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| 1 | Genome-wide association studies of lactation yields of milk, fat, protein and somatic cell score in New Zealand dairy goats显示文摘Background: Identifying associations between genetic markers and traits of economic importance will provide practical benefits for the dairy goat industry, enabling genomic prediction of the breeding value of individuals, and facilitating discovery of the underlying genes and mutations. Genome-wide association studies were implemented to detect genetic regions that are significantly associated with effects on lactation yields of milk(MY), fat(FY),protein(PY) and somatic cell score(SCS) in New Zealand dairy goats.Methods: A total of 4,840 goats were genotyped with the Caprine 50 K SNP chip(Illumina Inc., San Diego, CA).After quality filtering, 3,732 animals and 41,989 SNPs were analysed assuming an additive linear model. Four GWAS models were performed, a single-SNP additive linear model and three multi-SNP Bayes C models. For the single-SNP GWAS, SNPs were fitted individually as fixed covariates, while the Bayes C models fit all SNPs simultaneously as random effects. A cluster of significant SNPs were used to define a haplotype block whose alleles were fitted as covariates in a Bayesian model. The corresponding diplotypes of the haplotype block were then fit as class variables in another Bayesian model.Results: Across all four traits, a total of 43 genome-wide significant SNPs were detected from the SNP GWAS. At a genome-wide significance level, the single-SNP analysis identified a cluster of variants on chromosome 19 associated with MY, FY, PY, and another cluster on chromosome 29 associated with SCS. Significant SNPs mapped in introns of candidate genes(45%), in intergenic regions(36%), were 0–5 kb upstream or downstream of the closest gene(14%) or were synonymous substitutions(5%). The most significant genomic window was located on chromosome 19 explaining up to 9.6% of the phenotypic variation for MY, 8.1% for FY, 9.1% for PY and 1% for SCS.Conclusions: The quantitative trait loci for yield traits on chromosome 19 confirms reported findings in other dairy goat populations. There is benefit to be gained from using these results for genomic selection to improve milk production in New Zealand dairy goats. | Megan Scholtens Andrew Jiang Ashley Smith Mathew Littlejohn Klaus Lehnert Russell Snell Nicolas Lopez-Villalobos Dorian Garrick Hugh Blair | 2020 | Journal of Animal Science and Biotechnology2020，11，4： | 2 |
| 2 | Hepatitis C Virus Infects the Endothelial Cells of the Blood-Brain Barrier显示文摘 | Nicola F. Fletcher Garrick K. Wilson Jacinta Murray Ke Hu Andrew Lewis Gary M. Reynolds Zania Stamataki Luke W. Meredith Ian A. Rowe Guangxiang Luo Miguel A. Lopez–Ramirez Thomas F. Baumert Babette Weksler Pierre–Olivier Couraud Kwang Sik Kim Ignacio A. R | 2012 | Gastroenterology2012，，3： | 2 |
| 3 | Ovar-Mhc-ovine major histocompatibility complex: role in genetic resistance to diseases 显示文摘 | Dukkipati V S Blair H T Garrick D J | 2006 | N Z Vet J2006，54，4： | 1 |
| 4 | ' Ovar-Mhc'- ovine major histocompatibility complex: Structure and gene polymorphisms显示文摘 | Dukkipati V S Blair H T Garrick D J | 2006 | Genet Mol Res2006，5，4： | 1 |
| 5 | An expression system for a transporter of iron and other metals显示文摘 | GARRICK M D DOLAN K G | 2002 | Methods in Molecular Biology2002，196，： | 1 |
| 6 | Holmium Laser Enucleation of Prostate (HoLEP): The Methodist Hospital Experience With Greater Than 75 Gram Enucleations显示文摘 | RAMSAY L. KUO SAMUEL C. KIM JAMES E. LINGEMAN RYAN F. PATERSON STEPHANIE L. WATKINS GARRICK R. SIMMONS RONALD E. STEELE | 2003 | The Journal of Urology2003，，1： | 1 |
| 7 | Pallidal stimulation reduces treatment-induced dyskinesias in 'minimal-change' multiple system atrophy 显示文摘 | Huang Y Garrick R Cook R | 2005 | Mov Disord2005，20，8： | 1 |
| 8 | Waste tire fiber modified concrete显示文摘 | Li G Q Garrick G Eggers J | 2004 | Composites Part B2004，35，： | 1 |
| 9 | Nano-to-Millimeter Scale Integrated Systems显示文摘 | H Last M Deeds D Garrick R Kavetsky | 1999 | IEEE/ Tansaetions on Components and Packaging TeChnologies1999，，22： | 1 |
| 10 | Fitting Hierarchical Holographic Modeling Into the Theory of Scenario Structuring and a Resulting Refinement to the Quantitative Definition of Risk 显示文摘 | KAPLAN K HAIMES Y Y GARRICK B J | 2001 | Risk Analysis2001，21，5： | 1 |
| 11 | Lateral ankle instability 显示文摘 | Bouche R Richie D Garrick JG | 2013 | Foot Ankle Spec2013，6，3： | 1 |
| 12 | Development of wa- ste tire modified concrete显示文摘 | LI G STUBBLEFIELD M A GARRICK G | 2004 | Cement and Concrete Research2004，34，12： | 1 |
| 13 | The epidemiology of foot and an-kle injuries in sports显示文摘 | Garrick J G Requa R K | 1988 | Clin Sports Med1988，7，1： | 1 |
| 14 | Diabetes and mortality follow- ing acute coronary syndromes 显示文摘 | Sean M Garrick C Carolyn H | 2007 | JAMA2007，298，7： | 1 |
| 15 | Estimates of genomic inbreeding and identification of candidate regions that differ between Chinese indigenous sheep breeds显示文摘Background:A run of homozygosity(ROH)is a consecutive tract of homozygous genotypes in an individual that indicates it has inherited the same ancestral haplotype from both parents.Genomic inbreeding can be quantified based on ROH.Genomic regions enriched with ROH may be indicative of selection sweeps and are known as ROH islands.We carried out ROH analyses in five Chinese indigenous sheep breeds;Altay sheep(n=50 individuals),Large-tailed Han sheep(n=50),Hulun Buir sheep(n=150),Short-tailed grassland sheep(n=150),and Tibetan sheep(n=50),using genotypes from an Ovine Infinium HD SNP BeadChip.Results:A total of 18,288 ROH were identified.The average number of ROH per individual across the five sheep breeds ranged from 39(Hulun Buir sheep)to 78(Large-tailed Han sheep)and the average length of ROH ranged from 0.929 Mb(Hulun Buir sheep)to 2.544 Mb(Large-tailed Han sheep).The effective population size(Ne)of Altay sheep,Large-tailed Han sheep,Hulun Buir sheep,Short-tailed grassland sheep and Tibetan sheep were estimated to be 81,78,253,238 and 70 five generations ago.The highest ROH-based inbreeding estimate(FROH)was 0.0808 in Large-tailed Han sheep,whereas the lowest F_(ROH)was 0.0148 in Hulun Buir sheep.Furthermore,the highest proportion of long ROH fragments(>5 Mb)was observed in the Large-tailed Han sheep breed which indicated recent inbreeding.In total,49 ROH islands(the top 0.1% of the SNPs most commonly observed in ROH)were identified in the five sheep breeds.Three ROH islands were common to all the five sheep breeds,and were located on OAR2:12.2-12.3 Mb,OAR12:78.4-79.1 Mb and OAR13:53.0-53.6 Mb.Three breed-specific ROH islands were observed in Altay sheep(OAR15:3.4-3.8 Mb),Large-tailed Han sheep(ORA17:53.5-53.8 Mb)and Tibetan sheep(ORA5:19.8-20.2 Mb).Collectively,the ROH islands harbored 78 unique genes,including 19 genes that have been documented as having associations with tail types,adaptation,growth,body size,reproduction or immune response.Conclusion:Different ROH patterns were observed in five Chinese indigenous sheep breeds,which reflected their different population histories.Large-tailed Han sheep had the highest genomic inbreeding coefficients and the highest proportion of long ROH fragments indicating recent inbreeding.Candidate genes in ROH islands could be used to illustrate the genetic characteristics of these five sheep breeds.Our findings contribute to the understanding of genetic diversity and population demography,and help design and implement breeding and conservation strategies for Chinese sheep. | Jiaxin Liu Liangyu Shi Yang Li Liang Chen Dorian Garrick Lixian Wang Fuping Zhao | 2022 | Journal of Animal Science and Biotechnology2022，13，1： | 1 |
| 16 | Utilisation of genetic variation by marker assisted selection in commercial dairy cattle populations显示文摘 | Spelman R Garrick D J van Arendonk | 1999 | Livestock Production Science1999，59，： | 1 |
| 17 | Soluble nickel interferes with cellular iron homeostasis显示文摘 | Davidson T Chen H Garrick MD | 2005 | Mol Cell Biochem2005，279，12： | 1 |
| 18 | Gastric motility is a major factor in cold restraint-induced lesion formation in rats显示文摘 | Garrick T Buack S Bass P | 1986 | Am J Physiol Gastrointest Liver Physiol1986，250，2： | 1 |
| 19 | Ge- nome-wide association study identifies loci for bodycomposition and structural soundness traits in pigs 显示文摘 | FAN B ONTERU S K GARRICK D J | 2011 | PLoSOne2011，6，14： | 1 |
| 20 | DMT1 : a mammalian transporter for multiple metals显示文摘 | Garrick MD Dolan KG Horbinski C | 2003 | Biometals2003，16，1： | 1 |
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