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| 1 | Apolipoprotein E, angiotensin-converting enzyme and kallikrein gene polymorphisms and the risk of Alzheimer's disease and vascular dementia显示文摘 | Wang HK Fung HC Hsu WC Wu YR Lin JC Ro LS Chang KH Hwu FJ Hsu Y Huang SY Lee-Chen GJ Chen CM | 2006 | 中国生物学文摘2006，20，8： | 8 |
| 2 | Design,synthesis,and biological evaluation of novel benzimidazole derivatives and their interaction with calf thymus DNA and synergistic effects with clinical drugs显示文摘A series of new benzimidazole derivatives was synthesized and characterized by IR,1H NMR,13C NMR,MS,and HRMS spectra.All the new compounds were screened for their antimicrobial activities in vitro by a twofold serial dilution technique.The bioactive evaluation showed that 3,5-bis(trifluoromethyl)phenyl benzimidazoles were comparably or even more strongly antibacterial and antifungal than the reference drugs Chloromycin,Norfloxacin,and Fluconazole.The combination of2,4-difluorobenzyl benzimidazole derivative 5l and its hydrochloride 7 respectively with the antibacterials Chloromycin,Norfloxacin,and the antifungal Fluconazole was more sensitive to methicillin-resistant MRSA and Fluconazole-insensitive A.flavus.In addition,the interaction of compound 5l with calf thymus DNA demonstrated that this compound could effectively intercalate into DNA to form a compound 5l-DNA complex that might block DNA replication and thereby exert good antimicrobial activity. | ZHANG HuiZhen LIN JianMei RASHEED Syed ZHOU ChengHe | 2014 | Science China Chemistry2014，57，6： | 5 |
| 3 | Design,synthesis and biological evaluation of amino organophosphorus imidazoles as a new type of potential antimicrobial agents显示文摘A series of amino organophosphorus imidazoles were designed and synthesized as a novel structural type of antimicrobial agents.Bioactive evaluation in vitro showed that compound 3f exhibited equipotent or superior anti-methicillin-resistant Staphylococcus aureus(anti-MRSA) and anti-S. cerevisiae efficiencies(minimal inhibitory concentration(MIC)=2 μg/mL) to clinical drugs,and the combinations with antibacterial or antifungal drugs enhanced the antimicrobial efficiency. Highly active molecule 3f showed low propensity for bacteria to develop resistance, and the preliminary action mechanism studies demonstrated that 3f was membrane-active, but had no significant intercalation towards MRSA DNA. The computational study on 3f reasonably explained its high antimicrobial activity. Experimental data revealed that ground-state 3f-HSA complexes were formed mainly through hydrophobic interactions and hydrogen bonds with a spontaneous process, and the non-radioactive energy transfer from HSA to 3f occurred beyond F鰎ster resonance energy transfer theory. The participation of metal ions in 3f-HSA supramolucular system could increase the concentration of free compound 3f, and shorten its storage time and half-life in the blood to improve the maximum antimicrobial efficacy. | Wei-Wei Gao Syed Rasheed VijaiKumarReddy Tangadanchu Yi Sun Xin-Mei Peng Yu Cheng Feng-Xiu Zhang Jian-Mei Lin Cheng-He Zhou | 2017 | Science China Chemistry2017，60，6： | 3 |
| 4 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 5 | Randomized Clinical Trial of Cutting Balloon Angioplasty versus High-Pressure Balloon Angioplasty in Hemodialysis Arteriovenous Fistula Stenoses Resistant to Conventional Balloon Angioplasty显示文摘 | Syed Arafat Aftab Kiang Hiong Tay Farah G. Irani Richard Hoau Gong Lo Apoorva Gogna Benjamin Haaland Seck Guan Tan Siew Png Chng Shanker Pasupathy Hui Lin Choong Bien Soo Tan | 2013 | Journal of Vascular and Interventional Radiology2013，，： | 2 |
| 6 | Leptin in relation to hepatocellular carcinoma in patients with liver cirrhosis显示文摘 | WANG YY LIN SY | 2003 | Horm Res2003，60，4： | 1 |
| 7 | Synthesis and optoelectronic properties of arrayed p - type ZnO nanorods grown on ZnO film/Si wafer in aqueous so- lutions 显示文摘 | Lin C C Chen H P Chen SY | 2005 | Chem Phys Lett2005，404，13： | 1 |
| 8 | Branchiogenic squamous cell carcinoma: a case report显示文摘 | Lin YC Fang SY Huang RH | 2004 | Int J Oral Maxillofac Surg2004，33，： | 1 |
| 9 | Increased serum leptin concentrations correlate with soluble tumour necrosis factor receptor levels in patients with cirrhosis 显示文摘 | Lin SY Wang YY Sheu WH | 2002 | Clin Endocrinol (Oxf)2002，57，6： | 1 |
| 10 | Increase of disintergin metalloprotease 10 (ADAM10) expression in oral squamous cell carcinoma 显示文摘 | Ko SY Lin SC Wong YK | 2007 | Cancer Lett2007，245，12： | 1 |
| 11 | Abscess caused by Citrobacter koseri? infection: three case reports and a literature review显示文摘 | Lin SY Ho MW Yang YF | 2011 | In- tern Med2011，50，12： | 1 |
| 12 | Lactobacillus effects on cholesterol in vitro aml in viva results显示文摘 | Lin SY Ayres JW Willia JR | 1989 | Dairy sci1989，72，2： | 1 |
| 13 | Functional determinants of NS2B for activation of Japanese encephalitis virus NS3 protease显示文摘 | Lin CW Huang HD Shiu SY | | 0，，01： | 1 |
| 14 | Newborn genetic screening for hearing impairment:apreliminary study at a tertiary center显示文摘 | Wu CC Hung CC Lin SY | 2011 | PLoS One2011，6，22： | 1 |
| 15 | Functional role of matrix metalloproteinase-28 in the oral squamous cell carcinoma 显示文摘 | Lin MH Liu SY Su HJ | 2006 | Oral Oncol2006，42，9： | 1 |
| 16 | Functional role of matrix metalloproteinase-28 in the oral squamous cell carcinoma显示文摘 | Liu SY Su HJ | 2006 | Oral Oncol2006，42，9： | 1 |
| 17 | BRIT1/MCPH1 is a muhifunetional DNA damage responsive protein mediating DNA remodel-ing显示文摘 | Peng G Lin SY | 2009 | Cell Cycle2009，8，19： | 1 |
| 18 | Functional recoveyy among elderly people one year after hip fracture surgery 显示文摘 | LIN PC CHANG SY | 2004 | J Nurs Res2004，12，1： | 1 |
| 19 | Primary hepatic peripheral T-cell lymphoma in a patient with chronic hepatitis B infection显示文摘 | Leung VK Lin SY Loke TK | | 0，，： | 1 |
| 20 | Structural basis for the identification f the N terminal domain of coronavirus nucleo- capsid protein as an antiviral target 显示文摘 | Lin SY Liu CL Chang YM | 2014 | Med Chem2014，57，6： | 1 |
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