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| 1 | 益气活血补肾法对腰椎间盘突出症术后恢复的影响显示文摘目的探讨益气活血补肾法对腰椎间盘突出症术后患者功能活动及生活质量的临床疗效。方法选择2010年1月~2012年5月在广州南方医科大学附属南方医院脊柱骨科住院行手术治疗,术前中医辨证为肝肾亏虚的腰椎间盘突出症患者120例,经患者同意参加试验。采用随机数字表法随机分为观察组60例,对照组60例。对照组术后给予单纯西医常规对症治疗,观察组在西医常规对症治疗基础上给予益气活血补肾方。分别在各个观察时点对疼痛的视觉模拟评分(VAS系统)、JOA下腰痛评分、WHOQOL-BREF评分、住院天数、不良事件进行观察。结果 120例腰椎间盘突出症患者全部得到随访,进入结果分析,没有脱失。术后2、4、8周观察组在VAS、JOA、WHOQOL-BREF评分要优于对照组,有统计学差异(P〈0.01)。术后半年及1年后随访,观察组和对照组在VAS、WHOQOL-BREF评分之间无统计学意义(P〉0.01)。但在JOA评分方面,观察组要优于对照组,差异有统计学意义(P〈0.01)。结论益气活血补肾法对腰椎间盘突出症患者术后恢复,改善术后主要症状体征及减少不良事件方面存在优势。 | 郑少伟 Shaikh Atik Badshah 王健 蒋晖 李敏 陈国奋 | 2015 | 南方医科大学学报2015，35，1： | 27 |
| 2 | Association of CagA and VacA presence with ulcer and non-ulcer dyspepsia in a Turkish population显示文摘AIM: The mostly known genotypic virulence features, of H. pyloriare cytotoxin associated gene A (ragA) and Vacuolating cytotoxin gene A (VacA). We investigated the association of these major virulence factors with ulcer and non-ulcer dyspepsia in our region.METHODS: One hundred and forty two dyspeptic patients were studied (average age 44.8±15.9 years, range 15-87years, 64 males and 78 females). Antral and corpus biopsies were taken for detecting and genotyping of H. pylori. 107patients who were H. pylori positive by histological assessment were divided into three groups according to endoscopic findings: Duodenal ulcer (DU), gastric ulcer (GU)and non-ulcer dyspepsia (NUD). The polymerase chain reaction (PCR) was used to detect CagA and VacA genes of H.pylori using specific primers.RESULTS: H.pyloriwas isolated from 75.4 % (107/142) of the patients. Of the 107 patients, 66 (61.7 %) were cagApositive and 82 (76.6 %) were Vacl-positive. CagA gene was positively associated with DU and GU (P<0.01, P<0.02),but not with NUD (P>0.05). Although VacA positivity in ulcer patients was higher than that in NUD group, the difference was not statistically significant (P>0.05).CONCLUSION: There is a significantly positive association between CagA genes and DU and GU. The presence of VacA is not a predictive marker for DU, GU, and NUD in our patients. | Kantarceken Bulent Aladag Murat Atik Esin Koksal Fatih Harputluoglu MMMurat Harputluoglu Hakan Karincaoglu Melih Ares Mehmet Yildirim Bulent Hilmioglu Fatih | 2003 | World Journal of Gastroenterology2003，9，7： | 8 |
| 3 | STIM1和Orai1在骨肉瘤细胞HOS增殖和凋亡中的作用显示文摘目的探讨钙库操纵的钙内流(SOCE)组成蛋白STIM1和Orai1蛋白在骨肉瘤细胞系HOS增殖和凋亡中的作用。方法用shRNA干扰技术抑制STIM1和Orai1蛋白的表达。Western blot测定STIM1和Orai1的蛋白表达;激光共聚焦检测细胞Ca2+内流变化;噻唑蓝(MTT)比色法检测HOS细胞的增殖能力;流式细胞技术检测HOS细胞的凋亡变化。结果与空白对照组和转染negative-shRNA的对照组相比,转染48 h后STIM1-shRNA组STIM1蛋白的表达均明显降低(P<0.01),Orai1-shRNA组Orai1蛋白的表达也明显降低。抑制STIM1和Orai1蛋白后,细胞Ca2+内流减少。转染24、48和72 h后,STIM1-shRNA组及Orai1-shRNA组HOS细胞的增殖能力明显下降(P<0.01)。流式细胞检测显示,与control组和negative-shRNA组相比,转染48 h后细胞的周期受到明显抑制,而凋亡水平明显升高(P<0.01)。结论 STIM1和Orai1在骨肉瘤细胞HOS增殖中有重要作用,抑制STIM1和Orai1蛋白表达可以抑制HOS细胞增殖、促进凋亡。 | 郑少伟 陈国奋 王健 李郅涵 Shaikh Atik Badshah 李敏 张洋 史占军 | 2014 | 中华关节外科杂志(电子版)2014，8，2： | 6 |
| 4 | 长骨节段性缺损修复重建的理论及应用进展显示文摘背景:长骨节段性骨缺损修复重建方法众多,各有优缺点,限制了其广泛应用,仍是一个未完美解决的骨科难题。目的:综述近年国内外长骨节段性缺损的修复重建进展研究。方法:第一作者应用计算机检索1990年1月至2012年12月PubMed数据库、中国期刊全文数据库、维普数据库有关长骨节段性缺损修复重建的文章,英文检索词'bone defect,long bone reconstruction,tissue engineering of bone,scaffolds,bone reconstruction,bone graft,bone tumor;tumor resection,musculoskeletal tumors,regeneration,autografts';中文检索词'大段,骨缺损,骨肿瘤,软组织肿瘤,瘤段切除,组织工程,骨移植'。共检索到104篇相关文献,纳入52篇文献进一步研究。结果与结论:传统长骨节段性骨缺损的修复方法包括自体骨移植、异体骨移植、骨延长、人工假体置换等。研制适用于儿童保肢需要,符合儿童生长发育特点的假体成为儿童保肢的一个挑战课题。为了解决这一问题,人们研制出可以不断延长的假体,用于儿童骨肿瘤的保肢重建。随着医疗技术的进步,各种人工骨,尤其是骨组织工程和基因治疗在骨缺损修复中的逐步应用将进一步提高骨缺损的修复效果,是未来的研究方向。 | 李敏 陈国奋 王健 史占军 Shaikh Atik Badshah 郑少伟 | 2013 | 中国组织工程研究2013，17，43： | 6 |
| 5 | 全膝关节置换术后低位髌骨的处理策略及文献回顾显示文摘目的探讨全膝关节置换术后低位髌骨的诊断与治疗。方法回顾分析1例全膝关节置换术后低位髌骨的临床资料,并进行文献回顾分析。结果 1例55岁女性患者,右膝关节置换术后1年,以膝前痛、膝关节屈曲受限收入院。经膝关节正侧位X线片确诊为右膝关节置换术后低位髌骨,入院后行右侧髌骨表面置换及髌韧带松解术,有效地解除膝前痛及膝关节屈曲活动受限的症状,术后随访HSS评分显示患者膝关节疼痛、功能、关节活动度明显改善。结论全膝关节置换术后低位髌骨并不常见,正确的诊断与治疗对改善患者术后生活质量尤为重要。 | 王健 郑少伟 陈国奋 李郅涵 Shaikh Atik Badshah 李敏 张洋 史占军 | 2014 | 中国临床解剖学杂志2014，32，6： | 6 |
| 6 | Tracheobronchopathia osteochondroplastica: four cases显示文摘 | Dursun Tatar Gunes Senol Atike Demir Gulru Polat | 2012 | Chinese Medical Journal2012，，16： | 4 |
| 7 | 聚乳酸/羟基磷灰石纳米复合物对MC3T3-E1细胞增殖活性的影响显示文摘背景:研究表明聚乳酸/羟基磷灰石复合材料与自然骨结构和性能相似,具有骨传导性和良好的生物相容性。目的:观察聚乳酸/羟基磷灰石纳米复合物与成骨细胞株MC3T3-E1的生物相容性。方法:分别采用普通完全培养基(对照组)与聚乳酸/羟基磷灰石纳米复合物浸提液(实验组)培养第3代成骨细胞株MC3T3-E1,培养3,5,7 d,采用CCK-8法检测细胞的吸光度值;在培养第7,14天检测细胞碱性磷酸酶、骨钙素、Ⅰ型胶原、核心结合因子α1/成骨特异性转录因子表达。将聚乳酸/羟基磷灰石纳米复合物与第3代成骨细胞株MC3T3-E1共培养,培养7,14 d细胞骨架染色及扫描电镜观察细胞在支架材料上的形态。结果与结论:随着时间的延长,成骨细胞株MC3T3-E1的吸光度值明显增加,两组细胞吸光度值比较差异无显著性意义。实验组培养第7天细胞碱性磷酸酶活性高于对照组(P<0.05),培养第14天细胞碱性磷酸酶、Ⅰ型胶原、核心结合因子α1/成骨特异性转录因子表达高于对照组(P<0.05)。种植7 d后细胞在材料上贴附生长,细胞呈多角形;种植14 d后细胞较7 d前数目明显增多,且完全伸展,呈多角形和梭形。表明聚乳酸/羟基磷灰石纳米复合物对成骨细胞有良好的生物相容性,无细胞毒性。 | 李敏 唐元 atik badshah shaikh 史占军 王健 | 2014 | 中国组织工程研究2014，18，43： | 4 |
| 8 | 氩氦刀联合长段骨切除后原位回植手术治疗骨肉瘤1例及文献复习(英文)显示文摘[目的]骨肿瘤切除术后大段骨缺损重建一直是一个难题。重建方法众多,如肿瘤假体、同种异体移植物、牵张成骨、自体骨移植,各有其优点。本报道描述了氩氦刀冷冻探针联合大段肿瘤骨切除后原位回植治疗骨肉瘤的一种新技术。[方法]手术切除股骨下段骨肉瘤,经氩氦刀冷冻灭活肿瘤骨后原位回植解剖复位,钢板螺钉内固定。[结果]术中、术后短期患者无重大手术并发症。术后3个月随访时病人能脱拐行走,膝关节主动和被动活动范围0°~40°,x线摄片证实回植骨两端骨痂形成,但出现肺转移。术后15个月复查x线提示回植骨吸收明显,内固定松动,但无肿瘤复发。[结论]使用氩氦刀冷冻灭活骨肉瘤长段骨后原位回植达到生物重建,此方法简单而有效。但由于本研究病例数少,随访时间短,该方法的远期疗效还有待进一步研究。 | 陈国奋 Shaikh Atik Badshah 李敏 郑少伟 史占军 | 2014 | 中国矫形外科杂志2014，22，13： | 3 |
| 9 | Long-term observation of vitrectomy without subretinal hemorrhage management for massive vitreous hemorrhage secondary to polypoidal choroidal vasculopathy显示文摘AIM: To describe the long-term observation of vitrectomy without subretinal hemorrhage(SRH) management for massive vitreous hemorrhage(VH) secondary to polypoidal choroidal vasculopathy(PCV). METHODS: This is a retrospective, consecutive case series. A total of 86 eyes of 86 patients with >14d of massive VH associated with PCV were included. All patients underwent vitrectomy without SRH management, followed by intravitreal ranibizumab injections and/or photodynamic therapy(PDT) as needed. The main outcome measures were best-corrected visual acuity(BCVA), postoperative adverse events and the recurrence of VH. RESULTS: The average follow-up period was 25.5±9.2 mo(range 12-35 mo). Mean BCVA at baseline(2.16±0.39 logM AR)had improved significantly, both 3 mo after surgery(1.42±0.66 log MAR, P<0.001) and by the last visit(1.23±0.74 logM AR, P<0.001). The common postoperative complications included macular subretinal fibrosis in 14 eyes(16.3%) and ciliary body detachment in 4 eyes(4.7%).Nineteen eyes(22.1%) received following treatment with ranibizumab injections without/with PDT, and 15(17.4%)were resolved. Four eyes(4.7%) had recurrent hemorrhage during the follow-up period. In multiple regression analysis,thicker SRH(beta=0.33, P=0.025) in the preoperative B-scan and the presence of foveal subretinal fibrosis(beta=0.28, P=0.018) in the follow up were associated with poor postoperative BCVA. CONCLUSION: Vitrectomy without SRH management for massive VH secondary to PCV improved/stabilized visual function in the long-term observation. Eyes presenting with thicker SRH preoperatively and forming foveal subretinal fibrosis in the follow-up period tended to have worse BCVA. | Zhi-Xi Li Yi-Jun Hu Alp Atik Lin Lu Jie Hu | 2019 | International Journal of Ophthalmology(English edition)2019，12，12： | 3 |
| 10 | 合并肩袖损伤的肱二头肌长头腱病变固定与切断比较显示文摘[目的]对比分析合并肩袖损伤的肱二头肌长头腱(long head of biceps tendon,LHBT)病变固定与切断术的疗效.[方法]回顾性分析2018年1月-2020年6月关节镜治疗合并肩袖损伤的LHBT病变30例患者的临床资料.其中,11例行LHBT固定术(固定组),19例行LHBT切断术(切断组),两组均行肩袖修补.比较两组近期临床效果.[结果]两组患者均顺利完成手术,无严重并发症,两组手术时间、切口长度、失血量的差异均无统计学意义(P>0.05).与术前相比,末次随访时两组VAS评分均显著降低,而ASES评分显著增加(P<0.05);但是,相应时间点两组间VAS和ASES评分的差异均无统计学意义(P>0.05).单纯切断组出现1例Popeye畸形,术后两组患者屈伸肘部肌力无明显差异,肩关节主被动活动度无显著障碍.[结论]对合并肩袖损伤的LHBT病变治疗,LHBT固定术与LHBT切断术联合肩袖修补均有显著的近期临床疗效,但单纯腱切断术后有Popeye畸形发生可能. | 李敏 SHAIKH ATIK BADSHAH 彭赓 朱海伦 周震全 李亮 桑宏勋 | 2021 | 中国矫形外科杂志2021，29，24： | 3 |
| 11 | Inducible nitric oxide synthase and histopathological correlation in chronic viral hepatitis显示文摘 | Esin Atik Yusuf Onlen Lutfu Savas Figen Doran | 2007 | International Journal of Infectious Diseases2007，，1： | 2 |
| 12 | Screening of biological activities of Polygonum maritimum L.from A lgerian coast显示文摘Objective:To investigate the antioxidant and the antibacterial activities of crude extract from aerial part of Polygonum maritimumL.(Polygonaceae)(P.maritimum)and to find new actives biomolecules.Methods:The whole plant was collected from the Rechgoune coast(West of Algeria),and methanolic crude extract of aerial parts ofP.maritimum(PMCE)was prepared.The extract was tested against different bacterial strain and tested for his ability to neutralize free radical(DPPH)and to scavenge the H2O2.Results:PMCE had a very high content of total phenol,which was(352.49依18.03)mg/g dry weight,expressed as gallic acid equivalent.PMCE exhibited excellent antioxidant activity,as measured using DPPH and H2O2 scavenging assays.It also showed a high antibacterial activity against gram-positive bacterial strains:Bacillus cereus,Bacillus subtilisandStaphylococcus aureus with an highest MIC of 120μg/mL.Conclusions:The antioxidant and antibacterial activity of the PMCE is probably due to phenolic compounds present in the extract.The contemporary presence of antioxidant and antibacterialactivities in the PMCE suggests that this plant may be a source of bioactive substances with multifaceted activity. | Imad Abdelhamid El-Haci Fawzia Atik Bekkara Wissame Mazari Fay al Hassani Mohamed AmineDidi | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，8： | 2 |
| 13 | Extracorporeal membrane oxygenation with right axillary artery perfusion显示文摘 | Navia JL Atik FA | 2005 | Ann Thorac Surg2005，79，6： | 1 |
| 14 | Effects of hyaluronic acid on post-operative adhesion of tendon calcareous surgery: an experimental study in rats 显示文摘 | Tuncay I Ozbek H Atik B | 2002 | J Foot Ankle Surg2002，41，2： | 1 |
| 15 | Soft-tissue augmenta- tion of the middle and lower face using the deepithelial- ized submental flap显示文摘 | Tan O Atik B Parmaksizoglu D | 2007 | Plast Reconstr Surg2007，119，3： | 1 |
| 16 | Effects of hyaluronic acid on postoperative adhesion of tendon caicaneus surgery:an experimental study in rats显示文摘 | Tuncay I OzbekH Atik B | 2002 | Foot Ankle Surg2002，2，： | 1 |
| 17 | A new custom-made nostril retainer: the rubber of infusion set 显示文摘 | Tan O Atik B Vayvada H | 2006 | Plast Reconstr Surg2006，117，3： | 1 |
| 18 | Modeling of a mechanical cooling system with variable cooling capacity by using artificial neural network显示文摘 | Yilmaz S Atik K | 2007 | Applied Thermal Engineering2007，27，13： | 1 |
| 19 | Plastic surgical solutions for melkson rosenthal syndrome:facial liposuction and eheiloplast procedures 显示文摘 | Tan O Atik B Calka O | 2006 | Ann Hast Surg2006，56，3： | 1 |
| 20 | Photoinduced reactions in polymerized microemulsions显示文摘 | Atik S S Thomas J K | | 0，，14： | 1 |
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