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| 1 | 表观遗传学如何诠释人肿瘤转移microRNA的新作用显示文摘转移过程的特征是肿瘤细胞可通过血液系统播散到远端组织,然后这些变异的细胞在那里增殖,并形成继发性肿瘤,这也是肿瘤患者死亡最主要的原因。近年来,一系列重要的肿瘤相关基因陆续被报道,如钙粘素、层粘连蛋白、乙酰肝素硫酸盐、蛋白水解酶、血管生成抑制剂等。但是,这些基因在肿瘤转移中发生改变的机制尚不明了,因为尽管它们的表达普遍下调, | Amaia Lujambio Manel Esteller 南娟(翻译) 丁燕(翻译) 孙丹(校对) | 2009 | 中国肺癌杂志2009，12，8： | 11 |
| 2 | Cysteine proteases as therapeutic targets:does selectivity matter? A systematic review of calpain and cathepsin inhibitors显示文摘Cysteine proteases continue to provide validated targets for treatment of human diseases.In neurodegenerative disorders,multiple cysteine proteases provide targets for enzyme inhibitors,notably caspases,calpains,and cathepsins.The reactive,active-site cysteine provides specificity for many inhibitor designs over other families of proteases,such as aspartate and serine;however,a)inhibitor strategies often use covalent enzyme modification,and b)obtaining selectivity within families of cysteine proteases and their isozymes is problematic.This review provides a general update on strategies for cysteine protease inhibitor design and a focus on cathepsin B and calpain 1 as drug targets for neurodegenerative disorders;the latter focus providing an interesting query for the contemporary assumptions that irreversible,covalent protein modification and low selectivity are anathema to therapeutic safety and efficacy. | Marton Siklos Manel Ben Aissa Gregory R.J.Thatcher | 2015 | Acta Pharmaceutica Sinica B2015，5，6： | 11 |
| 3 | 基于数据分解的上海港集装箱吞吐量预测模型显示文摘根据“分而治之”的框架,分别运用经验模式分解(Empirical Mode Decomposition, EMD)算法和季节性自回归积分滑动平均(Seasonal Autoregressive Integrated Moving Average, SARIMA)算法,将月度集装箱吞吐量时间系列数据分解为不同特征的分量,用支持向量回归(Support Vector Regression, SVR)模型分别对各分量进行预测,EMD-SVR模型和SARIMA-SVR模型预测结果的平均绝对百分误差(Mean Absolute Percentage Errors, MAPE)分别为 5.18%和7.26%,与港口实际吞吐量均较为一致,优于SVR模型的8.55%、自回归积分滑动平均(Autoregressive Integrated Moving Average, ARIMA)模型的11.8%和灰色系统(Grey Model, GM(1,1))模型的10.1%,验证数据分解方法在上海港集装箱月度吞吐量预测中的可行性,支持间接性预测模型精度高于直接模型的观点。 | 冯宏祥 GRIFOLL Manel AGUSTI Martinmallofre 郑彭军 | 2019 | 中国航海2019，42，2： | 9 |
| 4 | Transanal endoscopic surgery in rectal cancer显示文摘Total mesorectal excision(TME) is the standard treatment for rectal cancer, but complications are frequent and rates of morbidity, mortality and genitourinary alterations are high. Transanal endoscopic microsurgery(TEM) allows preservation of the anal sphincters and, via its vision system through a rectoscope, allows access to rectal tumors located as far as 20 cm from the anal verge. The capacity of local surgery to cure rectal cancer depends on the risk of lymph node invasion. This means that correct preoperative staging of the rectal tumor is necessary. Currently, local surgery is indicated for rectal adenomas and adenocarcinomas invading the submucosa, but not beyond(T1). Here we describe the standard technique for TEM, the different types of equipment used, and the technical limitations of this approach. TEM to remove rectal adenoma should be performed in the same way as if the lesion were an adenocarcinoma, due to the high percentageof infiltrating adenocarcinomas in these lesions. In spite of the generally good results with T1, some authors have published surprisingly high recurrence rates; this is due to the existence of two types of lesions, tumors with good and poor prognosis, divided according to histological and surgical factors. The standard treatment for rectal adenocarcinoma T2N0M0 is TME without adjuvant therapy. In this type of adenocarcinoma, local surgery obtains the best results when complete pathological response has been achieved with previous chemoradiotherapy. The results with chemoradiotherapy and TEM are encouraging, but the scientific evidence remains limited at present. | Xavier Serra-Aracil Laura Mora-Lopez Manel Alcantara-Moral Aleidis Caro-Tarrago Carlos Javier Gomez-Diaz Salvador Navarro-Soto | 2014 | World Journal of Gastroenterology2014，20，33： | 8 |
| 5 | Does manual thrombus aspiration help optimize stent implantation in ST-segment elevation myocardial infarction?显示文摘AIM: To evaluate the impact of thrombus aspiration(TA) on procedural outcomes in a real-world ST-segment elevation myocardial infarction(STEMI) registry.METHODS: From May 2006 to August 2008, 542 consecutive STEMI patients referred for primary or rescue percutaneous coronary intervention were enrolled and the angiographic results and stent implantation characteristics were compared according to the performance of manual TA.RESULTS: A total of 456 patients were analyzable and categorized in TA group(156 patients; 34.2%) and non-TA(NTA) group(300 patients; 65.8%). Patientstreated with TA had less prevalence of multivessel disease(39.7% vs 54.7%, P = 0.003) and higher prevalence of initial thrombolysis in myocardial infarction flow < 3(P < 0.001) than NTA group. There was a higher rate of direct stenting(58.7% vs 45.5%, P = 0.009), with shorter(24.1 ± 11.8 mm vs 26.9 ± 15.7 mm, P = 0.038) and larger stents(3.17 ± 0.43 mm vs 2.93 ± 0.44 mm, P < 0.001) in the TA group as compared to NTA group. The number of implanted stents(1.3 ± 0.67 vs 1.5 ± 0.84, P = 0.009) was also lower in TA group. CONCLUSION: In an 'all-comers' STEMI population, the use of TA resulted in more efficient procedure leading to the implantation of less number of stents per lesion of shorter lengths and larger sizes. | Diego Fernández-Rodríguez Luis Alvarez-Contreras Victoria Martín-Yuste Salvatore Brugaletta Ignacio Ferreira Marta De Antonio Montserrat Cardona Vicens Martí Juan García-Picart Manel Sabaté | 2014 | World Journal of Cardiology2014，6，9： | 7 |
| 6 | Determination of drug,excipients and coating distribution in pharmaceutical tablets using NIR-CI显示文摘The growing interest of the pharmaceutical industry in Near Infrared-Chemical Imaging (NIR-CI) is a result of its high usefulness for quality control analyses of drugs throughout their production process (particularly of its non-destructive nature and expeditious data acquisition).In this work,the concentration and distribution of the major and minor components of pharmaceutical tablets are determined and the spatial distribution from the internal and external sides has been obtained.In addition,the same NIR-CI allowed the coating thickness and its surface distribution to be quantified.Images were processed to extract the target data and calibration models constructed using the Partial Least Squares (PLS) algorithms.The concentrations of Active Pharmaceutical Ingredient (API) and excipients obtained for uncoated cores were essentially identical to the nominal values of the pharmaceutical formulation.But the predictive ability of the calibration models applied to the coated tablets decreased as the coating thickness increased. | Anna Palou Jordi Cruz Marcelo Blanco Jaume Tomàs Joaquín de los Ríos Manel Alcalà | 2012 | Journal of Pharmaceutical Analysis2012，2，2： | 4 |
| 7 | Hepatic glycogenosis: An underdiagnosed complication of diabetes mellitus?显示文摘Hepatic glycogenosis(HG) is characterized by excessive glycogen accumulation in hepatocytes and represents a hepatic complication of diabetes that particularly occurs in patients with longstanding poorly controlled type 1 diabetes(T1D). HG has been reported to be a very rare disease, although it is believed to be extremely underdiagnosed because it is not possible to distinguish it from non-alcoholic fatty liver disease(NAFLD) unless a liver biopsy is performed. In contrast to HG, NAFLD is characterized by liver fat accumulation and is the more likely diagnosis for patients with type 2 diabetes and metabolic syndrome. The pathogenesis of HG involves the concomitant presence of insulin and excess glucose, which increases glycogen storage in the liver. HG is characterized by a transient elevation in liver transaminases and hepatomegaly. Differentiating between these two conditions is of the utmost importance because HG is a benign disease that is potentially reversible by improving glycemic control, whereas NAFLD can progress to cirrhosis. Therefore, HG should be suspected when liver dysfunction occurs in patients with poorly controlled T1 D. The aim of this article is to review the epidemiology, clinical characteristics, pathogenesis and histology of HG. | María Teresa Julián Núria Alonso Isabel Ojanguren Eduarda Pizarro Enric Ballestar Manel Puig-Domingo | 2015 | World Journal of Diabetes2015，6，2： | 4 |
| 8 | External Bacterial Flora and Antimicrobial Susceptibility Patterns of Staphylococcus spp. and Pseudomonas spp. Isolated from Two Household Cockroaches, Blattella germanica and Blatta orientalis显示文摘研究被执行估计在 Tebessa (东北阿尔及利亚) 从家庭收集的二只国内蟑螂(Blattella germanica 和 Blatta orientalis ) 的外部细菌的植物群的流行。三个主要的细菌的组是有教养的(全部氧气, enterobacteria,和 staphylococci ) 从蟑螂,和抗菌素的 14 个标本,危险性被测试因为葡萄球菌和 Pseudomonas 孤立。Culturing 证明来自不同家庭的蟑螂的全部的细菌的负担是可比较的(P < 0.001 ) 并且 enterobacteria 是昆虫表面的占优势的殖民者,与细菌的负担(2.1 ㄠ′吗?? | MENASRIA Taha TINE Samir MAHCENE Djaouida BENAMMAR Leyla MEGRI Rochdi BOUKOUCHA Mourad DEBABZA Manel | 2015 | Biomedical and Environmental Sciences2015，28，4： | 4 |
| 9 | 快速报告标准之二:严重性及因果关系评价显示文摘1引言按照明确的、国际公认的管理规定,制药公司必须收集药品安全性信息以便进行安全性评估并向上级主管部门报告。虽然不同国家的管理部门有不同的报告标准及时限要求,但共同要求严重的及存在因果关系的不良事件报告应通过速报形式提交行政管理部门。本文的目的是提供如何在个案病例回顾中进行严重性及因果关系评价的实用性指导。 | Manel De Silva Wijayasinghe Inna Pendrak Nicholas Rees 西安杨森药品安全部(译) | 2009 | 中国药物警戒2009，6，5： | 3 |
| 10 | The activatory long non-coding RNA DBE-T reveals the epigenetic etiology of facioscapulohumeral muscular dystrophy显示文摘 | Miguel Vizoso Manel Esteller | 2012 | Cell Research2012，22，10： | 3 |
| 11 | Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria显示文摘 | Ivaylo I. Ivanov Koji Atarashi Nicolas Manel Eoin L. Brodie Tatsuichiro Shima Ulas Karaoz Dongguang Wei Katherine C. Goldfarb Clark A. Santee Susan V. Lynch Takeshi Tanoue Akemi Imaoka Kikuji Itoh Kiyoshi Takeda Yoshinori Umesaki Kenya Honda Dan R. Littma | 2009 | Cell2009，，3： | 3 |
| 12 | Heuristics of node selection criteria to assess robustness of world airport network显示文摘The world airport network(WAN) is one of the networked infrastructures that shape today's economic and social activity, so its resilience against incidents affecting the WAN is an important problem. In this paper, the robustness of air route networks is extended by defining and testing several heuristics to define selection criteria to detect the critical nodes of the WAN.In addition to heuristics based on genetic algorithms and simulated annealing, custom heuristics based on node damage and node betweenness are defined. The most effective heuristic is a multiattack heuristic combining both custom heuristics. Results obtained are of importance not only for advance in the understanding of the structure of complex networks, but also for critical node detection. | Manel SORIA Oriol LORDAN JosMaría SALLAN | 2017 | Chinese Journal of Aeronautics2017，30，4： | 3 |
| 13 | Evaluation of hepatocellular carcinoma using SonoVue, a second generation ultrasound contrast agent: correlation with cellular differentiation显示文摘 | Carlos Nicolau Violeta Catalá Ramón Vilana Rosa Gilabert Luis Bianchi Manel Solé Mario Pagés Concepció Brú | 2004 | European Radiology2004，，6： | 2 |
| 14 | Transanal endoscopic microsurgery with 3-D (TEM) or high-definition 2-D transanal endoscopic operation (TEO) for rectal tumors. A prospective, randomized clinical trial显示文摘 | Xavier Serra-Aracil Laura Mora-Lopez Manel Alcantara-Moral Aleidis Caro-Tarrago Salvador Navarro-Soto | 2014 | International Journal of Colorectal Disease2014，，5： | 2 |
| 15 | A Challenging Approach to Improve the Low Affinity of Acrylic Fibres to Be Successfully Dyed with a Bio-Colorant Extracted from Grape Marc显示文摘Acrylic fibres are highly crystalline and non-polar polymers,which makes their dyeing a very difficult step that poses real technical challenges.In order to overcome this concern,it is intended in this paper to modify acrylic fibers by different methods namely cationisation using the Crosscolor DRT then amidoximation using hydroxylamine hydrochloride and ammonium acetate.The resulted samples were dyed then with the bio-colorant extracted from grape marc.The effect of the pretreatment on fibers fine structure using X-ray diffraction and the scanning electron microscope(SEM)images and its correlation with the colour strength of the dyed fabrics was investigated.The dyeing parameters,such as dye bath pH and temperature on the performances of this dyeing process were studied.Good dyeing qualities and new shades varying from brown to grey and dark green have been obtained following process optimization,mordanting and modification of acrylic fibers by the technique of cationisation. | Noureddine Baaka Manel Ben Ticha Wafa Haddar Mohamed Farouk Mhenni | 2019 | Journal of Renewable Materials2019，7，3： | 2 |
| 16 | Dynamic connectedness between stock markets in the presence of the COVID‑19 pandemic:does economic policy uncertainty matter?显示文摘This study investigates the dynamic connectedness between stock indices and the effect of economic policy uncertainty(EPU)in eight countries where COVID-19 was most widespread(China,Italy,France,Germany,Spain,Russia,the US,and the UK)by implementing the time-varying VAR(TVP-VAR)model for daily data over the period spanning from 01/01/2015 to 05/18/2020.Results showed that stock markets were highly connected during the entire period,but the dynamic spillovers reached unprecedented heights during the COVID-19 pandemic in the first quarter of 2020.Moreover,we found that the European stock markets(except Italy)transmitted more spillovers to all other stock markets than they received,primarily during the COVID-19 outbreak.Further analysis using a nonlinear framework showed that the dynamic connectedness was more pronounced for negative than for positive returns.Also,findings showed that the direction of the EPU effect on net connectedness changed during the pandemic onset,indicating that information spillovers from a given market may signal either good or bad news for other markets,depending on the prevailing economic situation.These results have important implications for individual investors,portfolio managers,policymakers,investment banks,and central banks. | Manel Youssef Khaled Mokni Ahdi Noomen Ajmi | 2021 | Financial Innovation2021，7，1： | 2 |
| 17 | Lemon juice clarification using fungal pectinolytic enzymes coupled to membrane ultrafiltration显示文摘 | Sameh Maktouf Mohamed Naifar Salma Jallouli Drira Semia Baklouti Manel Fendri Semia Ellouz Chaabouni | 2013 | Food and Bioproducts Processing2013，，： | 2 |
| 18 | Landscape genetics:combining landscape ecology and population genetics显示文摘 | Manel S | 2003 | Trends in Ecology and Evolution2003，18，18： | 1 |
| 19 | Detection of c-erbB-2/neu and fibroblast growth factor-3/INT-2 but not epidermal growth factor receptor gene amplification in endometrial cancer by differential polymerase chain reaction显示文摘 | Manel Esteller Angel Garcia Josep Maria M | 1995 | Cancer1995，75，8： | 1 |
| 20 | Pivotal Role of mTOR Signaling in Hepatocellular Carcinoma显示文摘 | Augusto Villanueva Derek Y. Chiang Pippa Newell Judit Peix Swan Thung Clara Alsinet Victoria Tovar Sasan Roayaie Beatriz Minguez Manel Sole Carlo Battiston Stijn van Laarhoven Maria I. Fiel Analisa Di Feo Yujin Hoshida Steven Yea Sara Toffanin Alex Ramos | 2008 | Gastroenterology2008，，6： | 1 |
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