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| 1 | Ontology-based Access Control for FAIR Data显示文摘This paper focuses on fine-grained,secure access to FAIR data,for which we propose ontology-based data access policies.These policies take into account both the FAIR aspects of the data relevant to access(such as provenance and licence),expressed as metadata,and additional metadata describing users.With this tripartite approach(data,associated metadata expressing FAIR information,and additional metadata about users),secure and controlled access to object data can be obtained.This yields a security dimension to the“A”(accessible)in FAIR,which is clearly needed in domains like security and intelligence.These domains need data to be shared under tight controls,with widely varying individual access rights.In this paper,we propose an approach called Ontology-Based Access Control(OBAC),which utilizes concepts and relations from a data set's domain ontology.We argue that ontology-based access policies contribute to data reusability and can be reconciled with privacy-aware data access policies.We illustrate our OBAC approach through a proof-of-concept and propose that OBAC to be adopted as a best practice for access management of FAIR data. | Christopher Brewster Barry Nouwt Stephan Raaijmakers Jack Verhoosel | 2020 | Data Intelligence2020，2，1： | 8 |
| 2 | 基因型测定对生猪生产者有怎样的用处显示文摘像SNPs、基因组选择和基因组育种类似术语在奶牛业早已为人们所熟悉了,与猪基因组测序相关的技术虽然在猪业起步较晚一些,但是现在的工作进行得不错。本文介绍了目前的工作进行情况以及该项技术给养殖业提供的前景。 | 何忠武 Christopher K.Tuggle Jack C.M.Dekkers | 2010 | 现代畜牧兽医2010，，12： | 6 |
| 3 | Outcomes of combination MRI-targeted and transperineal template biopsy in restaging low-risk prostate cancer for active surveillance显示文摘Objective:Active surveillance(AS)offers a strategy to reduce overtreatment and now is a widely accepted treatment option for low-risk prostate cancer.An ideal tool for risk-stratification would detect aggressive cancers and exclude such men from taking up AS in the first place.We evaluate if a combination of transperineal template biopsy with magnetic resonance imaging(MRI)-targeted biopsy identifies significant prostate cancer amongst men initially diagnosed with low-risk prostate cancer.Methods:This prospective,single-blinded study included men with low-risk prostate cancer(D’Amico’s Criteria)diagnosed on conventional transrectal ultrasound-guided biopsy.Patients first underwent multiparametric MRI of the prostate6 weeks after initial biopsy.Each suspicious lesion is mapped and assigned a Prostate Imaging Reporting and Data System(PIRADS)score.Template biopsy is first performed with the surgeon blinded to MRI findings followed by MRI-targeted biopsy using a robotic transperineal biopsy platform.Results:The age of the 19 men included is 65.4±4.9 years(mean±SD).Prostate specific antigen(PSA)at diagnosis and at the time of transperineal biopsy were comparable(7.3±1.7 ng/mL and 7.0±1.8 ng/mL,p Z 0.67),so were prostate volumes(34.2±8.9 mL and 32.1±13.4 mL,p Z 0.28).MRI-targeted biopsy had a higher percentage of cancer detection per core compared to template biopsy(11.7%vs.6.5%,p Z 0.02),this was more than 3 times superior for Gleason 7 disease(5.9%vs.1.6%,p<0.01).Four of 18(22.2%)patients with MRI lesions had significant disease with MRI-targeted biopsy alone.Three of 19 patients(15.8%)had significant disease with template biopsy alone.In combination,both techniques upclassified five patients(26.3%),all of whom underwent radical prostatectomy.Whole mount histology confirmed tumour location and grade.All six patients with PIRADS 5 lesions had cancer detected(66.6%significant disease).Conclusion:A combination of MRI-targeted and template biopsy may optimally risk-classify“low-risk”patients diagnosed on initial conventional transrectal ultrasonography(TRUS)prostate biopsy. | Kenneth Chen Kae Jack Tay Yan Mee Law Hakan Aydin Henry Ho Christopher Cheng John Shyi Peng Yuen | 2018 | Asian Journal of Urology2018，5，3： | 2 |
| 4 | Liver regeneration biology:Implications for liver tumour therapies显示文摘The liver has remarkable regenerative potential,with the capacity to regenerate after 75%hepatectomy in humans and up to 90%hepatectomy in some rodent models,enabling it to meet the challenge of diverse injury types,including physical trauma,infection,inflammatory processes,direct toxicity,and immunological insults.Current understanding of liver regeneration is based largely on animal research,historically in large animals,and more recently in rodents and zebrafish,which provide powerful genetic manipulation experimental tools.Whilst immensely valuable,these models have limitations in extrapolation to the human situation.In vitro models have evolved from 2-dimensional culture to complex 3 dimensional organoids,but also have shortcomings in replicating the complex hepatic micro-anatomical and physiological milieu.The process of liver regeneration is only partially understood and characterized by layers of complexity.Liver regeneration is triggered and controlled by a multitude of mitogens acting in autocrine,paracrine,and endocrine ways,with much redundancy and cross-talk between biochemical pathways.The regenerative response is variable,involving both hypertrophy and true proliferative hyperplasia,which is itself variable,including both cellular phenotypic fidelity and cellular trans-differentiation,according to the type of injury.Complex interactions occur between parenchymal and non-parenchymal cells,and regeneration is affected by the status of the liver parenchyma,with differences between healthy and diseased liver.Finally,the process of termination of liver regeneration is even less well understood than its triggers.The complexity of liver regeneration biology combined with limited understanding has restricted specific clinical interventions to enhance liver regeneration.Moreover,manipulating the fundamental biochemical pathways involved would require cautious assessment,for fear of unintended consequences.Nevertheless,current knowledge provides guiding principles for strategies to optimise liver regeneration potential. | Christopher Hadjittofi Michael Feretis Jack Martin Simon Harper Emmanuel Huguet | 2021 | World Journal of Clinical Oncology2021，12，12： | 2 |
| 5 | Elucidation of the life cycle of the endophytic genus Muscodor and its transfer to Induratia in Induratiaceae fam. nov., based on a polyphasic taxonomic approach显示文摘Molecular phylogenetic studies of cultures derived from some specimens of plant-inhabiting Sordariomycetes using ITS,LSU,rpb2 and tub2 DNA sequence data revealed close affinities to strains of Muscodor.The taxonomy of this biotechnologi-cally important genus,which exclusively consists of endophytes with sterile mycelia that produce antibiotic volatile secondary metabolites,was based on a rather tentative taxonomic concept.Even though it was accommodated in Xylariaceae,its phylo-genetic position had so far remained obscure.Our phylogeny shows that Muscodor species have affinities to the xylarialean genera Emarcea and Induratia,which is corroborated by the fact that their sexual states produce characteristic apiospores.These data allow for the integration of Muscodor in Induratia,i.e.the genus that was historically described first.The multi-locus phylogenetic tree clearly revealed that a clade comprising Emarcea and Induratia forms a monophylum separate from representatives of Xylariaceae,for which we propose the new family Induratiaceae.Divergence time estimations revealed that Induratiaceae has been diverged from the Xylariaceae+Clypeosphaeriaceae clade at 93(69-119)million years ago(Mya)with the crown age of 61(39-85)Mya during the Cretaceous period.The ascospore-derived cultures were studied for the production of volatile metabolites,using both,dual cultures for assessment of antimicrobial effects and extensive analyses using gas chromatography coupled with mass spectrometry(GC-MS).The antimicrobial effects observed were significant,but not as strong as in the case of the previous reports on Muscodor species.The GC-MS results give rise to some doubt on the validity of the previous identification of certain volatiles.Many peaks in the GC-MS chromatograms could not be safely identified by database searches and may represent new natural products.The isolation of these compounds by preparative chromatography and their subsequent characterisation by nuclear magnetic resonance(NMR)spectroscopy or total synthesis will allow for a more concise identification of these volatiles,and they should also be checked for their individual contri-bution to the observed antibiotic effects.This will be an important prerequisite for the development of biocontrol strains. | Milan C.Samarakoon Benjarong Thongbai Kevin D.Hyde Mark Brönstrup Ulrike Beutling Christopher Lambert Andrew N.Miller Jian‑Kui(Jack)Liu Itthayakorn Promputtha Marc Stadler | 2020 | Fungal Diversity2020，，2： | 2 |
| 6 | 3D biofabrication for tubular tissue engineering显示文摘 | lan Holland Jack Logan Jiezhong Shi Christopher McCormick Dongsheng Liu Wenmiao Shu | 2018 | Bio-Design and Manufacturing2018，1，2： | 2 |
| 7 | Harmful algal blooms and eutrophication: Examining linkages from selected coastal regions of the United States显示文摘 | Donald M. Anderson Joann M. Burkholder William P. Cochlan Patricia M. Glibert Christopher J. Gobler Cynthia A. Heil Raphael M. Kudela Michael L. Parsons J. E. Jack Rensel David W. Townsend Vera L. Trainer Gabriel A. Vargo | 2008 | Harmful Algae2008，，1： | 1 |
| 8 | Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone in patients with newly diagnosed diffuse large B-cell non-Hodgkin lymphoma: a phase 3 comparison of dose intensification with 14-day versus 21-day cycles显示文摘 | David Cunningham Eliza A Hawkes Andrew Jack Wendi Qian Paul Smith Paul Mouncey Christopher Pocock Kirit M Ardeshna John A Radford Andrew McMillan John Davies Deborah Turner Anton Kruger Peter Johnson Joanna Gambell David Linch | 2013 | The Lancet2013，，9880： | 1 |
| 9 | Trade Booms, Trade Busts and Trade Costs 显示文摘 | Jacks D S Christopher M M Novy D | 2011 | Journal of InternationalEconomics2011，83，2： | 1 |
| 10 | Classification System for Complete Edentulism显示文摘 | Thomas J.McGarry ArthurNimmo James F.Skiba Robert H.Ahlstrom Christopher R.Smith Jack H.Koumjian | 2005 | Journal of Prosthodontics2005，，1： | 1 |
| 11 | Anterior Cruciate Ligament Revision Reconstruction – Two-Year Results From the MOON Cohort显示文摘 | Rick Wright Warren Dunn Annunziato Amendola Jack Andrish David Flanigan Morgan Jones Christopher Kaeding Robert Marx Matthew Matava Eric McCarty Richard Parker Armando Vidal Michelle Wolcott Brian Wolf Kurt Spindler | 2007 | J Knee Surg2007，，04： | 1 |
| 12 | Impact of Nanometal Catalysts on tile Laser Vaporization Synthesis of Single Wall Sarbon Nanotubes 显示文摘 | Schauerman Christopher M Jack A | 2009 | Carbon2009，47，10： | 1 |
| 13 | Endothelial dysfunction contributes to severe COVID-19 in combination with dysregulated lymphocyte responses and cytokine networks显示文摘The systemic processes involved in the manifestation of life・threatening COVID-19 and in disease recovery are still incompletely understood,despite investigations focusing on the dysregulation of immune responses after SARS-CoV-2 infection.To define hallmarks of severe COVID-19 in acute disease(n=58)and in disease recovery in con valesce nt patie nts(n=28)from Han nover Medical School,we used flow cytometry and proteomics data with unsupervised clustering analyses.In our observational study,we combined analyses of immune cells and cytokine/chemokine networks with endothelial activation and injury.ICU patients displayed an altered immune signature with prolonged lymphopenia but the expansion of granulocytes and plasmablasts along with activated and terminally differentiated T and NK cells and high levels of SARS-CoV-2-specific antibodies.The core signature of seven plasma proteins revealed a highly inflammatory microenvironment in addition to endothelial injury in severe COVID-19.Changes within this sign ature were associated with either disease progression or recovery.In summary,our data suggest that besides a strong inflammatory response,severe COVID-19 is driven by endothelial activation and barrier disruption,whereby recovery depends on the regeneration of the endothelial integrity. | Louisa Ruhl Isabell Pink Jenny F.Kiihne Kerstin Beushausen Jana Keil Stella Christoph Andrea Sauer Lennart Boblitz Julius Schmidt Sascha David Hans-Martin Jack Edith Roth Markus Cornberg Thomas F.Schulz Tobias Welte Marius M.Hoper Christine S.Falk | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 1 |
| 14 | First radiative shock experiments on the SG-II laser显示文摘We report on the design and first results from experiments looking at the formation of radiative shocks on the ShenguangII(SG-II)laser at the Shanghai Institute of Optics and Fine Mechanics in China.Laser-heating of a two-layer CH/CH–Br foil drives a∼40 km/s shock inside a gas cell filled with argon at an initial pressure of 1 bar.The use of gas-cell targets with large(several millimetres)lateral and axial extent allows the shock to propagate freely without any wall interactions,and permits a large field of view to image single and colliding counter-propagating shocks with time-resolved,pointprojection X-ray backlighting(∼20µm source size,4.3 keV photon energy).Single shocks were imaged up to 100 ns after the onset of the laser drive,allowing to probe the growth of spatial nonuniformities in the shock apex.These results are compared with experiments looking at counter-propagating shocks,showing a symmetric drive that leads to a collision and stagnation from∼40 ns onward.We present a preliminary comparison with numerical simulations with the radiation hydrodynamics code ARWEN,which provides expected plasma parameters for the design of future experiments in this facility. | Francisco Suzuki-Vidal Thomas Clayson Chantal Stehlé Uddhab Chaulagain Jack W.D.Halliday Mingying Sun Lei Ren Ning Kang Huiya Liu Baoqiang Zhu Jianqiang Zhu Carolina De Almeida Rossi Teodora Mihailescu Pedro Velarde Manuel Cotelo John M.Foster Colin N.Danson Christopher Spindloe Jeremy P.Chittenden Carolyn Kuranz | 2021 | High Power Laser Science and Engineering2021，9，2： | 1 |
| 15 | Trade Costs, 1870 - 2000 显示文摘 | Jacks David S Christopher M Meissner and Dennis Novy | 2008 | The A- merican Economic Review2008，98，2： | 1 |
| 16 | Fluorescent PLLA-nanodiamond composites for bone tissue engineering显示文摘 | Qingwei Zhang Vadym N. Mochalin Ioannis Neitzel Isabel Y. Knoke Jingjia Han Christopher A. Klug Jack G. Zhou Peter I. Lelkes Yury Gogotsi | 2010 | Biomaterials2010，，1： | 1 |
| 17 | Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone in patients with newly diagnosed diffuse large B-cell non-Hodgkin lymphoma: a phase 3 comparison of dose intensification with 14-day versus 21-day cycles显示文摘 | David Cunningham Eliza A Hawkes Andrew Jack Wendi Qian Paul Smith Paul Mouncey Christopher Pocock Kirit M Ardeshna John A Radford Andrew McMillan John Davies Deborah Turner Anton Kruger Peter Johnson Joanna Gambell David Linch | 2013 | The Lancet . 2013 (9880)2013，，： | 1 |
| 18 | Trade Booms, Trade Busts, and Trade Costs 显示文摘 | Jacks David S Christopher M Meissner and Dennis Novy | 2011 | Journal of International Economics2011，83，： | 1 |
| 19 | Global transcriptional response of porcine mesenteric lymph nodes to Salmonella enterica serovar Typhimurium显示文摘 | Yanfang Wang Long Qu Jolita J. Uthe Shawn M.D. Bearson Daniel Kuhar Joan K. Lunney Oliver P. Couture Dan Nettleton Jack C.M. Dekkers Christopher K. Tuggle | 2007 | Genomics2007，，1： | 1 |
| 20 | VERNAUZATION1 Modulates Root System Architecture in Wheat and Barley显示文摘 | Kai P. Voss-Fels Hannah Robinson Stephen R. Mudge Cecile Richard Saul Newman Benjamin Wittkop Andreas Stahl Wolfgang Friedt Matthias Frisch lulian Gabur Anika Miller-Cooper Bradley C. Campbell Alison Kelly Glen Fox Jack Christopher Mandy Christopher Karine Chenu Jerome Franckowiak Emma S. Mace Andrew K. Borrell Howard Eagles David R. Jordan Jose R. Botella Graeme Hammer lan D. Godwin Ben Trevaskis Rod J. Snowdon Lee T. Hickey | 2018 | Molecular Plant2018，11，1： | 1 |
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