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| 1 | Interventional treatment for unresectable hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the sixth most common cancer and third leading cause of cancer-related death in the world. The Barcelona clinic liver cancer classification is the current standard classification system for the clinical management of patients with HCC and suggests that patients with intermediate-stage HCC benefit from transcatheter arterial chemoembolization(TACE). Interventional treatments such as TACE, balloon-occluded TACE, drug-eluting bead embolization, radioembolization, and combined therapies including TACE and radiofrequency ablation, continue to evolve, resulting in improved patient prognosis. However, patients with advanced-stage HCC typically receive only chemotherapy with sorafenib, a multi-kinase inhibitor, or palliative and conservative therapy. Most patients receive palliative or conservative therapy only, and approximately 50% of patients with HCC are candidatesfor systemic therapy. However, these patients require therapy that is more effective than sorafenib or conservative treatment. Several researchers try to perform more effective therapies, such as combined therapies(TACE with radiotherapy and sorafenib with TACE), modified TACE for HCC with arterioportal or arteriohepatic vein shunts, TACE based on hepatic hemodynamics, and isolated hepatic perfusion. This review summarizes the published data and data on important ongoing studies concerning interventional treatments for unresectable HCC and discusses the technical improvements in these interventions, particularly for advanced-stage HCC. | Satoru Murata Takahiko Mine Fumie Sugihara Daisuke Yasui Hidenori Yamaguchi Tatsuo Ueda Shiro Onozawa Shin-ichiro Kumita | 2014 | World Journal of Gastroenterology2014，20，37： | 38 |
| 2 | 4气门直喷式柴油机的涡流形成过程显示文摘降低排气污染是柴油机一项迫切而重要的任务。每缸4气门的布置方案是实现该目标而采取的一项先进技术。阐述了使用稳态气流装置。通过试验方法2气门和4气门缸盖的缸内空气运动的形成过程。试验时,分别使用示踪激光片技术(TLS)和激光多普勒测速仪(LDV)进行显像和测速。采用示踪激光片技术和激光多普勒测速仪进行显像并测量了2气门和4气门缸盖的缸内空气运动。2气门气缸盖主要依靠螺旋气道来的强旋涡产生涡流运动。当涡流向下流过气缸时,同时由气缸中心向气缸周边扩散。与此相反,4气门气缸盖则主要依靠切向和螺旋气道来的、沿气缸周边处的强气流产生涡流运动。随着气流的继续流动,外部气流不断影响内部气流。当诸如2气门与4气门缸盖间的气流图像变化很大时,最好采用脉动式涡流计而不是叶片式涡流计来测量总涡流强度。 | Aoyagi Y Yokota H Sugihara H 瞿俊鸣 | 1996 | 国外内燃机1996，28，1： | 8 |
| 3 | Evaluation of the relationship between hepatocellular carcinoma location and transarterial chemoembolization efficacy显示文摘AIM To evaluate the relationship between the location of hepatocellular carcinoma(HCC) and the efficacy of transarterial chemoembolization(TACE).METHODS We evaluated 115 patients(127 nodules), excluding recurrent nodules, treated with TACE between January 2011 and June 2014. TACE efficacy was evaluated according to m RECIST. The HCC location coefficient was calculated as the distance from the central portal portion to the HCC center(mm)/liver diameter(mm) on multiplanar reconstruction images rendered(MPR) to visualize bifurcation of the right and left branches of the portal vein and HCC center. The HCC location coefficient was compared between complete response(CR) and non-CR groups in Child-Pugh grade A and B patients.RESULTS The median location coefficient of HCC among all nodules, the right lobe, and the medial segment was significantly higher in the CR group than in the non-CR group in the Child-Pugh grade A patients(0.82 vs 0.62, P < 0.001; 0.71 vs 0.59, P < 0.01; 0.81 vs 0.49, P < 0.05, respectively). However, there was no significant difference in the median location coefficient of the HCC in the lateral segment between in the CR and in the non-CR groups(0.67 vs 0.65, P > 0.05). On the other hand, in the Child-Pugh grade B patients, the HCC median location coefficient in each lobe and segment was not significantly different between in the CR and in the non-CR groups.CONCLUSION Improved TACE efficacy may be obtained for HCC in the peripheral zone of the right lobe and the medial segment in Child-Pugh grade A patients. | Izumi Miki Satoru Murata Fumio Uchiyama Daisuke Yasui Tatsuo Ueda Fumie Sugihara Hidemasa Saito Hidenori Yamaguchi Ryusuke Murakami Chiaki Kawamoto Eiji Uchida Shin-ichiro Kumita | 2017 | World Journal of Gastroenterology2017，23，35： | 8 |
| 4 | Nature:单核细胞SatM导致组织纤维化显示文摘在一项新的研究中,来自日本大阪大学免疫学前沿研究中心(IFReC)的研究人员报道了一类新的他们称之为SatM的单核细胞。针对小鼠的研究表明SatNI可能是导致组织纤维化的原因,而且成为一种治疗很少有有效疗法的疾病的新药物靶标。 | Takashi Satoh, Katsuhiro Nakagawa, Fumihiro Yamane, Kiyoharu Fukushima, Isao Ebina Shizuo Akira Takashi Satoh, Katsuhiro Nakagawa, Fumihiro Yamane, Kiyoharu Fukushima, Isao Ebina Shizuo Akira Fuminori Sugihara Yoshichika Yoshioka Ryusuke Kuwahara Motooki Ashihara, Yosuke Minowa Isao Ebina Atsushi Kumanogoh Atsushi Kumanogoh | 2017 | 现代生物医学进展2017，17，3： | 7 |
| 5 | Potential mechanism of corpus-predominant gastritis after PPI therapy in Helicobacter pylori-positive patients with GERD显示文摘The long-term use of proton pump inhibitors(PPIs)exacerbates corpus atrophic gastritis in patients with Helicobacter pylori(H.pylori)infection.To identify a potential mechanism for this change,we discuss interactions between pH,bile acids,and H.pylori.Duodenogastric reflux,which includes bile,occurs in healthy individuals,and bile reflux is increased in patients with gastroesophageal reflux disease(GERD).Diluted human plasma and bile acids have been found to be significant chemoattractants and chemorepellents,respectively,for the bacillus H.pylori.Although only taurine conjugates,with a pKa of 1.8-1.9,are soluble in an acidic environment,glycine conjugates,with a pKa of 4.3-5.2,as well as taurine-conjugated bile acids are soluble in the presence of PPI therapy.Thus,the soluble bile acid concentrations in the gastric contents of patients with GERD after continuous PPI therapy are considerably higher than that in those with intact acid production.In the distal stomach,the high concentration of soluble bile acids is likely to act as a bactericide or chemorepellent for H.pylori.In contrast,the mucous layer in the proximal stomach has an optimal bile concentration that forms chemotactic gradients with plasma components required to direct H.pylori to the epithelial surface.H.pylori may then colonize in the stomach body rather than in the pyloric antrum,which may explain the occurrence of corpus-predominant gastritis after PPI therapy in H.pylori-positive patients with GERD. | Ken-ichi Mukaisho Tadashi Hagiwara Takahisa Nakayama Takanori Hattori Hiroyuki Sugihara | 2014 | World Journal of Gastroenterology2014，20，34： | 5 |
| 6 | 人类胚胎植入过程中的细胞黏附分子(英文)显示文摘人类胚胎植入过程不仅受到在进化上保守的机制调节,而且也受到人类一种独有的机制调节。有证据显示,细胞黏附分子L-选择蛋白和trophinin在人类胚胎植入过程扮演独特的角色。在本文中,我们描述了L-选择素和trophinin的黏蛋白糖配体的双重作用,也描述了trophinin相关蛋白bystin和tastin的双重作用。我们随后描述了滋养外胚层细胞和子宫内膜上皮细胞中由trophinin调节的信号转导。本综述也涵盖了钙依粘连蛋白和整合素在人类胚胎植入过程中的作用。 | Michiko N.Fukuda Kazuhiro Sugihara | 2012 | 生理学报2012，64，3： | 4 |
| 7 | A Multicenter Study on Oncologic Outcome of Laparoscopic Gastrectomy for Early Cancer in Japan显示文摘 | Seigo Kitano Norio Shiraishi Ichiro Uyama Kenichi Sugihara Nobuhiko Tanigawa | 2007 | Annals of Surgery2007，，1： | 4 |
| 8 | Surgical management and chemoradiotherapy of T1 rectal cancer显示文摘 | Hirotoshi Kobayashi Kenichi Sugihara | 2013 | Digestive Endoscopy2013，，： | 3 |
| 9 | Distribution of HBV genotypes among HBV carriers in Benin:phylogenetic analysis and virological characteristics of HBV genotype E显示文摘AIM: To determine the distribution of Hepatitis B virus (HBV) genotypes in Benin, and to clarify the virological characteristics of the dominant genotype.METHODS: Among 500 blood donors in Benin, 21 HBsAg-positive donors were enrolled in the study. HBV genotypes were determined by enzyme immunoassay and restriction fragment length polymorphism. Complete genome sequences were determined by PCR and direct sequencing.RESULTS: HBV genotype E (HBV/E) was detected in 20/21 (95.2%), and HBV/A in 1/21 (4.8%). From the age-specific prevalence of HBeAg to anti-HBe seroconversion (SC) in 19 HBV/E subjects, SC was estimated to occur frequently in late teens in HBV/E.The comparison of four complete HBV/E genomes from HBeAg-positive subjects in this study and five HBV/E sequences recruited from the database revealed that HBV/E was distributed throughout West Africa with very low genetic divers ity (nucleotide homology 96.7-99.2%).Based on the sequences in the basic core promoter (BCP)to precore region of the nine HBV/E isolates compared to those of the other genotypes, a nucleotide substitution in the BCP, G1757A, was observed in HBV/E.CONCLUSION: HBV/E is predominant in the Republic of Benin, and SC is estimated to occur in late teens in HBV/E. The specific nucleotide substitution G1757A in BCP, which might influence the virological characteristics,is observed in HBV/E. | Kei Fujiwara Yasuhito Tanaka Etsuro Orito Tomoyoshi Ohno Takanobu Kato Kanji Sugihara Izumi Hasegawa Mayumi Sakurai Kiyoaki Ito Atsushi Ozasa Yuko Sakamoto Isao Arita Ahmed El-Gohary Agossou Benoit Sophie I Ogoundele-Akplogan Namiko Yoshihara Ryuzo Ueda Masashi Mizokami | 2005 | World Journal of Gastroenterology2005，11，41： | 3 |
| 10 | The rationale behind complete mesocolic excision (CME) and a central vascular ligation for colon cancer in open and laparoscopic surgery显示文摘 | K. S?ndenaa P. Quirke W. Hohenberger K. Sugihara H. Kobayashi H. Kessler G. Brown V. Tudyka A. D’Hoore R. H. Kennedy N. P. West S. H. Kim R. Heald K. E. Storli A. Nesbakken B. Moran | 2014 | International Journal of Colorectal Disease2014，，4： | 3 |
| 11 | Ulcerative colitis patients in clinical remission demonstrate correlations between fecal immunochemical test results, mucosal healing, and risk of relapse显示文摘AIM: To assess the risk of relapse in ulcerative colitis(UC) patients in clinical remission using mucosal status and fecal immunochemical test(FIT) results. METHODS: The clinical outcomes of 194 UC patients in clinical remission who underwent colonoscopy were based on evaluations of Mayo endoscopic subscores(MESs) and FIT results.RESULTS: Patients with an MES of 0(n = 94, 48%) showed a ten-fold lower risk of relapse than those with an MES of 1-3(n = 100, 52%)(HR = 0.10, 95%CI: 0.05-0.19). A negative FIT result(fecal hemoglobin concentrations ≤ 100 ng/m L) was predictive of patients with an MES of 0, with a sensitivity of 0.94 and a specific of 0.76. Moreover, patients with a negative FIT score had a six-fold lower risk of clinical relapse than those with a positive score(HR = 0.17, 95%CI: 0.10-0.28). Inclusion of the distinguishing parameter, sustaining clinical remission > 12 mo, resulted in an even stronger correlation between negative FIT results and an MES of 0 with respect to the risk of clinical relapse(HR = 0.11, 95%CI: 0.04-0.23).CONCLUSION: Negative FIT results one year or more after remission induction correlate with complete mucosal healing(MES 0) and better prognosis. Performing FIT one year after remission induction may be useful for evaluating relapse risk. | Asuka Nakarai Jun Kato Sakiko Hiraoka Shiho Takashima Daisuke Takei Toshihiro Inokuchi Yuusaku Sugihara Masahiro Takahara Keita Harada Hiroyuki Okada | 2016 | World Journal of Gastroenterology2016，22，21： | 3 |
| 12 | Development of a novel endoscopic manipulation system: The Endoscopic operation robot显示文摘AIM: To develop and evaluate the endoscopic operation robot (EOR). The EOR is a robot system designed specifically for remote manipulation of the scope during gastrointestinal endoscopy by a seated endoscopist. METHODS: Total colonoscopy examinations using a colonoscopy training model were performed compared conventional insertion by manual manipulation and remote-controlled insertion, using the EOR. The author investigated the time taken for each of the 50 examinations. RESULTS: The median insertion time (in minutes) for each 10 examinations (EOR vs manual manipulation) was 73.70 ± 25.37 vs 3.77 ± 1.34 in the first group, 38.40 ± 6.24 vs 3.40 ± 0.97 in the second group, 27.6 ± 4.01 vs 2.70 ± 0.95 in the third group, 23.8 ± 3.65 vs 3.10 ± 0.88 in the fourth group, and 22.9 ± 5.02 vs 2.60 ± 1.08 in the fifth group.CONCLUSION: The study suggested the possibility of the clinical application of the EOR. | Keiichiro Kume Takeshi Kuroki Takahiro Sugihara Masafumi Shinngai | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，7： | 3 |
| 13 | Expression of 5-Lipoxygenase in human colorectal cancer显示文摘AIM: To evaluate the 5-lipoxygenases (Loxs) expression level in human colorectal cancer specimens in order to determine its clinicopathologic significance in human tumorigenesis. METHODS: The relative quantity of 5-Lox mRNA in paired 91 colorectal tumor and adjacent normal mucosa samples was determined by real time quantitative PCR. Additionally, the expression of 5-Lox and cyclooxygenase (Cox)-2 proteins was also examined using immunohistochemical staining methods. RESULTS: There was a marked increase in 5-Lox mRNA levels in the tumor compared with paired normal mucosa samples (P < 0.0001). Sixty six (72.5%) tumors showed high 5-Lox mRNA levels. The positivity rate of 5-Lox and Cox-2 protein expression was 68.7% and 79.1% respectively. There was a significant association between tumoral 5-Lox mRNA level and tumor size (Rho = 0.392, P = 0.0002), depth or vessel invasion. CONCLUSION: These results suggest that 5-Lox is up-regulated in colorectal cancer and that inhibition of its expression might be valuable in the prevention and treatment of colorectal cancer. | Labile Togba Soumaoro Satoru Iida Hiroyuki Uetake Megumi Ishiguro Yoko Takagi Tetsuro Higuchi Masamichi Yasuno Masayuki Enomoto Kenichi Sugihara | 2006 | World Journal of Gastroenterology2006，12，39： | 3 |
| 14 | Endoscopic appearance of AIDS-related gastrointestinal lymphoma with c-MYC rearrangements: Case report and literature review显示文摘Acquired immune deficiency syndrome (AIDS)-related lymphoma (ARL) remains the main cause of AIDS-related deaths in the highly active anti-retroviral therapy (HAART) era. Recently, rearrangement of MYC is associated with poor prognosis in patients with diffuse large B-cell lymphoma. Here, we report a rare case of gastrointestinal (GI)-ARL with MYC rearrangements and coinfected with Epstein-Barr virus (EBV) infection presenting with various endoscopic findings. A 38-yearold homosexual man who presented with anemia and was diagnosed with an human immunodeficiency virus infection for the first time. GI endoscopy revealed multiple dish-like lesions, ulcerations, bloody spots, nodular masses with active bleeding in the stomach, erythematous flat lesions in the duodenum, and multiple nodular masses in the colon and rectum. Magnified endoscopy with narrow band imaging showed a honeycomb-like pattern without irregular microvessels in the dish-like lesions of the stomach. Biopsy specimens from the stomach, duodenum, colon, and rectum revealed diffuse large B-cell lymphoma concomitant with EBV infection that was detected by high tissue EBV-polymerase chain reaction levels and Epstein-Barr virus small RNAs in situ hybridization. Fluorescence in situ hybridization analysis revealed a fusion between the immunoglobulin heavy chain (IgH) and c-MYC genes, but not between the IgH and BCL2 loci. After 1-mo of treatment with HAART and R-CHOP, endoscopic appearance improved remarkably, and the histological features of the biopsy specimens revealed no evidence of lymphoma. However, he died from multiple organ failure on the 139 th day after diagnosis. The cause of his poor outcome may be related to MYC rearrangement. The GI tract involvement in ARL is rarely reported, and its endoscopic findings are various and may be different from those in non-AIDS GI lymphoma; thus, we also conducted a literature review of GI-ARL cases. | Shohei Tanaka Naoyoshi Nagata Sohtaro Mine Toru Igari Taiichiro Kobayashi Jun Sugihara Haruhito Honda Katsuji Teruya Yoshimi Kikuchi Shinichi Oka Naomi Uemura | 2013 | World Journal of Gastroenterology2013，19，29： | 3 |
| 15 | Over-the-scope-clipping system for anastomotic leak after colorectal surgery:Report of two cases显示文摘An anastomotic leak is one of the major complications following colorectal surgery.Standard treatments for anastomotic leak are total parenteral nutrition or temporary ileostomy.The over-the-scope-clipping(OTSC)system was originally developed to treat intestinal perforation or to close the tissue after natural orifice transluminal endoscopic surgery.Two cases of successful management of an anastomotic leak after colorectal surgery using the OTSC system are reported.One patient avoided a temporary ileostomy.In the other,hospitalization was shortened by the use of the OTSC system.The OTSC system can be a potential option in the management of anastomotic leaks after colorectal surgery. | Hirotoshi Kobayashi Akifumi Kikuchi Satoshi Okazaki Megumi Ishiguro Toshiaki Ishikawa Satoru Iida Hiroyuki Uetake Kenichi Sugihara | 2014 | World Journal of Gastroenterology2014，20，24： | 2 |
| 16 | Crater and flank wear resistance of cutting tools having micro textured surfaces显示文摘 | Tatsuya Sugihara Toshiyuki Enomoto | 2013 | Precision Engineering2013，，： | 2 |
| 17 | Nearest Neighbourhood Operations with Generalized Voronoi Diagrams:A Review显示文摘 | OKABE A BOOTS B SUGIHARA K | 1994 | International Journal of Geographical Information Systems1994，8，1： | 2 |
| 18 | 临界转换的早期预警信号显示文摘从生态系统到金融市场和气候在内的很多复杂动力系统,都会有临界点,在这样的点上系统可能会发生突变,从而演变到一个对立的动力模式上。在这样的临界点到达之前对其进行预测极为困难,但是现在,不同科学领域的研究工作表明,普遍性的早期预警信号有迹可循。对一系列不同类型的系统来说,这些信号会指示是否正在趋近一个临界阈值。 | Marten Scheffer Jordi Bascompte William A. Brock Victor Brovkin Stephen R. Carpenter Vasilis Dakos Hermann Held Egbert H. van Nes Max Rietkerk George Sugihara 李迎春 闫伟 蒋长胜(译) 左玉玲(校) | 2009 | 国际地震动态2009，，9： | 2 |
| 19 | Over- and under-expressed microRNAs in human colorectal cancer显示文摘 | Kazuo Motoyama Hiroshi Inoue Yasushi Takatsuno Fumiaki Tanaka Koshi Mimori Hiroyuki Uetake Kenichi Sugihara Masaki Mori | 2009 | International Journal of Oncology2009，，4： | 2 |
| 20 | Indication and Benefit of Pelvic Sidewall Dissection for Rectal Cancer显示文摘 | Kenichi Sugihara M.D. Hirotoshi Kobayashi M.D. Tomoyuki Kato M.D. Takeo Mori M.D. Hidetaka Mochizuki M.D. Shingo Kameoka M.D. Kazuo Shirouzu M.D. Tetsuichiro Muto M.D | 2006 | Diseases of the Colon & Rectum2006，，11： | 2 |
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