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| 1 | Review on supermolecules as chemical drugs显示文摘Supramolecular medicinal chemistry field has been a quite rapidly developing,increasingly active and newly rising interdiscipline which is the new expansion of supramolecular chemistry in pharmaceu-tical sciences,and is gradually becoming a relatively independent scientific area. Supramolecular drugs could be defined as medicinal supermolecules formed by two or more molecules through non-covalent bonds. So far a lot of supermolecules as chemical drugs have been widely used in clinics. Supermolecules as chemical drugs,i.e. supramolecular chemical drugs or supramolecular drugs,which might have the excellences of lower cost,shorter period,higher potential as clinical drugs for their successful research and development,may possess higher bioavailability,better biocompatibility and drug-targeting,fewer multidrug-resistances,lower toxicity,less adverse effect,and better curative effects as well as safety,and therefore exhibit wide potential application. These overwhelming advan-tages have drawn enormous special attention. This paper gives the definition of supramolecular drugs,proposes the concept of supramolecular chemical drugs,and systematically reviews the recent ad-vances in the research and development of supermolecules,including organic and inorganic complex ones as chemical drugs in the area of antitumor,anti-inflammatory,analgesic,antimalarial,antibacterial,antifungal,antivirus,anti-epileptic,cardiovascular agents and magnetic resonance imaging agents and so on. The perspectives of the foreseeable future and potential application of supramolecules as chemical drugs are also presented. | ZHOU ChengHe GAN LinLing ZHANG YiYi ZHANG FeiFei WANG GuangZhou JIN Lei GENG RongXia | 2009 | Science China Chemistry2009，52，4： | 17 |
| 2 | A series of naphthalimide azoles: Design, synthesis and bioactive evaluation as potential antimicrobial agents显示文摘A series of naphthalimide azoles as potential antibacterial and antifungal agents were conveniently and efficiently synthesized starting from commercially available 6-bromobenzo[de]isochromene-1,3-dione. All the new compounds were characterized by NMR, IR, MS and HRMS spectra. Their antimicrobial activities were evaluated against four Gram-positive bacteria, four Gram-negative bacteria and two fungi using two-fold serial dilution technique. The biological assay indicated that most of the prepared compounds exhibited inhibition to the tested strains. In particular, the triazolium derivatives not only gave higher efficacy than their corresponding precursory azoles, but also demonstrated comparable or even better potency than the reference drugs Chloromycin, Orbifloxacin and Fluconazole. Some factors including structural fragments, pH and ClogP values of the target molecules were also preliminarily discussed. | DAMU Guri L. V. WANG QingPeng ZHANG HuiZhen ZHANG YiYi LV JingSong ZHOU ChengHe | 2013 | Science China Chemistry2013，56，7： | 8 |
| 3 | Synthesis and biological activities of thio-triazole derivatives as novel potential antibacterial and antifungal agents显示文摘A series of novel thio-triazole derivatives including thiols, thioethers and thiones as well as some corresponding triazolium compounds were conveniently and efficiently synthesized from commercially available halobenzyl halides and thiosemicarbazide. All the new compounds were characterized by 1 H NMR, 13 C NMR, FTIR, MS and HRMS spectra. Their antibacterial and antifungal activities in vitro were evaluated against four Gram-positive bacteria, four Gram-negative bacteria and two fungi by two-fold serial dilution technique. The preliminary bioassay indicated that some prepared triazoles exhibited effective antibacterial and antifungal activities. Especially, 3,4-dichlorobenzyl triazolethione and its triazolium derivatives displayed the most potent activities against all the tested strains. | WANG QingPeng ZHANG JingQing DAMU Guri L.V. WAN Kun ZHANG HuiZhen ZHOU ChengHe | 2012 | Science China Chemistry2012，55，10： | 7 |
| 4 | Design,synthesis,and biological evaluation of novel benzimidazole derivatives and their interaction with calf thymus DNA and synergistic effects with clinical drugs显示文摘A series of new benzimidazole derivatives was synthesized and characterized by IR,1H NMR,13C NMR,MS,and HRMS spectra.All the new compounds were screened for their antimicrobial activities in vitro by a twofold serial dilution technique.The bioactive evaluation showed that 3,5-bis(trifluoromethyl)phenyl benzimidazoles were comparably or even more strongly antibacterial and antifungal than the reference drugs Chloromycin,Norfloxacin,and Fluconazole.The combination of2,4-difluorobenzyl benzimidazole derivative 5l and its hydrochloride 7 respectively with the antibacterials Chloromycin,Norfloxacin,and the antifungal Fluconazole was more sensitive to methicillin-resistant MRSA and Fluconazole-insensitive A.flavus.In addition,the interaction of compound 5l with calf thymus DNA demonstrated that this compound could effectively intercalate into DNA to form a compound 5l-DNA complex that might block DNA replication and thereby exert good antimicrobial activity. | ZHANG HuiZhen LIN JianMei RASHEED Syed ZHOU ChengHe | 2014 | Science China Chemistry2014，57，6： | 5 |
| 5 | Chalcone-Benzotriazole Conjugates as New Potential Antimicrobial Agents: Design, Synthesis, Biological Evaluation and Synergism with Clinical Drugs显示文摘当新潜在的抗菌剂代理人被 1 H NMR, 13 C NMR,红外和 HRMS 系列。抗菌剂试金表明了目标混合物给了的那一些对好抗菌剂和抗真菌的活动中等。N-1 导出 benzotriazole 5e, N-2 导出对测试的一些的展出珍贵禁止的功效拉紧的 benzotriazole 6a。特别,衍生物 6a 对 C 给了优异抗真菌的功效。utilis, S。cerevisiae 和 A。flavus (MIC=0.01, 0.02, 0.02biguity,和在感情方面、支持的亲戚关系关系中产生的紧张的焦点,还也开发资源。主要争论是有 precarity ,和那种亲戚关系的不同模式,哪个主要在一个不明确的世界上被认为是安全,吗能事实上加重动荡的 condition.Lentrepreneuriat pr 賦?觧???铧????釦?觧???藦??藦????賧??????闧?闦?蓦?觧???? 吗?? | Hanbo Liu Lavanya Gopala Srinivasa Rao Avula Ponmani Jeyakkumar Xinmei Peng Chenghe Zhou Rongxia Geng | 2017 | Chinese Journal of Chemistry2017，35，4： | 1 |
| 6 | Reagentless chemiluminescence biosensor for determination of hydrogen peroxde based on the immobilization of horseradish peroxidase on biocompatible chitosan membrane显示文摘 | Zhou G Wang G Xu J ChengH | 2002 | Sensors and actuatorsB2002，81，： | 1 |
| 7 | Synthesis and evaluation of a class of new coumarin triazole derivatives as potential antimicrohial agents 显示文摘 | SHI Yuan ZHOU Chenghe | 2011 | Bioorganic & Medicinal Chemistry Letters2011，21，3： | 1 |
| 8 | Siliconization for Wall Conditioning and Its Effect on Plasma Performance in HL-2A Tokamak显示文摘 | DUAN Xuru CAO Zeng CUI Chenghe CAI Xiao SUN Hongjuan DING Xuantong PAN Yudong WANG Mingxu YANG Qingwei SONG Xianming LIU Dequan LIU Yi JI Xiaoquan CUI Zhengying ZHOU Yan LIU Yong 无 | 2006 | Southwestern Institute of Physics Annual Report2006，，1： | 0 |
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