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| 1 | Combining computer vision and deep learning to enable ultra-scale aerial phenotyping and precision agriculture:A case study of lettuce production显示文摘Aerial imagery is regularly used by crop researchers,growers and farmers to monitor crops during the growing season.To extract meaningful information from large-scale aerial images collected from the field,high-throughput phenotypic analysis solutions are required,which not only produce high-quality measures of key crop traits,but also support professionals to make prompt and reliable crop management decisions.Here,we report AirSurf,an automated and open-source analytic platform that combines modern computer vision,up-to-date machine learning,and modular software engineering in order to measure yield-related phenotypes from ultra-large aerial imagery.To quantify millions of in-field lettuces acquired by fixed-wing light aircrafts equipped with normalised difference vegetation index(NDVI)sensors,we customised AirSurf by combining computer vision algorithms and a deep-learning classifier trained with over 100,000 labelled lettuce signals.The tailored platform,AirSurf-Lettuce,is capable of scoring and categorising iceberg lettuces with high accuracy(>98%).Furthermore,novel analysis functions have been developed to map lettuce size distribution across the field,based on which associated global positioning system(GPS)tagged harvest regions have been identified to enable growers and farmers to conduct precision agricultural practises in order to improve the actual yield as well as crop marketability before the harvest. | Alan Bauer Aaron George Bostrom Joshua Ball Christopher Applegate Tao Cheng Stephen Laycock Sergio Moreno Rojas Jacob Kirwan Ji Zhou | 2019 | Horticulture Research2019，6，1： | 14 |
| 2 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 3 | Meta-analysis of the effects of 1-methylcyclopropene(1-MCP)treatment on climacteric fruit ripening显示文摘1-Methylcyclopropene(1-MCP)is an inhibitor of ethylene perception that is widely used to maintain the quality of several climacteric fruits during storage.A large body of literature now exists on the effects of 1-MCP on climacteric fruit ripening for different species and environmental conditions,presenting an opportunity to use meta-analysis to systematically dissect these effects.We classified 44 ripening indicators of climacteric fruits into five categories:physiology and biochemistry,quality,enzyme activity,color,and volatiles.Meta-analysis showed that 1-MCP treatment reduced 20 of the 44 indicators by a minimum of 22%and increased 6 indicators by at least 20%.These effects were associated with positive effects on delaying ripening and maintaining quality.Of the seven moderating variables,species,1-MCP concentration,storage temperature and time had substantial impacts on the responses of fruit to 1-MCP treatment.Fruits from different species varied in their responses to 1-MCP,with the most pronounced responses observed in rosaceous fruits,especially apple,European pear fruits,and tropical fruits.The effect of gaseous 1-MCP was optimal at 1μl/l,with a treatment time of 12–24 h,when the storage temperature was 0℃for temperate fruits or 20℃for tropical fruits,and when the shelf temperature was 20℃,reflecting the majority of experimental approaches.These findings will help improve the efficacy of 1-MCP application during the storage of climacteric fruits,reduce fruit quality losses and increase commercial value. | Jing Zhang Yuanchun Ma Chao Dong Leon A.Terry Christopher B.Watkins Zhifang Yu Zong-Ming(Max)Cheng | 2020 | Horticulture Research2020，7，1： | 7 |
| 4 | Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage显示文摘Asparaginyl endopeptidase (AEP ) 是有为在 P1 地点的天门冬素残余的偏爱的 endo/lysosomal 半胱氨酸 endopeptidase 并且在像使用费的受体 3/7/9 的成熟起一个重要作用。AEP 被知道为催化激活在酸的 pH 经历 autoproteolytic 成熟。这里,我们描述 AEP 酶原的水晶结构和 AEP 的成熟形式。在 AEP 和 caspases 之间的结构的比较在关键残余的作文并且在催化机制揭示了类似。Mutagenesis 研究作为为肽底层的劈开是必要的残余识别了 N44, R46, H150, E189, C191, S217/S218 和 D233。在成熟期间, AEP 的帽子领域的 autoproteolytic 劈开在核心领域上开创存取到活跃地点。出人意料地,一个中间的 autoproteolytic 成熟阶段被发现在近似 pH 4.5 在哪个部分激活的 AEP 能被颠倒回到它的酶原形式。这个唯一的特征被 AEP pH4.5 (AEP 在 pH 被成熟 4.5 并且在 pH 结晶 8.5 ) ,在哪个破肽契约被重新绑扎,结构被转变回到它的酶原形式。另外, AEP 禁止者 cystatin C 能被充分激活的 AEP 消化,但是不能被激活的组织蛋白酶消化。因此,我们第一次证明 cystatins 可以为活跃地点通过底层竞争调整 AEP 的活动。 | Lixia Zhao Tian Hua Christopher Crowley Heng Ru Xiangmin Ni Neil Shaw Lianying Jiao Wei Ding Lu Qu Li-Wei Hung Wei Huang Lei Liu Keqiang Ye Songying Ouyang Genhong Cheng Zhi-Jie Liu | 2014 | Cell Research2014，24，3： | 6 |
| 5 | Structural basis for termination of AIM2-mediated signaling by p202显示文摘 | Heng Ru Xiangmin Ni LixiaZhao Christopher Crowle Wei Ding Li-Wei Hung Neil Shaw Genhong Cheng Zhi-Jie Liu | 2013 | Cell Research2013，23，6： | 5 |
| 6 | Cenozoic Environmental Changes in the Northern Qaidam Basin Inferred from n-alkane Records显示文摘Cenozoic climatic and environmental changes in the arid Asian interior, and their possible relations with global climatic changes and the Tibetan Plateau uplift, have been intensively investigated and debated over past decades. Here we present 40-Myr(million years)-long n-alkane records from a continuous Cenozoic sediment sequence in the Dahonggou Section, Qaidam Basin, northern Tibetan Plateau, to infer environmental changes in the northern basin. A set of n-alkane indexes, including ACL, CPI and Paq, vary substantially and consistently throughout the records, which are interpreted to reflect relative contributions from terrestrial vascular plants vs. aquatic macrophytes, and thus indicate depositional environments. ACL values vary between 21 and 30; CPI values range from 1.0 to 8.0; and Paq values change from <0.1 to 0.8 over the past 40-Myr. We have roughly identified two periods, at 25.8–21.0 Ma(million years ago) and 13.0–17.5 Ma, with higher ACL and CPI and lower Paq values indicating predominant lacustrine environments. Lower ACL and CPI values, together with higher Paq values, occurred at >25.8 Ma, 17.5–21.0 Ma, and <13.0 Ma, corresponding to alluvial fan/river deltaic deposits and shallow lacustrine settings, consistent with the observed features in sedimentological facies. The inferred Cenozoic environmental changes in the northern Qaidam Basin appear to correspond to global climatic changes. | LIU Zhonghui ZHANG Kexin SUN Yuanyuan LIU Weiguo LIU Yusheng(Christopher) QUAN Cheng | 2014 | Acta Geologica Sinica(English Edition)2014，88，5： | 4 |
| 7 | Crystal structure and nucleotide selectivity of human IFIT5/ISG58显示文摘 | Feng Feng LingminYuan Yao E Wang Christopher Crowley Zongyang Lv Jingjing Li Yingfang Liu Genhong Cheng Su Zeng Huanhuan Liang | 2013 | Cell Research2013，23，8： | 4 |
| 8 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 9 | Agreement among 3 Methods to Measure Corneal Thickness: Ultrasound Pachymetry, Orbscan II, and Visante Anterior Segment Optical Coherence Tomography显示文摘 | Emmy Y.M. Li Shaheeda Mohamed Christopher K.S. Leung Srinivas K. Rao Arthur C.K. Cheng Carol Y.L. Cheung Dennis S.C. Lam | 2007 | Ophthalmology2007，，10： | 2 |
| 10 | Outcomes of combination MRI-targeted and transperineal template biopsy in restaging low-risk prostate cancer for active surveillance显示文摘Objective:Active surveillance(AS)offers a strategy to reduce overtreatment and now is a widely accepted treatment option for low-risk prostate cancer.An ideal tool for risk-stratification would detect aggressive cancers and exclude such men from taking up AS in the first place.We evaluate if a combination of transperineal template biopsy with magnetic resonance imaging(MRI)-targeted biopsy identifies significant prostate cancer amongst men initially diagnosed with low-risk prostate cancer.Methods:This prospective,single-blinded study included men with low-risk prostate cancer(D’Amico’s Criteria)diagnosed on conventional transrectal ultrasound-guided biopsy.Patients first underwent multiparametric MRI of the prostate6 weeks after initial biopsy.Each suspicious lesion is mapped and assigned a Prostate Imaging Reporting and Data System(PIRADS)score.Template biopsy is first performed with the surgeon blinded to MRI findings followed by MRI-targeted biopsy using a robotic transperineal biopsy platform.Results:The age of the 19 men included is 65.4±4.9 years(mean±SD).Prostate specific antigen(PSA)at diagnosis and at the time of transperineal biopsy were comparable(7.3±1.7 ng/mL and 7.0±1.8 ng/mL,p Z 0.67),so were prostate volumes(34.2±8.9 mL and 32.1±13.4 mL,p Z 0.28).MRI-targeted biopsy had a higher percentage of cancer detection per core compared to template biopsy(11.7%vs.6.5%,p Z 0.02),this was more than 3 times superior for Gleason 7 disease(5.9%vs.1.6%,p<0.01).Four of 18(22.2%)patients with MRI lesions had significant disease with MRI-targeted biopsy alone.Three of 19 patients(15.8%)had significant disease with template biopsy alone.In combination,both techniques upclassified five patients(26.3%),all of whom underwent radical prostatectomy.Whole mount histology confirmed tumour location and grade.All six patients with PIRADS 5 lesions had cancer detected(66.6%significant disease).Conclusion:A combination of MRI-targeted and template biopsy may optimally risk-classify“low-risk”patients diagnosed on initial conventional transrectal ultrasonography(TRUS)prostate biopsy. | Kenneth Chen Kae Jack Tay Yan Mee Law Hakan Aydin Henry Ho Christopher Cheng John Shyi Peng Yuen | 2018 | Asian Journal of Urology2018，5，3： | 2 |
| 11 | Thermal internal boundary layer and its effects on air pollutants during summer in a coastal city in North China显示文摘The thermal internal boundary layer(TIBL) is associated with coastal pollution dispersion,which can result in high concentrations of air pollutants near the surface of the Earth. In this study, boundary layer height data which were obtained using a ceilometer were used to assess the effect of the TIBL on atmospheric pollutants in Qinhuangdao, a coastal city in North China.A TIBL formed on 33% of summer days. When a TIBL formed, the sunshine duration was 2.4 hr longer, the wind speed was higher, the wind direction reflected a typical sea breeze, and the boundary layer height was lower from 9:00 LT to 20:00 LT compared to days without a TIBL. If no TIBL formed, the average concentrations of PM_(2.5) and PM_(10) decreased with increasing boundary layer height. However, when a TIBL was observed, the average concentrations of PM_(2.5) and PM_(10) increased with increasing boundary layer height. Because the air from the sea is clean, PM_(2.5) and PM_(10) concentrations reached minimums in the daytime at 16:00 LT. After16:00 LT, the PM_(2.5) and PM_(10) concentrations increased rapidly on days when a TIBL formed,which indicated that the TIBL leads to the rapid accumulation of atmospheric pollutants in the evening. Therefore, the maximum concentrations of particulate matters were larger when a TIBL formed compared to when no TIBL was present during the night. These results indicate that it is suitable for outdoor activities in the daytime on days with a TIBL in coastal cities. | Jie Wei Guiqian Tang Xiaowan Zhu Lili Wang Zirui Liu Mengtian Cheng Christoph Münkel Xin Li Yuesi Wang | 2018 | Journal of Environmental Sciences2018，30，8： | 2 |
| 12 | Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma显示文摘 | Janel L. Kopp Guido von Figura Erin Mayes Fen-Fen Liu Claire L. Dubois John P. Morris Fong Cheng Pan Haruhiko Akiyama Christopher V.E. Wright Kristin Jensen Matthias Hebrok Maike Sander | 2012 | Cancer Cell2012，，6： | 2 |
| 13 | Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy显示文摘 | Sinha Rohit Anthony You Seo-Hee Zhou Jin Siddique Mobin M Bay Boon-Huat Zhu Xuguang Privalsky Martin L Cheng Sheue-Yann Stevens Robert D Summers Scott A Newgard Christopher B Lazar Mitchell A Yen Paul M | 2012 | EN2012，，7： | 2 |
| 14 | Inhibition of intestinal and renal Na + -glucose cotransporter by naringenin显示文摘 | Jian Mei Li Chun Tao Che Clara B.S. Lau Po Sing Leung Christopher H.K. Cheng | 2005 | International Journal of Biochemistry and Cell Biology2005，，5： | 2 |
| 15 | Bufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation显示文摘 | Chuan-Ming Xie Wood Yee Chan Sidney Yu Jun Zhao Christopher H.K. Cheng | 2011 | Free Radical Biology and Medicine2011，，7： | 2 |
| 16 | ECG-gated reconstructed multi-detector row CT coronary angiography:effect of varying trigger delay on image quality显示文摘 | Cheng H Christoph R Becker AH | 2001 | Radiology2001，220，： | 1 |
| 17 | Effects of high-fructose corn syrup and sucrose on the pharmacokinetics of fructose and acute metabolic and hemodynamic responses in healthy subjects显示文摘 | MyPhuong T. Le Reginald F. Frye Christopher J. Rivard Jing Cheng Kim K. McFann Mark S. Segal Richard J. Johnson Julie A. Johnson | 2012 | Metabolism2012，，5： | 1 |
| 18 | Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans显示文摘 | Rhee Eugene P Cheng Susan Larson Martin G Walford Geoffrey A Lewis Gregory D McCabe Elizabeth Yang Elaine Farrell Laurie Fox Caroline S O’Donnell Christopher J Carr Steven A Vasan Ramachandran S Florez Jose C Clish Clary B Wang Thomas J Ger | 2011 | Journal of Clinical Investigation2011，，4： | 1 |
| 19 | Shear Behavior of Reinforced Concrete T-beams with Externally Bonded Fiber-Reinforced Polymer Sheets显示文摘 | Deniaud Christophe Cheng J J Roger | 2001 | ACI Structural Journal2001，98，3： | 1 |
| 20 | PCR-cloning and gene expression studies in common carp ( Cyprinus carpio ) insulin-like growth factor-II显示文摘 | Margaret C.L Tse Queenie P Vong Christopher H.K Cheng King Ming Chan | 2002 | BBA - Gene Structure and Expression2002，，1： | 1 |
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