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3569篇 您的检索式:作者名="Tsuda"
    题名 作者 年代 出处 被引量
1Chemotherapy and molecular targeting therapy for recurrent cervical cancer显示文摘For patients with primary stage IVB, persistent, or recurrent cervical cancer, chemotherapy remains the standard treatment, although it is neither curative nor associated with long-term disease control. In this review, we summarized the history of treatment of recurrent cervical cancer, and the current recommendation for chemotherapy and molecular targeted therapy. Eligible articles were identified by a search of the MEDLINE bibliographical database for the period up to November 30, 2014. The search strategy included the following any or all of the keywords: 'uterine cervical cancer', 'chemotherapy', and 'targeted therapies'. Since cisplatin every 21 days was considered as the historical standard treatment for recurrent cervical cancer, subsequent trials have evaluated and demonstrated activity for other agents including paclitaxel, gemcitabine, topotecan and vinorelbine among others. Accordingly, promising agents were incorporated into phase III trials. To examine the best agent to combine with cisplatin, several landmark phase III clinical trials were conducted by Gynecologic Oncology Group(GOG) and Japan Clinical Oncology Group(JCOG). Through, GOG204 and JCOG0505, paclitaxel/cisplatin(TP) and paclitaxel/carboplatin(TC) are now considered to be the recommended therapies for recurrent cervical cancer patients. However, the prognosis of patients who are already resistant to chemotherapy, are very poor. Therefore new therapeutic strategies are urgently required. Molecular targeted therapy will be the most hopeful candidate of these strategies. From the results of GOG240, bevacizumab combined with TP reached its primary endpoint of improving overall survival(OS). Although, the prognosis for recurrent cervical cancer patients is still poor, the results of GOG240 shed light on the usefulness of molecular target agents to chemotherapy in cancer patients. Recurrent cervical cancer is generally considered incurable and current chemotherapy regiments offer only modest gains in OS, particularly for patients with multiple poor prognostic factors. Therefore, it is crucial to consider not only the survival benefit, but also the minimization of treatment toxicity, and maximization of quality of life(QOL).Naotake Tsuda Hidemichi Watari Kimio Ushijima 2016Chinese Journal of Cancer Research2016,28,2:24
2Effectiveness of probiotic therapy for the prevention of relapse in patients with inactive ulcerative colitis显示文摘AIM: to evaluate the effectiveness of probiotic therapy for suppressing relapse in patients with inactive ulcerative colitis(UC).METHODS: Bio-Three tablets, each containing 2 mg of lactomin(Streptococcus faecalis T-110), 10 mg of Clostridium butyricum TO-A, and 10 mg of Bacillus mesentericus TO-A, were used as probiotic therapy.Sixty outpatients with UC in remission were randomly assigned to receive 9 Bio-Three tablets/day(BioThree group) or 9 placebo tablets/day(placebo group)for 12 mo in addition to their ongoing medications.Clinical symptoms were evaluated monthly or on the exacerbation of symptoms or need for additional medication. Fecal samples were collected to analyze bacterial DNA at baseline and 3-mo intervals. Terminal restriction fragment length polymorphism and cluster analyses were done to examine bacterial components of the fecal microflora.RESULTS: Forty-six patients, 23 in each group,completed the study, and 14 were excluded. The relapse rates in the Bio-Three and placebo groups were respectively 0.0% vs 17.4% at 3 mo(P = 0.036), 8.7%vs 26.1% at 6 mo(P = 0.119), and 21.7% vs 34.8%(P = 0.326) at 9 mo. At 12 mo, the remission rate was 69.5% in the Bio-Three group and 56.6% in the placebo group(P = 0.248). On cluster analysis of fecal flora, 7 patients belonged to cluster Ⅰ, 32 to cluster Ⅱ,and 7 to cluster Ⅲ.CONCLUSION: Probiotics may be effective formaintaining clinical remission in patients with quiescent UC, especially those who belong to cluster Ⅰ on fecal bacterial analysis.Yasushi Yoshimatsu Akihiro Yamada Ryuichi Furukawa Koji Sono Aisaku Osamura Kentaro Nakamura Hiroshi Aoki Yukiko Tsuda Nobuo Hosoe Nobuo Takada Yasuo Suzuki 2015World Journal of Gastroenterology2015,21,19:21
3Lifestyle-related disease in Crohn’s disease: Relapse prevention by a semi-vegetarian diet显示文摘AIM: To investigate whether semi-vegetarian diet (SVD) has a preventive effect against relapse of Crohn’s disease (CD) in patients who have achieved remission,who are a high-risk group for relapse.METHODS: A prospective,single center,2-year clinical trial was conducted.Twenty-two adult CD patients who achieved clinical remission either medically (n = 17) or surgically (n = 5) and consumed an SVD during hospitalization were advised to continue with an SVD and avoid known high-risk foods for inflammatory bowel disease.The primary endpoint was clinical relapse defi ned as the appearance of active symptoms of CD.Kaplan-Meier survival analysis was used to calculate the cumulative proportion of patients who had a relapse.A 2-year analysis of relapse rates of patients who followed an SVD and those who did not (an omnivorous diet group) was undertaken.RESULTS: SVD was continued by 16 patients (compliance 73%).Remission was maintained in 15 of 16 patients (94%) in the SVD group vs two of six (33%)in the omnivorous group.Remission rate with SVD was 100% at 1 year and 92% at 2 years.SVD showed signif icant prevention in the time to relapse compared to that in the omnivorous group (P = 0.0003,log rank test).The concentration of C-reactive protein was normal at the f inal visit in more than half of the patients in remission who were taking an SVD,who maintained remission during the study (9/15;60%),who terminated follow-up (8/12;67%),and who completed 2 years follow-up (7/10;70%).There was no untoward effect of SVD.CONCLUSION: SVD was highly effective in preventing relapse in CD.Mitsuro Chiba Toru Abe Hidehiko Tsuda Takeshi Sugawara Satoko Tsuda Haruhiko Tozawa Katsuhiko Fujiwara Hideo Imai 2010World Journal of Gastroenterology2010,16,20:17
4Modulation of Pain and Itch by Spinal Glia显示文摘Chronic pain and itch are a pathological operation of the somatosensory system at the levels of primary sensory neurons, spinal cord and brain. Pain and itch are clearly distinct sensations, and recent studies have revealed the separate neuronal pathways that are involved in each sensation. However, the mechanisms by which these sensations turn into a pathological chronic state are poorly understood. A proposed mechanism underlying chronic pain and itch involves abnormal excitability in dorsal horn neurons in the spinal cord. Furthermore, an increasing body of evidence from models of chronic pain and itch has indicated that synaptic hyperexcitability in the spinal dorsal horn might not be a consequence simply of changes in neurons, but rather of multiple alterations in glial cells.Thus, understanding the key roles of glial cells may provide us with exciting insights into the mechanisms of chronicity of pain and itch, and lead to new targets for treating chronic pain and itch.Makoto Tsuda 2018Neuroscience Bulletin2018,34,1:13
5云南南部野外与村内蚊虫群落特征的比较研究显示文摘目的 研究云南南部西双版纳州景洪市一亻爱伲族村寨野外及村内蚊虫群落结构 ,探讨蚊类群落在不同环境条件下的分布和种类组成。方法 采用人诱和牛诱 ( 8m× 8m× 2m蚊帐 )通宵捕蚊 ,用群落生态学方法计算群落结构、多样性和均匀性指数。结果 村内群落捕获蚊虫 2亚科 6属 11个亚属 3 6种 2 14 2 6只 ,野外群落捕获 2亚科 4属 10个亚属 3 8种 12 2 19只。两群落优势蚊种基本一致为三带喙库蚊、棕头库蚊、伪杂鳞库蚊、中华按蚊、菲律宾按蚊、克氏按蚊、乌头按蚊和可赫按蚊。优势度村内群落分别为 70 .73、3 1.3 7、2 9.92、3 6.11、2 5 .67、2 7.80、2 1.60、15 .5 8,野外群落分别为 5 8.18、3 1.86、2 9.13、3 4.91、16.5 5、2 6.77、2 4.0 6、2 1.45。多样性指数、均匀性指数和优势集中指数村内分别为 1.78、0 .45和 0 .83 ,野外分别为 2 .0 9、0 .5 8和 0 .81。结论 野外群落较村内丰富 ,两群落组成结构复杂 ,优势蚊种分布均匀。王学忠 杜尊伟 卢勇荣 朱国君 黄荣 顾云安 Masahiro TAKAGI Yoshio TSUDA 2003中国媒介生物学及控制杂志2003,14,5:12
6Irsogladine maleate and rabeprazole in non-erosive reflux disease: A double-blind, placebo-controlled study显示文摘AIM:To evaluate the efficacy of adding irsogladine maleate(IM) to proton-pump inhibitor(PPI) therapy in non-erosive reflux disease(NERD) treatment.METHODS:One hundred patients with NERD were recruited and randomized to receive rabeprazole plus IM(group I) or rabeprazole plus placebo(group P).The efficacy of the treatment was assessed using the Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease(FSSG) and the short form(SF)-36 quality of life questionnaires after four weeks of treatment.We also assessed whether patients with NERD with minimal changes(grade M) had different responses to the therapies compared with patients who did not have minimal changes(grade N).RESULTS:Group I and group P showed significant improvements in their FSSG scores after the treatment(from 17.9 ± 7.9 to 9.0 ± 7.6, and from 17.7 ± 7.3 to 11.2 ± 7.9, respectively, P = 0.0001), but there was no statistically significant difference between the FSSG scores in group I and those in group P.Subgroup analysis showed that significant improvements in the FSSG scores occurred in the patients in group I who had NERD grade N(modified Los Angeles classification)(7.8 ± 7.4 vs 12.5 ± 9.8, P = 0.041).The SF-36 scores for patients with NERD grade N who had received IM and rabeprazole were significantly improved in relation to their vitality and mental health scores.CONCLUSION:The addition of IM to rabeprazole significantly improves gastroesophageal reflux diseasesymptoms and the quality of the lives of patients with NERD grade N.Takayoshi Suzuki Masashi Matsushima Aya Masui Shingo Tsuda Jin Imai Jun Nakamura Yoko Tsukune Tetsufumi Uchida Hiroki Yuhara Muneki Igarashi Jun Koike Tetsuya Mine 2015World Journal of Gastroenterology2015,21,16:8
7ARID1A expression in gastric adenocarcinoma:Clinicopathological significance and correlation with DNA mismatch repair status显示文摘AIM:To analyze the mismatch repair(MMR)status and the ARID1A expression as well as their clinicopathological significance in gastric adenocarcinomas.METHODS:We examined the expressions of MMR proteins and ARID1A by immunohistochemistry in consecutive 489 primary gastric adenocarcinomas.The results were further correlated with clinicopathological variables.RESULTS:The loss of any MMR protein expression,indicative of MMR deficiency,was observed in 38cases(7.8%)and was significantly associated with an older age(68.6±9.2 vs 60.4±11.7,P<0.001),a female sex(55.3%vs 31.3%,P=0.004),an antral location(44.7%vs 25.7%,P=0.021),and a differentiated histology(57.9%vs 39.7%,P=0.023).Abnormal ARID1A expression,including reduced or loss of ARID1A expression,was observed in 109 cases(22.3%)and was significantly correlated with lymphatic invasion(80.7%vs 69.5%,P=0.022)and lymph node metastasis(83.5%vs 73.7%,P=0.042).The tumors with abnormal ARID1A expression more frequently indicated MMR deficiency(47.4%vs 20.2%,P<0.001).A multivariate analysis identified abnormal ARID1A expression as an independent poor prognostic factor(HR=1.36,95%CI:1.01-1.84;P=0.040).CONCLUSION:Our observations suggest that the AIRD1A inactivation is associated with lymphatic invasion,lymph node metastasis,poor prognosis,and MMR deficiency in gastric adenocarcinomas.Ryo Inada Shigeki Sekine Hirokazu Taniguchi Hitoshi Tsuda Hitoshi Katai Toshiyoshi Fujiwara Ryoji Kushima 2015World Journal of Gastroenterology2015,21,7:7
8Occurrence of perfluoroalkyl acids in precipitation from Shenyang,China显示文摘Perfluorosulfonates (PFSAs) and perfluorocarboxylates (PFCAs) in precipitation collected from Shenyang, China were determined. Snow samples were collected in the snow event on March 4, 2007 from 34 sites involving both the urban and suburban areas in Shenyang. The snowmelt was preconcentrated by solid phase extraction and analyzed using LC-MS method. Measurable amounts of perfluoroalkyl acids (PFAS) were found in precipitation samples from Shenyang, demonstrating that wet deposition is one possible pathway for the removing of the selected PFAS chemicals from atmosphere. Major PFAS detected were PFOS (<0.38―51 ng/L), PFOA (0.82―13 ng/L) and PFHpA (0.76―11 ng/L), with their mean concentration of 5.4, 3.3 and 2.9 ng/L, respectively. Other PFSAs and PFCAs were detected at much lower frequency or below the limit of detection in all the samples. The work presented here offers some basis for the investigation on the environmental behavior and the evaluation of human exposure to PFAS.LIU Wei DONG GuangHui JIN YiHe SASAKI Kazuaki SAITO Norimitsu SATO Itaru TSUDA Shuji NAKAYAMA Shoji F 2009Chinese Science Bulletin2009,54,14:6
9Mild closed head traumatic brain injury-induced changes in monoamine neurotransmitters in the trigeminal subnuclei of a rat model:mechanisms underlying orofacial allodynias and headache显示文摘Our recent findings have demonstrated that rodent models of closed head traumatic brain injury exhibit comprehensive evidence of progressive and enduring orofacial allodynias, a hypersensitive pain response induced by non-painful stimulation. These allodynias, tested using thermal hyperalgesia, correlated with changes in several known pain signaling receptors and molecules along the trigeminal pain pathway, especially in the trigeminal nucleus caudalis. This study focused to extend our previous work to investigate the changes in monoamine neurotransmitter immunoreactivity changes in spinal trigeminal nucleus oralis, pars interpolaris and nucleus tractus solitaries following mild to moderate closed head traumatic brain injury, which are related to tactile allodynia, touch-pressure sensitivity, and visceral pain. Our results exhibited significant alterations in the excitatory monoamine, serotonin, in spinal trigeminal nucleus oralis and pars interpolaris which usually modulate tactile and mechanical sensitivity in addition to the thermal sensitivity. Moreover, we also detected a robust alteration in the expression of serotonin, and inhibitory molecule norepinephrine in the nucleus tractus solitaries, which might indicate the possibility of an alteration in visceral pain, and existence of other morbidities related to solitary nucleus dysfunction in this rodent model of mild to moderate closed head traumatic brain injury. Collectively, widespread changes in monoamine neurotransmitter may be related to orofacial allodynhias and headache after traumatic brain injury.Golam Mustafa Jiamei Hou Rachel Nelson Shigeharu Tsuda Mansura Jahan Naweed S.Mohammad Joseph V.Watts Floyd J.Thompson Prodip Bose 2017Neural Regeneration Research2017,12,6:5
10Expression of cIAP-1 correlates with nodal metastasis in squamous cell carcinoma of the tongue显示文摘S. Qi S. Mogi H. Tsuda Y. Tanaka K. Kozaki I. Imoto J. Inazawa S. Hasegawa K. Omura 2008中国口腔颌面外科杂志2008,6,B05:5
11Lansoprazole-associated collagenous colitis:Diffuse mucosal cloudiness mimicking ulcerative colitis显示文摘There have only been a few reports on lansoprazole-associated collagenous colitis. Colonic mucosa of collagenous colitis is known to be endoscopically normal. We present a case of collagenous colitis where the mucosa showed diffuse cloudiness mimicking ulcerative colitis. A 70-year-old woman developed watery diarrhea four to nine times a day. She had interstitial pneumonia at 67 and reflux esophagitis at 70 years. Lansoprazole 30 mg/d had been prescribed for reflux esophagitis for nearly 6 mo. Lansoprazole was withdrawn due to its possible side effect of diarrhea. Colonoscopy disclosed diffuse cloudiness of the mucosa which suggested ulcerative colitis. Consequently sulfasalazine 2 g/d was started. The patient's diarrhea dramatically disappeared on the following day. However, biopsy specimens showed subepithelial collagenous thickening and infi ltration of inflammatory cells in the lamina propria, confirming the diagnosis of collagenous colitis. One month after sulfasalazine therapy was initiated, colonoscopic and histological abnormalities resolved completely. Five months later the diarrhea recurred. The findings on colonoscopy and histology were the same as before, confirming a diagnosis of collagenous colitis relapse. We found that the patient had begun to take lansoprazole again 3 mo ahead of the recent diarrhea. Withdrawal of lansoprazole promptly resolved the diarrhea. Endoscopic and histological abnormalities were also completely resolved, similar to the first episode. Retrospectively, the date of commencement of sulfasalazine and discontinuation of lansoprazole in the first episode was found to be the same. We conclude that this patient had lansoprazole-associated collagenous colitis.Mitsuro Chiba Takeshi Sugawara Haruhiko Tozawa Hidehiko Tsuda Toru Abe Takuo Tokairin Iwao Ono Eriko Ushiyama 2009World Journal of Gastroenterology2009,15,17:5
12玉米大斑病菌(Exserohilum turcicum)原生质体的分离及转化显示文摘玉米大斑病是严重危害玉米生产的一个世界性真菌病害。由于玉米大斑病菌 (Exserohilumturcicum)在无性生长过程中迅速产生黑色素 ,致使原生质体难以分离。测试了包括Fungase、Funcelase、Novozyme、Glucanex、Driselase、Uskizyme、Kitalase在内的 7种细胞壁降解酶及其组合、病原菌菌株和培养基对原生质体分离效果的影响。结果表明菌株的培养形态和菌丝的生长状态显著影响原生质体的分离效率 ;酶组合Kitalase +Glucanex +Driselase ,Kitalase+Glucanex和Kitalase +Uskizyme能够有效地分离玉米大斑病菌的原生质体。初步的转化试验表明 ,质粒pAN71可以用于该病原菌的转化。这些结果将为E .周永力 TANAKA Chihiro MATSUSHIMA Satoshi TSUDA Mitsuya 2003生物工程学报2003,19,3:4
13Observation of Inception of Sheet Cavitation from Free Nuclei显示文摘Prediction of inception of sheet cavitation on solid walls has been recognized to be very difficult, since it is significantly affected by the boundary layer flow characteristics, the population of free nuclei, the nuclei held in the wall roughness, the amount of dissolved air in liquid and so on. It has not sufficiently been made clear how the inception is affected by the conditions of water qualities and background flow characteristics. In this study, high speed observation of inception of sheet cavity from free nuclei is conducted for a two-dimensional convergent-divergent nozzle flow, where the sheet cavity forms just downstream of the nozzle throat. The effects of the amount of dissolved air and the free stream velocity on the inception process of sheet cavitation is examined. In addition, the bubble nuclei density, which is well known to be important factor for cavitation inception, is passively controlled by the filter installed in the tunnel. From the observations, it is confirmed that the nuclei number density significantly affects the formation of sheet cavity rather than the other two parameters. In conditions with large nuclei number density, the sheet cavity does not form, and bubbly cavitation appears instead. In the case with small nuclei number density, the sheet cavity forms from a single flowing nucleus and develops streamwisely and spanwisely. In the conditions with medium nuclei number density, the sheet cavity also forms but is shorter/narrower streamwisely/spanwisely, due to interaction of other nuclei flowing near the formed sheet cavity.Wakana TSURU Takafumi KONISHI Satoshi WATANABE Shin-ichi TSUDA 2017Journal of Thermal Science2017,26,3:4
14A nationwide molecular epidemiological study on hepatitis B virus in Indonesia: identification of two novel subgenotypes, B8 and C7显示文摘Mulyanto Sulaiman Ngongu Depamede Kiely Surayah Fumio Tsuda Koji Ichiyama Masaharu Takahashi Hiroaki Okamoto 2009Archives of Virology2009,,7:3
15日本图书馆情报学教育的未来趋势显示文摘日本的情报学教育现状多年来,图书馆界一直抱怨图书馆学院校不能培养出立即适应图书馆实际工作的学生。面对这一批评,图书馆学与情报学教育家们认为,教育的目标在于强化学生的基础理论知识,使其懂得自己的社会使命,能迅速地适应不同条件下的各类图书馆工作。然而,近些年来,由于电子信息技术的飞速发展及其在图书情报工作中的广泛应用,致使这一目标在实践中很少得以实施。早在1968年,当庆应大学图书馆学院决定在图书馆本科教育的基础上增设两年制硕士教育的时候就规定,本科生教育以传统的图书馆学课程为主,研究生则集中于有关情报学课程。凡原非图书馆学毕业的学生申请研究生学习。Yoshinari Tsuda 刘学和 1991大学图书馆学报1991,9,4:3
16Image-based autonomous navigation of Hayabusa2 using artificial landmarks: The design and brief in-flight results of the first landing on asteroid Ryugu显示文摘Hayabusa2 is an asteroid sample return mission carried out by the Japan Aerospace Exploration Agency.The spacecraft was launched in 2014 and arrived at the target asteroid Ryugu on June 27,2018.During the 1.5-year proximity phase,several critical operations(including two landing/sampling operations)were successfully performed.They were based on autonomous image-based descent and landing techniques.This paper describes an imagebased autonomous navigation scheme of the Hayabusa2 mission using artificial landmarks named target markers(TMs).Its basic algorithm,and the in-flight results of the first touchdown and its rehearsal,are shown.Naoko Ogawa Fuyuto Terui Yuya Mimasu Kent Yoshikawa Go Ono Seiji Yasuda Kota Matsushima Tetsuya Masuda Hiroki Hihara Junpei Sano Takashi Matsuhisa Satoshi Danno Manabu Yamada Yasuhiro Yokota Yuto Takei Takanao Saiki Yuichi Tsuda 2020Astrodynamics2020,4,2:2
17Clinical impact of c-Met expression and its gene amplification in hepatocellular carcinoma显示文摘Shunsuke Kondo Hidenori Ojima Hitoshi Tsuda Jun Hashimoto Chigusa Morizane Masafumi Ikeda Hideki Ueno Kenji Tamura Kazuaki Shimada Yae Kanai Takuji Okusaka 2013International Journal of Clinical Oncology2013,,2:2
18喷油嘴的改进对直喷柴油机的影响显示文摘改进直喷柴油机的性能,如降低氮氧化合物(NO_x)和颗粒(PM)排放,提高输出功率等,燃油喷注的雾化起着重要作用。为了获得良好的燃油雾化而又不增加燃油喷射压力,有效途径是增加在喷油嘴喷孔中的燃油流速。通过扩大喷孔进口处的圆角被证明是制造具有高燃油流速喷油嘴的非常有效和合适的方法。本文比较了高流速喷油嘴和常用喷油嘴在喷射特性和喷雾特性方面的差别,并且证实了具有高流速的喷油嘴改善了燃油喷注的雾化。本文最后列举了将高流速喷油嘴装在中型、自然吸气直喷柴油机上进行试验的情况。高流速喷油嘴改善了NO_x—PM的综合性能,提高发动机输出功率,因此证明了这是一种改善发动机性能的有效方法。Toshiyukiki Yoda Tomoyuki Tsuda 宓浩祥 1999内燃机燃油喷射和控制1999,,2:2
19A Biomechanical Comparison of Repair Techniques for Anterior Cruciate Ligament Tibial Avulsion Fracture Under Cyclic Loading显示文摘Harehiko Tsukada Yasuyuki Ishibashi Eiichi Tsuda Yasuharu Hiraga Satoshi Toh 2005Arthroscopy: The Journal of Arthroscopic and Related Surgery2005,,10:2
20Rendezvous to asteroid with highly uncertain ephemeris: Hayabusa2’s Ryugu-approach operation result显示文摘This paper describes the guidance and navigation technique used by Hayabusa2 for the asteroid rendezvous operation to reach Ryugu.The operation results,including the achieved guidance and navigation performance,are also summarized.Multiple assessment and navigation teams worked closely to provide reliable navigation solutions with a short solution delivery cycle.Although the uncertainty of the Ryugu’s ephemeris was considerable before Hayabusa2’s arrival,a combination of radiometric-optical hybrid navigation and a stochastic-constrained optimum guidance method was able to achieve an accuracy of less than 100 m and 1 cm/s,and the arrival was precisely timed.Yuichi Tsuda Hiroshi Takeuchi Naoko Ogawa Go Ono Shota Kikuchi Yusuke Oki Masateru Ishiguro Daisuke Kuroda Seitaro Urakawa Shin-ichiro Okumura Hayabusa2 Project Team 2020Astrodynamics2020,4,2:2
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