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| 1 | Current and future therapies for inherited cholestatic liver diseases显示文摘Familial intrahepatic cholestasis(FIC) comprises a group of rare cholestatic liver diseases associated with canalicular transport defects resulting predominantly from mutations in ATP8B1, ABCB11 and ABCB4. Phe-notypes range from benign recurrent intrahepatic cholestasis(BRIC), associated with recurrent cholestatic attacks, to progressive FIC(PFIC). Patients often suffer from severe pruritus and eventually progressive cholestasis results in liver failure. Currently, first-line treatment includes ursodeoxycholic acid in patients with ABCB4 deficiency(PFIC3) and partial biliary diversion in patients with ATP8B1 or ABCB11 deficiency(PFIC1 and PFIC2). When treatment fails, liver transplantation is needed which is associated with complications like rejection, post-transplant hepatic steatosis and recurrence of disease. Therefore, the need for more and better therapies for this group of chronic diseases remains. Here, we discuss new symptomatic treatment options like total biliary diversion, pharmacological diversion of bile acids and hepatocyte transplantation. Furthermore, we focus on emerging mutation-targeted therapeutic strategies, providing an outlook for future personalized treatment for inherited cholestatic liver diseases. | Wendy L van der Woerd Roderick HJ Houwen Stan FJ van de Graaf | 2017 | World Journal of Gastroenterology2017，23，5： | 11 |
| 2 | The Dynamic Pollen Tube Cytoskeleton: Live Cell Studies Using Actin-Binding and Microtubule- Binding Reporter Proteins显示文摘花粉试管在雌蕊以内伸长为授精把精子房间搬运到胚胎囊。生长专门在试管顶发生,显示花粉试管延伸一个很戏剧的极的房间生长过程。一个特点花粉试管特征它的细胞骨架,它精心地包括被组织并且动态肌动朊微细丝和微导管。花粉试管生长依赖于肌动朊细胞骨架;它的组织和规定被各种各样的途径广泛地检验了,包括荧光灯在实时房间标记肌动朊绑定蛋白质的蛋白质学习。用以前描述的 GFP-NtADF1 和 GFP-LlADF1,并且新肌动朊记者蛋白质 NtPLIM2b-GFP,我们重申占优势的肌动朊在伸长组织烟草和百合花粉试管,这长,沿着花粉试管胫的流的肌动朊电报,和包括更短的肌动朊电报的接近顶点的结构。肌动朊微细丝的接近顶点的收集经历动态变化,产生从 basket-shaped,的结构的外观或塑造漏斗,对一枚微妙的戒指像网孔。NtPLIM2b-GFP 为 Rho GTPases 与一个 guanine 核苷酸交换因素在联合被使用, AtROP-GEF1,说明这些肌动朊记者蛋白质的使用探索在极的细胞生长过程和它的肌动朊细胞骨架之间的连接。与肌动朊细胞骨架相反,微导管看起来不在在被子植物花粉试管支持极的房间生长过程起一个直接作用。从 Arabidopsis AtEB1 基于微导管结束绑定蛋白质使用微导管记者蛋白质, GFP-AtEB1,我们证明广泛的微导管在伸长联网改变动力学的度的花粉试管显示器。这些记者蛋白质提供万用的工具探索在极的花粉试管生长过程的主要结构、发信号的部件之间的功能的连接。 | Alice Y. Cheung Qiao-hong Duan Silvia Santos Costa Barend H.J. de Graaf Veronica S. DiStilio Jose Feijo Hen-Ming Wu | 2008 | Molecular Plant2008，1，4： | 10 |
| 3 | 污水资源化新途径——直接膜过滤用于农业灌溉显示文摘现代膜分离技术几乎能 10 0 %地筛滤污水中的病原菌和病毒 ,而其它溶解性营养成分则被大部分保留。因此 ,污水直接经膜过滤后的出水实际上就是一种植物生长所需的“营养液”。作为一种新的污水资源化方式 ,介绍了膜分离技术直接过滤污水后农灌的思路、国际研究动态 ,并阐述这一途径对有效解决我国水环境问题所带来的启示。 | 郝晓地 J.H.J.M.vander Graaf | 2003 | 给水排水2003，29，6： | 4 |
| 4 | Anaerobic ammonium oxidation discovered in a denitrifying fluidized bed reactor显示文摘 | A. Mulder A.A. van de Graaf L.A. Robertson J.G. Kuenen | 1995 | FEMS Microbiology Ecology1995，，3： | 3 |
| 5 | Anaerobic ammonium oxidation discovered in a denitrifying fluidized bed reactor显示文摘 | A. Mulder A.A. van de Graaf L.A. Robertson J.G. Kuenen | 1995 | FEMS Microbiology Ecology1995，，3： | 3 |
| 6 | Physiological and Biochemical Basis of Clinical Liver Function Tests: A Review显示文摘 | Lisette T. Hoekstra Wilmar de Graaf Geert A. A. Nibourg Michal Heger Roelof J. Bennink Bruno Stieger Thomas M. van Gulik | 2013 | Annals of Surgery2013，，1： | 3 |
| 7 | Randomised comparison of morbidity after D1 and D2 dissection for gastric cancer in 996 Dutch patients显示文摘 | J.J. Bonenkamp I. Songun K. Welvaart C.J.H. van de Velde J. Hermans M. Sasako J.T.M. Plukker P. van Elk H. Obertop D.J. Gouma C.W. Taat J. van Lanschot S. Meyer P.W. de Graaf M.F. von Meyenfeldt H. Tilanus | 1995 | The Lancet . 1995 (8952)1995，，： | 2 |
| 8 | Induction of Tumor Growth After Preoperative Portal Vein Embolization: Is It a Real Problem?显示文摘 | Wilmar Graaf Jacomina W. den Esschert Krijn P. Lienden Thomas M. Gulik | 2009 | Annals of Surgical Oncology2009，，2： | 2 |
| 9 | 健康女性隔日给予阿司匹林预防癌症、心血管疾病和胃肠道出血风险的个体化预测显示文摘阿司匹林在癌症和心血管疾病(cardiovascular disease,CVD)一级预防中的作用仍不清楚。该研究旨在确定女性使用阿司匹林治疗是否能改善发生癌症、CVD和重大消化道出血的风险。方法:对女性健康研究(一项随机试验,隔日服用阿司匹林100mg/安慰剂的临床实验)中拥有血浆样本的健康女性27 939人进行长期随访,个体化预测使用阿司匹林是否降低合并CVD、癌症和主要消化道出血的绝对风险。 | 刘莉 叶鹏 van Kruijsdijk RC Visseren FL Ridker PM Dorresteijn JA Buring JE van der Graaf Y Cook NR | 2014 | 中华高血压杂志2014，22，12： | 2 |
| 10 | Profiling human gut bacterial metabolism and its kinetics using [U‐<sup>13</sup>C]glucose and NMR显示文摘 | Albert A.de Graaf AnnetMaathuis Pieterde Waard Nicolaas E. P.Deutz CorDijkema Willem M.de Vos KoenVenema | 2010 | NMR Biomed2010，，1： | 2 |
| 11 | Portal Vein Embolization Before Liver Resection: A Systematic Review显示文摘 | K. P. Lienden J. W. Esschert W. Graaf S. Bipat J. S. Lameris T. M. Gulik O. M. Delden | 2013 | CardioVascular and Interventional Radiology2013，，1： | 2 |
| 12 | Grade of deceased donor liver macrovesicular steatosis impacts graft and recipient outcomes more than the Donor Risk Index显示文摘 | Esther Lde Graaf JamesKench PamelaDilworth Nicholas AShackel Simone IStrasser DavidJoseph HenryPleass MichaelCrawford Geoff WMcCaughan Deborah JVerran | 2012 | Journal of Gastroenterology and Hepatology2012，，3： | 2 |
| 13 | Autotrophlic growth of anaerobic ammonium-oxidizing microorganisms in a fluidized bed reactor 显示文摘 | Van de Graaf A A De Bruijn P Robertson L A | 1996 | Microbiology1996，142，8： | 2 |
| 14 | Systematic review of endoscopic mucosal resection versus transanal endoscopic microsurgery for large rectal adenomas显示文摘 | R. Barendse F. van den Broek E. Dekker W. Bemelman E. de Graaf P. Fockens J. Reitsma | 2011 | Endoscopy2011，，11： | 2 |
| 15 | DELPHI有机共轭体系MM力场的优化和应用显示文摘运用我们建议的SC一HMO方法优化了有机共轭烯烃的DELPHI MM力场.将优化所得力场和参数用于计算各类型101个共轭化合物的分子几何构型、生成热、偶极矩和IR频率等,结果可与MM3法相比. | 贡雪东 肖鹤鸣 Bastiaan Vande Graaf | 1997 | 化学学报1997，55，5： | 2 |
| 16 | Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial显示文摘 | Caroline AH Klazen Paul NM Lohle Jolanda de Vries Frits H Jansen Alexander V Tielbeek Marion C Blonk Alexander Venmans Willem Jan J van Rooij Marinus C Schoemaker Job R Juttmann Tjoen H Lo Harald JJ Verhaar Yolanda van der Graaf Kaspar J van Everdingen Al | 2010 | 2010 (9746)2010，，9746： | 2 |
| 17 | Incisional inferior Lumbar hernia显示文摘 | De Graaf R Van Heesewijk JP | 2005 | JBR-BTR2005，88，3： | 1 |
| 18 | Speculation on whether a vaccine against cryptosporidiosis is a reality or fantasy 显示文摘 | De Graaf D C Spano F Petry F | 1999 | Int J Parasitol1999，29，8： | 1 |
| 19 | A comparison of 13C NMR measurements of the rates of glutamine synthesis and the tricarboxylic acid cycle during oral and intravenous administration of glucose显示文摘 | Mason G F Falk Petersen K de Graaf R A | 2003 | Brain Res Protoc2003，10，3： | 1 |
| 20 | Speculation on whether a vaccine against cryptosporidiosis is a reality or fantasy显示文摘 | GRAAF D SPANO F PETRY F | 1999 | Int J Parasitol1999，29，8： | 1 |
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