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| 1 | 子宫内膜异位症的诊断和管理:NICE指南概要显示文摘子宫内膜异位症是最常见的妇科疾病之一。生育年龄(15~49岁)妇女的发病率约为10%。子宫内膜异位症是英国第二位最常见的妇科疾病,仅次于子宫肌瘤。子宫内膜异位症是激素依赖性疾病,与月经周期相关。确切的发病原因不清,但普遍认为与经血逆流,促使子宫内膜细胞生长并定植于盆腔有关。 | Laura Kuznetsov Katharina Dworzynski Melanie Davies Caroline Overton 李卫华 朱磊 | 2018 | 英国医学杂志中文版2018，21，3： | 11 |
| 2 | Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies显示文摘在地岬基因的 Oncogenic 变化在人的癌症是很普通的,导致有描绘得好的选择优点,而且不太听说得好的危险的房间。我们执行了一幅大规模 loss-of-function 屏幕识别被转变 KRAS 的结肠癌房间,然而并非由缺乏这 oncogene 的衍生物要求的基因。最高得分的基因然后在 KRAS 变异、野类型的癌症房间的一块更大的面板被测试。表示 oncogenic KRAS 的癌症房间被发现高度依赖于抄写因素 GATA2 和 DNA 复制开始管理者 CDC6。与已知的目标用许多药扩大这分析,我们发现有变异的 KRAS 的癌症房间与 topoisomerase 抑制显示出选择嗜好到 proteasome 功能,以及合成致命性。联合指向引起的这些功能改善了相对野类型的房间 KRAS 变异的房间杀死。这些观察建议新奇目标和在地岬变异的癌症为最佳的效果联合存在治疗的新方法,它传统地被看作对治疗高度倔强。 | Michael Steckel Miriam Molina-Arcas Britta Weigelt Michaela Marani Patricia H Warne Hanna Kuznetsov Gavin Kelly Becky Saunders Michael Howell Julian Downward David C Hancock | 2012 | Cell Research2012，22，8： | 5 |
| 3 | Combination of epidural electrical stimulation with ex vivo triple gene therapy for spinal cord injury:a proof of principle study显示文摘Despite emerging contemporary biotechnological methods such as gene-and stem cell-based therapy,there are no clinically established therapeutic strategies for neural regeneration after spinal cord injury.Our previous studies have demonstrated that transplantation of genetically engineered human umbilical cord blood mononuclear cells producing three recombinant therapeutic molecules,including vascular endothelial growth factor(VEGF),glial cell-line derived neurotrophic factor(GDNF),and neural cell adhesion molecule(NCAM)can improve morpho-functional recovery of injured spinal cord in rats and mini-pigs.To investigate the efficacy of human umbilical cord blood mononuclear cells-mediated triple-gene therapy combined with epidural electrical stimulation in the treatment of spinal cord injury,in this study,rats with moderate spinal cord contusion injury were intrathecally infused with human umbilical cord blood mononuclear cells expressing recombinant genes VEGF165,GDNF,NCAM1 at 4 hours after spinal cord injury.Three days after injury,epidural stimulations were given simultaneously above the lesion site at C5(to stimulate the cervical network related to forelimb functions)and below the lesion site at L2(to activate the central pattern generators)every other day for 4 weeks.Rats subjected to the combined treatment showed a limited functional improvement of the knee joint,high preservation of muscle fiber area in tibialis anterior muscle and increased H/M ratio in gastrocnemius muscle 30 days after spinal cord injury.However,beneficial cellular outcomes such as reduced apoptosis and increased sparing of the gray and white matters,and enhanced expression of heat shock and synaptic proteins were found in rats with spinal cord injury subjected to the combined epidural electrical stimulation with gene therapy.This study presents the first proof of principle study of combination of the multisite epidural electrical stimulation with ex vivo triple gene therapy(VEGF,GDNF and NCAM)for treatment of spinal cord injury in rat models.The animal protocols were approved by the Kazan State Medical University Animal Care and Use Committee(approval No.2.20.02.18)on February 20,2018. | Filip Olegovich Fadeev Farid Vagizovich Bashirov Vahe Arshaluysovich Markosyan Andrey Alexandrovich Izmailov Tatyana Vyacheslavovna Povysheva Mikhail Evgenyevich Sokolov Maxim Sergeevich Kuznetsov Anton Alexandrovich Eremeev Ilnur Ildusovich Salafutdinov Albert Anatolyevich Rizvanov Hyun Joon Lee Rustem Robertovich Islamov | 2021 | Neural Regeneration Research2021，16，3： | 4 |
| 4 | Zonal disintegration of rocks around underground workings, Part 1: Data of in situ observations显示文摘 | E. I. Shemyakin G. L. Fisenko M. V. Kurlenya V. N. Oparin V. N. Reva F. P. Glushikhin M. A. Rozenbaum é. A. Tropp Yu. S. Kuznetsov | 1987 | Soviet Mining Science1987，，3： | 3 |
| 5 | Strength and Toughness of Steel Fibre Reinforced Reactive Powder Concrete Under Blast Loading显示文摘The blast resistance of structures used in buildings needs to be investigated due to the increased threat of a terrorist attack. The damage done by Composition B or Powergel to steel fibre reinforced reactive powder concrete (SFRPC) panels and ordinary reinforced concrete (RC) panels of equivalent static flexural strength is compared. A 0.5 kg charge was detonated at a distance of 0.1 m from the 1.3 m×1.0 m×0. 1 m (thick) panels, which were simply supported and spaning 1.3m. Dynamic displacement measurements, high-speed video recording and visual examination of the panels for spall and breach were undertaken. The SFRPC panels withstood the bare charge blast better than the reinforced ordinary concrete panels. Neither type of panel was breached using a 0.5 kg charge. The RC panel exhibited more spalling when Composition B was used. Under successive Composition B loading conditions, the RC panel was breached. In comparison the SFRPC panel was not breached. Exposure to fragmenting charge loading conditions confirmed these performance differences between the SFRPC panel and the reinforced ordinary concrete panel. | KUZNETSOV Valerian A REBENTROST Mark WASCHL John | 2006 | Transactions of Tianjin University2006，12，B09： | 3 |
| 6 | Zonal disintegration of rocks around underground workings. Part II: Rock fracture simulated in equivalent materials显示文摘 | E. I. Shemyakin G. L. Fisenko M. V. Kurlenya V. N. Oparin V. N. Reva F. P. Glushikhin M. A. Rozenbaum E. A. Tropp Yu. S. Kuznetsov | 1987 | Soviet Mining Science1987，，4： | 2 |
| 7 | Narrow-Band Imaging: Potential and Limitations显示文摘 | K. Kuznetsov R. Lambert J.-F. Rey | 2006 | Endoscopy2006，，01： | 2 |
| 8 | Influence of small polarons on the optical properties of Mg:LiNbO 3 crystals显示文摘 | KITAEVA G Kh KUZNETSOV K A PENIN A N | 2002 | Phys Rev B2002，65，05： | 2 |
| 9 | Efficacy of a combination of dutasteride, tadalafil, and solifenacin in the treatment of previously unsuccessful patients显示文摘Objective To evaluate the efficacy and safety of simultaneous administration of dutasteride,tadalafil and solifenacin in the treatment of benign prostatic hyperplasia(BPH)with overactive bladder symptoms and lower urinary tract obstruction in previously unsuccessfully treated men.Methods Patients in Group A(n=97)received dutasteride 0.5 mg/day,tadalafil 2.5 mg/day,and solifenacin 2.5 mg/day;Group B(n=95)received dutasteride 0.5 mg/day,tadalafil 5 mg/day,and solifenacin 5 mg/day;Group C(n=103)received dutasteride 0.5 mg/day,tadalafil 20 mg/day,and solifenacin 10 mg/day.The functional status of the lower urinary tract was assessed using the International Prostate Symptom Score(I-PSS),Overactive Bladder Questionnaire(OABq),International Index of Erectile Function(IIEF),and Male Sexual Health Questionnaire Ejaculatory Dysfunction(MSHQ-EjD)as well as uroflowmetry.Results The total score of the sexual function remained unchanged in Group B of patients 81.3 points vs.80.2 points(p>0.05)according to MSHQ-EjD,61.4 points vs.51.2 points(p>0.05)according to IIEF data.The total assessment of symptoms of hyperactivity significantly decreased in Group C according to OABq data after the 4th week of the study(17.5 points vs.26.1 points,p<0.05)and remained below the baseline until the end of the study(15.2 points).Conclusions The simultaneous administration of standard doses of dutasteride,solifenacin,and tadalafil for 3 months is safe,effective,and can be recommended for patients with BPH to reduce symptoms of obstruction and hyperactivity of the bladder and maintain sexual function. | Kirill Kosilov Irina Kuzina Vladimir Kuznetsov Olga Barabash Ekaterina Fedorishcheva | 2022 | Asian Journal of Urology2022，9，1： | 2 |
| 10 | Investment and Innovation State Support of Agriculture in Russia as a Condition of WTO显示文摘 | Kuznetsov Vladimir V. Arkhipov Aleksey Y. Soldatova Irina Y. | 2013 | China-USA Business Review2013，12，7： | 2 |
| 11 | The interplay of osteogenesis and hematopoiesis: expression of a constitutively active PTH/PTHrP receptor in osteogenic cells perturbs the establishment of hematopoiesis in bone and of skeletal stem cells in the bone marrow显示文摘 | KUZNETSOV SA RIMINUCCI M ZIRAN N | 2004 | J Cell Biol2004，167，6： | 1 |
| 12 | New ferro-carbon adsorbents for magnetically guided transport of anti-cancer drugs 显示文摘 | Kuznetsov A A Filippov V I Kuznetsov O A | 1999 | Journal of Magnetism And Magnetic Materials1999，194，13： | 1 |
| 13 | Albumin cobalt binding ability inassessment of myocardial ischemia in patients with acute coronarysyndrome 显示文摘 | Kremneva LV Kuznetsov VA | 2008 | Klin Med(Mosk)2008，86，4： | 1 |
| 14 | Clinical manifestations and risk factors of coronary artery disease in patients with diabetes mellitus in western Siberia显示文摘 | Kuznetsov VA Yaroslavskaya EI Bessonova MI | 2010 | Int J Circumpolar Health2010，69，3： | 1 |
| 15 | Transformation of hydrocarbons on zeolites of type Y:I Promoting effect of olefins on the rate of catalytic cracking of paraffins显示文摘 | ANUFRIEV D M KUZNETSOV P N IONE K G | 1980 | Journal of Catalysis1980，65，1： | 1 |
| 16 | Regular and anomalous extraordi- nary optical transmission at the THz-gap显示文摘 | KUZNETSOV S A NANARRO-CIA M KUBA- REV V V | 2009 | Op-tics Express2009，17，11： | 1 |
| 17 | Flow-lnjection Spectrophotometry of Nitrites Based on the Diazotization Reac- tions of Azine Dyes 显示文摘 | Kuznetsov V V Zemyatova S V | 2007 | Journal of Analytical Chemistry2007，，62： | 1 |
| 18 | Embryonic hybrid cells: a powerful tool for studying pluripotency and reprogramming of the differentiated cell chromosomes显示文摘 | Serov O Matveeva N Kuznetsov S | 2001 | An Acad Bras Cienc2001，73，4： | 1 |
| 19 | Schlieren technique to insitu monitor rapidly-growing KDP crystal surface 显示文摘 | Bredikhin V I Galushkina G L Kuznetsov S P | 2002 | Crystal Growth2002，19，12： | 1 |
| 20 | Simulation of coupled turbulent flow and heat transfer in the wedge-shaped pool of a twin-roll strip casting process显示文摘 | Kim W S Kim D S Kuznetsov A V | 2000 | International Journal of Heat and Mass Transfer2000，43，： | 1 |
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