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| 1 | Precore/basal core promoter mutants and hepatitis B viral DNA levels as predictors for liver deaths and hepatocellular carcinoma显示文摘AIM: To conduct a retrospective study in 400 chronic hepatitis B patients in order to identify hepatitis B viral factors associated with complications of liver disease or development of hepatocellular carcinoma.METHODS: The mean follow-up time was 83.6 ± 39.6 mo. Alpha-fetoprotein test and abdominal ultrasound were used for cancer surveillance. Hepatitis B basal core promoter mutants, precore mutants, genotypes, hepatitis B viral DNA (HBV DNA) level and hepatitis B e antigen (HBeAg) were measured. Univariate analysis and logistic regression were used to assess odds ratios for viral factors related to liver deaths and hepatocellular carcinoma development. RESULTS: During follow-up, 38 patients had liver deaths not related to hepatocellular carcinoma. On multivariate analysis, older age [odds ratio: 95.74 (12.13-891.31); P < 0.0001], male sex [odds ratio: 7.61 (2.20-47.95); P = 0.006], and higher log10 HBV DNA [odds ratio: 4.69 (1.16-20.43); P < 0.0001] were independently predictive for these liver related deaths. Also, 31 patients developed hepatocellular carcinoma. Multivariate analysis showed that older age [odds ratio: 26.51 (2.36-381.47); P = 0.007], presence of precore mutants [odds ratio: 4.23 (1.53-19.58); P = 0.02] and presence of basal core promoter mutants [odds ratio: 2.93 (1.24-7.57); P = 0.02] were independent predictors for progression to hepatocellular carcinoma.CONCLUSION: Our results show that high levels of baseline serum HBV DNA are associated with non- hepatocellular carcinoma-related deaths of liver failure, while genetic mutations in the basal core promoter and precore regions are predictive for development of hepatocellular carcinoma. | Myron J Tong Lawrence M Blatt Jia-Horng Kao Jason Tzuying Cheng William G Corey | 2006 | World Journal of Gastroenterology2006，12，41： | 11 |
| 2 | Functional Interaction of the SNARE Protein NtSyp121 in Ca^2+ Channel Gating, Ca^2+ Transientsand ABA Signalling of Stomatal Guard Cells显示文摘有特别圈套的总科,膜泡 trafficking 蛋白质为在植物的细胞的发信号是批评的现在成长证据。从这个实验室的工作首先表明了那一可溶,禁止(主导否定) SNARE NtSyp121 的碎片堵住了 K+ 和 Cl 隧道回答到压力相关的荷尔蒙 abscisic 酸(骆驼毛的织物) ,但是在信号中介上关于功能的影响未解决一个问题,特别在调停 Ca2+ 的发信号的事件上。这里,我们报导为 SNARE 的行动的一个模式在 Ca2+ 隧道 gating 和它的作为结果的效果通过改变直接调停了在上 cytosolic 免费[Ca2+]([Ca2+] 我) 举起。我们发现表示 NtSyp121 的一样的禁止的碎片堵住唤起骆驼毛的织物的有气孔的闭合,但是仅仅部分面对 NO 压制有气孔的闭合施主,厉声说,它支持[Ca2+] i 举起独立于血浆膜 Ca2+ 隧道。与这些观察一致,在血浆膜的Ca2+隧道 gating 被 SNARE 碎片以在为触发上升在减少潜力有效的一种方式改变[Ca2+]我,并且我们直接证明它在 vivo 的表示导致显著抑制唤起[Ca2+] i transients 。这些观察为在植物房间血浆膜的与Ca2+隧道的 SNARE 的功能的联合提供主要证据并且,因为[Ca2+]我在警卫房间在K+和 Cl 隧道水流的控制起一个关键作用,他们在有气孔的闭合期间与离子隧道规定为圈套集成强调重要机制。 | Sergei Sokolovski Adrian Hills Robert A. Gay Michael R. Blatt | 2008 | Molecular Plant2008，1，2： | 11 |
| 3 | Distributed Differences Structures Underlie Gating between the Kin Channel KAT1 and the Kout Channel SKOR显示文摘 | Janin Riedelsberger Tripti Sharma Wendy Gonzalez Pawel Gajdanowicz Samuel Elias Morales-Navarro Carlos Garcia-Mata Bernd Mueller-Roeber Fernando Danilo Gonzalez-Nilo Michael R. Blatt Ingo Dreyer | 2010 | Molecular Plant2010，3，1： | 2 |
| 4 | Imaging Electronic Structure of Carbon Nanotubes by Voltage-Contrast Scanning Electron Microscopy显示文摘We introduce voltage-contrast scanning electron microscopy(VC-SEM)for visual characterization of the electronic properties of single-walled carbon nanotubes.VC-SEM involves tuning the electronic band structure and imaging the potential profi le along the length of the nanotube.The resultant secondary electron contrast allows to distinguish between metallic and semiconducting carbon nanotubes and to follow the switching of semiconducting nanotube devices,as confi rmed by in situ electrical transport measurements.We demonstrate that high-density arrays of individual nanotube devices can be rapidly and simultaneously characterized.A leakage current model in combination with fi nite element simulations of the device electrostatics is presented in order to explain the observed contrast evolution of the nanotube and surface electrodes.This work serves to fi ll a void in electronic characterization of molecular device architectures. | Aravind Vijayaraghavan Sabine Blatt Christoph Marquardt Simone Dehm Raghav Wahi Frank Hennrich Ralph Krupke | 2008 | Nano Research2008，1，4： | 2 |
| 5 | Drug-induced liver injury and COVID-19:A review for clinical practice显示文摘Coronavirus disease 2019(COVID-19)consists of a systemic disease that can present many complications.The infection presents broad clinical symptoms and a high rate of transmissibility.In addition to severe acute respiratory syndrome,the patients manifest complications beyond the respiratory system.The frequency of liver damage in COVID-19 patients ranges from 14.8% to 53% of patients.One should pay attention to drug-induced liver injury(DILI)in patients with COVID-19,especially considering the off-label use of drugs in prophylactic and therapeutic regimens applied on large scales.This review aims to present relevant information on the medication used so far in COVID-19 patients and its possible hepatotoxicity.We reviewed liver damage in patients with COVID-19 on PubMed and Virtual Health Library to investigate DILI cases.Four studies were selected,involving the medicines remdesivir,tocilizumab and a pharmacovigilance analysis study.The hepatotoxicity profile of drugs presented in the literature considers use in accordance to usual posology standards for treatment.However,drugs currently used in the management of COVID-19 follow different dosages and posology than those tested by the pharmaceutical industry.The deficiency of uniformity and standardization in the assessment of hepatotoxicity cases hinders the publication of information and the possibility of comparing information among healthcare professionals.It is suggested that severe liver injury in COVID-19 patients should be reported in pharmacovigilance institutions,and physicians should pay attention to any considerable abnormal liver test elevation as it can demonstrate unknown drug hepatotoxicity.Liver disorders in COVID-19 patients and the use of several concomitant off-label medications—with a potential risk of further damaging the liver-should at least be a warning sign for rapid identification and early intervention,thus preventing liver damage from contributing to severe impairment in patients. | Gabriela Xavier Ortiz Gabriele Lenhart Matheus William Becker Karin Hepp Schwambach Cristiane Valle Tovo Carine Raquel Blatt | 2021 | World Journal of Hepatology2021，13，9： | 2 |
| 6 | Adalimumab drug and antibody levels as predictors of clinical and laboratory response in patients with Crohn’s disease显示文摘 | Y. Mazor R. Almog U. Kopylov D. Ben Hur A. Blatt A. Dahan M. Waterman S. Ben‐Horin Y. Chowers | 2014 | Aliment Pharmacol Ther2014，，6： | 2 |
| 7 | Pregnancy outcome in long-term survivors ofchildhood cancer显示文摘 | Blatt J | 1999 | Med Pediatr Oncol1999，33，9： | 1 |
| 8 | 'Teach 1, do 1 better': superior communication skills in senior medical students serving as standardized patient-examiners for their junior peers显示文摘 | SASSON VA BLATT B KALLENBERG G | 1999 | Academic Medicine1999，74，12： | 1 |
| 9 | Prognostic factors for anaplastic astrocytomas 显示文摘 | Compostella A Tosoni A Blatt V | 2007 | J Neurooncol2007，81，3： | 1 |
| 10 | An interactive-synergetic approach to the assessment of personality vulnerability to depression:Illustration using the adolescent version of the depressive experiences questionnaire显示文摘 | Shahar G Gallagher EF Blatt SJ | 2004 | J Clin Psyehol2004，60，： | 1 |
| 11 | The effect of repeated heat and cold exposureon serum protein composition in man 显示文摘 | Blatt WF Kerkay J | 1967 | Can J Physiol Pharma-col1967，45，4： | 1 |
| 12 | Drug resistance of mycobacterium tuberculosis strains in southern Brazil显示文摘 | Grutzmacher LK Dalmarco EM Blatt SL | | 0，，01： | 1 |
| 13 | Potential drug interactions in patients with rheumatoid arthritis显示文摘 | BAGATINI F BLATT C R MALISKA G | 2011 | Rev Bras Reumatol2011，51，1： | 1 |
| 14 | Tough Love i How communal schemas and contracting prac- tices build relational capital in entrepreneurial teams 显示文摘 | Blatt R | 2009 | Academy of Management Review2009，34，3： | 1 |
| 15 | Murray, Origin of Sedimentary Rocks显示文摘 | Blatt Middleton | 1980 | New Jersey : PRENTICE-HALL INC Englewood Cliffs1980，1980，： | 1 |
| 16 | Prognostic factors for anaplastic astrocytomas 显示文摘 | Compostella A Tosoni A Blatt V | 2007 | Neuro - Oncol2007，81，3： | 1 |
| 17 | Superparamagnetic clustering of data显示文摘 | BLATT M WISEMAN S DOMANY E | 1996 | Phys Rev Lett1996，76，： | 1 |
| 18 | Tough love: How communal schemas and con- tracting practices build relational capital in entrepreneur- ial teams显示文摘 | Blatt R | 2009 | Academy of Management Review2009，34，3： | 1 |
| 19 | ST myocardial infarction with spontaneouscoronary rePerfus 显示文摘 | UIEL N MORAVSKY G BLATT A | 2006 | Harefuah2006，145，： | 1 |
| 20 | Interpersonal relatedness, self-definition, and their motivational orientation during adolescence: A heorical and empirical integration显示文摘 | Shahar Golan Henrich Christopher C Blatt Sidney j | 2003 | Developmental Psychology2003，39，3： | 1 |
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