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| 1 | Recurrence or metastasis of HCC:predictors,early detection and experimental antiangiogenic therapy显示文摘AIM To investigate the predictors forrecurrence or metastasis of HCC,and toevaluate the effect of antiangiogenic therapy onthe growth of transplantable human HCC in nudemice.METHODS RT-PCR was used to measure theexpression of matrix metalloproteinase-9(MMP-9)and vascular endothelial growth factor(VEGF)in 56 pairs of nontumorous liver andtumor samples.Sixty blood samples from humanHCC were examined by nested RT-PCR to find outAFP mRNA.Recombinant human endostatin andpolyclonal antibody against VEGF wereadministered to treat human HCC transplanted innude mice.RESULTS Thirty of 56 HCC samples showedstronger expression of MMP-9 in tumoroustissues than in nontumorous tissues.Fifteen ofthe 26 patients with relative expression level ofMMP-9 more than 0.34 developed tumorrecurrence or metastasis,whereas only 7 of 30patients with relative expression level less than0.34 developed tumor recurrence(P<0.05).There was no significant difference in therelative expression level of VEGF betweenpatients with postoperative recurrence ormetastasis and those without recurrence.AFPmRNA was detectable in 53.3% of patients withHCC.The sensitivity and specificity of AFPmRNA as a marker to detect hematogenousdissemination of HCC cells was 81.8% and84.4%,respectively.Recombinant human endostatin and polyclonal antibody against VEGFinhibited the growth of transplantable HCC innude mice by 52.2% and 45.7%,respectively.CONCLUSION MMP-9 expression in HCCcorrelates with the postoperative recurrence ormetastasis of HCC.Patients with high level ofMMP-9 expression in HCC are susceptible tometastasis.AFP mRNA could serve as anindicator of hematogenous spreading of HCCcells in circulation and a predictor of recurrenceor metastasis of HCC.Antiangiogenesis may bean adjuvant therapy for HCC. | Jiang YF Yang ZH Hu JQ | 2000 | World Journal of Gastroenterology2000，6，1： | 57 |
| 2 | A GC-based metabonomics investigation of type 2 diabetes by organic acids metabolic profile显示文摘 | Yuan, KL Kong, HW Guan, YF Yang, J Xu, GX | 2007 | 中国生物学文摘2007，21，11： | 26 |
| 3 | Awakening concentration of desflurane is decreased in patients with obstructive jaundice显示文摘 | Song JG Cao YF Yang LQ Yu WF Li Q Song JC Fu XY Fu Q | 2005 | 第二军医大学学报2005，26，8： | 15 |
| 4 | Apoptosis of circulating lymphocytes induced by whole body γ-irradiation and its mechanism显示文摘 | Cui YF Gao YB Yang H | 1999 | J Environ Pathol Toxicol Oncol1999，18，： | 2 |
| 5 | Molecular mechanism of damage and repair of mouse thymus lymphocytes induced by radiation显示文摘 | Cui YF Yang H Wu SX | 2002 | CMJ2002，115，7： | 2 |
| 6 | Abscess caused by Citrobacter koseri? infection: three case reports and a literature review显示文摘 | Lin SY Ho MW Yang YF | 2011 | In- tern Med2011，50，12： | 1 |
| 7 | Treatment of vitiligo by transplantation of cultured pure melanocyte suspension:analysis of 120 cases显示文摘 | Chen YF Yang PY Hu DN | 2004 | J Am Acad Dermatol2004，51，1： | 1 |
| 8 | Homeochronous usage fratruc- tural bone allog rafts with vascularized fibular autografts for biologi- cal repair of massive bone defects in the lower extremities after bone tumor excision显示文摘 | Yang YF Zhang GM Xu ZH | 2010 | Reconstr Microsurg2010，26，： | 1 |
| 9 | H2S generated by heart in rat and its effect on cardiac function 显示文摘 | Geng B Yang JH Qi YF | 2004 | Biochem Biophys Res Commun2004，313，2： | 1 |
| 10 | Aberrant RNA splicing in RHD 7 - 9 exons of DEL individuals in Taiwan : a mechanism study 显示文摘 | Lin HC Eng HL Yang YF | 2010 | Bio- chim Biophys Acta2010，1800，6： | 1 |
| 11 | Multihase CT angiography versus single-hase CT angiography:comparison of image quality and radiation dose显示文摘 | Yang CY Chen YF Lee CW | | 0，，： | 1 |
| 12 | Preparative isolation of triterpenoids from Ganoderma lucidum by counter-current chromatography combined with pH-zone-refining 显示文摘 | Cheng CR Li YF Xu PP Feng RH Yang M Guan SH Guo DA | 2012 | Food Chem2012，130，： | 1 |
| 13 | Exploratory analyses of efficacy data from major depressive disorder trials submitted to the US Food and Drug Administration in support of new drug applications 显示文摘 | Khin NA Chen YF Yang Y | 2011 | J Clin Psychiatry2011，72，： | 1 |
| 14 | Protective effects of intermedin/adrenomedullin2 on ischemia/reperfusion injury in isolated rat hearts显示文摘 | Qi YF Jia YX | 2005 | Peptides2005，26，3： | 1 |
| 15 | Biological and molecular basis of human breast cancer显示文摘 | Russo J Yang X Hu YF | 1998 | Front Biosci1998，3，： | 1 |
| 16 | Hepatitis B e antigen and the risk of hepatocellular carcinoma显示文摘 | Yang HI Lu SN Liaw YF | 2002 | N Engl J Med2002，347，3： | 1 |
| 17 | Clay minerals in a soil chronosequence derived from basalt on Hainan Island, China and its implication for pedogenesis显示文摘 | He Y Li DC Velde B Yang YF Huang CM Gong ZT Zhang GL | 2008 | Geoderma2008，148，： | 1 |
| 18 | Squalene synthase induces tumor necrosis factor receptor 1 enrichment in lipid rafts to promote lung cancer metastasis显示文摘 | Yang YF Jan YH Liu YP | 2014 | Am J Respir Criti Care Med2014，190，6： | 1 |
| 19 | Reduced arterial elasticity is associated with endothelial dysfunction in persons of advancing age : comparative study of noninvasive pulse wave analysis and laser Doppler blood flow measurement 显示文摘 | Tao J Jin YF Yang Z | 2004 | Am J Hypertens2004，17，8： | 1 |
| 20 | H2S generated by heart in rat and its effects on cardiac function 显示文摘 | Geng B Yang JH Qi YF | 2004 | Biochem Biophys Res Commun2004，313，2： | 1 |
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