|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Rifaximin ameliorates hepatic encephalopathy and endotoxemia without affecting the gut microbiome diversity显示文摘AIM To determine the efficacy of rifaximin for hepatic encephalopathy(HE) with the linkage of gut microbiome in decompensated cirrhotic patients.METHODS Twenty patients(12 men and 8 women; median age, 66.8 years; range, 46-81 years) with decompensated cirrhosis(Child-pugh score > 7) underwent cognitive neuropsychological testing, endotoxin analysis, and fecal microbiome assessment at baseline and after 4 wk of treatment with rifaximin 400 mg thrice a day. HE was determined by serum ammonia level and number connection test(NCT)-A. Changes in whole blood endotoxin activity(EA) was analyzed by endotoxinactivity assay. Fecal microbiome was assessed by 16 S ribosome RNA(rR NA) gene sequencing.RESULTS Treatment with rifaximin for 4 wk improved hyperammonemia(from 90.6 ± 23.9 μg/d L to 73.1 ± 33.1 μg/dL; P < 0.05) and time required for NCT(from 68.2 ± 17.4 s to 54.9 ± 20.3 s; P < 0.05) in patients who had higher levels at baseline. Endotoxin activity was reduced(from 0.43 ± 0.03 to 0.32 ± 0.09; P < 0.05) in direct correlation with decrease in serum ammonia levels(r = 0.5886, P < 0.05). No statistically significant differences were observed in the diversity estimator(Shannon diversity index) and major components of the gut microbiome between the baseline and after treatment groups(3.948 ± 0.548 at baseline vs 3.980 ± 0.968 after treatment; P = 0.544), but the relative abundances of genus Veillonella and Streptococcus were lowered.CONCLUSION Rifaximin significantly improved cognition and reduced endotoxin activity without significantly affecting the composition of the gut microbiome in patients with decompensated cirrhosis. | Kosuke Kaji Hiroaki Takaya Soichiro Saikawa Masanori Furukawa Shinya Sato Hideto Kawaratani Mitsuteru Kitade Kei Moriya Tadashi Namisaki Takemi Akahane Akira Mitoro Hitoshi Yoshiji | 2017 | World Journal of Gastroenterology2017，23，47： | 14 |
| 2 | Immunological Effects of Silica and Asbestos显示文摘Silicosis patients(SILs) and patients who have been exposed to asbestos develop not only respiratory diseases but also certain immunological disorders. In particular,SIL sometimes complicates autoimmune diseases such as systemic scleroderma,rheumatoid arthritis(known as Caplan syndrome) ,and systemic lupus erythematoses. In addition,malignant complications such as lung cancer and malignant mesothelioma often occurr in patients exposed to asbestos,and may be involved in the reduction of tumor immunity. Although silica-induced disorders of autoimmunity have been explained as adjuvant-type effects of silica,more precise analyses are needed and should reflect the recent progress in immunomolecular findings. A brief summary of our investigations related to the immunological effects of silica/asbestos is presented. Recent advances in immunomolecular studies led to detailed analyses of the immunological effects of asbestos and silica. Both affect immuno-competent cells and these effects may be associated with the pathophysiological development of complications in silicosis and asbestos-exposed patients such as the occurrence of autoimmune disorders and malignant tumors,respectively. In addition,immunological analyses may lead to the development of new clinical tools for the modification of the pathophysiological aspects of diseases such as the regulation of autoimmunity or tumor immunity using cell-mediated therapies,various cytokines,and molecule-targeting therapies. In particular,as the incidence of asbestos-related malignancies is increasing and such malignancies have been a medical and social problem since the summer of 2005 in Japan,efforts should be focused on developing a cure for these diseases to eliminate nationwide anxiety. | Takemi Otsuki Megumi Maeda Shuko Murakami Hiroaki Hayashi Yoshie Miura Masayasu Kusaka Takashi Nakano Kazuya Fukuoka Takumi Kishimoto Fuminori Hyodoh Ayako Ueki Yasumitsu Nishimura | 2007 | Cellular & Molecular Immunology2007，4，4： | 9 |
| 3 | Decrease in Serum Amyloid a Protein Levels Following Three-month Stays in Negatively Charged Particle-dominant Indoor Air Conditions显示文摘Objective The changes in serum adipokines and cytokines related to oxidative stress were examined during 3 months ‘Off to On' and ‘On to Off' periods using negatively charged particle-dominant indoor air conditions(NCPDIAC).Methods Seven volunteers participated in the study,which included ‘OFF to 3 months ON' periods(ON trials) for a total of 16 times,and ‘ON to 3 months OFF'(OFF trials) periods for a total of 13 times.Results With the exception of one case,serum amyloid A(SAA) levels decreased significantly during the ON trials.Conclusion Considering that SAA is an acute phase reactive protein such as C reactive protein(CRP),this observed decrease might indicate the prevention of cardiovascular and atherosclerotic changes,since an increase in high-sensitive CRP is associated with the subsequent detection of these events. | Suni Lee Shoko Yamamoto Yasumitsu Nishimura Hidenori Matsuzaki Kei Yoshitome Tamayo Hatayama Miho Ikeda YU Min Nagisa Sada Naoko Kumagai-Takei Takemi Otsuki | 2018 | Biomedical and Environmental Sciences2018，31，5： | 5 |
| 4 | Dual therapy with zinc acetate and rifaximin prevents from ethanolinduced liver fibrosis by maintaining intestinal barrier integrity显示文摘BACKGROUND Hepatic overload of gut-derived lipopolysaccharide dictates the progression of alcoholic liver disease(ALD)by inducing oxidative stress and activating Kupffer cells and hepatic stellate cells through toll-like receptor 4 signaling.Therefore,targeting the maintenance of intestinal barrier integrity has attracted attention for the treatment of ALD.Zinc acetate and rifaximin,which is a nonabsorbable antibiotic,had been clinically used for patients with cirrhosis,particularly those with hepatic encephalopathy,and had been known to improve intestinal barrier dysfunction.However,only few studies focused on their efficacies in preventing the ALD-related fibrosis development.AIM To investigate the effects of a combined zinc acetate with rifaximin on liver fibrosis in a mouse ALD model.METHODS To induce ALD-related liver fibrosis,female C57BL/6J mice were fed a 2.5%(v/v)ethanol-containing Lieber-DeCarli liquid diet and received intraperitoneal carbon tetrachloride(CCl4)injection twice weekly(1 mL/kg)for 8 wk.Zinc acetate(100 mg/L)and/or rifaximin(100 mg/L)were orally administered during experimental period.Hepatic steatosis,inflammation and fibrosis as well as intestinal barrier function were evaluated by histological and molecular analyses.Moreover,the direct effects of both agents on Caco-2 barrier function were assessed by in vitro assays.RESULTSIn the ethanol plus CCl4-treated mice,combination of zinc acetate and rifaximin attenuated oxidative lipid peroxidation with downregulation of Nox2 and Nox4.This combination significantly inhibited the Kupffer cells expansion and the proinflammatory response with blunted hepatic exposure of lipopolysaccharide and the toll-like receptor 4/nuclear factor kB pathway.Consequently,liver fibrosis and hepatic stellate cells activation were efficiently suppressed with downregulation of Mmp-2,-9,-13,and Timp1.Both agents improved the atrophic changes and permeability in the ileum,with restoration of tight junction proteins(TJPs)by decreasing the expressions of tumor necrosis factorαand myosin light chain kinase.In the in vitro assay,both agents directly reinforced ethanol or lipopolysaccharide-stimulated paracellular permeability and upregulated TJPs in Caco-2 cells.CONCLUSION Dual therapy with zinc acetate and rifaximin may serve as a strategy to prevent ALD-related fibrosis by maintaining intestinal barrier integrity. | Yuki Fujimoto Kosuke Kaji Norihisa Nishimura Masahide Enomoto Koji Murata Soichi Takeda Hiroaki Takaya Hideto Kawaratani Kei Moriya Tadashi Namisaki Takemi Akahane Hitoshi Yoshiji | 2021 | World Journal of Gastroenterology2021，27，48： | 4 |
| 5 | Obstruction of st jude medical valves in the aortic position: histology and immunohistochemistry of pannus显示文摘 | Hideki Teshima Nobuhiko Hayashida Hirohisa Yano Masaru Nishimi Eiki Tayama Shuji Fukunaga Hidetoshi Akashi Takemi Kawara Shigeaki Aoyagi | 2003 | The Journal of Thoracic and Cardiovascular Surgery2003，，2： | 2 |
| 6 | LES Analysis of the Aerodynamic Surface Properties for Turbulent Flows over Building Arrays with Various Geometries显示文摘 | NAKAYAMA H TAKEMI T NAGAI H | | 0，，： | 1 |
| 7 | KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation显示文摘 | Takuya Abe Masamichi Ishiai Yoshifumi Hosono Akari Yoshimura Shusuke Tada Noritaka Adachi Hideki Koyama Minoru Takata Shunichi Takeda Takemi Enomoto Masayuki Seki | 2008 | Cellular Signalling2008，，11： | 1 |
| 8 | A new food guide in Japan: the Japanese food guide Spinning Top 显示文摘 | Yoshiike N Hayashi F Takemi Y | 2007 | Nutr Rev2007，65，4： | 1 |
| 9 | CHRONIC HEPATITIS C: HEPATIC IRON CONTENT DOES NOT CORRELATE WITH RESPONSE TO ANTIVIRAL THERAPY显示文摘 | Pereira Patricia da Silva Fucuta Silva Ivonete Sandra de Souza E Uehara Silvia Naomi de Oliveira Emori Christini Takemi Lanzoni Valéria Pereira Silva Antonio Eduardo Benedito Ferraz Maria Lucia Gomes | 2009 | Revista do Instituto de Medicina Tropical de S茫o Paulo2009，，6： | 1 |
| 10 | 猪隐秘杆菌型出血性坏死性脾炎显示文摘六月龄去势公猪表现昏睡、食欲不振、站立困难。尸检发现脾脏边缘呈多重出血灶。从脾脏、肾脏、肌肉和肝脏中分离出革兰氏阳性杆菌,对分离株(TO16177)的16S rDNA基因序列比较分析发现,其可能与未发表过的隐秘杆菌属HJ57-14E菌株(登记号:gi18873551)(比较675bp个碱基,相似性达99.7%)为同一个属。脾脏组织切片的组织学检查发现呈广泛性坏死和炎症,其中革兰氏阳性杆菌显而易见。肝脏中可见多病灶的坏死斑。免疫组织化学检测发现,分离株与抗化脓性隐秘杆菌属(Arcanobacterium pyogenes)和内氏放线菌(Actinomyces naeslundii)的多克隆抗体具有交叉反应,且与后者的交叉反应更强烈。相似的反应也见于扁桃体的化脓灶中分离株,偶尔也见于脾脏和淋巴结中的分离株。本研究结果表明,这种未公开发布的隐秘杆菌属的细菌会引起生长肥育猪多器官功能衰竭,而后继发急性出血性坏死性脾炎。 | 任彬(译) 常飞(校) Takemi OHBA Tomoyuki Shibahara Hideki Kobayashi Masanori Kubo Ariko Takaahima ShigenoriImai Satoshi Murakami Koichi Kadota | 2007 | 国外畜牧学(猪与禽)2007，，4： | 1 |
| 11 | Hypercalcemic complication in patients with oral squamous cell carcinoma 显示文摘 | Iwase M Takemi T Manabe M | 2003 | Int J Oral Maxillofac Surg2003，32，2： | 1 |
| 12 | Downregulation of microRNA-34 induces cell proliferation and invasionof human mesothelial cells显示文摘 | Norimitsu Tanaka Shinichi Toyooka Junichi Soh Kazunori Tsukuda Kazuhiko Shien Masashi Furukawa Takayuki Muraoka Yuho Maki Tsuyoshi Ueno Hiromasa Yamamoto Hiroaki Asano Takemi Otsuki Shinichiro Miyoshi | 2013 | Oncology Reports2013，，6： | 1 |
| 13 | Ex- pression levels of estrogen receptor - a, estrogen receptor - b, co- activators,and corepressors in breast cancer 显示文摘 | Junichi Kurebayashi Takemi Otsuki Hironori Kunisue | 2000 | Clin Cancer Res2000，6，： | 1 |
| 14 | Calcining conditions for YBa2Cu3O7 films by metalorganic deposition using trifluoroacetates 显示文摘 | Toshiharu Niwa Takeshi Araki Takemi Muroga | 2003 | IEEE Transactions on Applied Superconductivity2003，13，2： | 1 |
| 15 | Effectiveness and safety of banabamin tablet containing extract from banaba in patients with mild type 2 diabetes显示文摘 | Yoshio Ikeda Jui-Tung Chen Takemi Mtsuda | 1999 | Japan Pharmacology & Therapeutics1999，27，： | 1 |
| 16 | Histological evolution of hepatitis C virus infection after renal transplantation显示文摘 | Silvia Naomi Oliveira Uehara Christini Takemi Emori Patrícia da Silva Fucuta Pereira Renata M. Perez José Osmar Medina Pestana Valéria Pereira Lanzoni Ivonete Sandra Souza e Silva Antonio Eduardo Benedito Silva Maria Lucia Cardoso Gomes Ferraz | 2012 | Clin Transplant2012，，6： | 1 |
| 17 | EDM of micro-rods by self-drilled holes显示文摘 | Minoru Yamazaki Takemi Suzuki Noritoshi Mori Masanori Kunieda | 2004 | Journal of Materials Processing Technology2004，149，13： | 1 |
| 18 | Modeling technological learning and its application for clean coal technologies in Japan显示文摘 | Toshihiko Nakata Takemi Sato Hao Wang Tomoya Kusunoki Takaaki Furubayashi | | 0，，88： | 1 |
| 19 | A non-contact vital sign monitoring system for ambulances using dual-frequency microwave radars显示文摘 | Satoshi Suzuki Takemi Matsui Hiroshi Kawahara | 2009 | Medical and Biological Engineering and Computing2009，47，1： | 1 |
| 20 | EDM of micro-rods by self-dillled holes显示文摘 | Minoru Yamazaki Takemi Syzuki Noritoshi Moil | 2004 | Journal of Materials Proceding Technology2004，149，13： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员