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| 1 | Clinical significance of the low normal sperm morphology value as proposed in the fifth edition of the WHO Laboratory Manual for the Examination and Processing of Human Semen显示文摘为 4% 词法上正常的精子的精子形态学的低截止价值在世界健康组织的新编辑求婚了) 在精液分析上用手,与最近一致是出版价值并且为正常精子形态学在报导吝啬的价值反映衰落的趋势。为词法上正常的精子的减少的价值多年以来可能由于几个因素。第一是为精子形态学的评估的严格的标准的介绍。因为增加否定环境影响,另外的原因可以在精液参数为精子形态学畸形和建议减少包括另外的标准的介绍。尽管在它的自己上最新建议的很低的正常当原来为根据严格的标准评估的精子形态学报导了,价值不能为男性的富饶潜力提供强壮的预兆的价值,好预兆的价值能仍然被获得如果整体,为精子形态学评估的严格的途径和现在可得到的另外的精子形态学参数被跟随,因为某些形态学模式和精子畸形现在被知道具有强壮的 progno 另外,技术方法论的更好国际的标准化,精子形态学评估标准和标准化国际外部质量控制(EQC ) 的解释上的一致策划,具有最大的重要性维持精子形态学的好预兆的价值。 | Roelof Menkveld | 2010 | Asian Journal of Andrology2010，12，1： | 132 |
| 2 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 3 | Measurement and significance of sperm morphology显示文摘测量或评估和人的精子形态学的临床的意义总是是潜在的并且仍然是为男性的富饶的决心的精液分析的一个争论方面。在这评论,为精子形态学的评估标准的发展的背景将被讨论。严格的标准定义和为精子形态学评估的标准的使用上的批评的方面将在正常精子形态学价值为衰落象可能的原因一样被讨论并且我们怎么能为导致是的低正常参考价值的这现象妥协,出版了在 2010 用手为考试并且人的精液处理。可能的答案之一可以是把更多的注意给一小部分反常精子形态学范畴和精子形态学模式的包括。它在这评论被结束如果正确地并且小心并且用构画出在的存在指南的严格的申请做 2010 用手,精子形态学测量仍然有一个很重要的角色在男富饶潜力的临床的评估玩。 | Roelof Menkveld Cas AG Holleboom Johann PT Rhemrev | 2011 | Asian Journal of Andrology2011，13，1： | 11 |
| 4 | Molecular mechanisms of heavy metal tolerance and evolution in invertebrates显示文摘跟随基因组学革命,我们对应力位于防卫下面的分子的机制的知识极大地被扩展了。在强壮的选择压力下面,许多动物可以发展提高的应力忍耐。这能被改变蛋白质的结构完成(通过在基因的编码区域的变化) 或由改变蛋白质的数量(通过在 transcriptional 的变化规定) 。进化的后者类型能被替换在兴趣(cis 规章的变化) 或由改变 transcriptional 管理者蛋白质(trans 规章的变化) 的结构或数量的基因的倡导者完成。metallothionein 系统是在重金属的上下文的最好学习的压力反应系统之一。Metallothionein 表示被假定被金属抄写因素 1 调整(MTF-1 ) ;然而,直到现在, MTF-1 的参与仅仅为一些脊椎动物和果蝇被证明了。象线虫和蚯蚓那样的无脊椎动物上的数据建议 metallothionein 正式就职的另外的机制可能是在场的。Cd 忍耐的详细研究为土壤生活跳虫的种被做, Orchesella cincta。种类是完了的这的 metallothionein 基因在暴露金属的领域人口表示了。metallothionein 倡导者的分析表明了有功能的意义,出现在简历记者试金的广泛的多型性。在比较 20 张不同人口的研究,高快车的倡导者等位基因的频率断然在土壤与金属的集中被相关,特别 Cd。跳虫学习证明涉及细胞的应力反应的基因的那个 cis 规章的变化可以贡献金属公差的进化。 | Thierry K. S. Janssens Dick Roelofs Nico M. van Straalen | 2009 | Insect Science2009，16，1： | 9 |
| 5 | COX-2 polymorphisms-765G→C and-1195A→G and colorectal cancer risk显示文摘AIM:To determine the possible modulating effect of the COX-2 polymorphisms,-765G→C and-1195A→G, on the risk of colorectal cancer(CRC)in a Dutch population. METHODS:This case-control study includes 326 patients with CRC and 369 age-and gender-matched controls.Genotypes of the COX-2 polymorphisms -765G→C and-1195A→G were determined by polymerase chain reaction-based restriction fragment length polymorphism.COX-2 genotypes and haplotypes were analyzed and odds ratios with 95%confi- dence intervals were estimated by logistic regression. RESULTS:The-765GG genotype was associated with an increased risk of developing CRC(OR,1.45; 95%CI,1.03-2.04).No significant difference was observed in the genotype distribution of the-1195A→ G polymorphism between patients and controls.The GG/AC haplotype was present significantly less often in patients than in controls(OR 0.44;95%CI,0.22-0.85). When the AC,AG and GG haplotypes were investigated separately,the AC haplotype showed a tendency to be less frequent in patients than in controls(OR(AG/AC)0.78; 95%CI,0.57-1.06). CONCLUSION:The-765GG genotype is associatedwith an increased risk of developing CRC and the GG/ AC haplotype seems to protect against CRC.These findings suggest a modulating role for the COX-2 polymorphisms-765G→C and-1195A→G in the development of CRC in a Dutch population. | Juliёt H Hoff Rene HM te Morsche Hennie MJ Roelofs Elise MJ van der Logt Fokko M Nagengast Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，36： | 6 |
| 6 | Disparities of conjugating protective enzyme activities in the colon of patients with adenomas and carcinomas显示文摘AIM:To investigate the metabolic enzymatic capacity of the colon mucosa to detoxify noxious carcinogenic compounds.METHODS:We investigated the activity of 2 conjugating enzymes-the microsomal uridine glucuronosyltransferase(UGT)and the cytosomal glutathione S-transferase(GST)in the uninvolved mucosa of the colon transversum and sigmoideum in patients with adenomatous polyps and colorectal cancer.Biopsies were taken from the mucosa during colonoscopies which were done for clinical(diagnostic)reasons.After storage,the biopsy material was homogenized and after differential centrifugation the enzyme assays were performed with 4-nitrophenol(UGT)and 1-chloro 2,4-dinitrobenzene(GST)as substrates.RESULTS:About 48 patients were included of which28 had adenomas and 20 had colorectal carcinomas confirmed by histopathology.Enzyme activities were expressed as nmol/mg per minute protein for the GST and as pmol/mg per minute protein for the UGT.Analysis of variance(F-test)indicated that both enzymes were more widely distributed in adenoma than in cancer patients.The means±SD were smaller for cancer patients:GST for adenomas 268±152 vs 241±69 for carcinomas and UGT for adenomas 197±200 vs 150±86 for carcinomas.CONCLUSION:Compared to patients with adenomatous colon polyps those with colorectal carcinoma exhibited a lower capacity of detoxifying enzyme metabolism and their activities clustered over a smaller range. | Harald P Hoensch Hennie MJ Roelofs Lutz Edler Wilhelm Kirch Wilbert HM Peters | 2013 | World Journal of Gastroenterology2013，19，36： | 3 |
| 7 | Assessment of oxidative stress in chronic pancreatitis patients显示文摘AIM: To assess the levels of antioxidant capacity and oxidative damage in blood of chronic pancreatitis (CP) patients in comparison with those in healthy control sub- jects, by using several different analytical techniques. METHODS: Thirty-five CP patients and 35 healthy con- trol subjects were investigated prospectively with re- spect to plasma levels of thiols, ferric reducing ability of plasma (FRAP, i.e. antioxidant capacity), levels of protein carbonyls and thiobarbituric acid reactive substances (TBARS). Additionally, we evaluated the production of reactive oxygen species (ROS) in whole blood. RESULTS: The antioxidative thiols including cysteine, cysteinylglycine and glutathione were significantly lower in CP patients. In addition, the non-enzymatic antioxi- dant capacity was significantly lower in CP patients, which correlated with the amount of oxidative protein (protein carbonyls) and the extent of lipid damage (TBARS), both were significantly higher in CP patients. The ROS production in whole blood after stimulation with phorbol 12-myritate 13-acetaat, demonstrated a strong tendency to produce more ROS in CP patients. CONCLUSION: Oxidative stress may contribute to the pathogenesis of chronic pancreatitis by decreasing anti- oxidant capacity and increasing oxidative damage in CP patients may be a rationale for intervention with antioxi- dant therapy. | Mariette Verlaan Hennie MJ Roelofs Annie van Schaik Geert JA Wanten Jan BMJ Jansen Wilbert HM Peters Joost PH Drenth | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 8 | Physiological and Biochemical Basis of Clinical Liver Function Tests: A Review显示文摘 | Lisette T. Hoekstra Wilmar de Graaf Geert A. A. Nibourg Michal Heger Roelof J. Bennink Bruno Stieger Thomas M. van Gulik | 2013 | Annals of Surgery2013，，1： | 3 |
| 9 | A typology for the classification, description and valuation of ecosystem functions, goods and services显示文摘 | Rudolf S de Groot Matthew A Wilson Roelof M.J Boumans | 2002 | Ecological Economics2002，，3： | 3 |
| 10 | An α‐E‐catenin ( CTNNA1 ) mutation in hereditary diffuse gastric cancer显示文摘 | Ian J Majewski Irma Kluijt Annemieke Cats Thomas S Scerri Daphne Jong Roelof JC Kluin Samantha Hansford Frans BL Hogervorst Astrid J Bosma Ingrid Hofland Marcel Winter David Huntsman Jos Jonkers Melanie Bahlo René Bernards | 2013 | J. Pathol2013，，4： | 2 |
| 11 | Development of a Rapid Risk and Impact Assessment Tool to Enhance Response to Environmental Emergencies in the Early Stages of a Disaster: A Tool Developed by the European Multiple Environmental Threats Emergency NETwork (EMETNET) Project显示文摘Every year,numerous environmental disasters and emergencies occur across the globe with far-reaching impacts on human health and the environment.The ability to rapidly assess an environmental emergency to mitigate potential risks and impacts is paramount.However,collating the necessary evidence in the early stages of an emergency to conduct a robust risk assessment is a major challenge.This article presents a methodology developed to help assess the risks and impacts during the early stages of such incidents,primarily to support the European Union Civil Protection Mechanism but also the wider global community in the response to environmental emergencies.An online rapid risk and impact assessment tool has also been developed to promote enhanced collaboration between experts who are working remotely,considering the impact of a disaster on the environment and public health in the short,medium,and long terms.The methodology developed can support the appropriate selection of experts and assets to be deployed to affected regions to ensure that potential public health and environmental risks and impacts are mitigated whenever possible.This methodology will aid defensible decision making,communication,planning,and risk management,and presents a harmonized understanding of the associated impacts of an environmental emergency. | Emma-Jane Goode Eirian Thomas Owen Landeg Raquel Duarte-Davidson Lisbeth Hall Jolanda Roelofs Sjors Schulpen Arnout De Bruin Elisabeth Wigenstam Birgitta Liljedahl Annica Waleij Louise Simonsson Ann Göransson Nyberg | 2021 | International Journal of Disaster Risk Science2021，12，4： | 2 |
| 12 | Effect of hepatic artery embolization on liver hypertrophy response in a rabbit liver VX2tumor model显示文摘BACKGROUND:Portal vein embolization not only induces hypertrophy of the non-embolized liver,but also enhances tumor growth.The latter could be prevented by embolizing the hepatic arteries supplying the tumor-bearing liver segments.This study aimed to determine the effects of transcatheter arterial embolization(TAE)on tumor volume and liver regeneration in a rabbit VX2 tumor model.METHODS:Twenty-three rabbits underwent subcapsular tumor implantation with a VX2 tumor.Two weeks after implantation,18 rabbits were used for TAE experiments,5were for sham controls.Tumor response and liver regeneration response of the embolized cranial and non-embolized caudal liver lobes were assessed by CT volumetry,liver to body weight index,and the amount of proliferating hepatocytes.RESULTS:All super-selective arterial tumor embolization procedures were performed successfully.Despite embolization,the tumor volume increased after an initial steady state.The tumor volume after embolization was smaller than that of the sham group,but this difference was not significant.Massive necrosis of the tumor,however,was seen after embolization,without damage of the surrounding liver parenchyma.There was a significant atrophy response of the tumor bearing cranial lobe after super-selective arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized,caudal lobe.This regeneration response was confirmed histologically by a significantly higher number of proliferating hepatocytes on the Ki-67 stained slides.CONCLUSIONS:Super-selective,bland arterial coil embolization causes massive necrosis of the tumor,despite increase of volume on CT scan.Atrophy of the tumor bearing liver lobe is seen after arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized lobe,despite absence of histological damage of the tumor-surrounding liver parenchyma. | Krijn P van Lienden Lisette T Hoekstra Jessica D van Trigt Joris J Roelofs Otto M van Delden Thomas M van Gulik | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，6： | 2 |
| 13 | Enrichment, Phylogenetic Analysis and Detection of a Bacterium That Performs Enhanced Biological Phosphate Removal in Activated Sludge显示文摘 | Rolf P.X. Hesselmann Christoph Werlen Dittmar Hahn Jan Roelof van der Meer Alexander J.B. Zehnder | 1999 | Systematic and Applied Microbiology1999，，3： | 2 |
| 14 | Various behavioral signs of estrus and their relationship with time of ovulation in dairy cattle显示文摘 | Roelofs J B van Eerdenburg F J C M Soede N M | 2005 | Theriogenology2005，63，5： | 1 |
| 15 | A theory of lexical access in speech production显示文摘 | Levelt W Roelofs A A.S.Meyer | | 0，，22： | 1 |
| 16 | MIF production by dendritic cells is differentially egulated by Toll-like receptors and increased during rheumatoid arthritis显示文摘 | Popa C van Lieshout A W Roelofs M F etal | 2006 | Cytokine2006，36，12： | 1 |
| 17 | Scan time and patient dose for thoracic imaging in neonates and small children using axial volumetric320-detector row CT compared to helical 64-,32-,and 16-detector row CT acquisitions显示文摘 | Kroft LJ Roelofs JJ Geleijns J | 2010 | Pediatr Radiol2010，40，： | 1 |
| 18 | An MEG study of picture naming 显示文摘 | Leveh W J M Roelofs A Meyer A S | 1998 | Journal of Cognitive Neuroscience1998，10，5： | 1 |
| 19 | Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study 显示文摘 | Duijvestein M Vos AC Roelofs H | 2010 | Gut2010，59，12： | 1 |
| 20 | Science显示文摘 | Nojima S Schal C Webster F X Santangelo R G Roelofs W L | 2005 | 307:11042005，307，： | 1 |
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