 2019 | International Journal of Plant Engineering and Management2019，24，3： | 0 |
| 12 | Measurement of Linear Momentum Transfer in Ar+Bi and Ar+Ag Systems at 25MeV/u显示文摘Measurement of Linear Momentum Transfer in Ar+Bi and Ar+Ag Systems at 25MeV/uMeasurementofLinearMomentumTransferinAr+BiandAr+... | Wu Enjiu Jin Genming Zheng Jiwen Yin Shuzhi Tan Jilian Zhang Chun Jin Weiyang Song Mingtao Li Zuyu Wu Heyu Wang Sufang He Zhiyoap Jiang DongXing and Qian Xing | 1995 | IMP & HIRFL Annual Report1995，，0： | 0 |
| 13 | Light Charged Particles Emitted from Central Collision in Reaction of 25MeV/u ^(40)Ar on ^(nat)Ag显示文摘Light Charged Particles Emitted from Central Collision in Reaction of 25MeV/u ^(40)Ar on ^(nat)AgLightChargedParticlesEmittedf... | Yin Shuzhi Jin Weiyang Jin Genming Zhang Chun Zheng Jiwen Wu Enjiu Tan Jilian Song Mingtao Li Zuyu Wang Sufang Wu Heyu He Ziyong Jiang Doughing and Qian Xing | 1995 | IMP & HIRFL Annual Report1995，，0： | 0 |
| 14 | Relation of Temperature and Excitation Energies of Hot Nuclei in Reactions of ^(40)Ar+^(nat)Ag at 25MeV/u显示文摘Relation of Temperature and Excitation Energies of Hot Nuclei in Reactions of ^(40)Ar+^(nat)Ag at 25MeV/uRelationofTemperature... | Yin Shuzhi Jin Weiyang Jin Genming Zhang Chun Zheng Jiwen Wu Enjiu Tan Jilian Song Mingtao Li Zuyu Wang Sufang Wu Heyu He Zhiyong Jiang Dongxing and Qian Xing | 1995 | IMP & HIRFL Annual Report1995，，0： | 0 |
| 15 | Light Charged Particle Measurement in Coincidence with Fission Fragments in Reaction of 25MeV/u ^(40)Ar+^(209)Bi显示文摘Light Charged Particle Measurement in Coincidence with Fission Fragments in Reaction of 25MeV/u ^(40)Ar+^(209)BiLightChargedPa... | Zhang Chun Zheng Jiwen Wu Enjiu Yin Shuzhi Wang Sufang Jin Weiyang Jin Genming Tan Jilian Song Mingtao Li Zuyu Wu Heyu He Zhiyong Jiang Dongxing and Qian Xing | 1995 | IMP & HIRFL Annual Report1995，，0： | 0 |
| 16 | Production and Characterization of Hot Nuclei in Ar Induced Reactions at 25 MeV/u | Wu, Enjiu Jing, Genming Zheng, Jiwen Yin, Shuzhi Tan, Jilian Zhang, Chun Jin, Weiyang Song, Mintao Li, Zhuyu Wu, Heyu Wang, Shufang He, Zhiyong Jiang, Dongxing Qian, Xing | 1996 | Chinese journal of nuclear physics1996，，3： | 0 |
| 17 | Correlative Measurements of Fission Fragments and Light Particles(α,p)in Reactions of ^(40)Ar+^(209)Bi,^(nat)Ag at 25MeV/u显示文摘Correlative Measurements of Fission Fragments and Light Particles(α,p)in Reactions of ^(40)Ar+^(209)Bi,^(nat)Ag at 25MeV/u￥WuE?.. | Wu Enjiu Jing Genming Yin Shuzhi Zheng Jiwen Tan Jilian Song Mintao Jin Weiyang Zhang Chun Li Zhuyu Wu Heyu Guo Zhongyan Wang Shufang He Zhiyong Jiang Dongxing and Qian Xing | 1994 | IMP & HIRFL Annual Report1994，，0： | 0 |
| 18 | Evaporation of Intermediate-mass Fragments from Hot-nuclei Produced by 25MeV/u ^(40)Ar Bombarding ^(159)Tb Target显示文摘Evaporation of Intermediate-mass Fragments from Hot-nuclei Produced by 25MeV/u^(40)Ar Bombarding^(159)Tb Target￥JiangDongxing;... | Jiang Dongxing Qian Xing Qian Tao Hua Hui Lin Junsong Wu Enjiu Zheng Jiwen Jing Genming Yin Shuzhi Tan Jilin Jing Weiyang Song Mingtao Li Zuyu and He Zhiyong | 1994 | IMP & HIRFL Annual Report1994，，0： | 0 |
| 19 | Neutralization activity of influenza A virus humanized antibodies against new subtypes of influenza viruses显示文摘Antibodies are ideal for controlling the influenza A virus,but their effect on newly emerging strains is unclear.Here,we assessed the neutralization activity of the humanized monoclonal antibodies(mAbs)F10,H98 and H40 against circulating influenza viruses(H5N1,H1N1,H3N2 and H7N7 and new subtypes viruses H5N6 and H7N9).The results showed that all the three humanized mAbs(F10,H98 and H40)displayed different degrees of virus neutralization activities when encountered with different subtypes of influenza viruses.Remarkably,the humanized monoclonal antibody F10 produced higher and broader neutralization titers(range 25–1.56μg/ml)than those of the other two humanized mAbs(H98(range 50–3.12μg/ml),H40(range 50–5.56μg/ml))to against the viruses H5N1,H1N1,H3N2,H7N7,H5N6 and H7N9.This mAb may represent a new class of heterosubtypic neutralizing humanized mAb that could replace vaccines and chemical drugs. | Jing Liu Tiecheng Wang Ying Xie Yuanguo Li Jian He Xinghai Zhang Weiyang Sun Na Feng Chuan Qin Yuwei Gao Xianzhu Xia | 2019 | Biosafety and Health2019，1，3： | 0 |
| 20 | Spatial and temporal distributions of mercury species and controlling factors in Hongfeng Reservoir, Guizhou, China显示文摘 | Tianrong HE Xinbin FENG Guangle QIU Weiyang BAI Zhonggen LI Julia LU | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
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