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| 1 | Decision modelling for economic evaluation of liver transplantation显示文摘As the gap between a shortage of organs and the immense demand for liver grafts persists, every available donor liver needs to be optimized for utility, urgency and equity. To overcome this challenge, decision modelling might allow us to gather evidence from previous studies as well as compare the costs and consequences of alternative options. For public health policy and clinical intervention assessment, it is a potentially powerful tool. The most commonly used types of decision analytical models include decision trees, the Markov model, microsimulation, discrete event simulation and the system dynamic model. Analytic models could support decision makers in the field of liver transplantation when facing specific problems by synthesizing evidence, comprising all relevant options, generalizing results to other contexts, extending the time horizon and exploring the uncertainty. For modeling studies of economic evaluation for transplantation, understanding the current nature of the disease is crucial, as well as the selection of appropriate modelling techniques. The quality and availability of data is another key element for the selection and development of decision analytical models. In addition, good practice guidelines should be complied, which is important for standardization and comparability between economic outputs. | Zhi Qu Christian Krauth Volker Eric Amelung Alexander Kaltenborn Jill Gwiasda Lena Harries Jan Beneke Harald Schrem Sebastian Liersch | 2018 | World Journal of Hepatology2018，10，11： | 6 |
| 2 | Acute coronary syndrome in the older adults显示文摘1 Introduction Coronary heart disease remains the leading cause of death in the developed world.Advanced age is the single strongest risk factor for coronary artery disease (CAD) and independent predictor for poor outcomes following an acute coronary syndrome (ACS).ACS refers to a spectrum of conditions compatible with acute myocardial ischemia and/or infarction due to various degrees of reduction in coronary blood flow as a result of plaque rupture/erosion and thrombosis formation or supply and demand mismatch. | Xuming DAI Jan Busby-Whitehead Karen P Alexander | 2016 | Journal of Geriatric Cardiology2016，13，2： | 5 |
| 3 | Stable ischemic heart disease in the older adults显示文摘1 Introduction Ischemic heart disease is caused by atherosclerotic and/or thrombotic obstruction of coronary arteries.Clinical spectrum of ischemic heart disease expands from asymptomatic atherosclerosis of coronary arteries to acute coronary syndromes (ACS) including unstable angina,acute myocardial infarction (non-ST elevation myocardial infarction and ST elevation myocardial infarction). | Xuming DAI Jan Busby-Whitehead Daniel E Forman Karen P Alexander | 2016 | Journal of Geriatric Cardiology2016，13，2： | 5 |
| 4 | Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling显示文摘Skeletal health relies on architectural integrity and sufficient bone mass, which are maintained through a tightly regulated equilibrium of bone resorption by osteoclasts and bone formation by osteoblasts. Genetic studies have linked the gene coding for low-density lipoprotein receptor-related protein1(Lrp1) to bone traits but whether these associations are based on a causal molecular relationship is unknown. Here, we show that Lrp1 in osteoblasts is a novel regulator of osteoclast activity and bone mass.Mice lacking Lrp1 specifically in the osteoblast lineage displayed normal osteoblast function but severe osteoporosis due to highly increased osteoclast numbers and bone resorption. Osteoblast Lrp1 limited receptor activator of NF-κB ligand(RANKL) expression in vivo and in vitro through attenuation of platelet-derived growth factor(PDGF-BB) signaling. In co-culture, Lrp1-deficient osteoblasts stimulated osteoclastogenesis in a PDGFRβ-dependent manner and in vivo treatment with the PDGFR tyrosine kinase inhibitor imatinib mesylate limited RANKL production and led to complete remission of the osteoporotic phenotype. These results identify osteoblast Lrp1 as a key regulator of osteoblast-to-osteoclast communication and bone mass through a PDGF–RANKL signaling axis in osteoblasts and open perspectives to further explore the potential of PDGF signaling inhibitors in counteracting bone loss as well as to evaluate the importance of functional LRP1 gene variants in the control of bone mass in humans. | Alexander Bartelt Friederike Behler-Janbeck F.Timo Beil Till Koehne Brigitte Müller Tobias Schmidt Markus Heine Laura Ochs Tayfun Yilmaz Martin Dietrich Jan P.Tuckermann Michael Amling Joachim Herz Thorsten Schinke Joerg Heeren Andreas Niemeier | 2018 | Bone Research2018，6，1： | 5 |
| 5 | Laparoscopy in Combination with Fast Track Multimodal Management is the Best Perioperative Strategy in Patients Undergoing Colonic Surgery: A Randomized Clinical Trial (LAFA-study)显示文摘 | Malaika S. Vlug Jan Wind Markus W. Hollmann Dirk T. Ubbink Huib A. Cense Alexander F. Engel Michael F. Gerhards Bart A. van Wagensveld Edwin S. van der Zaag Anna A.W. van Geloven Mirjam A.G. Sprangers Miguel A. Cuesta Willem A. Bemelman | 2011 | Annals of Surgery2011，，6： | 3 |
| 6 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 7 | Electrochemical top-down synthesis of C-supported Pt nanoparticles with controllable shape and size:Mechanistic insights and application显示文摘In this work,we demonstrate the power of a simple top-down electrochemical erosion approach to obtain Pt nanoparticle with controlled shapes and sizes(in the range from-2 to-10 nm).Carbon supported nanoparticles with narrow size distributions have been synthesized by applying an alternating voltage to macroscopic bulk platinum structures,such as disks or wires.Without using any surfactants,the size and shape of the particles can be changed by adjusting simple parameters such as the applied potential,frequency and electrolyte composition.For instance,application of a sinusoidal AC voltage with lower frequencies results in cubic nanoparticles;whereas higher frequencies lead to predominantly spherical nanoparticles.On the other hand,the amplitude of the,sinusoidal signal was found to affect the particle size;the lower the amplitude of the applied AC signal,the smaller the resulting particle size.Pt/C catalysts prepared by this approach showed 0.76 A/mg mass activity towards the oxygen reduction reaction which is-2 times higher than the state-of-the-art commercial Pt/C catalyst(0.42 A/mg)from Tanaka.In addition to this,we discussed the mechanistic insights about the nanoparticle formation pathways. | Batyr Garlyyev Sebastian Watzele Johannes Fichtner Jan Michalicka Alexander Schokel Anatoliy Senyshyn Andrea Perego Dingjie Pan Hany A.El-Sayed Jan M.Macak Plamen Atanassov Iryna V.Zenyuk Aliaksandr S.Bandarenka | 2021 | Nano Research2021，14，8： | 2 |
| 8 | Harnessing the power of immersive virtual reality-visualization and analysis of 3D earth science data sets显示文摘The availability and quantity of remotely sensed and terrestrial geospatial data sets are on the rise.Historically,these data sets have been analyzed and quarried on 2D desktop computers;however,immersive technologies and specifically immersive virtual reality(iVR)allow for the integration,visualization,analysis,and exploration of these 3D geospatial data sets.iVR can deliver remote and large-scale geospatial data sets to the laboratory,providing embodied experiences of field sites across the earth and beyond.We describe a workflow for the ingestion of geospatial data sets and the development of an iVR workbench,and present the application of these for an experience of Iceland’s Thrihnukar volcano where we:(1)combined satellite imagery with terrain elevation data to create a basic reconstruction of the physical site;(2)used terrestrial LiDAR data to provide a geo-referenced point cloud model of the magmatic-volcanic system,as well as the LiDAR intensity values for the identification of rock types;and(3)used Structure-from-Motion(SfM)to construct a photorealistic point cloud of the inside volcano.The workbench provides tools for the direct manipulation of the georeferenced data sets,including scaling,rotation,and translation,and a suite of geometric measurement tools,including length,area,and volume.Future developments will be inspired by an ongoing user study that formally evaluates the workbench’s mature components in the context of fieldwork and analyses activities. | Jiayan Zhao Jan Oliver Wallgrün Peter C.LaFemina Jim Normandeau Alexander Klippel | 2019 | Geo-Spatial Information Science2019，22，4： | 2 |
| 9 | Vertical stratification of physical, chemical and biological components in two saline lakes Shira and Shunet (South Siberia, Russia)显示文摘 | Andrey G. Degermendzhy Egor S. Zadereev Denis Yu. Rogozin Igor G. Prokopkin Yuri V. Barkhatov Alexander P. Tolomeev Elena B. Khromechek Jan H. Janse Wolf M. Mooij Ramesh D. Gulati | 2010 | Aquatic Ecology2010，，3： | 2 |
| 10 | Enrichment, Phylogenetic Analysis and Detection of a Bacterium That Performs Enhanced Biological Phosphate Removal in Activated Sludge显示文摘 | Rolf P.X. Hesselmann Christoph Werlen Dittmar Hahn Jan Roelof van der Meer Alexander J.B. Zehnder | 1999 | Systematic and Applied Microbiology1999，，3： | 2 |
| 11 | Where are we now?Re-visiting the Digital Earth through human-centered virtual and augmented reality geovisualization environments显示文摘The original Digital Earth concept,formulated by Al Gore(1998),is essentially a virtual reality system.In this(imagined)system,users are able to freely explore all possible recorded knowledge or information about the Earth though an interactive interface.While we imagine such an interface primarily as visual for now,it can be expected that in the future other senses will be engaged,allowing for even more realistic virtual experiences.Even though‘realism’in the experience is desirable(i.e.,it feels real),immersive experiences provided by visualization environments can go beyond reality,as they can be enhanced with queryable information.Of course one can also create fictitious experiences and simulations in such environments;including information about possible pasts(e.g.,ancient Rome)and futures(e.g.,a planned neighborhood);or spaces that we cannot(easily)directly experience(e.g.,the Moon,Mars,other far-away spaces,under the oceans,core of the earth,etc.). | Arzu Çöltekin Danielle Oprean Jan Oliver Wallgrün Alexander Klippel | 2019 | International Journal of Digital Earth2019，12，2： | 2 |
| 12 | Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial显示文摘 | Caroline AH Klazen Paul NM Lohle Jolanda de Vries Frits H Jansen Alexander V Tielbeek Marion C Blonk Alexander Venmans Willem Jan J van Rooij Marinus C Schoemaker Job R Juttmann Tjoen H Lo Harald JJ Verhaar Yolanda van der Graaf Kaspar J van Everdingen Al | 2010 | 2010 (9746)2010，，9746： | 2 |
| 13 | Long-term outcome after an early invasive versus selective invasive treatment strategy in patients with non-ST-elevation acute coronary syndrome and elevated cardiac troponin T (the ICTUS trial): a follow-up study显示文摘 | Alexander Hirsch Fons Windhausen Jan GP Tijssen Freek WA Verheugt Jan Hein Cornel Robbert J de Winter | 2007 | The Lancet . 2007 (9564)2007，，9564： | 1 |
| 14 | Managed by the Other:Cultural Anxieties in Two Anglo-Americanized Swedish Firms显示文摘 | Alexander Styhre Sofia Brjesson Jan Wickenberg | 2006 | International Journal of Human Resource Management2006，17，7： | 1 |
| 15 | Relation Between the Assessment of Microvascular Injury by Cardiovascular Magnetic Resonance and Coronary Doppler Flow Velocity Measurements in Patients With Acute Anterior Wall Myocardial Infarction显示文摘 | Alexander Hirsch Robin Nijveldt Joost D.E. Haeck Aernout M. Beek Karel T. Koch José P.S. Henriques Rene J. van der Schaaf Marije M. Vis Jan Baan Robbert J. de Winter Jan G.P. Tijssen Albert C. van Rossum Jan J. Piek | 2008 | Journal of the American College of Cardiology2008，，23： | 1 |
| 16 | Expression of the aging gene p66Shc is increased in peripheral blood monocytes of patients with acute coronary syndrome but not with stable coronary artery disease显示文摘 | Fabian C. Franzeck Danielle Hof Remo D. Spescha Matthias Hasun Alexander Akhmedov Jan Steffel Yi Shi Francesco Cosentino Felix C. Tanner Arnold von Eckardstein Willibald Maier Thomas F. Lüscher Christophe A. Wyss Giovanni G. Camici | 2011 | Atherosclerosis2011，，1： | 1 |
| 17 | Imaging primary lung cancers in mice to study radiation biology显示文摘 | DAVID G JAN G ALEXANDER R | 2010 | Int J Radiat Oncol Biol Phys2010，76，4： | 1 |
| 18 | Cross- contamination of non-target feedingstuffs by Nicarba-zin authorised for use as a feed additive显示文摘 | Jan Alexander Guójón Atli Auóunsson Diane Benford | | 0，，： | 1 |
| 19 | Multigene Analysis Can Discriminate Between Ulcerative Colitis, Crohn’s Disease, and Irritable Bowel Syndrome显示文摘 | Petra von Stein Robert Lofberg Nikolai V. Kuznetsov Alexander W. Gielen Jan–Olov Persson Rolf Sundberg Karin Hellstrom Anders Eriksson Ragnar Befrits Ake Ost Oliver D. von Stein | 2008 | Gastroenterology2008，，： | 1 |
| 20 | Do Magnetic Resonance Imaging and Ultrasound Add Anything to the Preoperative Workup of Parotid Gland Tumors?显示文摘 | Jacob Alexander de Ru Maarten S. van Leeuwen Peter Paul G. van Benthem Birgitta K. Velthuis Daisy M.D.S. Sie-Go Gerrit Jan Hordijk | 2007 | Journal of Oral and Maxillofacial Surgery2007，，5： | 1 |
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