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| 1 | Management of thrombocytopenia due to liver cirrhosis:A review显示文摘Thrombocytopenia is a common complication in liver disease and can adversely affect the treatment of liver cirrhosis,limiting the ability to administer therapy and delaying planned surgical/diagnostic procedures because of an increased risk of bleeding.Multiple factors,including splenic sequestration,reduced activity of the hematopoietic growth factor thrombopoietin,bone marrow suppression by chronic hepatitis C virus infection and anti-cancer agents,and antiviral treatment with interferon-based therapy,can contribute to the development of thrombocytopenia in cirrhotic patients.Of these factors,the major mechanisms for thrombocytopenia in liver cirrhosis are(1)platelet sequestration in the spleen;and(2)decreased production of thrombopoietin in the liver.Several treatment options,including platelet transfusion,interventional partial splenic embolization,and surgical splenectomy,are now available for severe thrombocytopenia in cirrhotic patients.Although thrombopoietin agonists and targeted agents are alternative tools for noninvasively treating thrombocytopenia due to liver cirrhosis,their ability to improve thrombocytopenia in cirrhotic patients is under investigation in clinical trials.In this review,we propose a treatment approach to thrombocytopenia according to our novel concept of splenic volume,and we describe the current management of thrombocytopenia due to liver cirrhosis. | Hiromitsu Hayashi Toru Beppu Ken Shirabe Yoshihiko Maehara Hideo Baba | 2014 | World Journal of Gastroenterology2014，20，10： | 19 |
| 2 | Polyvinylchloride (PVC) and natural rubber films plasticized with a natural polymeric plasticizer obtained through polyesterification of rice fatty acid显示文摘 | Mariana Altenhofen da Silva Melissa Gurgel Adeodato Vieira André Costa Gomes Ma?umoto Marisa Masumi Beppu | 2011 | Polymer Testing2011，，5： | 3 |
| 3 | Anti–IL-5 therapy reduces mast cell and IL-9 cell numbers in pediatric patients with eosinophilic esophagitis显示文摘 | Iris M. Otani Arjun A. Anilkumar Robert O. Newbury Monica Bhagat Lisa Y. Beppu Ranjan Dohil David H. Broide Seema S. Aceves | 2013 | The Journal of Allergy and Clinical Immunology2013，，6： | 3 |
| 4 | Magnifying endoscopy with narrow-band imaging is useful in the differential diagnosis between low-grade adenoma and early cancer of superficial elevated gastric lesions显示文摘 | Shinichiro Maki Kenshi Yao Takashi Nagahama Takahiro Beppu Takashi Hisabe Yasuhiro Takaki Fumihito Hirai Toshiyuki Matsui Hiroshi Tanabe Akinori Iwashita | 2013 | Gastric Cancer2013，，2： | 3 |
| 5 | Long-term outcomes of extended radical resection combined with intraoperative radiation therapy for pancreatic cancer显示文摘 | Hiroshi Takamori Takehisa Hiraoka Keiichiro Kanemitsu Tatsuya Tsuji Hiroshi Tanaka Akira Chikamoto Kei Horino Toru Beppu Masahiko Hirota Hideo Baba | 2008 | Journal of Hepato - Biliary - Pancreatic Surgery2008，，6： | 2 |
| 6 | Functional assessment versus conventional volumetric assessment in the prediction of operative outcomes after major hepatectomy显示文摘 | Hiromitsu Hayashi Toru Beppu Hirohisa Okabe Hideyuki Kuroki Shigeki Nakagawa Katsunori Imai Hidetoshi Nitta Akira Chikamoto Takatoshi Ishiko Hideo Baba | 2014 | Surgery2014，，： | 2 |
| 7 | Measurement of frac- tional anisotropy using diffusion tensor MRI in supratento- rial astrocytic tumors 显示文摘 | Beppu T houe T Shibata Y | 2003 | J Neurooncology2003，63，2： | 1 |
| 8 | Measurement of fractional anisotropy using diffusion tensor MRI in supratentorial astrocytic tumors显示文摘 | Beppu T Inoue T Shibata Y | 2003 | J Neurooncol2003，63，2： | 1 |
| 9 | Intestinal involvement in Wegener' s granulomatosis diagnosed and followed up by double balloon enteroscopy 显示文摘 | Beppu K Osada T Inoue K | 2011 | Intern Med2011，50，3： | 1 |
| 10 | Mechanism of mitral regurgi-tation in patients with nyocardial infarction:a study using real time two-dimensional Doppler flow imaging and echocardio-graphy显示文摘 | Izumi S Miyatake K Beppu S | | 0，，： | 1 |
| 11 | Preoperative portal veinembolization (PVE) for patients with hepatocellular carcinomacan improve resectability and may improve disease-free survival显示文摘 | Okabe H Beppu T Ishiko T | 2011 | J Surg Oncol2011，104，6： | 1 |
| 12 | Urinary concentrations of bile acid glucuronides and sulfates in hepatobiliary diseases显示文摘 | Takikawa H Beppu T Seyama Y | 1984 | Gastroenterol Jpn1984，19，2： | 1 |
| 13 | The lateral upper arm flap : Anatomy and clinical applications 显示文摘 | Katsaros J Schusterman M Beppu M | 1984 | Ann Plast Surg1984，12，6： | 1 |
| 14 | Cloning,sequencing,and characterization of the gene encoding the smallest subunit of the three component membrane-bound alcohol dehydrogenase from Acetobacter pasteurianus显示文摘 | Kondo K Beppu T Horinouchi S | | 0，，： | 1 |
| 15 | Damage evaluation of concrete plates by high-velocity impact 显示文摘 | BEPPU M MIWA K ITOH M KATAYAMA M OHNO T | 2008 | International Journal Impact Engineering2008，35，： | 1 |
| 16 | Principle of a noninvasive method of measurements 显示文摘 | Harada Y Sugawara M Beppu T | 1987 | Heart Vessels1987，3，： | 1 |
| 17 | The lateral upper arm flap:anatomy and clinical applications显示文摘 | Katsaros J Schusterman M Beppu M | 1984 | Ann Plast Surg1984，12，6： | 1 |
| 18 | A phase II study of radiotherapy after hyperbaric oxygenation combined with interferon-beta and nimustine hydrochloride to treat supratentorial malignant gliomas显示文摘 | Beppu T Kamada K Nakamura R | 2003 | J Neurooncol2003，61，2： | 1 |
| 19 | High incidence of tumors in diabetic thrombin activatable fibrinolysis inhibitor and apolipoprotein E double-deficient mice显示文摘 | Beppu T Gil-Bernabe P Boveda-Ruiz D | 2010 | J Thromb Haemost2010，8，11： | 1 |
| 20 | The cloning and expression of chymosin (rennin) genes in microorganisms显示文摘 | BEPPU T | 1993 | Trends Biotechnol1993，，1： | 1 |
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