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| 1 | Elucidation of the life cycle of the endophytic genus Muscodor and its transfer to Induratia in Induratiaceae fam. nov., based on a polyphasic taxonomic approach显示文摘Molecular phylogenetic studies of cultures derived from some specimens of plant-inhabiting Sordariomycetes using ITS,LSU,rpb2 and tub2 DNA sequence data revealed close affinities to strains of Muscodor.The taxonomy of this biotechnologi-cally important genus,which exclusively consists of endophytes with sterile mycelia that produce antibiotic volatile secondary metabolites,was based on a rather tentative taxonomic concept.Even though it was accommodated in Xylariaceae,its phylo-genetic position had so far remained obscure.Our phylogeny shows that Muscodor species have affinities to the xylarialean genera Emarcea and Induratia,which is corroborated by the fact that their sexual states produce characteristic apiospores.These data allow for the integration of Muscodor in Induratia,i.e.the genus that was historically described first.The multi-locus phylogenetic tree clearly revealed that a clade comprising Emarcea and Induratia forms a monophylum separate from representatives of Xylariaceae,for which we propose the new family Induratiaceae.Divergence time estimations revealed that Induratiaceae has been diverged from the Xylariaceae+Clypeosphaeriaceae clade at 93(69-119)million years ago(Mya)with the crown age of 61(39-85)Mya during the Cretaceous period.The ascospore-derived cultures were studied for the production of volatile metabolites,using both,dual cultures for assessment of antimicrobial effects and extensive analyses using gas chromatography coupled with mass spectrometry(GC-MS).The antimicrobial effects observed were significant,but not as strong as in the case of the previous reports on Muscodor species.The GC-MS results give rise to some doubt on the validity of the previous identification of certain volatiles.Many peaks in the GC-MS chromatograms could not be safely identified by database searches and may represent new natural products.The isolation of these compounds by preparative chromatography and their subsequent characterisation by nuclear magnetic resonance(NMR)spectroscopy or total synthesis will allow for a more concise identification of these volatiles,and they should also be checked for their individual contri-bution to the observed antibiotic effects.This will be an important prerequisite for the development of biocontrol strains. | Milan C.Samarakoon Benjarong Thongbai Kevin D.Hyde Mark Brönstrup Ulrike Beutling Christopher Lambert Andrew N.Miller Jian‑Kui(Jack)Liu Itthayakorn Promputtha Marc Stadler | 2020 | Fungal Diversity2020，，2： | 2 |
| 2 | Prehospital fibrinolysis with dual antiplatelet therapy in ST-elevation acute myocardial infarction: a substudy of the randomized double blind CLARITY-TIMI 28 trial显示文摘 | Freek W. A. Verheugt Gilles Montalescot Marc S. Sabatine Louis Soulat Yves Lambert Frédéric Lapostolle Jennifer Adgey Christopher P. Cannon | 2007 | Journal of Thrombosis and Thrombolysis2007，，3： | 1 |
| 3 | Centrifugal osteopetrosis: appendicular sclerosis with relative sparing of the vertebrae显示文摘 | Christopher S. Kovacs M.D. F.R.C.P.C. Robert G. W. Lambert M.B. Guy J. Lavoie M.D. F.R.C.S.C. Dr. Kerry Siminoski M.D. F.R.C.P.C | 1995 | Skeletal Radiology1995，，1： | 1 |
| 4 | The endoxylanases from family 11: computer analysis of protein sequences reveals important structural and phylogenetic relationships 显示文摘 | Amalia Sapag Johan Wouters Christophe Lambert | 2002 | Journal of Biotechnology2002，，2： | 1 |
| 5 | Super-hydrophobic, highly adhesive, polydimethylsiloxane (PDMS) surfaces显示文摘 | Morgan M. Stanton Robert E. Ducker John C. MacDonald Christopher R. Lambert W. Grant McGimpsey | 2011 | Journal of Colloid And Interface Science2011，，1： | 1 |
| 6 | Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis显示文摘 | Christopher J Sinal Masahiro Tohkin Masaaki Miyata Jerrold M Ward Gilles Lambert Frank J Gonzalez | 2000 | Cell2000，，6： | 1 |
| 7 | Quantification of Circulating Regulatory T Cells by Flow Cytometry in Kidney Transplant Patients After Basiliximab Induction Therapy显示文摘 | Farida Abadja Eric Alamartine Fran?ois Berthoux Christophe Mariat Christian Genin Claude Lambert | 2010 | Transplantation2010，，3： | 1 |
| 8 | Synthesis and Spectroscopic Properties of a Hexapyrenyl-Benzene Derivative显示文摘 | Dirk Rausch Christoph Lambert | 2006 | Org Lett2006，8，22： | 1 |
| 9 | Comparison of open and closed hyperthermic intraperitoneal chemotherapy: Results from the United States hyperthermic intraperitoneal chemotherapy collaborative显示文摘BACKGROUND Cytoreductive surgery(CRS)with hyperthermic intraperitoneal chemotherapy(HIPEC)for peritoneal carcinomatosis can be performed in two ways:Open or closed abdominal technique.AIM To evaluate the impact of HIPEC method on post-operative and long-term survival outcomes.METHODS Patients undergoing CRS with HIPEC from 2000-2017 were identified in the United States HIPEC collaborative database.Post-operative,recurrence,and overall survival outcomes were compared between those who received open vs closed HIPEC.RESULTS Of the 1812 patients undergoing curative-intent CRS and HIPEC,372(21%)patients underwent open HIPEC and 1440(79%)underwent closed HIPEC.There was no difference in re-operation or severe complications between the two groups.Closed HIPEC had higher rates of 90-d readmission while open HIPEC had a higher rate of 90-d mortalities.On multi-variable analysis,closed HIPEC technique was not a significant predictor for overall survival(hazards ratio:0.75,95%confidence interval:0.51-1.10,P=0.14)or recurrence-free survival(hazards ratio:1.39,95%confidence interval:1.00-1.93,P=0.05)in the entire cohort.These findings remained consistent in the appendiceal and the colorectal subgroups.CONCLUSION In this multi-institutional analysis,the HIPEC method was not independently associated with relevant post-operative or long-term outcomes.HIPEC technique may be left to the discretion of the operating surgeon. | Jennifer L Leiting Jordan M Cloyd Ahmed Ahmed Keith Fournier Andrew J Lee Sophie Dessureault Seth Felder Jula Veerapong Joel M Baumgartner Callisia Clarke Harveshp Mogal Charles A Staley Mohammad Y Zaidi Sameer H Patel Syed A Ahmad Ryan J Hendrix Laura Lambert Daniel E Abbott Courtney Pokrzywa Mustafa Raoof Christopher J LaRocca Fabian M Johnston Jonathan Greer Travis E Grotz | 2020 | World Journal of Gastrointestinal Oncology2020，12，7： | 1 |
| 10 | Chemisorption andreactivity of furan on Pd {111} 显示文摘 | Ormerod R Mark Baddeley Christopher J HardacreChristopher Lambert Richard M | 1996 | Surface Science1996，360，123： | 1 |
| 11 | Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition显示文摘 | Randy K. Bledsoe Valerie G. Montana Thomas B. Stanley Chris J. Delves Christopher J. Apolito David D. McKee Thomas G. Consler Derek J. Parks Eugene L. Stewart Timothy M. Willson Millard H. Lambert John T. Moore Kenneth H. Pearce H.Eric Xu | 2002 | Cell2002，，1： | 1 |
| 12 | Lenormandins A—G,new azaphilones from Hypoxylon lenormandii and Hypoxylon jaklitschii sp.nov.,recognised by chemotaxonomic data显示文摘Seven new azaphilone pigments named lenormandins A–G were isolated from stromata(fruiting bodies)of the xylariaceous fungus,Hypoxylon lenormandii using preparative High Performance Liquid Chromatography(HPLC)and their structures were elucidated by NMR spectroscopy,high resolution mass spectrometry and other spectral methods.Their occurrence in herbarium specimens(including various type materials collected in the 19th and early 20th century)and several fresh collections was studied by analytical HPLC with diode array and mass spectrometric detection(HPLC-DAD/MS),revealing that this group of pigments is specific for Hypoxylon lenormandii from various geographic regions and otherwise only occurs in closely related taxa,i.e.H.sublenormandii and an undescribed fungus from Sri Lanka,for which we propose the name H.jaklitschii.The status of the new species was established by using molecular phylogenetic data based on ITS and partial beta-tubulin sequences,and by detailed morphological studies. | Eric Kuhnert Frank Surup Esteban B.Sir Christopher Lambert Kevin D.Hyde Adriana I.Hladki Andrea I.Romero Marc Stadler | 2015 | Fungal Diversity2015，，2： | 1 |
| 13 | Phylogenetic and chemotaxonomic resolution of the genus Annulohypoxylon(Xylariaceae)including four new species显示文摘This study deals with an extensive evaluation focusing on phylogenetic and chemotaxonomic infrageneric relationships of the genus Annulohypoxylon(Xylariaceae,Ascomycota),whose species are ubiquitously associated with seed plants as endophytes and saprotrophs in all forested areas of the world.Using evidence from phylogenetic,chemotaxonomic and morphological data,various varieties within the genus are raised to species level,leading to the new combinations for A.areolatum(:A.bovei var.microsporum),A.macrosporum(:A.leptascum var.macrosporum),and A.microdiscum(:A.moriforme var.microdiscum).Annulohypoxylon substygium nom.nov.is applied for A.stygium var.annulatumand the four new tropical and subtropical species A.massivum,A.violaceopigmentum,A.viridistratum and A.yungensis are introduced.Furthermore,A.leucadendri is excluded from the genus as its morphological characters disagree with the generic concept,the recently erected A.palmicola is synonymized with A.leptascum and A.austrobahiense has been reassigned to the genus Hypoxylon.In addition,the key taxa A.annulatum and A.truncatum have been reinvestigated and epitypes have been defined.For the first time,a dichotomous key to the genus is provided.A phylogenetic b-tubulin tree in conjunction with stromatal HPLC profiles clearly shows that Annulohypoxylon comprises two distinct lineages.The A.cohaerens/multiforme group might eventually warrant segregation into a new genus as further molecular data become available. | Eric Kuhnert Esteban B.Sir Christopher Lambert Kevin D.Hyde Adriana I.Hladki Andrea I.Romero Manfred Rohde Marc Stadler | 2017 | Fungal Diversity2017，，4： | 0 |
| 14 | Physiological and druggable skipping of immunoglobulin variable exons in plasma cells显示文摘The error-prone V(D)J recombination process generates considerable amounts of nonproductive immunoglobulin(Ig)pre-mRNAs.We recently demonstrated that aberrant Ig chains lacking variable(V)domains can be produced after nonsense-associated altered splicing(NAS)events.Remarkably,the expression of these truncated Ig polypeptides heightens endoplasmic reticulum stress and shortens plasma cell(PC)lifespan.Many questions remain regarding the molecular mechanisms underlying this new truncated Ig exclusion(TIE-)checkpoint and its restriction to the ultimate stage of B-cell differentiation.To address these issues,we evaluated the extent of NAS of Ig pre-mRNAs using an Ig heavy chain(IgH)knock-in model that allows for uncoupling of V exon skipping from TIE-induced apoptosis.We found high levels of V exon skipping in PCs compared with B cells,and this skipping was correlated with a biallelic boost in IgH transcription during PC differentiation.Chromatin analysis further revealed that the skipped V exon turned into a pseudo-intron.Finally,we showed that hypertranscription of Ig genes facilitated V exon skipping upon passive administration of splice-switching antisense oligonucleotides(ASOs).Thus,V exon skipping is coupled to transcription and increases as PC differentiation proceeds,likely explaining the late occurrence of the TIE-checkpoint and opening new avenues for ASO-mediated strategies in PC disorders. | Mohamad Omar Ashi Nivine Srour Jean-Marie Lambert Anne Marchalot Ophelie Martin Sandrine Le Noir Eric Pinaud Maria Victoria Ayala Christophe Sirac Jerome Sauliere Jerome Moreaux Michel Cogne Laurent Delpy | 2019 | Cellular & Molecular Immunology2019，16，10： | 0 |
| 15 | The contribution of fungi to the global economy显示文摘Fungi provide ecological and environmental services to humans, as well as health and nutritional benefits, and are vital to numerousindustries. Fermented food and beverage products from fungi are circulating in the market, generating billions of USD.However, the highest potential monetary value of fungi is their role in blue carbon trading because of their ability to sequesterlarge amounts of carbon in the soil. There are no conclusive estimates available on the global monetary value of fungi, primarilybecause there are limited data for extrapolation. This study outlines the contribution of fungi to the global economy and providesa first attempt at quantifying the global monetary value of fungi. Our estimate of USD 54.57 trillion provides a starting point thatcan be analysed and improved, highlighting the significance of fungi and providing an appreciation of their value. This paperidentifies the different economically valuable products and services provided by fungi. By giving a monetary value to all importantfungal products, services, and industrial applications underscores their significance in biodiversity and conservation. Furthermore,if the value of fungi is well established, they will be considered in future policies for effective ecosystem management. | Allen Grace T.Niego Christopher Lambert Peter Mortimer Naritsada Thongklang Sylvie Rapior Miriam Grosse Hedda Schrey Esteban Charria‑Girón Arttapon Walker Kevin D.Hyde Marc Stadler | 2023 | Fungal Diversity2023，，4： | 0 |
| 16 | High quality genome sequences of thirteen Hypoxylaceae(Ascomycota)strengthen the phylogenetic family backbone and enable the discovery of new taxa显示文摘The Hypoxylaceae(Xylariales,Ascomycota)is a diverse family of mainly saprotrophic fungi,which commonly occur in angiosperm-dominated forests around the world.Despite their importance in forest and plant ecology as well as a prolific source of secondary metabolites and enzymes,genome sequences of related taxa are scarce and usually derived from envi-ronmental isolates.To address this lack of knowledge thirteen taxonomically well-defined representatives of the family and one member of the closely related Xylariaceae were genome sequenced using combinations of Illumina and Oxford nanopore technologies or PacBio sequencing.The workflow leads to high quality draft genome sequences with an average N50 of 3.0 Mbp.A backbone phylogenomic tree was calculated based on the amino acid sequences of 4912 core genes reflecting the current accepted taxonomic concept of the Hypoxylaceae.A Percentage of Conserved Proteins(POCP)analysis revealed that 70%of the proteins are conserved within the family,a value with potential application for the definition of family boundaries within the order Xylariales.Also,Hypomontagnella spongiphila is proposed as a new marine derived lineage of Hypom.monticulosa based on in-depth genomic comparison and morphological differences of the cultures.The results showed that both species share 95%of their genes corresponding to more than 700 strain-specific proteins.This difference is not reflected by standard taxonomic assessments(morphology of sexual and asexual morph,chemotaxonomy,phylogeny),preventing species delimitation based on traditional concepts.Genetic changes are likely to be the result of environmental adaptations and selective pressure,the driving force of speciation.These data provide an important starting point for the establishment of a stable phylogeny of the Xylariales;they enable studies on evolution,ecological behavior and biosynthesis of natural products;and they significantly advance the taxonomy of fungi. | Daniel Wibberg Marc Stadler Christopher Lambert Boyke Bunk Cathrin Spröer Christian Rückert Jörn Kalinowski Russell JCox Eric Kuhnert | 2021 | Fungal Diversity2021，，1： | 0 |
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