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| 1 | Alterations of tumor suppressor and tumor-related genes in the development and progression of gastric cancer显示文摘胃的癌症的发展和前进包含肿瘤的很多基因、渐成说的改变压制或并且肿瘤相关的基因。区分的癌的多数从肠的遇见的无形的粘膜和展览在结构上产生改变的肿瘤压制或基因,由 p53 代表了,它经由经典二点击的机制被使失去活性,即杂合现象(LOH ) 的损失和留下的等位基因的变化。在某些染色体部位的 LOH 在肿瘤前进期间积累。约 20% 区分的癌经由倡导者 CpG 岛的 hypermethylation 在激活由于 hMLH1 显示出 mutator 小径肿瘤发生的证据,并且展出高周波的微卫星不稳定性。相反,无差别的癌很少展出在结构上改变的肿瘤压制或基因。例如,当 E-cadherin 的甲基化经常在无差别的癌被观察时,这基因的变化通常与前进被联系从区分了到无差别的癌。肿瘤的 Hypermethylation 压制或并且包括 APC, CHFR, DAP-kinase,两重棉包线, E-cadherin, GSTP1, hMLH1, p16, PTEN, RASSF1A, RUNX3,和 TSLC1,肿瘤相关的基因能被检测在区分并且在改变频率的无差别的癌。然而, hypermethylation 的意义根据这些基因的分析 genomic 区域,和 hypermethylation 变化能也在非肿瘤的胃的上皮在场。特定的基因的倡导者脱甲基例如魔术师和 synuclein Y,能在两种组织学的类型的进步阶段期间发生,并且与耐心的预后被联系。因此,当胃的致癌作用的分子的小径依赖于组织学的背景时,特定的基因改变装仍然被用于风险评价,诊断,和预后。 | Gen Tamura | 2006 | World Journal of Gastroenterology2006，12，2： | 105 |
| 2 | Shear wave velocity is a useful marker for managing nonalcoholic steatohepatitis显示文摘AIM:To investigate whether a noninvasive measurement of tissue strain has a potential usefulness for management of nonalcoholic steatohepatitis(NASH).METHODS:In total 26 patients,23 NASHs and 3 normal controls were enrolled in this study.NASH was staged based on Brunt criterion.At a region of interest(ROI),a shear wave was evoked by implementing an acoustic radiation force impulse(ARFI),and the propagation velocity was quantif ied.RESULTS:Shear wave velocity(SWV) could be reproducibly quantified at all ROIs in all subjects except for 4 NASH cases,in which a reliable SWV value was not calculated at several ROIs.An average SWV of 1.34 ± 0.26 m/s in fibrous stage 0-1 was significantly slower than 2.20 ± 0.74 m/s and 2.90 ± 1.01 m/s in stages 3 and 4,respectively,but was not significantly different from 1.79 ± 0.78 m/s in stage 2.When a cutoff value was set at 1.47 m/s,receiver operating characteristic analysis showed significance to dissociate stages 3 and 4 from stage 0-1(P=0.0092) with sensitivity,specificity and area under curve of 100%,75% and 94.2%,respectively.In addition,the correlation between SWV and hyaluronic acid was significant(P<0.0001),while a tendency toward negative correlation was observed with serum albumin(P=0.053).CONCLUSION:The clinical implementation of ARFI provides noninvasive repeated evaluations of liver stiffness at an arbitrary position,which has the potential to shed new light on NASH management. | Akihiko Osaki Tomoyuki Kubota Takeshi Suda Masato Igarashi Keisuke Nagasaki Atsunori Tsuchiya Masahiko Yano Yasushi Tamura Masaaki Takamura Hirokazu Kawai Satoshi Yamagiwa Toru Kikuchi Minoru Nomoto Yutaka Aoyagi | 2010 | World Journal of Gastroenterology2010，16，23： | 30 |
| 3 | 雷暴冲击风模拟及其荷载的风洞试验研究显示文摘为了研究在突变气流作用下结构的空气动力特性,介绍了利用主动控制风洞模拟突变气流的试验研究。首先通过该风洞模拟出了雷暴冲击风阵风剖面;然后,采用'阶跃流法'模拟了风速突变的时程;最后将高层结构模型置于该突变气流中,观测在特殊气流中结构表面风压以及结构空气动力学参数的变化特征。试验结果表明,利用主动控制风洞模拟出的雷暴冲击风阵风剖面同理论的相似性达到90%以上,突变气流会使高层结构整体产生较大的非定常升力,并且在结构表面产生较大的非定常风压。 | 赵杨 曹曙阳 Yukio Tamura 段忠东 S. Ozono | 2009 | 振动与冲击2009，28，4： | 24 |
| 4 | IMPROVEMENT OF BUBBLE MODEL FOR CAVITATING FLOW SIMULATIONS显示文摘In the present research, a bubble dynamics based model for cavitating flow simulations is extended to higher void fraction region for wider range of applications. The present bubble model is based on the so-called Rayleigh-Plesset equation that calculates a temporal bubble radius with the surrounding liquid pressure and is considered to be valid in an area below a certain void fraction. The solution algorithm is modified so that the Rayleigh-Plesset equation is no more solved once the bubble radius (or void fraction) reaches at a certain value till the liquid pressure recovers above the vapor pressure in order to overcome this problem. This procedure is expected to stabilize the numerical calculation. The results of simple two-dimensional flow field are presented compared with the existing bubble model. | TAMURA Y. MATSUMOTO Y. | 2009 | Journal of Hydrodynamics2009，21，1： | 23 |
| 5 | 柱面壳体表面风压分布特性风洞试验研究显示文摘基于刚性模型的风洞试验,在不同风攻角及场地条件下,对考虑不同长跨比的柱面壳体表面风压分布进行了同步测量.根据测量结果对壳体表面风压场特性进行了分析,包括风压系数、整体风力系数、脉动风压自功率谱及互功率谱、风压场本征正交分解特性、雷诺数对壳体表面风压分布的影响等.结果表明,此类曲面模型表面风压分布受雷诺数影响明显,且模型曲面特性使得风场本征正交分解的前几阶特征模态对整个风压分布的贡献增大. | 李元齐 Tamura Yukio 沈祖炎 | 2006 | 同济大学学报(自然科学版)2006，34，11： | 18 |
| 6 | Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by azoxymethane in mice显示文摘AIM:To investigate the causal relationship between hypoadiponectinemia and colorectal carcinogenesis in in vivo experimental model,and to determine the con-tribution of adiponectin defi ciency to colorectal cancer development and proliferation.METHODS:We examined the influence of adiponectin defi ciency on colorectal carcinogenesis induced by the administration of azoxymethane(AOM)(7.5 mg/kg,in-traperitoneal injection once a week for 8 wk),by using adiponectin-knockout(KO) mice.RESULTS:At 53 wk after the fi rst AOM treatment,KOmice developed larger and histologically more progres-sive colorectal tumors with greater frequency com-pared with wild-type(WT) mice,although the tumor incidence was not different between WT and KO mice.KO mice showed increased cell proliferation of colorec-tal tumor cells,which correlated with the expression levels of cyclooxygenase-2(COX-2) in the colorectal tumors.In addition,KO mice showed higher incidence and frequency of liver tumors after AOM treatment.Thirteen percent of WT mice developed liver tumors,and these WT mice had only a single tumor.In contrast,50% of KO mice developed liver tumors,and 58% of these KO mice had multiple tumors.CONCLUSION:Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by AOM in mice.This study strongly suggests that hypoadiponectinemia could be involved in the pathogenesis for colorectal cancer and liver tumor in human subjects. | Tamao Nishihara Miyako Baba Morihiro Matsuda Masahiro Inoue Yasuko Nishizawa Atsunori Fukuhara Hiroshi Araki Shinji Kihara Tohru Funahashi Shinji Tamura Norio Hayashi Hiroyasu Iishi Iichiro Shimomura | 2008 | World Journal of Gastroenterology2008，14，42： | 12 |
| 7 | Significance of lead aVR in acute coronary syndrome显示文摘The 12-lead electrocardiogram(ECG)is a crucial tool in the diagnosis and risk stratification of acute coronary syndrome(ACS).Unlike other 11 leads,lead aVR has been long neglected until recent years.However,recent investigations have shown that an analysis of ST-segment shift in lead aVR provides useful information on the coronary angiographic anatomy and risk stratification in ACS.ST-segment elevation in lead aVR can be caused by(1)transmural ischemia in the basal part of the interventricular septum caused by impaired coronary blood flow of the first major branch originating from the left anterior descending coronary artery;(2)transmural ischemia in the right ventricular outflow tract caused by impaired coronary blood flow of the large conal branch originating from the right coronary artery;and(3)reciprocal changes opposite to ischemic or non-ischemic ST-segment depression in the lateral limb and precordial leads.On the other hand,ST-segment depression in lead aVR can be caused by transmural ischemia in the inferolateral and apical regions.It has been recently shown that an analysis of T wave in lead aVR also provides useful prognostic information in the general population and patients with prior myocardial infarction.Cardiologists should pay more attention to the tracing of lead aVR when interpreting the12-lead ECG in clinical practice. | Akira Tamura | 2014 | World Journal of Cardiology2014，6，7： | 11 |
| 8 | Genomic characterization of esophageal squamous cellcarcinoma:insights from next-generation sequencing显示文摘Two major types of cancer occur in the esophagus: squamous cell carcinoma, which is associated with chronic smoking and alcohol consumption, and adenocarcinoma, which typically arises in gastric reflux-associated Barrett's esophagus. Although there is increasing incidence of esophageal adenocarcinoma in Western counties, esophageal squamous cell carcinoma(ESCC) accounts for most esophageal malignancies in East Asia, including China and Japan. Technological advances allowing for massively parallel, high-throughput next-generation sequencing(NGS) of DNA have enabled comprehensive characterization of somatic mutations in large numbers of tumor samples. Recently, several studies were published in which whole exome or whole genome sequencing was performed in ESCC tumors and compared with matched normal DNA. Mutations were validated in several genes, including in TP53, CDKN2 A, FAT1, NOTCH1, PIK3 CA, KMT2 D and NFE2L2, which had been previously implicated in ESCC. Several new recurrent alterations have also been identified in ESCC. Combining the clinicopathological characteristics of patients with information obtained from NGS studies may lead to the development of effective diagnostic and therapeutic approaches for ESCC. As this research becomes more prominent, it is important that gastroenterologist become familiar with the various NGS technologies and the results generated using these methods. In the present study, we describe recent research approaches using NGS in ESCC. | Yasushi Sasaki Miyuki Tamura Ryota Koyama Takafumi Nakagaki Yasushi Adachi Takashi Tokino | 2016 | World Journal of Gastroenterology2016，22，7： | 10 |
| 9 | IRF family proteins and type I interferon induction in dendritic cells显示文摘树枝状的房间(DC ) 在造血的房间的一张次要的人口,生产类型我干扰素(IFN ) 和另外的 cytokines 并且为天生的免疫是必要的。他们也是有势力抗原演讲者并且调整适应免疫。在 DC 子类型血浆之中似细胞的 DC (pDC ) 生产类型的最高的数量我 IFN。另外,象 IL-12 和 IL-10 那样的支持 inflammatory 和反煽动性的 cytokines 响应象发信号的受体(TLR ) 一样并且在病毒的感染之上的代价在 DC 被导致。在 IRF 家庭的蛋白质控制 DC 活动的许多方面。IRF-8 和 IRF-4 为 DC 开发是必要的。他们差别控制四个 DC 子集的开发。IRF-8-/- 老鼠大部分缺乏 pDC 和 CD8alpha+ DC,当 IRF-4-/- 老鼠缺乏 CD4+DC 时。IRF-8-/- , IRF4-/- ,两倍猛烈老鼠有仅仅很少 CD8a-CD4-DC 那缺乏 MHC II。IRF 蛋白质也控制类型我在 DC 的 IFN 正式就职。IRF-7,在 TLR 发信号之上激活不仅在 pDC,而且在常规 DC (cDC ) 为 IFN 正式就职被要求, non-DC 房间打字。IRF-3 贡献在成纤维细胞感应的 IFN,在在 DC 感应的 IFN 是非必需的。我们的最近的证据揭示那种类型我在 DC 感应的 IFN 非常依赖于 IRF-8,它在 DC 在 IFN 基因正式就职的反馈阶段行动。类型我在 pDC 感应的 IFN 被 MyD88 调停依赖发信号小径,并且不同于在另外的房间采用的小径,它主要依靠 TLR3 和 RIG-I 家庭蛋白质。另外的支持 inflammatory cytokines 以一种 IRF-5 依赖方式被生产。然而, IRF-5 没为 IFN 正式就职被要求,建议为类型的正式就职的分开的机制的存在我 IFN 和其它支持 inflammatory cytokines。激活的 DC 接着生产的 IFN 和另外的 cytokines 预付 DC 成熟并且改变 DC 的显型和功能。这些过程也是可能的被 IRF 家庭蛋白质管理。 | Prafullakumar Tailor Tomohiko Tamura Keiko Ozato | 2006 | Cell Research2006，16，2： | 9 |
| 10 | Cranial base chordoma——long term outcome and review of the literature显示文摘BACKGROUND: The purpose of this study is to clarify the latest long-term therapeutic result for cranial base chordomas.We are seeking an improvement of long term therapeutic outcome through a review of cranial base chordomas treated in | Yoneoka Y Tsumanuma I Fukuda M Tamura T Morii K Tanaka R Fujii Y | 2008 | 中国神经肿瘤杂志2008，6，3： | 9 |
| 11 | Cholangiopancreatography troubleshooting:the usefulness of endoscopic retrieval of migrated biliary and pancreatic stents显示文摘BACKGROUND:Stent migration in the hepatopancreatic duct might arise as one of the rare complications associated with biliary or pancreatic stenting.Although there are some procedures to retrieve the migrated stent,including surgical,percutaneous,and endoscopic approaches,endoscopy should be attempted first because it is least invasive.This study set out to evaluate the usefulness of endoscopic retrieval of migrated biliary and pancreatic stents.METHODS:Plastic stents that migrated in the bile duct(35 patients)or pancreatic duct(2)were retrieved with endoscopic retrograde cholangiopancreatography.Devices used were snare forceps,a basket catheter,grasping forceps,biopsy forceps,a balloon catheter,and the Soehendra stent retriever.RESULTS:Endoscopic retrieval of migrated stents was performed successfully in 36(97.0%)of the 37 patients.The devices utilized for successful treatment were basket catheter(13 patients),grasping forceps(10),snare forceps(8),balloon catheter(3),biopsy forceps(1),and the Soehendra stent retriever(1).The unsuccessfully treated patient with chronic pancreatitis underwent surgery since the guide wire did not move forward due to bile duct stenosis,and there was also duodenal stenosis.One patient developed mild pancreatitis after withdrawal of the stent;the pancreatitis was relieved with conservative treatment.CONCLUSIONS:Endoscopic retrieval of migrated biliary and pancreatic stents appears to be useful because of its safety and low invasiveness.However,various forceps should be prepared for the retrieval of a migrated stent. | Yuji Sakai Toshio Tsuyuguchi Takeshi Ishihara Harutoshi Sugiyama Reiko Eto Tatsuya Fujimoto Shin Yasui Ryo Tamura Seiko Togo Motohisa Tada Osamu Yokosuka | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，6： | 8 |
| 12 | 多国荷载规范中阵风荷载因子的比较研究显示文摘将我国的《建筑结构荷载规范》(GB5009-2001)与美国(ASCE7-98)、日本(RLB-AIJ2004)、加拿大(NBC1990)和澳大利亚(AS1170.2)几国规范进行了比较研究.首先总结了各国规范所采用的Davenport提出的经典抗风设计方法——阵风荷载因子法(GLF),然后对包括平均风速剖面、湍流强度、脉动风速谱类型进行了比较.美日加澳都将GLF取为一个恒量,相当于'位移风振系数',中国规范中的风振系数却是随高度变化的量,相当于'惯性力风振系数'. | 赵杨 段忠东 Yukio Tamura 武岳 | 2010 | 哈尔滨工程大学学报2010，31，11： | 8 |
| 13 | 利用HHT方法对非平稳风力的时频分析显示文摘非平稳信号的分析方法是信号分析领域中的一个重要问题。以风洞试验获得的非平稳风压信号和升力系数信号为研究对象,采用HHT方法对信号进行时频分析。HHT(Hilbert-Huang transform)方法可以获得有意义的瞬时频率,从而给出频率随时间变化的精确表达;信号最终被表示为时频平面上的能量分布,成为Hilbert谱;该方法适用于分析生活中普遍存在的大量频率随时间变化的非线性、非平稳信号,可将复杂的信号直接分离成从高频到低频的若干阶固有模态函数。分析结果虽然没有表现出明显的频谱分布特性,但与以往HHT分析结果提取的固有模态函数不同,如果对该试验获得的非平稳信号提取的固有模态是低频部分的残余信号,忽略其他高频信号,则风压时程和升力系数时程的残余信号曲线就可以分别回归为一个线性函数和一个正弦函数。这也说明,该非平稳信号的主成分仍然是由平稳信号组成的,可以用分析平稳信号的方法进行时程分析。 | 赵杨 武岳 曹曙阳 段忠东 Yukio Tamura S. Ozono | 2011 | 振动与冲击2011，30，2： | 7 |
| 14 | 几种非平稳分析方法对非平稳风力时程的比较分析显示文摘非平稳信号的分析方法是信号分析领域中的一个重要问题。本文以风洞试验获得的非平稳风压信号和升力系数信号为研究对象,分别采用短时傅里叶变换、Wigner-Ville分布,小波变换方法和Hilbert-Huang变换(HHT)方法对信号进行时频分析。分析结果表明,由于短时傅里叶变换、Wigner-Ville分布,小波变换方法都是基于傅里叶变换,因此,得到的频谱特性都大致相同,只是在分析的精细程度上有所差异;HHT方法可以获得有意义的瞬时频率,从而给出频率随时间变化的精确表达,信号最终被表示为时频平面上的能量分布,成为Hilbert谱,该方法适用于分析生活中普遍存在的大量频率随时间变化的非线性、非平稳信号,可将复杂的信号直接分离成从高频到低频的若干阶固有模态函数。另一方面,无论用哪一种分析方法都可以看出,风速和风压信号的能量大多分布在低频部分,高频部分所占比例很少,而升力信号的能量大多分布在高频部分,低频部分所占比例很少。本文采用HHT方法提取起控制作用的信号主成分。 | 赵杨 曹曙阳 武岳 Tamura Yukio 段忠东 Ozono S. | 2011 | 土木工程学报2011，44，9： | 7 |
| 15 | Diagnosis and management of pancreatic neuroendocrine tumor in von Hippel-Lindau disease显示文摘The pancreatic manifestations seen in patients with von Hippel-Lindau(VHL) disease are subdivided into 2 categories:pancreatic neuroendocrine tumors(NET),and cystic lesions,including simple cyst and serous cystadenoma.The VHL-associated cystic lesions are generally asymptomatic and do not require any treatment,unless they are indistinguishable from other cystic tumor types with malignant potential.Because pancreatic NET in VHL disease are non-functioning and have malignant potential,it is of clinical importance to find and diagnose these as early as possible.It will be recommended that comprehensive surveillance using dynamic computed tomography for abdominal manifestations,including pancreatic NET,should start from the age of 15 years in VHL patients.Unlike sporadic non-functioning NET without VHL disease,in which surgical resection is generally recommended,VHL patients at lower metastatic risk of pancreatic NET should be spared the risks of operative resection. | Kenji Tamura Isao Nishimori Tetsuhide Ito Ichiro Yamasaki Hisato Igarashi Taro Shuin | 2010 | World Journal of Gastroenterology2010，16，36： | 6 |
| 16 | Stapled gastro/duodenojejunostomy shortens reconstruction time during pylorus-preserving pancreaticoduodenectomy显示文摘AIM:To investigate whether a stapled technique is superior to the conventional hand-sewn technique for gastro/duodenojejunostomy during pylorus-preserving pancreaticoduodenectomy(PpPD).METHODS:In October 2010,we introduced a mechanical anastomotic technique of gastro-or duodenojejunostomy using staplers during PpPD.We compared clinical outcomes between 19 patients who underwent PpPD with a stapled gastro/duodenojejunostomy(stapled anastomosis group)and 19 patients who underwent PpPD with a conventional hand-sewn duodenojejunostomy(hand-sewn anastomosis group).RESULTS:The time required for reconstruction was significantly shorter in the stapled anastomosis group than in the hand-sewn anastomosis group(186.0±29.4 min vs 219.7±50.0 min,P=0.02).In addition,intraoperative blood loss was significantly less(391.0±212.0 mL vs 647.1±482.1 mL,P=0.03)and the time to oral intake was significantly shorter(5.4±1.7d vs 11.3±7.9 d,P=0.002)in the stapled anastomosis group than in the hand-sewn anastomosis group.There were no differences in the incidences of delayed gastric emptying and other postoperative complications between the groups.CONCLUSION:These results suggest that stapled gastro/duodenojejunostomy shortens reconstruction time during PpPD without affecting the incidence of delayed gastric emptying. | Norihiro Sato Kei Yabuki Shiro Kohi Yasuhisa Mori Noritaka Minagawa Toshihisa Tamura Aiichiro Higure Koji Yamaguchi | 2013 | World Journal of Gastroenterology2013，19，48： | 6 |
| 17 | Influence of Kupffer cells and platelets on ischemia-reperfusion injury in mild steatotic liver显示文摘AIM: To investigate the effect of mild steatotic liver on ischemia-reperfusion injury by focusing on Kupffer cells (KCs) and platelets. METHODS: Wistar rats were divided into a normal liver group (N group) and a mild steatotic liver group (S group) induced by feeding a choline-deficient diet for 2 wk. Both groups were subjected to 20 min of warm ischemia followed by 120 min of reperfusion. The number of labeled KCs and platelets in sinusoids and the blood perfusion in sinusoids were observed by intravital microscopy (IVM), which was performed at 30, 60 and 120 min after reperfusion. To evaluate serum alanine aminotransferase as a marker of liver deterioration, blood samples were taken at the same time as IVM.RESULTS: In the S group, the number of platelets adhering to KCs decreased significantly compared with the N group (120 after reperfusion; 2.9±1.1 cells/acinus vs 4.8±1.2 cells/acinus, P<0.01). The number of KCs in sinusoids was significantly less in the S group than in the N group throughout the observation periods (before ischemia, 19.6±3.3 cells/acinus vs 28.2±4.1 cells/acinus, P<0.01 and 120 min after reperfusion, 29.0±4.3 cells/acinus vs 40.2±3.3 cells/acinus, P<0.01). The blood perfusion of sinusoids 120 min after reperfusion was maintained in the S group more than in the N group. Furthermore, elevation of serum alanine aminotransferase was lower in the S group than in the N group 120 min after reperfusion (99.7±19.8 IU/L vs 166.3±61.1 IU/L, P=0.041), and histological impairment of hepatocyte structure was prevented in the S group. CONCLUSION: Ischemia-reperfusion injury in mild steatotic liver was attenuated compared with normal liver due to the decreased number of KCs and the reduction of the KC-platelet interaction. | Koichi Ogawa Tadashi Kondo Takafumi Tamura Hideki Matsumura Kiyoshi Fukunaga Tatsuya Oda Nobuhiro Ohkohchi | 2013 | World Journal of Gastroenterology2013，19，9： | 6 |
| 18 | Endoscopic papillary large balloon dilation for removal of bile duct stones显示文摘AIM:To investigate the efficacy and outcomes of endoscopic papillary large balloon dilation(EPLBD)for bile duct stones in a multicenter prospective study.METHODS:Lithotomy by EPLBD was conducted in 124patients with bile duct stones≥13 mm in size or with three or more bile duct stones≥10 mm.After endoscopic sphincterotomy,the papilla was dilated using balloons 12-20 mm in diameter fitting the bile duct diameter.RESULTS:The success rate of first-time lithotomy was 86.3%(107/124)and the final lithotomy success rate was 100%(124/124).Lithotripsy was needed in10 of the 124(13.6%)patients.Adverse events due to the treatment procedure occurred in 6(4.8%)patients,all of which were mild.Performing large balloon dilation after endoscopic sphincterotomy in patients with large stones or multiple stones in the bile duct is considered to ensure the safety of treatment and to reduce the need for lithotripsy.CONCLUSION:It is suggested that treatment by EPLBD for large bile duct stones may be safe and useful. | Yuji Sakai Toshio Tsuyuguchi Yoshiaki Kawaguchi Nobuto Hirata So Nakaji Katsuya Kitamura Shigeru Mikami Tatsuya Fujimoto Masashi Ijima Eishin Kurihara Shuhei Oana Takayoshi Nishino Ryo Tamura Dai Sakamoto Masato Nakamura Takao Nishikawa Harutoshi Sugiyama Hitoshi Yoshida Tetsuya Mine Osamu Yokosuka | 2014 | World Journal of Gastroenterology2014，20，45： | 6 |
| 19 | Adiponectin deficiency exacerbates lipopolysaccharide/ D-galactosamine-induced liver injury in mice显示文摘瞄准:在 Kupffer 房间的功能上检验 adiponectin 的效果,脂肪的多糖(LPS ) 的关键调节的人导致了肝损伤。方法:D-galactosamine (GalN ) 和 LPS intraperitoneally 被注入 adiponectin-/- 老鼠和野类型老鼠。Kupffer 房间,从 Sprague-Dawley 孤立老鼠,是 preincubated 与或没有 adiponectin,然后与 LPS 对待。结果:在猛烈老鼠, GalN/LPS 注射显著地降低了幸存率,显著地提起了丙氨酸转氨酶和肿瘤坏死 factor-alpha (TNF-alpha ) 的血浆层次并且显著地减少了与野类型老鼠相比的 IL-10 层次。在肝的 TNF-alpha 基因表示是哪个更高并且 IL-10 的那些比在野类型老鼠在猛烈老鼠是更低的。在有教养的 adiponectin-pre-treated Kupffer 房间, LPS 显著地降低了 TNF-alpha 层次并且在培养基和他们的各自的基因表示层次提起了 IL-10 层次,与没有 adiponectin-pre-treatment 的 Kupffer 房间相比。结论:Adiponectin supresses TNF-alpha 生产并且响应 LPS 刺激由 Kupffer 房间导致 IL-10 生产,并且 adiponectin 的缺乏提高导致 LPS 的肝损伤。 | Hitoshi Matsumoto Shinji Tamura Yoshihiro Kamada Shinichi Kiso Juichi Fukushima Akira Wada Norikazu Maeda Shinji Kihara Tohru Funahashi Yuji Matsuzawa Iichiro Shimomura Norio Hayashi | 2006 | World Journal of Gastroenterology2006，12，21： | 5 |
| 20 | Efficacy of endoluminal gastroplication in Japanese patients with proton pump inhibitor-resistant,non-erosive esophagitis显示文摘AIM:To evaluate the efficacy,safety,and long-term outcomes of endoluminal gastroplication(ELGP) in patients with proton pump inhibitor(PPI)-resistant,nonerosive reflux disease(NERD).METHODS:The subjects were NERD patients,diagnosed by upper endoscopy before PPI use,who had symptoms such as heartburn or reflux sensations two or more times a week even after 8 wk of full-dose PPI treatment.Prior to ELGP,while continuing full-dose PPI medication,patients' symptoms and quality of life(QOL) were assessed using the questionnaire for the diagnosis of reflux disease,the frequency scale for symptoms of gastro-esophageal reflux disease(FSSG),gastrointestinal symptoms rating scale,a 36-item short-form.In addition,24-h esophageal pH monitoring or 24-h intraesophageal pH/impedance(MII-pH) monitoring was performed.The Bard EndoCinch TM was used for ELGP,and 2 or 3 plications were made.After ELGP,all acid reducers were temporarily discontinued,and medication was resumed depending on the development and severity of symptoms.Three mo after ELGP,symptoms,QOL,pH or MII-pH monitoring,number of plications,and PPI medication were evaluated.Further,symptoms,number of plications,and PPI medication were evaluated 12 mo after ELGP to investigate long-term effects.RESULTS:The mean FSSG score decreased significantly from before ELGP to 3 and 12 mo after ELGP(19.1 ± 10.5 to 10.3 ± 7.4 and 9.3 ± 9.9,P < 0.05,respectively).The total number of plications decreased gradually at 3 and 12 mo after ELGP(2.4 ± 0.8 to 1.2 ± 0.8 and 0.8 ± 1.0,P < 0.05,respectively).The FSSG scores in cases with no remaining plications and in cases with one or more remaining plications were 4.4 and 2.7,respectively,after 3 mo,and 2.0 and 2.8,respectively,after 12 mo,showing no correlation to plication loss.On pH monitoring,there was no difference in the percent time pH < 4 from before ELGP to 3 mo after.Impedance monitoring revealed no changes in the number of reflux episodes or the symptom index for reflux events from before ELGP to 3 mo after,but the symptom sensitivity index decreased significantly 3 mo after ELGP(16.1 ± 12.9 to 3.9 ± 8.3,P < 0.01).At 3 mo after ELGP,6 patients(31.6%) had reduced their PPI medication by 50% or more,and 11 patients(57.9%) were able to discontinue PPI medication altogether.After 12 mo,3 patients(16.7%) were able to reduce the amount of PPI medication by 50% or more,and 12 patients(66.7%) were able to discontinue PPI medication altogether.A high percentage of cases with remaining plications had discontinued PPIs medication after 3 mo,but there was no difference after 12 mo.No serious complications were observed in this study.CONCLUSION:ELGP was safe,resulted in significant improvement in subjective symptoms,and allowed less medication to be used over the long term in patients with PPI-refractory NERD. | Kentaro Tokudome Yasushi Funaki Makoto Sasaki Shinya Izawa Yasuhiro Tamura Akihito Iida Naotaka Ogasawara Toshihiro Konagaya Yoshifumi Tokura Kunio Kasugai | 2012 | World Journal of Gastroenterology2012，18，41： | 5 |
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