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| 1 | Locally advanced nasopharyngeal carcinoma:Current and emerging treatment strategies显示文摘Although nasopharyngeal carcinoma(NPC)is a widespread malignant tumor,it is particularly frequent in Southeast Asia.Although T1 tumors can be effectively controlled with exclusive radiotherapy,this treatment modality is insufficient for most NPC patients,who present with locally advanced disease at diagnosis.In fact,for stages ranging from T2b N0 to T4 N3,definitive scientific evidence supports the use of concurrent platinum-based chemotherapy with standard external beam radiotherapy.This treatment approach has shown a statistically significant advantage in terms of overall survival,with respect to radiotherapy alone.Several trials have also investigated the use of neoadjuvant and adjuvant chemotherapy in combination with radiotherapy or chemo-radiotherapy.Platinum compounds,anthracyclines and taxanes are among the chemotherapy agents employed.This review focuses on the clinical results obtained in the field of adjuvant/concurrent/neoadjuvant chemotherapy for locally advanced NPC,for which exclusive concurrent chemo-radiotherapy currently represents the standard treatment approach. | Francesco Perri Davide Bosso Carlo Buonerba Giuseppe Di Lorenzo Giuseppina Della Vittoria Scarpati | 2011 | World Journal of Clinical Oncology2011，2，12： | 24 |
| 2 | Cabazitaxel in castration resistant prostate cancer with brain metastases: 3 case reports显示文摘Prostate cancer is the most common non-cutaneous malignancy for men. The skeleton is the most common metastatic site but, following an improvement in survival, metastases in uncommon sites are being found more frequently in clinical practice, especially brain metastases. Despite the new drugs now available for metastatic castration resistant prostate cancer, no clinical evidence exists about their effectiveness on brain metastases. We describe the clinical history of 3 patients treated with cabazitaxel plus whole brain radiotherapy. These case reports demonstrate that cabazitaxel is highly active and well tolerated in brain metastases. | Sabino De Placido Pasquale Rescigno Piera Federico Carlo Buonerba Davide Bosso Livio Puglia Michela Izzo Tania Policastro Giuseppe Di Lorenzo | 2014 | World Journal of Clinical Cases2014，2，6： | 2 |
| 3 | Effect of erythromycin on gallbladder emptying in diabetic patients with and without autonomic neuropathy and high levels of motilin显示文摘 | Stefano Fiorucci MD Luciano Scionti MD Rachele Bosso MD Antonio Desando MD Paolo Bottini MD Cecilia Marino MD Prof. Antonio Morelli MD | 1992 | Digestive Diseases and Sciences1992，，11： | 2 |
| 4 | Erythromycin stimulates gallbladder emptying and motilin release by atropine-sensitive pathways显示文摘 | Dr. Stefano Fiorucci MD Rachele Bosso MD Antonio Morelli MD | 1992 | Digestive Diseases and Sciences1992，，11： | 2 |
| 5 | Proteomic knowledge of human aquaporins显示文摘 | FulvioMagni CeciliaSarto DavideTicozzi MonicaSoldi NiccolòBosso PaoloMocarelli Marzia GalliKienle | 2006 | Proteomics2006，，20： | 2 |
| 6 | Effects of genetic polymorphisms CYP1A1,GSTM1,GSTT1 and GSTP1 on urinary 1-hydroxypyrene levels in sugarcane workers 显示文摘 | Do Vale Bosso RM Amorim LMF Andrade SJ | 2006 | Sci Total Environ2006，370，： | 1 |
| 7 | Effect of erythromycin on ga llbladderemptying in diabetic patients with and without autonomic neuropathy an d high levels ofmotilin显示文摘 | Fiorucci S Bosso R Desando A | 1992 | Dig Dis Sci1992，37，11： | 1 |
| 8 | Lead Bioaccessibility in Soil and Mine Wastes After Immobilization with Phosphate显示文摘 | Sérgio T. Bosso Jacinta Enzweiler R?mulo S. Angélica | 2008 | Water, Air, and Soil Pollution . 2008 (1-4)2008，，： | 1 |
| 9 | Management of chronic heart failure:Role of home echocardiography in monitoring care programs显示文摘AIM:To identify a possible role of home echocardiography for monitoring chronic heart failure(CHF)patients.METHODS:We prospectively investigated 118 patients hospitalized during the last year for CHF who could not easily reach the pertaining District Healthcare Center.The patients were followed up with 2 home management programs:one including clinical and electrocardiographic evaluations and also periodic home echocardiographic examinations(group A),the other including clinical and electrocardiographic evaluations only(group B).RESULTS:At the end of the 18-mo follow-up no significant differences were observed between the 2 groups as regards the primary endpoint:rehospitalization occurred in 4 patients of the group A and in 6 patients of the group B;major cardiovascular events occurred in 2 and in 3 patients,respectively.No significant differences were observed with respect to the secondary endpoints:one vascular event appeared in both the groups,3 cardiovascular deaths occurred in group A and 2 in group B.No significant differences were observed between the 2 groups as regards the composite endpoint of death plus hospitalization.CONCLUSION:Home echocardiography for monitoring of CHF patients does not improve the cardiovascular endpoints.In our CHF patients,a low incidence of vascular events was observed. | Silvia Soreca Sergio Aprile Andrea Cardone Giovanni Carella Biagio Fimiani Franco Guarnaccia Giosuè Santoro Valentina Apuzzi Giorgio Bosso Antonio Valvano Giovanni Zito Ugo Oliviero | 2012 | World Journal of Cardiology2012，4，3： | 1 |
| 10 | The antimicrobial armamentarium:evaluating current and future treatment options显示文摘 | Bosso JA | 2005 | Pharmacotherapy2005，25，102： | 1 |
| 11 | Role of angiotensin Ⅱ in sympathetic nervous system induced left ventriculat dysfunction 显示文摘 | Bosso FJ Jarjoura DG Pilati CF | 1999 | Can J Physiol Pharmacol1999，77，10： | 1 |
| 12 | The impact of endoscopic sinus surgery and aspirin desensitization on psychological burden in aspirin-exacerbated respiratory disease显示文摘Background:Aspirin-exacerbated respiratory disease(AERD)is an aggressive inflammatory disorder of the upper and lower respiratory tract.Corticosteroids,leukotriene modifiers,endoscopic sinus surgery(ESS),aspirin(ASA)desensitization,and biological immu-nomodulators are currently used to treat the disorder.Objective:The objective of this study was to determine the psychosocial impact of ESS and ASA desensitization on AERD patients.Methods:All AERD patients who underwent complete ESS were divided into two cohorts based on ASA desensitization status.The psychosocial metrics of the SNOT-22 were collected and analyzed at the following time points:pre-operative,1-month,3-month,6-month,and 12-month after ESS.Results:One hundred and eighty-four AERD patients underwent ESS from November 2009 to November 2018.From this group,130 patients underwent ASA desensitization(AD cohort)and 54 patients remained non-desensitized(ND cohort).AD patients showed a significantly greater reduction in total SNOT-22 scores over the study period compared to ND patients(p=0.0446).Analysis of SNOT-22 psychosocial metrics showed a significantly greater improvement in patient productivity in the AD cohort when compared to the ND cohort(p=0.0214).Further,a sub-group analysis accounting for subject attrition showed a significantly greater improvement in both productivity and concentration in AD patients when compared to the ND cohort(productivity:p=0.0068;concentration:p=0.0428).Conclusions:ESS followed by ASA desensitization decreases the overall psychosocial burden in AERD patients with a significant improvement in perceived productivity and concentration.This has significant implications given the psychosocial impact of chronic diseases. | Tran Locke Auddie Sweis Theodore Lin Brian Sweis Patrick Gleeson Michael Kohanski Nithin Adappa James Palmer John Bosso | 2020 | World Journal of Otorhinolaryngology-Head and Neck Surgery2020，6，4： | 1 |
| 13 | A data envelopment analysis approach to measure the mutual fund performance显示文摘 | Bosso A Funari S | | 0，，： | 1 |
| 14 | Clinical pharmacy and pharmaceutical care 显示文摘 | Bosso JA | 2004 | Pharmacotherapy2004，24，： | 1 |
| 15 | Motor evoked potential monitoring improves outcome after surgery for intrameduUary spinal cord tumors: a historical control study显示文摘 | Sala F Palandri G Bosso E | 2006 | Neursurgery2006，58，6： | 1 |
| 16 | Bioaecessible lead in soils, slag, and mine wastes from an abandoned mining district in Brazil 显示文摘 | Bosso S T Enzweiler J | 2008 | Environmental Geochemistry and Health2008，30，： | 1 |
| 17 | Real-time Implementation of aTraction Control Algorithm on a Scaled Roller Rig显示文摘 | Bosso N Zampieri N | 2013 | Vehicle System Dynamics?2013，51，4： | 1 |
| 18 | Endoscopic sinus surgery and aspirin desensitization improve otologic-specific SNOT-22 scores显示文摘Objective:There are few studies evaluating the impact of Aspirin-exacerbated respiratory disease(AERD)treatment on otologic symptoms.The aim of this study is to evaluate the effects of endoscopic sinus surgery(ESS)and aspirin desensitization(AD)on otologic symptoms in subjects with AERD.Methods:Retrospective chart review of adult patients diagnosed with AERD at our tertiary Care Academic Medical Center-Otorhinolaryngology Department.Charts of adult patients diagnosed with AERD who underwent ESS and ASA desensitization at our institution’s AERD Center from 2016 to 2019 were reviewed.Sino-Nasal Outcomes Test 22-item survey(SNOT-22)scores were evaluated for patients at various time points including:pre-surgery,post-surgery/pre-aspirin desensitization,and various times post-desensitization up to>12 months.Within the SNOT-22,otologic-specific subdomain scores were evaluated at similar time points.Patients on immunomodulatory medications other than corticosteroids were excluded from analysis.Results:SNOT-22 scores were analyzed for 121 patients.There was a significant improvement in overall SNOT scores from pre-surgery(44.62)to post surgery/pre-desensitization(23.34)(P<0.0005).Similarly,SNOT-22 otologic-specific scores also improved after surgery prior to desensitization(3.19-2.04)(P=0.005).Following AD,the improvement in the overall SNOT-22 continued to improve for up to 12 months(P<0.005).While the otologic-specific SNOT-22 scores remained stable after surgery and ASA desensitization.Conclusion:ESS and AD reduce otologic-specific SNOT-22 scores and parallel trends in overall SNOT-22 scores.The effect of treatment is durable over the course of 12 months.Future work should aim to correlate otologic SNOT-22 scores with objective otologic data. | James G.Naples Andrew Corr Siddhant Tripathi Morgan Berman Jason A.Brant Michael J.Ruckenstein John Bosso | 2020 | World Journal of Otorhinolaryngology-Head and Neck Surgery2020，6，4： | 1 |
| 19 | Antibiotic discontinuation rates associated with positive respiratory viral panel and low procalcitonin results in proven or suspected respiratory infections显示文摘 | Timbrook T Maxam M Bosso J | 2015 | Infect Dis Ther2015，4，3： | 1 |
| 20 | The antimicrobial armamentarium:evaluating current and future treatment options显示文摘 | BOSSO JA | 2005 | Pharmacotherapy2005，25，102： | 1 |
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