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| 1 | Arterial steroid injection therapy can inhibit the progression of severe acute hepatic failure toward fulminant liver failure显示文摘AIM: To utilize transcatheter arterial steroid injection therapy (TASIT) via the hepatic artery to reduce hepatic macrophage activity in patients with severe acute hepatic failure.METHODS: Thirty-four patients with severe acute hepatic failure were admitted to our hospital between June 2002 to June 2006 providing for the possibility of liver transplantation (LT). Seventeen patients were treated using traditional liver supportive procedures, and the other 17 patients additionally underwent TASIT with 1000 mg methylprednisolone per day for 3 continuous days. RESULTS: Of the 17 patients who received TASIT, 13 were cured without any complications, 2 died, and 2 underwent LT. Of the 17 patients who did not receive TASIT, 4 were self-limiting, 7 died, and 6 underwent LT. Univariate logistic analysis revealed that ascites, serum albumin, prothrombin time, platelet count, and TASIT were significant variables for predicating the prognosis. Multivariate logistic regression analysis using stepwise variable selection showed that prothrombin time, platelet count, and TASIT were independent predictive factors. CONCLUSION: TASIT might effectively prevent the progression of severe acute hepatic failure to a fatal stage of fulminant liver failure. | Kazuhiro Kotoh Munechika Enjoji Makoto Nakamuta Tsuyoshi Yoshimoto Motoyuki Kohjima Shusuke Morizono Shinsaku Yamashita Yuki Horikawa Kengo Yoshimitsu Tsuyoshi Tajima Yoshiki Asayama Kousei Ishigami Masakazu Hirakawa | 2006 | World Journal of Gastroenterology2006，12，41： | 13 |
| 2 | Synthesis and luminescent properties of low oxygen contained Eu^(2+)-doped Ca-α-SiAlON phosphor from calcium cyanamide reduction显示文摘A new convenient calcium cyanamide (CaCN2) reduction route was developed to synthesize the Eu2+ activated Ca-α-SiAlON phosphors containing low oxygen content. The luminescence properties of the obtained products were investigated for white LEDs applica- tion. The critical Eu2+ concentration in various hosts and its effect on the photoluminescence properties were studied. The optimized sample (10at.% Eu2+ vs. Ca2+) could be efficiently excited by the current GaN/InGaN blue LED chips and provided emission intensity competitive with that of YAG:Ce3+ (P46-Y3) standard, revealing that this phosphor was a potential candidate for phosphor-converted white LEDs. | PIAO Xianqing Ken-ichi Machida Takashi Horikawa Hiromasa Hanzawa | 2008 | Journal of Rare Earths2008，26，2： | 7 |
| 3 | 负载金催化剂上CO氧化反应活性与金属氧化物载体中金属-氧结合能之间的关系(英文)显示文摘讨论了金属氧化物载体(MO_x)对其负载纳米金催化剂(Au/MO_x)上CO氧化反应的影响.采用典型的共沉淀法和沉积-沉淀法在完全相同的焙烧条件下制备了一系列MO_x负载金催化剂,以CO氧化转化50%时的反应温度(T_(1/2))定量评价了MO_x载体和Au/MO_x催化剂的催化活性.进一步将MO_x载体与相应Au/MO_x催化剂的T_(1/2)值之差对MO_x载体的金属-氧结合能做曲线进行关联,发现二者呈明显的火山型关系.这一结果表明,采用具有适当金属-氧结合能(300–500 atom O)的MO_x可大大提高沉积于其上的Au纳米颗粒的催化活性. | Takashi Fujita Masanori Horikawa Takashi Takei Tom Murayama Masatake Haruta | 2016 | Chinese Journal of Catalysis2016，37，10： | 3 |
| 4 | Efficacy of long-term rifaximin treatment for hepatic encephalopathy in the Japanese显示文摘BACKGROUND Hepatic encephalopathy(HE)is a complication of liver cirrhosis and can result in neuropsychological and neuromuscular dysfunctions in patients.Rifaximin,an antibiotic,has been reported to decrease the occurrence of overt HE and also improve cognitive function in studies from Europe and the United States of America.There is not enough evidence of the relationship between the long-term use of rifaximin and its clinical effects in the Japanese.AIM To determine the clinical effects of long-term rifaximin therapy in decompensated liver cirrhosis patients,with overt HE or hyperammonemia.METHODS In this single-center retrospective observational cohort study,we reviewed the data of 38 patients who had taken rifaximin at the dose of 1200 mg/d for more than 24 wk.The primary outcome measured was the efficacy of long-term rifaximin use,and secondary outcome measured was the safety of its long-term use as determined by its influence on portosystemic shunts as well as Escherichia coli-related infections.Moreover,we compared the prognosis between the rifaximin group and control cases,matched for hepatic elasticity assessed by magnetic resonance ela-stography,age,and Child-Pugh classification.RESULTS Of the 38 patients included in the study,12(31.6%)had overt HE,27(71.1%)had complications of esophageal varices,and 9(23.7%)had hepatocellular carcinoma(HCC).The control group was matched for age,Child-Pugh classification,liver stiffness,and presence of HCC.The median of serum ammonia level before treatment was 104μg/dL(59-297),and 2 wk after treatment,it significantly decreased to 85μg/dL(34-153)(P=0.002).A significantly low value of 80.5μg/dL(44-150)was maintained 24 wk after treatment.The long-term use of rifaximin did not cause a decline in liver function.Diarrhea occurred in 2 patients,who improved with the administration of probiotics,and there were no cases of aborted rifaximin therapy owing to adverse events.In patients with Child C,the survival was short,but there was no significant difference compared with that of the control group.CONCLUSION Rifaximin therapy improves overt HE.The long-term use of rifaximin in the Japanese is effective and safe. | Shinya Nishida Koichi Hamada Noriyuki Nishino Daizo Fukushima Ryota Koyanagi Yoshinori Horikawa Yoshiki Shiwa Satoshi Saitoh | 2019 | World Journal of Hepatology2019，11，6： | 3 |
| 5 | Single-nucleotide polymorphisms in HORMAD1 may be a risk factor for azoospermia caused by meiotic arrest in Japanese patients显示文摘基因机制作为一些男不孕的一个原因被含有,还糟糕被理解。成熟分裂为复制对细菌房间和必需品唯一。synaptonemal 建筑群是为染色体配对,分离和再结合的一个批评部件。因为猛烈雄的老鼠是不肥沃的, Hormad1 为哺乳动物的 gametogenesis 是必要的。在早 pachytene 阶段和 synaptonemal 建筑群的 Hormad1 缺乏的睾丸展览 meiotic 拘捕不能被设想。为了分析人的 HORMAD1 基因缺点与人的精子缺乏被联系的假设,由 meiotic 拘捕引起了, mutational 分析被诊断,精子缺乏源于 meiotic 的 30 个日本人的直接顺序分析在所有编码区域执行拘捕。由顺序分析,三个多型性地点,单个核苷酸多型性 1 (c。163A > G ) , SNP2 (c。501T > G ) 并且 SNP3 (c。918C > T ) ,在 exons 被发现 3, 8 和 10。有精子缺乏和 80 个正常的证明怀孕的、肥沃的人的 30 个病人为 HORMAD1 多型性被分析。SNP1 和 SNP2 与人的精子缺乏由完全的早 meiotic 拘捕引起了被联系(P< 0.05 ) 。我们建议 HORMAD1 让必要 meiotic 在人的精子发生工作。 | Toshinobu Miyamoto Aldra Tsujimura Yasushi Miyagawa Eitetsu Koh Mikio Namiki Michiharu Horikawa Yasuaki Saijo Kazuo Sengoku | 2012 | Asian Journal of Andrology2012，14，4： | 3 |
| 6 | High-density and wide-bandwidth optical interconnects with silicon optical interposers [Invited]显示文摘One of the most serious challenges facing exponential performance growth in the information industry is the bandwidth bottleneck in interchip interconnects.We propose a photonics–electronics convergence system in response to this issue.To demonstrate the feasibility of the system,we fabricated a silicon optical interposer integrated with arrayed laser diodes,spot-size converters,optical splitters,optical modulators,photodetectors,and optical waveguides on a single silicon substrate.Using this system,20 Gbps error-free data links and a 30 Tbps∕cm2 bandwidth density were achieved.This bandwidth density is sufficient to meet the interchip interconnect requirements for the late 2010s. | Yutaka Urino Tatsuya Usuki Junichi Fujikata Masashige Ishizaka Koji Yamada Tsuyoshi Horikawa Takahiro Nakamura Yasuhiko Arakawa | 2014 | Photonics Research2014，2，3： | 3 |
| 7 | Efficacy of non-invasive elastometry on staging of hepatic fibrosis显示文摘 | Hidetsugu Saito Shinichiro Tada Nobuhiro Nakamoto Kumi Kitamura Hitomi Horikawa Satoshi Kurita Yoshimasa Saito Hirokata Iwai Hiromasa Ishii | 2004 | Hepatology Research2004，，2： | 2 |
| 8 | Discrimination between different types of white matter edema with diffusionweighted MR imaging 显示文摘 | Naruse S Horikawa Y | 1993 | J Magn Reson Imaging1993，3，： | 1 |
| 9 | Genetic variation in the gene encoding calpain-10 is assiociated with type 2 diabetes mellitus显示文摘 | Horikawa YOda N Cox NJ | 2000 | Nat Genet2000，26，2： | 1 |
| 10 | Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis 显示文摘 | Matsushita T Horikawa M Iwata Y Tedder T F | 2010 | J Immunol2010，185，4： | 1 |
| 11 | Molecular cloning and characterization of a novel truncated from(ClC-2 beta) of ClC-2 alpha(ClC-2G) in rabbit heart显示文摘 | Furukawa T Horikawa S Terai T | 1995 | FEBS Lett1995，375，： | 1 |
| 12 | Interleukin-23 and interleukin-27 exert quite different antitumor and vaccine effects on poorly immunogenic melanoma显示文摘 | Oniki S Nagai H Horikawa T | 2006 | cancer Res2006，66，12： | 1 |
| 13 | Genetic variations in mi croRNA-related genes are associated with survival and recur- rence in patients with renal cell carcinoma显示文摘 | Lin J Horikawa Y Tamboli P | 2010 | Carcinogenesis2010，31，10： | 1 |
| 14 | Acylated catechinderivatives:inhibitors of DNA polymerase andangiogenesis显示文摘 | Mizushina Y Saito A Horikawa K | 2011 | Front Biosci2011，，3： | 1 |
| 15 | Regulatory B cells ( B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis显示文摘 | Matsushita T Horikawa M Iwata Y | 2010 | J Immunol2010，185，4： | 1 |
| 16 | Melanocyte mitogens induceboth melanocyte chemokinesis and chemotaxis显示文摘 | Horikawa T Yohn J J | 1995 | J InvestDermatol1995，104，2： | 1 |
| 17 | Low-dose cytarabine and aclarubicin in combination with granulocyte colony-stimulating factor for elderly patients with previously untreated acute myeloid leukemia显示文摘 | Hitoshi Suzushima Naoko Wada Hiroshi Yamasaki Kenichiro Eto Taizo Shimomura Michiko H. Kugimiya Kentaro Horikawa Shintaro Nishimura Hiroyuki Tsuda Hiroaki Mitsuya Norio Asou | 2009 | Leukemia Research2009，，5： | 1 |
| 18 | N2 fixation variability in the oligotrophic Sulu Sea, western equatorial Pacific region over the past 83 kyr显示文摘 | HORIKAWA K MINAGAWA M KATO Y | 2006 | Journal of Oceanography2006，62，： | 1 |
| 19 | Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis 显示文摘 | Matsushita T Horikawa M Iwata Y | 2010 | J Irnmunol2010，185，4： | 1 |
| 20 | Cloning and characterization of the promoter region of telomerase reverse transcriptase gene显示文摘 | Horikawa I Cable P L Afshari C | 1999 | Cancer Res1999，59，4： | 1 |
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