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| 1 | 利用地理信息系统数据库分析钉螺空间区域的分布显示文摘目的 利用地理信息系统(GIS)数据库分析中国大陆钉螺的空间区域分布。方法 收集中国九省34 个种群钉螺等位基因实验所得的种群遗传变异资料以及钉螺易感性实验资料,建立数据库。以世界数字地图为背景,在ArcView 3.0 a 软件上与钉螺的遗传变异和易感性数据库相联。采用ArcView 空间分析和GIS重叠分析功能进行区域划分。收集1995 年AVHRRNDVI卫星图像组合成流行季节的卫星图像,并重叠各种群钉螺的杂合指数、多态位点百分率和血吸虫感染率分布图,进行图像分类。结果 空间分析结果,将钉螺遗传杂合性指数、多态位点百分率和钉螺感染率的分布图,划分成西部和东部二大区域,各区域内有各种类型。三层分布图与AVHRRNDVI卫星图像重叠分析后,显示出西部四川、西部云南、中部江湖洲滩和东南部沿海4 个明显不同的区域。结论 首次运用GIS分析种群遗传学资料,佐证了中国大陆钉螺种群结构为分裂亚群结构,并可区分出多个亚种的理论。 | 周晓农 TK Kristensen 洪青标 孙乐平 M Fuentes JB Malone | 1999 | 中华预防医学杂志1999，33，6： | 27 |
| 2 | 生物技术与制浆造纸工业(上)显示文摘就生物技术在制浆造纸工业的应用现况及其前景作出综述。文章涉及的三个主要方面包括导致木素降解的真菌体系及其应用,多糖类降解体系及其利用,以及其他体系的生物技术。在论述中,特别注意到介绍可望在中国应用的某些最新成果。 | 张厚民 Kirk,TK | 1994 | 中国造纸1994，13，4： | 21 |
| 3 | 呼吸道病毒与气道上皮细胞的免疫调控显示文摘气道是人体与外界交流的重要通道,每天人体经气道吸入空气可达10 000~20 000升,因此不可避免地需要与环境中大量的致病微生物长期接触。与'职业型(professional)'免疫细胞类似,气道上皮细胞(AECs)具有天然免疫功能,能侦测病原体(如不同种属的呼吸道病毒)的入侵并迅速产生宿主免疫反应。近年来的研究发现,为避免慢性炎症和维持免疫稳态,作为'非职业型(non-professional)'免疫细胞的AECs具有重要的调控气道局部免疫力的功能,这些功能包括:(1)AECs可高水平表达模式识别受体(PRRs),又称病原相关模式(PAMP),如Toll样受体家族(TLRs)、维A酸诱导基因Ⅰ(RIG-Ⅰ)样受体等,这些受体的存在使得AECs具有灵敏的病原侦测功能。(2)AECs通过调节天然免疫反应的灵敏度,发挥天然免疫和获得性免疫的调节器作用,在气道微环境中通过与'职业型'免疫细胞的互相作用,使针对病原体的宿主免疫反应达到可控的程度。(3)AECs免疫调节功能的缺失或破坏可能引起慢性气道炎症性疾病的发生和发展。本综述聚焦AECs如何通过直接作用和间接作用调控气道免疫能力,应对呼吸道病毒这一类重要的气道病原体感染,并着重阐明由于AECs调控机制的缺失和改变导致气道黏膜免疫功能失调和炎症(如急性和慢性鼻-鼻窦炎)的机制。 | 严彦 王昭妮 洪海裕 陈锴升 王筱惠 Luukkainen Annika Chow Vincent TK 王德云 | 2017 | 解放军医学杂志2017，42，10： | 9 |
| 4 | Endoscopic hemoclip treatment for bleeding peptic ulcer显示文摘AIM To evaluate the efficacy of endoscopichemoclip in the treatment of bleeding pepticulcer.METHODS Totally,40 patients with F1a andFib hemorrhagic activity of peptic ulcers wereenrolled in this uncontrolled prospective studyfor endoscopic hemoclip treatment.We used anewly developed rotatable clip-device for theapplication of hemoclip(MD850)to stopbleeding.Endoscopy was repeated if there wasany sign or suspicion of rebleeding,and re-clipping was performed if necessary andfeasible.RESULTS Initial hemostatic rate by clippingwas 95%,and rebleeding rate was only 8%.Ultimate hemostatic rates were 87%,96%,and93% in the Fla and Flb subgroups,and totalcases,respectively.In patients with shock onadmission,hemoclipping achieved ultimatehemostasis of 71% and 83% in F1a and F1bsubgroups,respectively.Hemostasis reached100% in patients without shock regardless ofhemorrhagic activity being F1a or F1b.Theaverage number of clips used per case was 3.0(range 2-5).Spurting bleeders required moreclips on average than did oozing bleeders(3.4versus 2.8).We observed no obviouscomplications,no tissue injury,or impairmentof ulcer healing related to hemoclipping.CONCLUSION Endoscopic hemoclip placementis an effective and safe method.With theimprovement of the clip and application device,the procedure has become easier and much moreefficient.Endoscopic hemoclipping deservesfurther study in the treatment of bleeding pepticulcers. | Lai YC Yang SS Wu CH Chen TK | 2000 | World Journal of Gastroenterology2000，6，1： | 6 |
| 5 | In utero transplantation of human bone marrow-derived multipotent mesenchymal stem cells in mice显示文摘 | Chou SH Kuo TK Liu M Lee OK | 2006 | 中国生物学文摘2006，20，5： | 6 |
| 6 | A population-based follow-up study on gallstone disease among type 2 diabetics in Kinmen,Taiwan显示文摘瞄准:估计发生并且在 Kinmen 在类型 2 糖尿病患者之中为胆石疾病(GSD ) 冒因素的风险,台湾。方法:为 GSD 的一个屏蔽节目被采用了即时腹的超声在病人们有 fasted 至少八个小时以后,检验腹的区域的二位专家执行。屏蔽,它在 2001 被进行,包含了与类型 2 糖尿病诊断的 848 个病人。在有流行 GSD 的 63 个题目的排除以后,没有 GSD 的 377 个参加者为秒轮屏蔽在 2002 被邀请。281 的一个总数(74.5%) 使遭到是 re-examined。结果:在 281 类型之中没在首先屏蔽有 GSD 的 2 名糖尿病患者, 10 在 2002 开发了 GSD。发生每年是 3.56%(95% CI:1.78% 每 year-6.24% 每年) 。用一个考克斯回归模型,变老(RR = 1.07, 95% CI:1.00-1.14 ) ,腰圆周(RR = 1.12, 95% CI:1.01-1.29 ) ,并且中高音(RR = 1.13, 95%CI:1.01-1.26 ) 看起来显著地与 GSD 的开发被相关。结论:老年是为 GSD 的发展的一个已知的风险因素。我们那更大的腰圆周和提高的中高音铺平的学习表演也在 Kinmen 在类型 2 糖尿病患者之中与 GSD 的发展被联系。 | Tao-Hsin Tung Hsiao-Man Ho Hui-Chuan Shih Pesus Chou Jorn-Hon Liu Victor TK Chen De-Chuan Chan Chi-Ming Liu | 2006 | World Journal of Gastroenterology2006，12，28： | 6 |
| 7 | 生物技术与制浆造纸工业(下)显示文摘文章就生物技术在制浆造纸工业的应用现况及其前景,作出综述。文章涉及的三个主要方面包括导致木素降解的真菌体系及其应用,多糖类降解体系及其利用,以及其他体系的生物技术。在论述中,特别注意到介绍可望在中国应用的某些最新成果。 | 张厚民 Kirk,TK | 1994 | 中国造纸1994，13，5： | 5 |
| 8 | 生物信息学的通天塔显示文摘对各种完整基因组的测序是一种重大的成就,但是由此所积累的大量数据才刚刚开始得到阐释.乍看来,任务(理解这些数据)是很直接了当的:对各种基因进行定位并对编码区进行翻译以建立它们的蛋白质产物;进行相似性(similarity)检索以与已知序列建立关系,并且通过进化关系上的推断来确定基因的功能;最后,使用已知的或者模型衍生的结构来根据结构推断功能.鉴于使用的数据量大,此过程应该尽可能自动化. | Attw.,TK 李伟 | 2001 | 世界科学2001，，1： | 4 |
| 9 | Anti-inflammatory activity of the leaf extacts of Gendarussa vulgaris Nees显示文摘Objective:To evaluate the anti-inflammatory property of the leaf exacts of Gendarussa vulgaris(G.vulgarix) Nees.Methods:G.vulgarix Nees of the family Apocynaceae is a medium sized tree grown in semishade or no shade and is common in the Ernad and Nilambur taluks of Kerala. Various parts of this plant have been used in the treatment of ulcers,sores,inflammation, dyspepsia,healing of wounds,etc.The present study aimed at the evaluation of anti-inflammatory property of the aqueous and alcoholic extracts of the leaves by both in vitro and in vivo methods. In vitro method was estimated by human red blood cell membrane stabilisation(HRBC) method and in vivo method was estimated on the carrageenan induced paw oedima.Results:Both the methods showed significant anti-inflammatory property of the different extracts tested. Conclusions:The alcoholic extract at a concentration of 300 mg/mL showed potent activity on comparing with the standard drug diclofenac sodium. | TK Mohamed Saleem AK Azeem C Dilip C Sankar NV Prasanth R Duraisami | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，2： | 3 |
| 10 | Inhibitory activities of extracts of Rumex dentatus, Commelina benghalensis, Ajuga bracteosa, Ziziphus mauritiana as well as their compounds of gallic acid and emodin against dengue virus显示文摘Objective: To investigate the inhibitory effects against dengue virus serotype 2(DENV-2) by five different fractions(extracted by methanol, ethanol, benzene, chloroform and n-hexane) of Rumex dentatus, Commelina benghalensis, Ajuga bracteosa and Ziziphus mauritiana, as well as their constituents(gallic acid, emodin, and isovanillic acid). Methods: All the samples were tested for cytotoxicity on baby hamster kidney cells by MTT assay and for anti-DENV-2 activity by plaque reduction neutralization assay using two DENV-2 doses(45 and 90 plaqueforming units or PFU). Results: All the samples except isovanillic acid exhibited significant prophylactic effects against DENV-2 infectivity(without cytotoxicity) when administered to cells before infection, but were not effective when given 6 h post-infection. The methanol extract of Rumex dentatus demonstrated the highest antiviral efficacy by inhibiting DENV-2 replication, with IC_(50) of 0.154 μg/mL and 0.234 μg/mL, when added before infection with 45 and 90 PFU of virus, respectively. Gallic acid also exhibited significant antiviral effects by prophylactic treatment prior to virus adsorption on cells, with IC_(50) of 0.191 μg/mL and 0.522 μg/mL at 45 and 90 PFU of DENV-2 infection, respectively. Conclusions: The highly potent activities of the extracts and constituent compounds of these plants against DENV-2 infectivity highlight their potential as targets for further research to identify novel antiviral agents against dengue. | Riffat Batool Ejaz Aziz Tariq Mahmood Benny KH Tan Vincent TK Chow | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，4： | 3 |
| 11 | Single-port laparoscopic cholecystectomy vs standard laparoscopic cholecystectomy:A non-randomized,agematched single center trial显示文摘AIM: To compare the safety of single-port laparoscopic cholecystectomies with standard four-port cholecystectomies.METHODS: Between January 2011 and December 2012 datas were gathered from 100 consecutive patients who received a single-port cholecystectomy. Patient baseline characteristics of all 100 single-port cholecystectomies were collected(body mass index, age, etc.) in a database. This group was compared with 100 age-matched patients who underwent a conventional laparoscopic cholecystectomy in the same period. Retrospectively, per- and postoperative data were added. The two groups were compared to each other using independent t-tests and χ2-tests, P values below 0.05 were considered significantly different.RESULTS: No differences were found between both groups regarding baseline characteristics. Operating time was significantly shorter in the total single-port group(42 min vs 62 min, P < 0.05); in procedures performed by surgeons the same trend was seen(45 min vs 59 min, P < 0.05). Peroperative complications between both groups were equal(3 in the single-port group vs 5 in the multiport group; P = 0.42). Although not significant less postoperative complications were seen in the single-port group compared with the multiport group(3 vs 9; P = 0.07). No statistically significant differences were found between both groupswith regard to length of hospital stay, readmissions and mortality. CONCLUSION: Single-port laparoscopic cholecystectomy has the potential to be a safe technique with a low complication rate, short in-hospital stay and comparable operating time. Single-port cholecystectomy provides the patient an almost non-visible scar while preserving optimal quality of surgery. Further prospective studies are needed to prove the safety of the single-port technique. | Yoen TK van der Linden Koop Bosscha Hubert A Prins Daniel J Lips | 2015 | World Journal of Gastrointestinal Surgery2015，7，8： | 2 |
| 12 | 超声乳化联合小梁切除术中使用丝裂霉素C临床观察显示文摘目的 评价超声乳化联合小梁切除术中使用丝裂霉素C(MMC)的效果和安全性。方法 回顾性随访联合手术65例 73眼 ,术中使用MMC组 3 4例 3 7眼 ,未用MMC的对照组 3 1例 3 6眼。对比两组手术前后的眼压、视力及术后并发症。结果 术后 1年 ,MMC组眼压从术前 (17 87± 5 41)mmHg降至 (11 61± 5 12 )mmHg ,对照组从术前 (18 82± 2 82 )mmHg降至(14 86± 2 91)mmHg ,MMC组与对照组相比眼压下降差异具有显著意义 (P =0 0 2 8)。术后 2组平均视力都显著提高 (P <0 0 1) ,但提高程度的差异无显著意义 (P =0 876)。结论 白内障超声乳化联合小梁切除术中使用MMC(0 4mg/ml ,5mins) | 杨瑾 LIM Boon Ang Paul TK CHEW | 2003 | 眼外伤职业眼病杂志2003，25，8： | 2 |
| 13 | 慢性阻塞性肺疾病急性加重的标准化测量显示文摘背景和目的:COPD急性加重(AECOPD)反复发生是COPD病情进展的重要原因之一,减少AECOPD发生频率也是对COPD进行干预的主要目标之一。但是到目前为止,评估AECOPD的发生频率、严重程度和持续时间尚无有效的、标准化的监测工具。 | Leidy NK Wilcox TK Jones PW 白澎 孙永昌 | 2011 | 中华结核和呼吸杂志2011，34，9： | 2 |
| 14 | Apoptosis after traumatic brain injury显示文摘 | Raghupathi R Graham DI McIntosh TK | 2000 | J Neurotrauma2000，17，10： | 2 |
| 15 | 纤维素酶活力的测定显示文摘 | Ghos.,TK 张玉臻 | 1989 | 应用微生物1989，，2： | 2 |
| 16 | preliminary study of D-dimer as a possible marker of acute bowel ischaemia 显示文摘 | Acosta S Nilsson TK Bjorck M | 2001 | Br J Surg2001，88，3： | 2 |
| 17 | Acute respiratory distress syndrome in critically ill patients with severe acute respiratory syndrome 显示文摘 | Lew TW Kwek TK Tai D | 2003 | JAMA2003，290，： | 2 |
| 18 | Attenuated fibrinolysis and accelerated atherogenesis in type 2 diabetic patients显示文摘 | Schneider DJ Nordt TK Sobel BE | | 0，，： | 2 |
| 19 | Risk of dementia after stroke in a hospitalized cohort:results of longitudinal study显示文摘 | Tatemichi TK Paik M Bagiella E | 1994 | Neurology1994，44，： | 2 |
| 20 | Induction of Smad6 mRNA by bone morphogenetic proteins显示文摘 | Takase M Imamura T Sampath TK | 1998 | Biochem Biophys Res Commu1998，244，1： | 2 |
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