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| 1 | Rural land use spatial allocation in the semiarid loess hilly area in China:Using a Particle Swarm Optimization model equipped with multi-objective optimization techniques显示文摘Semiarid loess hilly areas in China are enduring a series of environmental conflicts between urban expansion,cultivated land conservation,soil erosion and water shortage,and require land use allocation to reconcile these environmental conflicts.We argue that the optimized spatial allocation of rural land use can be achieved by a Particle Swarm Optimization (PSO) model in conjunction with multi-objective optimization techniques.Our study focuses on Yuzhong County of Gangsu Province in China,a typical catchment on the Loess Plateau,and proposes a land use spatial optimization model.The model maximizes land use suitability and spatial compactness based on a variety of constraints,e.g.optimal land use structure and restrictive areas,and employs an improved PSO algorithm equipped with a determinant initialization method and a dynamic weighted aggregation (DWA) method to obtain the optimized land use spatial pattern.The results suggest that (1) approximately 4% of land use should be reallocated and these changes would alleviate the environmental conflicts in the study area;(2) the major reshuffling is slope farmland and newly added construction and cultivated land,whereas the unchanged areas are largely forests and basic farmland;and (3) the PSO is capable of optimizing rural land use allocation,and the determinant initialization method and DWA can improve the performance of the PSO. | LIU YaoLin LIU DianFeng LIU YanFang HE JianHua JIAO LiMin CHEN YiYun HONG XiaoFeng | 2012 | Science China Earth Sciences2012，55，7： | 23 |
| 2 | Annual cost of illness of stomach and esophageal cancer patientsin urban and rural areas in China: A multi-center study显示文摘Objective: Stomach and esophageal cancer are imposing huge threats to the health of Chinese people whereas there were few studies on the financial burden of the two cancers.Methods: Costs per hospitalization of all patients with stomach or esophageal cancer discharged between September 2015 and August 2016 in seven cities/counties in China were collected, together with their demographic information and clinical details. Former patients in the same hospitals were sampled to collect information on annual direct non-medical cost, indirect costs and annual number of hospitalization. Annual direct medical cost was obtained by multiplying cost per hospitalization by annual number of hospitalization. Annual cost of illness(ACI)was obtained by adding the average value of annual direct medical cost, direct non-medical cost and indirect cost,stratified by sex, age, clinical stage, therapy and pathologic type in urban and rural areas. Costs per hospitalization were itemized into eight parts to calculate the proportion of each part. All costs were converted to 2016 US dollars(1 USD=6.6423 RMB).Results: Totally 19,986 cases were included, predominately male. Mean ages of stomach cancer and urban patients were lower than that of esophageal cancer and rural patients. ACI of stomach and esophageal cancer patients were $10,449 and $13,029 in urban areas, and $2,927 and $3,504 in rural areas, respectively. Greater ACI was associated with male, non-elderly patients as well as those who were in stage I and underwent surgeries.Western medicine fee took the largest proportion of cost per hospitalization.Conclusions: The ACI of stomach and esophageal cancer was tremendous and varied substantially among the population in China. Preferential policies of medical insurance should be designed to tackle with this burden and further reduce the health care inequalities. | Zhixun Yang Hongmei Zeng Ruyi Xia Qian Liu Kexin Sun Rongshou Zheng Siwei Zhang Changfa Xia He Li Shuzheng Liu Zhiyi Zhang Yuqin Liu Guizhou Guo Guohui Song Yigong Zhu Xianghong Wu Bingbing Song Xianzhen Liao Yanfang Chen Wenqiang Wei Guihua Zhuang Wanqing Chen | 2018 | Chinese Journal of Cancer Research2018，30，4： | 22 |
| 3 | Meso-damage cracking characteristics analysis for rock and soil aggregate with CT test显示文摘The aim of this paper is to investigate the damage cracking characteristics of rock and soil aggregate(RSA)by X-ray computed tomography(CT)under uniaxial compressive loading.The mean CT value for the region of interest(ROI)is used to analyze the cracking characteristics.Also,the mathematical morphology method based on the image threshold segmentation is used to obtain characteristic parameters of cracks to describe the cracking evolution of RSA.Results show that the elastic mismatch between rock blocks and soil matrix is the primary reason for RSA cracking.The mean CT value for the RSA specimen,rock block inclusions,and their adjacent soil regions decreases with the increasing stress level.However,it is more sensitive for block inclusions than soil regions.Using the image segmentation method,length,area and mean width of cracks obey to power function distribution.Crack statistical characteristics are closely related to the rock block’s distribution and morphology.These results may be useful to reveal the mesoscopic cracking mechanism,establish meso-damage evolution equation,and constitutive relation for RSA. | WANG Yu LI Xiao ZHANG Bo WU YanFang | 2014 | Science China(Technological Sciences)2014，57，7： | 21 |
| 4 | Isolation,characterization,and phylogenic analysis of three new severe fever with thrombocytopenia syndrome bunyavirus strains derived from Hubei Province,China显示文摘Hubei Province is a major epidemic area of severe fever with thrombocytopenia syndrome bunyavirus(SFTSV) in China. However, to date, a few SFTSV strains have been isolated from Hubei Province, preventing effective studies of epidemic outbreaks. Here, we report three confirmed patients(2015–2016) with typical symptoms of severe fever with thrombocytopenia syndrome disease(SFTS) who were farmers resident in different regions in Hubei Province. Three new SFTSV strains were isolated from the serum samples of each patient. Characterization of viral growth properties showed that there were no significant differences in virus production. All strains were completely sequenced, and phylogenetic analysis showed that unlike the other strains from Hubei province, which belonged to the SFTSV C3 genotype, one of the three strains belonged to the SFTSV C2 genotype. These results suggested that multiple SFTSV genotypes have been circulating in Hubei Province, providing insights into SFTSV evolution and improving our understanding of SFTSV prevalence in Hubei Province. | Yanfang Zhang Shu Shen Junming Shi Zhengyuan Su Mingyue Li Wenjing Zhang Mengmeng Li Zhihong Hu Cheng Peng Xin Zheng Fei Deng | 2017 | Virologica Sinica2017，32，1： | 21 |
| 5 | Analysis of the Fungal Community in Apple Replanted Soil Around Bohai Gulf显示文摘Apple replant disease(ARD) is a frequently occurring plant disease in replanted orchards around Bohai Gulf, which causes growth inhibition and even death of plants. The aim of this study was to investigate the etiology of ARD around Bohai Gulf. In this study, the primary growth inhibition of apple seedlings was evaluated in ten replanted soils, sampled around Bohai Gulf. A fungal clone library was used to identify changes in the structure and composition of the soil fungal community. The results revealed that the Simpson diversity indices of Laizhou and Pulandian orchards were higher than others, presenting severe ARD. Ascomycota dominated around Bohai Gulf at the phyla level. Fusarium and Saccharomyces were abundant in all replanted soils. In addition, correlations between the relative abundance of fungal genera in soils and the severity of ARD were analyzed. The results showed that Fusarium was correlated positively with the severity of ARD, but Mortierella was negatively correlated. Furthermore, the quantitative PCR of Fusarium oxysporum, which was regarded as a factor of ARD, was performed. Overall, this study demonstrated that ARD was strongly associated with an unbalanced microbial ecosystem with more pathogenic fungi, while Fusarium in the apple replanted soil was the key factor for ARD around Bohai Gulf. | WANG Gongshuai YIN Chengmiao PAN Fengbing WANG Xiaobao XIANG Li WANG Yanfang WANG Jinzheng TIAN Changping CHEN Jie MAO Zhiquan | 2018 | Horticultural Plant Journal2018，4，5： | 21 |
| 6 | Cold adaptation in pigs depends on UCP3 in beige adipocytes显示文摘 | Jun Lin Chunwei Cao Cong Tao Rongcai Ye Meng Dong Qiantao Zheng Chao Wang Xiaoxiao Jiang Guosong Qin Changguo Yan Kui Li John R. Speakman Yanfang Wang Wanzhu Jin Jianguo Zhao | 2017 | Journal of Molecular Cell Biology2017，9，5： | 20 |
| 7 | The value of vegetation ecosystem services:a case of Qinling-Daba Mountains显示文摘According to differences in vegetation types and their coverage, combining the latest research, using theory and method on the value of vegetation ecosystem services, this paper not only calculated goods produced by different types of vegetation but also estimated the value of various vegetation ecosystem services and set up database, GIS and eco-account of vegetation ecosystem. The result was as follows: the value of vegetation’s primary productivity, soil and fertility conservation, water conservation, CO 2 fixation and O 2 release was 199.6 billion yuan/a, 22.64 billion yuan/a, 22.66 billion yuan/a, 352.24 billion yuan/a and 374.19 billion yuan/a, respectively. The total value of ecosystem services was 968.33 billion yuan/a. The temperate deciduous broad-leaved forest had the highest contribution rate, accounting for 16.42%. The result of value can reflect regional reality more exactly. | REN Zhiyuan,ZHANG Yanfang,LI Jing(College of Tourism and Environment, Shaanxi Normal University, Xi’an 710062, China) | 2003 | Journal of Geographical Sciences2003，13，2： | 20 |
| 8 | Linear Quadratic Differential Game Strategies with Two-pursuit Versus Single-evader显示文摘In order to intercept the future targets that are characterized by high maneuverability, multiple interceptors may be launched and aimed at single target. The scenario of two missiles P and Q intercepting a single target is modeled as a two-pursuit single-evader non-zero-sum linear quadratic differential game. The intercept space is decomposed into three subspaces which are mutually disjoint and their union covers the entire intercept space. The effect of adding the second interceptor arises in the intercept space of both P and Q (PQ-intercept space). A guidance law is derived from the Nash equilibrium strategy set (NESS) of the game. Simulation studies are focused on the PQ-intercept space. It is indicated that 1) increasing the target's maneuverability will enlarge PQ-intercept space; 2) the handover conditions will be released if the initial zero-effort-miss (ZEM) of both interceptors has opposite sign; 3) overvaluation of the target's maneuverability by choosing a small weight coefficient will generate robust performance with respect to the target maneuvering command switch time and decrease the fuel requirement; and 4) cooperation between interceptors increases the interception probability. | LIU Yanfang QI Naiming TANG Zhiwei | 2012 | Chinese Journal of Aeronautics2012，25，6： | 19 |
| 9 | Enhancing the antihepatitis B virus immune response by adefovir dipivoxil and entecavir therapies显示文摘Chronicity of hepatitis B(CHB)infection is characterized by a weak immune response to the virus.Entecavir(ETV)and adefovir dipivoxil(ADV)are effective in suppressing hepatitis B virus(HBV)replication.However,the underlying immune mechanism in the antiviral response of patients treated with nucleoside or nucleotide analogs is not clearly understood.In this study,regulatory T cells(Tregs)and intracellular cytokines,including IL-2,interferon(IFN)-γ,tumor-necrosis factor(TNF)-α and IL-4,were measured prior to and at 12,24,36 and 48 weeks after treatment with ETV or ADV.The cytokines were increased from 24 to 48 weeks after treatment.Higher levels of Th1 cytokines were observed with ETV(n=29)versus ADV(n=28)treatment.By contrast,the numbers of Tregs in both groups were decreased.The altered cytokine profile and cellular component was accompanied by a decrease in HBV DNA levels in both groups,which may contribute to their therapeutic effect in CHB infection.Our findings suggest that the antiviral effect of the drugs may be attributed not only to their direct effect on virus suppression but also to their immunoregulatory capabilities. | Yanfang Jiang Wanyu Li Lei Yu Jingjing Liu Guijie Xin Hongqing Yan Pinghui Sun Hong Zhang Damo Xu Junqi Niu | 2011 | Cellular & Molecular Immunology2011，8，1： | 16 |
| 10 | Effect of pre-deformation on the stress corrosion cracking susceptibility of aluminum alloy 2519显示文摘The effects of pre-deformation and strain rate on the stress corrosion cracking (SCC) behavior of aluminum alloy 2519 in air and in 3.5% NaCl water solution were investigated by means of slow strain rate tension (SSRT), scanning elec- tron microscopy (SEM), and transmission electron microscopy (TEM). The results indicate that the alloy is susceptible to SCC in 3.5% NaCl water solution and not in air. At the same pre-deformation, the alloy is more susceptible to SCC at 1.33 × 10·5 s·1 than at 6.66 × 10·5 s·1. Moreover, it is more susceptible to SCC at free pre-deformation than at 10% pre-deformation at the same strain rate. The number of θ precipitated along the grain boundaries is reduced and distributed discontinuously, at the same time, the precipitate-free zones (PFZ) become narrow and the susceptibility to stress corrosion cracking is reduced after 10% pre-deformation. | LI Huizhong ZHANG Xinming CHEN Mingan LI Yanfang LIANG Xiaopeng | 2007 | Rare Metals2007，26，4： | 15 |
| 11 | ZmCOL3, a CCT gene represses flowering in maize by interfering with the circadian clock and activating expression of ZmCCT显示文摘Flowering time is a trait vital to the adaptation of flowering plants to different environments.Here, we report that CCT domain genes play an important role in flowering in maize(Zea mays L.).Among the 53 CCT family genes we identified in maize, 28 were located in flowering time quantitative trait locus regions and 15 were significantly associated with flowering time, based on candidate-gene association mapping analysis.Furthermore, a CCT gene named ZmCOL3 was shown to be a repressor of flowering.Overexpressing ZmCOL3 delayed flowering time by approximately 4 d, in either long-day or short-day conditions.The absence of one cytosine in the ZmCOL3 3'UTR and the presence of a 551 bp fragment in the promoter region are likely the causal polymorphisms contributing to the maize adaptation from tropical to temperate regions.We propose a modified model of the maize photoperiod pathway, wherein ZmCOL3 acts as an inhibitor of flowering either by transactivating transcription of ZmCCT, one of the key genes regulating maize flowering, or by interfering with the circadian clock. | Minliang Jin Xiangguo Liu Wei Jia Haijun Liu Wenqiang Li Yong Peng Yanfang Du Yuebin Wang Yuejia Yin Xuehai Zhang Qing Liu Min Deng Nan Li Xiyan Cui Dongyun Hao Jianbing Yan | 2018 | Journal of Integrative Plant Biology2018，60，6： | 14 |
| 12 | The Application of BP Networks to Land Suitability Evaluation显示文摘The back propagation (BP) model of artificial neural networks (ANN) has many good qualities comparing with ordinary methods in land suitability evaluation.Through analyzing ordinary methods’ limitations,some sticking points of BP model used in land evaluation,such as network structure,learning algorithm,etc.,are discussed in detail,The land evaluation of Qionghai city is used as a case study.Fuzzy comprehensive assessment method was also employed in this evaluation for validating and comparing. | LIU Yanfang JIAO Limin | 2002 | Geo-Spatial Information Science2002，5，1： | 14 |
| 13 | Highly Stretchable,Elastic,and Sensitive MXene-Based Hydrogel for Flexible Strain and Pressure Sensors显示文摘Electronic skin is driving the next generation of cutting-edge wearable electronic products due to its good wearability and high accuracy of information acquisition.However,it remains a challenge to fulfill the requirements on detecting full-range human activities with existing flexible strain sensors.Herein,highly stretchable,sensitive,and multifunctional flexible strain sensors based on MXene-(Ti_(3)C_(2)T_(x)-)composited poly(vinyl alcohol)/polyvinyl pyrrolidone double-network hydrogels were prepared.The uniformly distributed hydrophilic MXene nanosheets formed a three-dimensional conductive network throughout the hydrogel,endowing the flexible sensor with high sensitivity.The strong interaction between the double-network hydrogel matrix and MXene greatly improved the mechanical properties of the hydrogels.The resulting nanocomposited hydrogels featured great tensile performance(2400%),toughness,and resilience.Particularly,the as-prepared flexible pressure sensor revealed ultrahigh sensitivity(10.75 kPa^(-1))with a wide response range(0-61.5 kPa),fast response(33.5 ms),and low limit of detection(0.87 Pa).Moreover,the hydrogel-based flexible sensors,with high sensitivity and durability,could be employed to monitor fullrange human motions and assembled into some aligned devices for subtle pressure detection,providing enormous potential in facial expression and phonation recognition,handwriting verification,healthy diagnosis,and wearable electronics. | Yao Lu Xinyu Qu Wen Zhao Yanfang Ren Weili Si Wenjun Wang Qian Wang Wei Huang Xiaochen Dong | 2020 | Research2020，，1： | 14 |
| 14 | Risk factors and long-term health consequences of macrosomia:a prospective study in Jiangsu Province,China显示文摘We sought to determine risk factors associated with fetal macrosomia and to explore the long-term consequence of infant macrosomia at the age of 7 years.A prospective population based cohort study was designed to examine the associations between maternal and perinatal characteristics and the risk of macrosomia.A nested case-control study was conducted to explore the long-term health consequence of infant macrosomia.The mean maternal age of the macrosomia group was 24.74±3.32 years,which is slightly older than that in the control group(24.35±3.14 years,P = 0.000).The mean maternal body mass index(BMI) at early pregnancy was 22.75±2.81 kg/m 2,which was also higher than that in the control group(21.76±2.59 kg/m 2,P = 0.000).About 64.6% of macrosomic neonates were males,compared with 51.0% in the control group(P = 0.000).Compared with women with normal weight(BMI:18.5-23.9 kg/m 2),women who were overweight(BMI:24-27.9 kg/m 2) or obese(BMI ≥ 28 kg/m 2),respectively,had a 1.69-fold(P = 0.000) and a 1.49-fold(P = 0.000) increased risks of having a neonate with macrosomia,while light weight(BMI<18.5 kg/m 2) women had an approximately 50% reduction of the risk.Furthermore,macrosomia infant had a 1.52-fold and 1.50-fold risk,respectively,of developing overweight or obesity at the age of 7 years(P = 0.001 and P = 0.000).Older maternal age,higher maternal BMI at early pregnancy and male gender were independent risk factors of macrosomia.Macrosomic infant was associated with an increased predisposition to develop overweight or obesity at the beginning of their childhood. | Shouyong Gu Xiaofei An Liang Fang Xiaomin Zhang Chunyan Zhang Jingling Wang Qilan Liu Yanfang Zhang Yongyue Wei Zhibin Hu Feng Chen Hongbing Shen | 2012 | The Journal of Biomedical Research2012，26，4： | 14 |
| 15 | Risk analysis of flood control operation mode with forecast information based on a combination of risk sources显示文摘Risk analysis of reservoir flood control operation mode with forecast information (FCOMFI) is an important basis for the design and implementation of FCOMFI. Most of current researches on this issue are incomplete as they only consider flood forecast errors, but not many other uncertainties in reservoir routing. In order to obtain an integrated risk rate of FCOMFI, this paper analyzes four uncertainties, i.e. hydrological, hydraulic, stage-storage uncertainty and time-delay uncertainty, as well as their probability distributions. On the basis of this analysis, an integrated risk analysis model of FCOMFI for reservoirs and its lower reach is established involving the above-mentioned four uncertainties, and this model is solved by Monte Carlo simulation based on Latin hypercube sampling. The simulation results, with Baiguishan reservoir as the example, show that the integrated risk rates of FCOMFI are less than those of the flood control operation mode without forecast information. This article presents the highest limited water level that satisfies flood control safety requirements of the lower reach. | DIAO YanFang & WANG BenDe School of Faculty of Infrastructure Engineering, Dalian University of Technology, Dalian 116024, China | 2010 | Science China(Technological Sciences)2010，53，7： | 10 |
| 16 | M1 muscarinic acetylcholine receptor in Alzheimer's disease显示文摘The degeneration of cholinergic neurons and cholinergic hypofunction are pathologies associated with Alzheimer's disease(AD). Muscarinic acetylcholine receptors(mAChRs) mediate acetylcholine-induced neurotransmission and five mAChR subtypes(M1–M5) have been identified. Among them, M1 mAChR is widely expressed in the central nervous system and has been implicated in many physiological and pathological brain functions. In addition, M1 mAChR is postulated to be an important therapeutic target for AD and several other neurodegenerative diseases. In this article, we review recent progress in understanding the functional involvement of M1 mAChR in AD pathology and in developing M1 mAChR agonists for AD treatment. | Shangtong Jiang Yanfang Li Cuilin Zhang Yingjun Zhao Guojun Bu Huaxi Xu Yun-Wu Zhang | 2014 | Neuroscience Bulletin2014，30，2： | 10 |
| 17 | Structure and receptor-binding properties of an airborne transmissible avian infl uenza A virus hemagglutinin H5(VN1203mut)显示文摘Avian infl uenza A virus continues to pose a global threat with occasional H5N1 human infections,which is em-phasized by a recent severe human infection caused by avian-origin H7N9 in China.Luckily these viruses do not transmit effi ciently in human populations.With a few ami-no acid substitutions of the hemagglutinin H5 protein in the laboratory,two H5 mutants have been shown to obtain an air-borne transmission in a mammalian ferret model.Here in this study one of the mutant H5 proteins devel-oped by Kawaoka’s group(VN1203mut)was expressed in a baculovirus system and its receptor-binding properties were assessed.We herein show that the VN1203mut had a dramatically reduced binding affi nity for the avianα2,3-linkage receptor compared to wild type but showed no detectable increase in affi nity for the humanα2,6-linkage receptor,using Surface Plasmon Resonance techonology.Further,the crystal structures of the VN1203mut and its complexes with either human or avian receptors demon-strate that the VN1203mut binds the human receptor in the same binding manner(cis conformation)as seen for the HAs of previously reported 1957 and 1968 pandemic influenza viruses.Our receptor binding and crystallo-graphic data shown here further confi rm that the ability to bind the avian receptor has to decrease for a higher hu-man receptor binding affi nity.As the Q226L substitution is shown important for obtaining human receptor binding,we suspect that the newly emerged H7N9 binds human receptor as H7 has a Q226L substitution. | Xishan Lu Yi Shi Wei Zhang Yanfang Zhang Jianxun Qi George F Gao | 2013 | Protein & Cell2013，4，7： | 9 |
| 18 | One-step base editing in multiple genes by direct embryo injection for pig trait improvement显示文摘The precise and simultaneous acquisition of multiple beneficial alleles in the genome is in great demand for the development of elite pig breeders. Cytidine base editors(CBEs) that convert C:G to T:A have emerged as powerful tools for single-nucleotide replacement. Whether CBEs can effectively mediate C-to-T substitution at multiple sites/loci for trait improvement by direct zygote injection has not been verified in large animals. Here, we determined the editing efficiency of four CBE variants in porcine embryonic fibroblast cells and embryos. The findings showed that hA3A-BE3-Y130F and hA3A-eBE-Y130F consistently resulted in increased base-editing efficiency and low toxic effects in embryonic development. Further, we verified that using a one-step approach, direct zygote microinjection of the CBE system can generate pigs harboring multiple point mutations.Our process resulted in a stop codon in CD163 and myostatin(MSTN) and introduced a beneficial allele in insulin-like growth factor-2(IGF2). The pigs showed disrupted expression of CD163 and MSTN and increased expression of IGF2, which significantly improved growth performance and infectious disease resistance. Our approach allows immediate introduction of multiple mutations in transgene-free animals to comprehensively improve economic traits through direct embryo microinjection,providing a potential new route to produce elite pig breeders. | Ruigao Song Yu Wang Qiantao Zheng Jing Yao Chunwei Cao Yanfang Wang Jianguo Zhao | 2022 | Science China(Life Sciences)2022，65，4： | 9 |
| 19 | Studies on Differential Nuclear Translocation Mechanism and Assembly of the Three Subunits of the Arabidopsis thaliana Transcription Factor NF-Y显示文摘真核细胞的抄写因素 NF-Y 由三个子单元(A, B,和 C ) 组成,它在分别地由 10, 13,和 13 基因组成的 multigene 家庭被编码为 Arabidopsis thaliana。原则上,子单元的所有潜在的联合为 heterotrimeric 建筑群的集会是可能的。我们瞄准了估计每个子单元的概率参予 NF-Y 的集会。在家庭们显示的 NF-Y 子单元的所有成员之中的物理相互作用的评估为在全部建筑群前的 NF-YB/NF-YC heterodimerization 的一个强壮的要求能被完成。借助于修改酵母,到 heterotrimeric 建筑群的所有三个子单元的二混血儿的系统汇编被表明。用 GFP 熔化构造, NF -- 你和在原子核的 NF-YC 本地化被表明,当 NF-YB 完全作为 NF-YC-associated heterodimer NF-YC 被进口进原子核时。二个 Arabidopsis 子单元的这骑在背肩上的运输不同于不是自养的有机体的 NF-Y heterotrimer 的进口。基于 histone-fold-motifs 的一个肽结构模型,在 intramolecular 之中结合的二硫化物保存了 NF-YB 的半胱氨酸残余,它在人和曲霉属菌 nidulans 为 NF-YB 和 NF-YC 的调整氧化还原作用的集会负责,能为 Arabidopsis NF-YB 被排除。 | Dieter Hackenberg Yanfang Wu Andrea Voigt Robert Adams Peter Schramm Bernhard GrimmI | 2012 | Molecular Plant2012，5，4： | 9 |
| 20 | Potential targets for protecting against hippocampal cell apoptosis after transient cerebral ischemiareperfusion injury in aged rats显示文摘Mitochondria play an important role in neuronal apoptosis caused by cerebral ischemia, and the role is mediated by the expression of mitochondrial proteins. This study investigated the involvement of mitochondrial proteins in hippocampal cell apoptosis after transient cerebral ischemia-reperfusion injury in aged rats using a comparative proteomics strategy. Our experimental results show that the aged rat brain is sensitive to ischemia-reperfusion injury and that transient ischemia led to cell apoptosis in the hippocampus and changes in memory and cognition of aged rats. Differential proteomics analysis suggested that this phenomenon may be mediated by mitochondrial proteins associated with energy metabolism and apoptosis in aged rats. This study provides potential drug targets for the treatment of transient cerebral ischemia-reperfusion injury. | Xiangyu Ji Li'na Zhang Ran Liu Yingzhi Liu Jianfang Song He Dong Yanfang Jia Zangong Zhou | 2014 | Neural Regeneration Research2014，9，11： | 9 |
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