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| 1 | ARID1A expression in gastric adenocarcinoma:Clinicopathological significance and correlation with DNA mismatch repair status显示文摘AIM:To analyze the mismatch repair(MMR)status and the ARID1A expression as well as their clinicopathological significance in gastric adenocarcinomas.METHODS:We examined the expressions of MMR proteins and ARID1A by immunohistochemistry in consecutive 489 primary gastric adenocarcinomas.The results were further correlated with clinicopathological variables.RESULTS:The loss of any MMR protein expression,indicative of MMR deficiency,was observed in 38cases(7.8%)and was significantly associated with an older age(68.6±9.2 vs 60.4±11.7,P<0.001),a female sex(55.3%vs 31.3%,P=0.004),an antral location(44.7%vs 25.7%,P=0.021),and a differentiated histology(57.9%vs 39.7%,P=0.023).Abnormal ARID1A expression,including reduced or loss of ARID1A expression,was observed in 109 cases(22.3%)and was significantly correlated with lymphatic invasion(80.7%vs 69.5%,P=0.022)and lymph node metastasis(83.5%vs 73.7%,P=0.042).The tumors with abnormal ARID1A expression more frequently indicated MMR deficiency(47.4%vs 20.2%,P<0.001).A multivariate analysis identified abnormal ARID1A expression as an independent poor prognostic factor(HR=1.36,95%CI:1.01-1.84;P=0.040).CONCLUSION:Our observations suggest that the AIRD1A inactivation is associated with lymphatic invasion,lymph node metastasis,poor prognosis,and MMR deficiency in gastric adenocarcinomas. | Ryo Inada Shigeki Sekine Hirokazu Taniguchi Hitoshi Tsuda Hitoshi Katai Toshiyoshi Fujiwara Ryoji Kushima | 2015 | World Journal of Gastroenterology2015，21，7： | 7 |
| 2 | Clinical impact of c-Met expression and its gene amplification in hepatocellular carcinoma显示文摘 | Shunsuke Kondo Hidenori Ojima Hitoshi Tsuda Jun Hashimoto Chigusa Morizane Masafumi Ikeda Hideki Ueno Kenji Tamura Kazuaki Shimada Yae Kanai Takuji Okusaka | 2013 | International Journal of Clinical Oncology2013，，2： | 2 |
| 3 | Multicenter study evaluating the clinical performance of the OSNA assay for the molecular detection of lymph node metastases in gastric cancer patients显示文摘 | Koshi Kumagai Noriko Yamamoto Isao Miyashiro Yasuhiko Tomita Hitoshi Katai Ryoji Kushima Hitoshi Tsuda Yuko Kitagawa Hiroya Takeuchi Makio Mukai Masayuki Mano Hidetaka Mochizuki Yo Kato Nariaki Matsuura Takeshi Sano | 2014 | Gastric Cancer2014，，2： | 2 |
| 4 | The deep-space multi-object orbit determination system and its application to Hayabusa2’s asteroid proximity operations显示文摘The deep-space multi-object orbit determination system(DMOODS)and its application in the asteroid proximity operation of the Hayabusa2 mission are described.DMOODS was developed by the Japan Aerospace Exploration Agency(JAXA)for the primary purpose of determining the trajectory of deep-space spacecraft for JAXA’s planetary missions.The weighted least-squares batch filter is used for the orbit estimator of DMOODS.The orbit estimator supports more than 10 data types,some of which are used for relative trajectory measurements between multiple space objects including natural satellites and small bodies.This system consists of a set of computer programs running on Linux-based consumer PCs on the ground,which are used for orbit determination and the generation of radiometric tracking data,such as delta differential one-way ranging and doppler tracking data.During the asteroid proximity phase of Hayabusa2,this system played an essential role in operations that had very strict navigation requirements or operations in which few optical data were obtained owing to special constraints on the spacecraft attitude or distance from the asteroid.One example is orbit determination during the solar conjunction phase,in which the navigation accuracy is degraded by the effect of the solar corona.The large range bias caused by the solar corona was accurately estimated with DMOODS by combining light detection and ranging(LIDAR)and ranging measurements in the superior solar conjunction phase of Hayabusa2.For the orbiting operations of target markers and the MINERVA-II2 rover,the simultaneous estimation of six trajectories of four artificial objects and a natural object was made by DMOODS.This type of simultaneous orbit determination of multi-artificial objects in deep-space has never been accomplished before. | Hiroshi Takeuchi Kent Yoshikawa Yuto Takei Yusuke Oki Shota Kikuchi Hitoshi Ikeda Stefania Soldini Naoko Ogawa Yuya Mimasu Go Ono Fuyuto Terui Naoya Sakatani Manabu Yamada Toru Kouyama Shingo Kameda Takanao Saiki Yuichi Tsuda | 2020 | Astrodynamics2020，4，4： | 2 |
| 5 | Low-dose cytarabine and aclarubicin in combination with granulocyte colony-stimulating factor for elderly patients with previously untreated acute myeloid leukemia显示文摘 | Hitoshi Suzushima Naoko Wada Hiroshi Yamasaki Kenichiro Eto Taizo Shimomura Michiko H. Kugimiya Kentaro Horikawa Shintaro Nishimura Hiroyuki Tsuda Hiroaki Mitsuya Norio Asou | 2009 | Leukemia Research2009，，5： | 1 |
| 6 | Individualization of breast cancer based on histopathological features and molecular alterations 显示文摘 | HITOSHI TSUDA | 2008 | Breast Cancer2008，，15： | 1 |
| 7 | HER- 2 testing on core needle biopsy speeimens from primary breast cancers: interobserver reproducibility and concordance with surgi- cally resected specimens显示文摘 | Hitoshi Tsuda Masalumi Kurosumi Shinobu Umemura | 2010 | BMC Cancer2010，10，： | 1 |
| 8 | Comparison of HER2 status between surgically resected specimens and matched biopsy specimens of gastric intestinal-type adenocarcinoma显示文摘 | Hiroshi Yoshida Noriko Yamamoto Hirokazu Taniguchi Ichiro Oda Hitoshi Katai Ryoji Kushima Hitoshi Tsuda | 2014 | Virchows Archiv2014，，2： | 1 |
| 9 | Bright-Field Dual-Color Chromogenic In Situ Hybridization for Diagnosing Echinoderm Microtubule-Associated Protein-Like 4-Anaplastic Lymphoma Kinase-Positive Lung Adenocarcinomas显示文摘 | Akihiko Yoshida Koji Tsuta Hiroaki Nitta Yutaka Hatanaka Hisao Asamura Ikuo Sekine Thomas M. Grogan Masashi Fukayama Tatsuhiro Shibata Koh Furuta Takashi Kohno Hitoshi Tsuda | 2011 | Journal of Thoracic Oncology2011，，10： | 1 |
| 10 | Gene and chromosomal alterations in sporadic breast cancer: correlation with histopathological features and implications for genesis and progression显示文摘 | Hitoshi Tsuda | 2009 | Breast Cancer2009，，3： | 1 |
| 11 | Comprehensive Histologic Analysis of ALK-Rearranged Lung Carcinomas显示文摘 | Akihiko Yoshida Koji Tsuta Harumi Nakamura Takashi Kohno Fumiaki Takahashi Hisao Asamura Ikuo Sekine Masashi Fukayama Tatsuhiro Shibata Koh Furuta Hitoshi Tsuda | 2011 | The American Journal of Surgical Pathology2011，，8： | 1 |
| 12 | Clinical proteomics identified ATP-dependent RNA helicase DDX39 as a novel biomarker to predict poor prognosis of patients with gastrointestinal stromal tumor显示文摘 | Kazutaka Kikuta Daisuke Kubota Tsuyoshi Saito Hajime Orita Akihiko Yoshida Hitoshi Tsuda Yoshiyuki Suehara Hitoshi Katai Yasuhiro Shimada Yoshiaki Toyama Koichi Sato Takashi Yao Kazuo Kaneko Yasuo Beppu Yasufumi Murakami Akira Kawai Tadashi Kondo | 2011 | Journal of Proteomics2011，，4： | 1 |
| 13 | Proteomic-based identification of the APC-binding protein EB1 as a candidate of novel tissue biomarker and therapeutic target for colorectal cancer显示文摘 | Yutaka Sugihara Hirokazu Taniguchi Ryoji Kushima Hitoshi Tsuda Daisuke Kubota Hiroshi Ichikawa Kano Sakamoto Yukiko Nakamura Takeshi Tomonaga Shin Fujita Tadashi Kondo | 2012 | Journal of Proteomics2012，，17： | 1 |
| 14 | Usefulness and Limitation of Multiple Endoscopic Biopsy Sampling fer Epidermal Growth Factor Receptor and c-erbB-2 Testing in Patients with Gastric Adenocarcinoma显示文摘 | Mikihiko Kimura Hitoshi Tsuda Daisaku Morita | 2005 | Japanese Journal of Clinical Oncology2005，35，6： | 1 |
| 15 | Microinvasive Breast Carcinoma with Extensive Involvement of level III Axillary Lymph Nodes: a Case Report 显示文摘 | Kimihito Fujii Takashi Fukutomi Hitoshi Tsuda | 1998 | Japanese Journal of Clinical Ontology1998，28，1： | 1 |
| 16 | FOXP1, an Estrogen-Inducible Transcription Factor, Modulates Cell Proliferation in Breast Cancer Cells and 5-Year Recurrence-Free Survival of Patients with Tamoxifen-Treated Breast Cancer显示文摘 | Takashi Shigekawa Nobuhiro Ijichi Kazuhiro Ikeda Kuniko Horie-Inoue Chikako Shimizu Shigehira Saji Kenjiro Aogi Hitoshi Tsuda Akihiko Osaki Toshiaki Saeki Satoshi Inoue | 2011 | Hormones and Cancer2011，，5： | 1 |
| 17 | A 2-Mb Sequence-Ready Contig Map and a Novel Immunoglobulin Superfamily Gene IGSF4 in the LOH Region of Chromosome 11q23.2显示文摘 | Hiroki Gomyo Yasuhito Arai Akira Tanigami Yoshinori Murakami Masahira Hattori Fumie Hosoda Kyoko Arai Yukiko Aikawa Hitoshi Tsuda Setsuo Hirohashi Shuichi Asakawa Nobuyoshi Shimizu Eiichi Soeda Yoshiyuki Sakaki Misao Ohki | 1999 | Genomics1999，，： | 1 |
| 18 | Prognostic significance of the overexpression of c-erbB-2 protein in adenocarcinoma of the uterine cervix显示文摘 | Toshimasa Kihana M D Hitoshi Tsuda M D Shinichi Teshima | 1994 | Cancer1994，，1： | 1 |
| 19 | Effect ofLiF addition at preparation of LiCoO2 on its properties as an active material oflithium secondary battery显示文摘 | Okayama Tsunemi Tsuda Hitoshi et a1 | 1998 | Journal of Fluorine Chemistry1998，87，2： | 1 |
| 20 | Bcl‐2, B cl‐6, and the I nternational P rognostic I ndex are prognostic indicators in patients with diffuse large B ‐cell lymphoma treated with rituximab‐containing chemotherapy显示文摘 | Akiko Miyagi Maeshima Hirokazu Taniguchi Suguru Fukuhara Noriyuki Morikawa Wataru Munakata Dai Maruyama Sung‐Won Kim Takashi Watanabe Yukio Kobayashi Kensei Tobinai Hitoshi Tsuda | 2012 | Cancer Sci2012，，： | 1 |
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