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| 1 | ARID1A expression in gastric adenocarcinoma:Clinicopathological significance and correlation with DNA mismatch repair status显示文摘AIM:To analyze the mismatch repair(MMR)status and the ARID1A expression as well as their clinicopathological significance in gastric adenocarcinomas.METHODS:We examined the expressions of MMR proteins and ARID1A by immunohistochemistry in consecutive 489 primary gastric adenocarcinomas.The results were further correlated with clinicopathological variables.RESULTS:The loss of any MMR protein expression,indicative of MMR deficiency,was observed in 38cases(7.8%)and was significantly associated with an older age(68.6±9.2 vs 60.4±11.7,P<0.001),a female sex(55.3%vs 31.3%,P=0.004),an antral location(44.7%vs 25.7%,P=0.021),and a differentiated histology(57.9%vs 39.7%,P=0.023).Abnormal ARID1A expression,including reduced or loss of ARID1A expression,was observed in 109 cases(22.3%)and was significantly correlated with lymphatic invasion(80.7%vs 69.5%,P=0.022)and lymph node metastasis(83.5%vs 73.7%,P=0.042).The tumors with abnormal ARID1A expression more frequently indicated MMR deficiency(47.4%vs 20.2%,P<0.001).A multivariate analysis identified abnormal ARID1A expression as an independent poor prognostic factor(HR=1.36,95%CI:1.01-1.84;P=0.040).CONCLUSION:Our observations suggest that the AIRD1A inactivation is associated with lymphatic invasion,lymph node metastasis,poor prognosis,and MMR deficiency in gastric adenocarcinomas. | Ryo Inada Shigeki Sekine Hirokazu Taniguchi Hitoshi Tsuda Hitoshi Katai Toshiyoshi Fujiwara Ryoji Kushima | 2015 | World Journal of Gastroenterology2015，21，7： | 7 |
| 2 | Impact of time from diagnosis to chemotherapy in advanced gastric cancer: A Propensity Score Matching Study to Balance Prognostic Factors显示文摘BACKGROUND It is unclear whether treatment delay affects the clinical outcomes of chemotherapy in advanced gastric cancer(A-GC).AIM To assess whether treatment delay affects the clinical outcomes of chemotherapy in A-GC.METHODS This single-center retrospective study examined consecutive patients with A-GC between April 2012 and July 2018. In total, 110 patients with stage Ⅳ A-GC who underwent chemotherapy were enrolled. We defined the wait time(WT) as the interval between diagnosis and chemotherapy initiation. We evaluated the influence of WT on overall survival(OS).RESULTS The mean OS was 303 d. The median WT was 17 d. We divided the patients into early and elective WT groups, with a 2-wk cutoff point. There were 46 and 64 patients in the early and elective WT groups, respectively. Compared with the elective WT group, the early WT group had significantly lower albumin(Alb)levels and higher neutrophil/lymphocyte ratios and C-reactive protein(CRP)levels but not a lower performance status. The elective WT group underwent more combination chemotherapy than did the early WT group. OS was different between the two groups(230 d vs 340 d, respectively). Multivariate analysis revealed that higher CRP levels, lower Alb levels and monotherapy were significantly related to a poor prognosis. To minimize potential selection bias,patients in the elective WT group were 1:1 propensity score matched with patients in the early WT group; no significant difference in OS was found(303 d vs 311 d, respectively, log-rank P = 0.9832).CONCLUSION A longer WT in patients with A-GC does not appear to be associated with a worse prognosis. | Tsutomu Nishida Aya Sugimoto Ryo Tomita Yu Higaki Naoto Osugi Kei Takahashi Kaori Mukai Tokuhiro Matsubara Dai Nakamatsu Shiro Hayashi Masashi Yamamoto Sachiko Nakajima Koji Fukui Masami Inada | 2019 | World Journal of Gastrointestinal Oncology2019，11，1： | 4 |
| 3 | A case-matched comparison of the short-term outcomes between laparoscopic and open abdominoperineal resection for rectal cancer显示文摘 | Ryo Inada Seiichiro Yamamoto Taihei Oshiro Masashi Takawa Shin Fujita Takayuki Akasu | 2014 | Surgery Today2014，，4： | 1 |
| 4 | Risk Factors for Anastomotic Leakage After Laparoscopic Surgery for Rectal Cancer Using a Stapling Technique显示文摘 | Seiichiro Yamamoto Shin Fujita Takayuki Akasu Ryo Inada Yoshihiro Moriya Seiichiro Yamamoto | 2012 | Surgical Laparoscopy, Endoscopy & Percutaneous Techniques2012，，3： | 1 |
| 5 | Effectiveness of an energy-consumption information system for residential buildings显示文摘 | Tsuyoshi Ueno Ryo Inada Osamu Saeki | 2006 | Applied Energy2006，83，8： | 1 |
| 6 | CFD simulations and experiments of flow fluetuations around a steam control valve显示文摘 | RYO Morita FUMIO Inada MIEHITSUGU Mori | 2007 | ASME Journal of Fluids Engineering2007，129，1： | 1 |
| 7 | Intussusception due to rectal adenocarcinoma in a young adult:A case report显示文摘An intussusception due to colonic adenocarcinoma has sometimes been reported.However,to the best of our knowledge,reports of intussusception due to rectal adenocarcinoma are extremely rare.In this report,the case of a young man with rectal adenocarcinoma causing intussusception is described.A 24-year-old man visited a hospital complaining of abdominal pain,and an upper rectal cancer was diagnosed by colonoscopy.Computed tomography showed intussusception caused by a large tumor in the pelvis and absence of distant metastases.Locally advanced rectal cancer causing intussusception was diagnosed,and a low anterior resection was performed.Intraoperatively,repair of the invagination could not be accomplished easily;therefore,the repair was abandoned.Instead,the tumor was removed en bloc to avoid dissemination of the cancer.Histopathologically,the tumor was diagnosed as a poorly differentiated adenocarcinoma,pStageⅡA.The patient has no evidence of recurrence at 10 mo after the operation. | Ryo Inada Takeshi Nagasaka Toshiaki Toshima Yoshiko Mori Yoshitaka Kondo Hiroyuki Kishimoto Toshiyoshi Fujiwara | 2014 | World Journal of Gastroenterology2014，20，35： | 0 |
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