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| 1 | Clinical characteristics and outcome of a cohort of 101 patients with hepatocellular carcinoma显示文摘AIM To conduct a cohort study of 101 patients with hepatocellular carcinoma (HCC) presenting to a tertiary care medical referral center in Germany between 1997 and 1999.METHODS AND RESULTS Data were retrospectively analyzed by chart review. In 95cases (72 males and 23 females) sufficient data were available for analysis. Twenty-five (29%)of 8.5 patients were HBsAg or anti-HBc positive,21/85 (25%) were anti-HCV positive, and 6/85(7%) were positive for both HBV and HCV-markers. Age was significantly lower in HBV-positive patients than in the other two groups.Thirty-one (34%) of 90 patients had histories of alcohol abuse, In 79/ 94 (84%) patients,cirrhosis was diagnosed. Of these cirrhotic patients, 29/79 (37%) belonged to Child-Pugh's group (CHILD) A, 32/79 (40%) to CHILD B, and 18/79 (23%) to CHILD C. AFP was elevated in 61/91 (67%) patients. A single tumor nodule was found in 38/94 (40%), more than one nodule in 31/94 (34%), and 25/94 (26%) had a diffusely infiltrating tumor, i.e. the tumor margins could not be seen on imaging procedures. Portal vein thrombosis was present in 19/ 94 (20%).Imaging data consistent with lymph node metastases were found in 10/92 (11%), while distant metastases were found in 8/93 (9%).According to Okuda 28/94 (30%) were grouped to stage Ⅰ, 53/94 (56%) were grouped to stage Ⅱ, and 13/94 (14%) were grouped to stage Ⅲ.Survival data were available for 83 patients. The Kaplan-Meier estimate for median survival was 8.4 months. Factors influencing survival were the Okuda score, the presence of portal vein thrombosis, and the presence of ascites. The presence of non-complicated liver cirrhosis by itself, distant metastases, or infection with hepatitis viruses did not influence survival. AFP positivity by itself did not influence survival,though patients with an AFP value greater than 100μg/L did experience shortened survival.Treatment besides tamoxifen or supportive care was associated with prolonged survival. The influence of therapy on survival was most pronounced in Okuda stage Ⅱ patients. There was longer survival in those Okuda stage Ⅱpatients who were treated with percutaneous ethanol injection.CONCLUSION Even in a Iow incidence area such as Germany, the majority of HCC is caused by viral hepatitis and therefore potentially preventable. Reflecting the high proportion of advanced stage tumors in our patients, the median survival was poor. Patients who received active therapy had a longer survival. | Christian Rabe Tillmann Pilz Christoph Klostermann Marc Berna Hans H.Schild Tilman Sauerbruch Wolfgang H.Caselmann | 2001 | World Journal of Gastroenterology2001，7，2： | 60 |
| 2 | Antimicrobial activity of green tea extract against isolates of methicillin-resistant Staphylococcus aureus and multi-drug resistant Pseudomonas aeruginosa显示文摘Objective:To evaluate antibacterial activity of the Indonesian water soluble green tea extract,Camellia sinensis,against clinical isolates of methicillin-resistantStaphylococcus aureus (S.aureus)(MRSA)and multi-drug resistant Pseudomonas aeruginosa(MDR-P.aeruginosa).Methods:Antimicrobial activity of green tea extract was determined by the disc diffusion method and the minimum inhibitory concentration(MIC)was determined by the twofold serial broth dilutions method.The tested bacteria using in this study were the standard strains and multi-drug resistant clinical isolates of S.aureus and P.aeruginosa,obtained from Laboratory of Clinical Microbiology,Faculty of Medicine,University of Indonesia.Results:The results showed that the inhibition zone diameter of green tea extracts forS.aureus ATCC 25923 and MRSA were(18.970依0.287)mm,and(19.130依0.250)mm respectively.While the inhibition zone diameter forP.aeruginosa ATCC 27853 and MDR-P.aeruginosawere(17.550依0.393)mm and(17.670依0.398)mm respectively.The MIC of green tea extracts againstS.aureus ATCC 25923 and MRSA were 400μg/mL and 400μg/mL,respectively,whereas the MIC for P.aeruginosa ATCC 27853 and MDR-P.aeruginosawere 800μg/mL,and 800μg/mL,respectively.Conclusions:Camellia sinensisleaves extract could be useful in combating emerging drug-resistance caused by MRSA andP.aeruginosa. | Maksum Radji Rafael Adi Agustama Berna Elya Conny Riana Tjampakasari | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，8： | 8 |
| 3 | L-carnitine alleviates sciatic nerve crush injury in rats:functional and electron microscopy assessments显示文摘Several studies have demonstrated that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats with diabetes mellitus.It is hypothesized that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats.Rat sciatic nerve was crush injured by a forceps and exhibited degenerative changes.After intragastric administration of 50 and 100 mg/kg L-carnitine for 30 days,axon area,myelin sheath area,axon diameter,myelin sheath diameter,and numerical density of the myelinated axons of injured sciatic nerve were similar to normal,and the function of injured sciatic nerve also improved significantly.These findings suggest that L-carnitine exhibits neuroprotective effects on sciatic nerve crush injury in rats. | ümmü Zeynep Avsar Umit Avsar Ali Aydin Muhammed Yayla Berna Ozturkkaragoz Harun Un Murat Saritemur Tolga Mercantepe | 2014 | Neural Regeneration Research2014，9，10： | 3 |
| 4 | Framework for Measuring the Resilience of Utility Poles of an Electric Power Distribution Network显示文摘The utility poles of an electric power distribution system are frequently damaged by wind-related disasters.This study notes that the wooden poles are particularly vulnerable to such disasters and the failures of the poles can cause a network-level failure leading to short-or longterm power outages. To mitigate the problem, this study proposes a framework for measuring the resilience of the wooden utility poles based on the angular deflection of a pole due to the wind force. Given the existing inclination angle of a pole, the angular deflection is measured by finite element analysis using ANSYS~? Workbench^1 to determine the resilience area under various wind speeds. For this, the conditions of load and support for a pole, which are called boundary conditions in ANSYS~?, are generated. The proposed framework also includes an approach to cost–benefit analysis that compares different strategies for corrective action. The results of the case study in which the framework was applied show that the proposed framework can be effectively utilized by electric power distribution companies to increase the resilience of their systems. | MdMorshedul Alam Berna Eren Tokgoz Seokyon Hwang | 2019 | International Journal of Disaster Risk Science2019，10，2： | 3 |
| 5 | A review of enhanced oil recovery(EOR)methods applied in Kazakhstan显示文摘Application of enhanced oil recovery methods in Kazakhstan has been ongoing for decades alongside the continued discovery of new oil and gas fields in the Pre-Caspian Basin.The objective of this review is to provide an overview of the hydrocarbon reserves and production,and the status of the petroleum industry in Kazakhstan,with a focus on the EOR methods and projects being applied to recover those reserves.A summary of the specific EOR methods in use was prepared,and existing enhanced recovery projects in Kazakhstan were reviewed and their successes and challenges were investigated.The performance of these projects in the context of EOR performance indicators such as capillary number and mobility ratio,as well as operational and environmental issues,were examined.Recommendations for current and potential applications of EOR in Kazakhstan were also discussed.The widespread application of thermal EOR methods,in use for decades in Kazakhstan’s older fields,was found to be successful,with very favorable impacts on mobility ratio from the addition of thermal energy to the reservoirs.Miscible EOR methods in Kazakhstan have had more limited success,with some significant challenges due to high concentration of hydrogen sulfide in the injected gas.Polymer injection started in the late 1960s,achieving good results.A recent polymer injection pilot project has shown some promise,with a favorable impact on mobility ratio and oil production,although the project has not yet been expanded beyond two polymer injectors.These results indicate the huge potential of existing and future EOR projects.This review is the first compilation of Kazakhstan’s existing oil and gas reserves,production,and EOR project performance,and should be seen as a guide to the existing applications of EOR methods in Kazakhstan. | Bianca Anne Bealessio Natalia ABlanquez Alonso Nicholas John Mendes Anna Vladimirovna Sande Berna Hascakir | 2021 | Petroleum2021，7，1： | 2 |
| 6 | Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival显示文摘 | Berna C. ?zdemir Tsvetelina Pentcheva-Hoang Julienne L. Carstens Xiaofeng Zheng Chia-Chin Wu Tyler R. Simpson Hanane Laklai Hikaru Sugimoto Christoph Kahlert Sergey V. Novitskiy Ana De Jesus-Acosta Padmanee Sharma Pedram Heidari Umar Mahmood Lynda Chin Ha | 2014 | Cancer Cell2014，，： | 2 |
| 7 | Enteral glutamine pretreatment does not decrease plasma endotoxin level induced by ischemia-reperfusion injury in rats显示文摘AIM:To investigate whether oral glutamine pretreatment prevents impairment of intestinal mucosal integrity during ischemia-reperfusion (I/R) in rats. METHODS: The study was performed as two series with 40 rats in each. Each series of animals was divided into four groups. The first group was used as a control. Animals in the second group were only pretreated with oral glutamine, 1 g/kg for 4 d. The third group received a normal diet, and underwent intestinal I/R, while the fourth group was pretreated with oral glutamine in the same way, and underwent intestinal I/R. Intestinal mucosal permeability to 51Cr-labeled EDTA was measured in urine in the first series of animals. In the second series, histopathological changes in intestinal tissue and plasma endotoxin levels were evaluated. RESULTS: Intestinal I/R produced a significant increase in intestinal permeability, plasma endotoxin level and worsened histopathological alterations. After intestinal I/R, permeability was significantly lower in glutamine- treated rats compared to those which received a normal diet. However, no significant change was observed in plasma endotoxin levels or histopathological findings. CONCLUSION: Although glutamine pretreatment seems to be protective of intestinal integrity, upon I/R injury, such an effect was not observable in the histopathological changes or plasma endotoxin level. | Arda Demirkan Erkin Orazakunov Berna Sava■ M Ayhan Kuzu Mehmet Melli | 2008 | World Journal of Gastroenterology2008，14，3： | 2 |
| 8 | Postharvest quality of integrated and organically produced apple fruit显示文摘 | E. Róth A. Berna K. Beullens S. Yarramraju J. Lammertyn A. Schenk B. Nicola? | 2007 | Postharvest Biology and Technology2007，，1： | 2 |
| 9 | Mechanism of polymer adsorption on shale surfaces: Effect of polymer type and presence of monovalent and divalent salts显示文摘This paper studies the adsorption behavior of representative guar-based polymers onto the surface of source rock outcrop samples to provide a better picture of the interaction(s)of polymers with these rocks.Outcrop samples from the Barnett,Eagle Ford,and Marcellus shales were collected,analyzed for mineralogy and total organic content,and then exposed to different polymer solutions under elevated temperature and moderately elevated pressure.Viscosities of these polymer solutions were measured before and after exposure to the rock samples to establish a correlation between polymer adsorption and rock mineralogy and/or organic content.Results indicate a direct correlation between polymer adsorption and both rock mineralogy.Cationic polymers are shown to be more prone to adsorption onto the surface of the rock than non-ionic polymers.The results from this work establish that fluid-rock interactions are significant and that further research regarding shale polymer interactions and its effects on hydrocarbon production is needed with representative downhole shale samples given the trends now shown with outcrop samples. | Sudiptya Banerjee Zaid R.Abdulsattar Kaylaychi Agim Robert H.Lane Berna Hascakir | 2017 | Petroleum2017，3，3： | 2 |
| 10 | Stem cells and diabetes显示文摘 | Berna G Leon-Quinto T Ensenat-Waser R | 2001 | Biomed Pharmacother2001，55，4： | 1 |
| 11 | 显示文摘 | Sofia B Roche E Berna G | 2000 | Diabetes2000，49，： | 1 |
| 12 | Cellular MRI contrast via eoexpression of transferrin receptor and ferritin 显示文摘 | Deans AE Wadghiri YZ Bernas LM | 2006 | Magn Reson Med2006，56，： | 1 |
| 13 | Localsearch genetic algorithm for optimal design of reliable net2works显示文摘 | Berna Denig Fulya Altiparmak Alice E Smith | 1997 | Transaction on Evolution Computation1997，，9： | 1 |
| 14 | Analysis of interleukin-1alpha ( IL-1alpha ) and interleukin-8 ( IL-8 ) expression and release in in vitro reconstructed human epidermis for the prediction of in vivo skin irritation and/or sensitization 显示文摘 | Coquette A Berna N Vandenbosch A | 2005 | Toxieol in Vitro2005，17，3： | 1 |
| 15 | Postharvest quality of integrated and organically produced apple fruit显示文摘 | Róth E Berna A Beullens K | 2007 | Postharvest Biology and Technology2007，45，1： | 1 |
| 16 | Role of CCK/gastrin receptors in gastrointestinal/metabolic diseases and results of human studies using gastrin/CCK receptor agonists/antagonists in these diseases显示文摘 | Berna MJ Jensen RT | 2007 | Curr Top Med Chem2007，7，12： | 1 |
| 17 | Hypoxia-induced increase in intracellular calcium concentration in endothelial cells:Role of the Na+-glucose cotransporter显示文摘 | Nancy Berna Thierry Arnould Jose Remacle | | 0，，01： | 1 |
| 18 | Intralobar sequestration in adult patients显示文摘 | Berna P Cazes A Bagan P Riquet M | | 0，，： | 1 |
| 19 | Refinement of a rodent model of peripheral lymphedema显示文摘 | Witte MH Bernas M | 1999 | Lymphology1999，32，： | 1 |
| 20 | Insulin - secreting cells derived from embryonic stem ceils normalize glycemia in streptozo- tocin - induced diabetic mice 显示文摘 | Soria B Roche E Berna G | 2000 | Diabetes2000，49，2： | 1 |
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