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| 1 | Prognostic value of KRAS and BRAF mutations in curatively resected colorectal cancer显示文摘AIM: To investigate the prognostic role of KRAS and BRAF mutations after adjustment for microsatellite instability(MSI) status in Japanese colorectal cancer(CRC) population.METHODS: We assessed KRAS and BRAF mutations and MSI status in 813 Japanese patients with curatively resected, stage Ⅰ-Ⅲ CRC and examined associations of these mutations with disease-free survival(DFS) and overall survival(OS) using uni- and multivariate Cox proportional hazards models.RESULTS: KRAS and BRAF mutations were detected in 312(38%) of 812 and 40(5%) of 811 tumors, respectively. KRAS mutations occurred more frequently in females than in males(P = 0.02), while the presence of BRAF mutations was significantly associated with the female gender(P = 0.006), proximal tumor location(P < 0.001), mucinous or poorly differentiated histology(P < 0.001), and MSI-high tumors(P < 0.001). After adjusting for relevant variables, including MSI status, KRAS mutations were associated with poorer DFS(HR = 1.35; 95%CI: 1.03-1.75) and OS(HR = 1.46; 95%CI: 1.09-1.97). BRAF mutations were poor prognostic factors for DFS(HR = 2.20; 95%CI: 1.19-4.06) and OS(HR = 2.30; 95%CI: 1.15-4.71). Neither the BRAF by MSI interaction test nor the KRAS by MSI interaction test yielded statistically significant results for DFS and OS.CONCLUSION: KRAS and BRAF mutations are associated with inferior survival, independent of MSI status, inJapanese patients with curatively resected CRC. | Shigenori Kadowaki Miho Kakuta Shuhei Takahashi Akemi Takahashi Yoshiko Arai Yoji Nishimura Toshimasa Yatsuoka Akira Ooki Kensei Yamaguchi Keitaro Matsuo Kei Muro Kiwamu Akagi | 2015 | World Journal of Gastroenterology2015，21，4： | 14 |
| 2 | Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: a randomised phase 3 study显示文摘 | Narikazu Boku Seiichiro Yamamoto Haruhiko Fukuda Kuniaki Shirao Toshihiko Doi Akira Sawaki Wasaburo Koizumi Hiroshi Saito Kensei Yamaguchi Hiroya Takiuchi Junichiro Nasu Atsushi Ohtsu | 2009 | Lancet Oncology2009，，11： | 5 |
| 3 | Interleukin 10 inhibits interferon γ- and tumor necrosis factor α-stimulated activation of NADPH oxidase 1 in human colonic epithelial cells and the mouse colon显示文摘 | Mai Kamizato Kensei Nishida Kiyoshi Masuda Keiko Takeo Yuta Yamamoto Tomoko Kawai Shigetada Teshima-Kondo Toshihito Tanahashi Kazuhito Rokutan | 2009 | Journal of Gastroenterology2009，，12： | 2 |
| 4 | Long-term outcomes after endoscopic sphincterotomy versus endoscopic papillary balloon dilation for bile duct stones显示文摘 | Ichiro Yasuda Naotaka Fujita Hiroyuki Maguchi Osamu Hasebe Yoshinori Igarashi Akihiko Murakami Hidekazu Mukai Tsuneshi Fujii Kenji Yamao Kensei Maeshiro Tomoko Tada Takeshi Tsujino Yutaka Komatsu | 2010 | Gastrointestinal Endoscopy2010，，6： | 2 |
| 5 | Endoscopic sphincterotomy and endoscopic papillary balloon dilatation for bile duct stones: a prospective randomized controlled multicenter trial显示文摘 | Naotaka Fujita Hiroyuki Maguchi Yutaka Komatsu Ichiro Yasuda Osamu Hasebe Yoshinori Igarashi Akihiko Murakami Hidekazu Mukai Tsuneshi Fujii Kenji Yamao Kensei Maeshiro | 2003 | Gastrointestinal Endoscopy2003，，2： | 2 |
| 6 | Sustainable Development: Framework for a general theory显示文摘 | Kensei H | 1998 | Human Systems Management1998，17，4： | 1 |
| 7 | Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: a randomised phase 3 study显示文摘 | Narikazu Boku Seiichiro Yamamoto Haruhiko Fukuda Kuniaki Shirao Toshihiko Doi Akira Sawaki Wasaburo Koizumi Hiroshi Saito Kensei Yamaguchi Hiroya Takiuchi Junichiro Nasu Atsushi Ohtsu | 2009 | Lancet Oncology2009，，11： | 1 |
| 8 | Visualization of nascent tumor angiogenesis in lung and liver metastasis by differential dual-color fluorescence imaging in nestin-linked-GFP mice显示文摘 | Yasuyuki Amoh Michael Bouvet Lingna Li Kazuhiko Tsuji A. R. Moossa Kensei Katsuoka Robert M. Hoffman | 2006 | Clinical & Experimental Metastasis (-)2006，，7： | 1 |
| 9 | Effect of low-density lipoprotein cholesterol apheresis on blood viscosity显示文摘 | Moriarty PM Gibson CA Kensey KR | 2004 | Am J Cardiol2004，93，8： | 1 |
| 10 | Patterns and Predictors of Fast Food Consumption After Acute Myocardial Infarction显示文摘 | Adam C. Salisbury Paul S. Chan Kensey L. Gosch Donna M. Buchanan John A. Spertus | 2011 | The American Journal of Cardiology2011，，8： | 1 |
| 11 | Phase II study of S-1 as first-line treatment for elderly patients over 75 years of age with advanced gastric cancer: the Tokyo Cooperative Oncology Group study显示文摘 | Wasaburo Koizumi Toshikazu Akiya Atsushi Sato Toshikazu Sakuyama Eisaku Sasaki Takashi Tomidokoro Tsutomu Hamada Mototsugu Fujimori Yoshinori Kikuchi Ken Shimada Tetsuya Mine Kensei Yamaguchi Tsuneo Sasaki Minoru Kurihara | 2010 | Cancer Chemotherapy and Pharmacology2010，，： | 1 |
| 12 | Reaction of amino acids in a supercritical water-flow reactor simulating submarine hydrothermal systems显示文摘 | Nazrul I Taleo K Kensei K | 2003 | Bulletin of the Chemical Society of Japan2003，76，6： | 1 |
| 13 | Prognostication and Risk-Adapted Therapy of Hodgkin’s Lymphoma Using Positron Emission Tomography显示文摘 | Yvette L. Kasamon Kensei Tobinai | 2010 | Advances in Hematology2010，，： | 1 |
| 14 | Recanalization of obstructed arteries with a flexible, rotating tip catheter 显示文摘 | Kensey KR Nash JE Abrahams C | 1987 | Radiology1987，165，2： | 1 |
| 15 | A novel regulatory pathway for cholesterol degradation via lactostatin 显示文摘 | Kensei M | 2007 | Biochem Biophysical Res Communications2007，352，3： | 1 |
| 16 | Detection of RB Germline Mutations Using Exon-by-exon Heteroduplex Analysis Compared with SSCP显示文摘Purpose: To compare heteroduplex analysis with SSCP and to develop a simple and effective method for mutational screening of RB gene.Materials and Methods: Leukocyte DNA was prepared from 12 unrelated Japanese patients with hereditary retinoblstoma. PCR combined with simultaneous nonisotopic heteroduplex and SSCP analysis was used to screen leukocyte DNA for such mutations, exon-by-exon, without the use of restriction endonu-clease digestion. PCR was conducted using 28 pairs of primers flanking all 27 ex-ons and the promoter region of the RB gene, with PCR products ranging from 159bp to 326bp. Mutations were identified by sequencing.Results: Heterozygous germline mutations were detected in 8 of 12 Japanese patients. The mutations were identified by sequencing as follows; G→C/acceptor of exon 11, T insertion/codon 389, C→T/codon 455, 33bp insertion/codon 455 (C GA), G→T/codon 533, C→T/codon 579, C deletion/codon 674, and C→T/ codon 787.Conclusion: Our results suggest that small RB gene mutations | Kensei Minoda | 1996 | Eye Science1996，16，3： | 1 |
| 17 | Effects of the non-Newtonian viscosity of blood in flows in a diseased arterial vessel--part 1 : steady flows显示文摘 | Cho Y I Kensey K R | 1991 | JBiorheol1991，28，34： | 1 |
| 18 | Variation of whole blood viscosity using Rhelog(TM)-a new scanning capillary viscometer显示文摘 | Wang S H Boss A H Kensey K R | 2003 | Clinica Chimica Acta2003，33，2： | 1 |
| 19 | Nucleolin as cell surface receptor for tumor necrosis factor-α inducing protein: a carcinogenic factor of Helicobacter pylori显示文摘 | Tatsuro Watanabe Hideaki Tsuge Takahito Imagawa Daisuke Kise Kazuya Hirano Masatoshi Beppu Atsushi Takahashi Kensei Yamaguchi Hirota Fujiki Masami Suganuma | 2010 | Journal of Cancer Research and Clinical Oncology2010，，6： | 1 |
| 20 | Electron micrscopic observation of established chondrocytes derived from human intervertebral disc hermia(KTN-1) and role of macrophages in spontaneous regression of degenerated tissues显示文摘 | Michiyo T Kensei N | 2001 | Sipne J2001，1，6： | 1 |
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