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| 1 | Endobiliary radiofrequency ablation for malignant biliary obstruction显示文摘BACKGROUND: The cornerstone of palliative treatment for inoperable extrahepatic cholangiocarcinoma is the relief of malignant biliary obstruction. The most commonly applied method is endoscopic stenting. However, the procedure can be complicated with stent obstruction. In this respect, endobiliary radiofrequency ablation may serve as an adjunctive tool for prolonging the stent patency. METHODS: Patients who underwent endoscopic retrograde cholangiopancreatography for differential diagnosis and/ or palliative treatment after the diagnosis of inoperable extrahepatic cholangiocarcinoma between March 2011 and January 2012 were analyzed. Those in whom endobiliary radiofrequency ablation and endoscopic stenting was successfully performed were included in the study. Technical details of the procedure, duration of stent patency, length of hospital stay, short-term morbidity and mortality rate were documented. RESULTS: Seventeen patients were analyzed, and 10 patients were included in the study. The morbidity and mortality rate within the first 30 days after the procedure was 20% and 0%, respectively. In 2 patients, mild pancreatitis occurred because of the endobiliary procedure. In 1 patient, endobiliary decompression could not be achieved, and therefore, percutaneous transhepatic biliary drainage was carried out. The median duration of stent patency in 9 patients with successful biliary decompression was 9 months (range 6-15). CONCLUSION: Endobiliary radiofrequency ablation seems to be safe and feasible as a palliative measure and may prolong the stent patency and overall survival in patients with malignant biliary obstruction due to inoperable extrahepatic cholangio-carcinoma. | Halil Alis Cetin Sengoz Murat Gonenc Mustafa Uygar Kalayci Ali Kocatas | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，4： | 25 |
| 2 | Migrated endoclip and stone formation after cholecystectomy:A new danger of acute pancreatitis显示文摘Endoclip migration into the common bile duct following laparoscopic cholecystectomy (LC) is an extremely rare complication. Migrated endoclip into the common bile duct can cause obstruction,serve as a nidus for stone formation,and cause cholangitis. We report a case of obstructive jaundice and acute biliary pancreatitis due to choledocholithiasis caused by a migrated endoclip 6 mo after LC. The patient underwent early endoscopic retrog-rade cholangiopancreatography (ERCP) with endoscopic sphincterotomy and stone extraction. | Kemal Dolay Halil Alis Aliye Soylu Gulum Altaca Ersan Aygun | 2007 | World Journal of Gastroenterology2007，13，47： | 6 |
| 3 | Effects of moisture damage on asphalt mixtures显示文摘The reduction in the ability of bitumen to bond with the aggregate surface due to the infiltration of moisture has been recognised for years, and this deterioration phenomenon is called moisture damage. In general, the loss of bonding between bitumen and aggregate shortens the service life of the top layer of the pavement. Many investigations have been conducted to understand the mechanisms of moisture damage due to the loss of bonding strength between bitumen and aggregate and to find ways to improve and strengthen the bond to mitigate the effect of moisture. This paper reviews the extensive literature on the loss of bitumen-aggregate bonding strength due to moisture damage in asphalt mixtures.The general description of the theories and mechanisms that explain the effect of the thermodynamic, chemical, physical and mechanical characteristics of the bitumen and aggregate on the bonding phenomenon are discussed in this paper. In addition, the causes of and contributing factors to moisture damage and methods to improve the bond between bitumen and aggregates are also discussed. Moreover, a description of the test methods that can be used to evaluate moisture damage in poorly bonded and compacted mixtures are also presented. Special attention is given to a well-known method, known as the pulloff test, which has been successfully used to evaluate aggregate-binder bond strength, both for laboratory and in-situ tests. This includes the test methods, the factors that affect the bonding strength results and their correlation with other test method. A review of the failure mode of bitumen under the pull-off loading test is discussed in the final section of this paper. | Hend Ali Omar Nur Izzi MdYusoff Muhammad Mubaraki Halil Ceylan | 2020 | Journal of Traffic and Transportation Engineering(English Edition)2020，7，5： | 3 |
| 4 | Phase I study on the safety and preliminary efficacy of allogeneic mesenchymal stem cells in hypoxic-ischemic encephalopathy显示文摘BACKGROUND Hypoxic-ischemic encephalopathy(HIE)is a leading cause of morbidity and mortality in the adult as well as in the neonate,with limited options for treatment and significant dysfunctionality.AIM To investigate the safety and preliminary efficacy of allogeneic mesenchymal stem cells(MSCs)in HIE patients.METHODS Patients who had HIE for at least 6 mo along with significant dysfunction and disability were included.All patients were given Wharton’s jelly-derived MSCs at 1×106/kg intrathecally,intravenously,and intramuscularly twice a month for two months.The therapeutic effects and prognostic implications of MSCs were evaluated by multiple follow-ups.Functional independence measure(FIM),modified Ashworth,and Karnofsky scales were used to assess any side effects,neurological and cognitive functions,and overall outcomes.RESULTS The 8 subjects included in the study had a mean age of 33.25±10.18 years.Mean HIE exposure and mean post-HIE durations were 45.63±10.18 and 19.67±29.04 mo,respectively.Mean FIM score was 18.38±1.06,mean modified Ashworth score was 43.5±4.63,and mean Karnofsky score was 20.For the first 24 h,5 of the patients experienced a subfebrile state,accompanied by mild headaches due to intrathecally administration and muscle pain because of intramuscularly administration.Neurological and functional examinations,laboratory tests,electroencephalography,and magnetic resonance imaging were performed to assess safety of treatment.Mean FIM score increased by 20.88±3.31 in the first month(P=0.027)and by 31.38±14.69 in 12 mo(P=0.012).The rate of patients with an FIM score of 126 increased from 14.58%to 16.57%in the first month and 24.90%in 12 mo.CONCLUSION Multiple triple-route Wharton’s jelly-derived MSC administrations were found to be safe for HIE patients,indicating neurological and functional improvement.Based on the findings obtained here,further randomized and placebo research could be performed. | Serdar Kabataş ErdinçCivelek Necati Kaplan Eyüp Can Savrunlu Gülseli Berivan Sezen Mourat Chasan Halil Can Ali Genç Yener Akyuva Osman Boyalı Furkan Diren Erdal Karaoz | 2021 | World Journal of Experimental Medicine2021，11，2： | 2 |
| 5 | Reticulated platelet levels in patients with ulcerative colitis显示文摘 | Hasan Kayahan Mesut Akarsu Mehmet Ali Ozcan Serdal Demir Halil Ates Belkis Unsal Hale Akpinar | 2007 | International Journal of Colorectal Disease2007，，12： | 2 |
| 6 | Feasibility of allogeneic mesenchymal stem cells in pediatric hypoxic-ischemic encephalopathy: Phase I study显示文摘BACKGROUND Hypoxic-ischemic encephalopathy(HIE)is one of the leading causes of death and long-term neurological impairment in the pediatric population.Despite a limited number of treatments to cure HIE,stem cell therapies appear to be a potential treatment option for brain injury resulting from HIE.AIM To investigate the efficacy and safety of stem cell-based therapies in pediatric patients with HIE.METHODS The study inclusion criteria were determined as the presence of substantial deficit and disability caused by HIE.Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)were intrathecally(IT),intramuscularly(IM),and intravenously administered to participants at a dose of 1×10^(6)/kg for each administration route twice monthly for 2 mo.In different follow-up durations,the effect of WJ-MSCs administration on HIE,the quality of life,prognosis of patients,and side effects were investigated,and patients were evaluated for neurological,cognitive functions,and spasticity using the Wee Functional Independence Measure(Wee FIM)Scale and Modified Ashworth(MA)Scale.RESULTS For all participants(n=6),the mean duration of exposure to hypoxia was 39.17+18.82 min,the mean time interval after HIE was 21.83±26.60 mo,the mean baseline Wee FIM scale score was 13.5±0.55,and the mean baseline MA scale score was 35±9.08.Three patients developed only early complications such as low-grade fever,mild headache associated with IT injection,and muscle pain associated with IM injection,all of which were transient and disappeared within 24 h.The treatment was evaluated to be safe and effective as demonstrated by magnetic resonance imaging examinations,electroencephalographies,laboratory tests,and neurological and functional scores of patients.Patients exhibited significant improvements in all neurological functions through a 12-mo follow-up.The mean Wee FIM scale score of participants increased from 13.5±0.55 to 15.17±1.6 points(mean±SD)at 1 mo(z=-1.826,P=0.068)and to 23.5±3.39 points at 12 mo(z=-2.207,P=0.027)post-treatment.The percentage of patients who achieved an excellent functional improvement(Wee FIM scale total score=126)increased from 10.71%(at baseline)to 12.03%at 1 mo and to 18.65%at 12 mo posttreatment.CONCLUSION Both the triple-route and multiple WJ-MSC implantations were safe and effective in pediatric patients with HIE with significant neurological and functional improvements.The results of this study support conducting further randomized,placebo-controlled studies on this treatment in the pediatric population. | Serdar Kabatas Erdinç Civelek Eyüp Can Savrunlu Necati Kaplan Osman Boyalı Furkan Diren Halil Can Ali Genç Tunç Akkoç Erdal Karaöz | 2021 | World Journal of Stem Cells2021，13，5： | 2 |
| 7 | The rs2228570 Variant of the Vitamin D Receptor Gene is Associated with Essential Tremor显示文摘Dear Editor,Essential tremor(ET)is one of the most common movement disorders of unknown etiology[1,2],having an overall prevalence of 4%in the general population[2].The age at onset has been reported to be between 15 years and 20 years,and penetrance to be complete at between50 years and 70 years.It seems to be a progressive neurological disorder,and can lead to substantial disability in some patients.Although it presents some degree of clinical variability,it occurs in sporadic(SET)and familial(FET)forms with heterogeneity of expression between and within families[3].ET is characterized essentially by a postural and kinetic tremor most often affecting the arms,but it can also affect other parts of the body[4].Nonetheless,familial expression of ET has been linked to some loci[5–7]. | Ali Sazci Nihal Uren Halil Atilla Idrisoglu Emel Ergul | 2019 | Neuroscience Bulletin2019，35，2： | 2 |
| 8 | The protective effects of ozone therapy in a rat model of acetaminophen-induced liver injury显示文摘 | Husamettin Gul Bulent Uysal Erdinc Cakir Halil Yaman Enis Macit Ali Osman Yildirim Yusuf Emrah Eyi Umit Kaldirim Emin Oztas Emin Ozgur Akgul Tuncer Cayci Mehmet Ozler Turgut Topal Sukru Oter Ahmet Korkmaz Mehmet Toygar Suzi Demirbag | 2012 | Environmental Toxicology and Pharmacology2012，，1： | 1 |
| 9 | Decolorization of synthetic dyes by white rot fungi, involving laccase enzyme in the process 显示文摘 | Emrah A Erkurt Ali Unyayar Halil Kumbur | 2007 | Process Biochemistry2007，42，： | 1 |
| 10 | Relation of Red Cell Distribution Width With Presence and Severity of Coronary Artery Ectasia显示文摘 | Turgay Isik Mustafa Kurt Erkan Ayhan Huseyin Uyarel Ibrahim Halil Tanboga Ali Fuat Korkmaz Ahmet Kaya Serdar Sevimli | 2012 | Clinical and Applied Thrombosis/Hemostasis2012，，5： | 1 |
| 11 | Clinical Features of Isolated Ventricular Noncompaction in Adults Long-Term Clinical Course, Echocardiographic Properties, and Predictors of Left Ventricular Failure显示文摘 | Dursun Aras Omac Tufekcioglu Kumral Ergun Ozcan Ozeke Ali Yildiz Serkan Topaloglu Bulent Deveci Onur Sahin Halil Lutfi Kisacik Sule Korkmaz | 2006 | Journal of Cardiac Failure2006，，9： | 1 |
| 12 | The relation of serum gamma-glutamyl transferase levels with coronary lesion complexity and long-term outcome in patients with stable coronary artery disease显示文摘 | Enbiya Aksakal Ibrahim Halil Tanboga Mustafa Kurt Mehmet Ali Kayg?n Ahmet Kaya Turgay Isik Mehmet Ekinci Serdar Sevimli Mahmut Acikel | 2012 | Atherosclerosis2012，，2： | 1 |
| 13 | Enhanced postoperative recovery pathways in emergency surgery: a randomised controlled clinical trial显示文摘 | Murat Gonenc Ahmet Cem Dural Ferhat Celik Cevher Akarsu Ali Kocatas Mustafa Uygar Kalayci Yasar Dogan Halil Alis | 2014 | The American Journal of Surgery2014，，6： | 1 |
| 14 | Correlation of technetium-99m MIBI and thallium-201 retention in solitary cold thyroid nodules with postoperative histopathology显示文摘 | Tanju Yusuf Erdil Kutlan ?zker Levent Kabasakal Bedii Kanmaz Kerim S?nmezoglu Kayhan ?etin Atasoy Halil Turgut Turoglu Ilhami Uslu Ali Tan Isitman ?etin ?nsel | 2000 | European Journal of Nuclear Medicine2000，，6： | 1 |
| 15 | Effects of the Application of Different Concentrations of NaN3 for Different Times on the Morphological and Cytogenetic Characteristics of Barley (Hordeum vulgate L.) Seedlings显示文摘 | Ali Irfan ILBAS Yasemin EROGLU Halil Erhan EROGLU | 2005 | Journal of Integrative Plant Biology2005，47，9： | 1 |
| 16 | Endoscopic and histopathological evaluation of acute gastric injury in high-dose acetaminophen and nonsteroidal anti-inflammatory drug ingestion with suicidal intent显示文摘瞄准:由于高剂量的 acetaminophen 和 nonsteroidal 的摄取评估尖锐胃的损害的内视镜、组织病理学说的方面关于一些的反煽动性的药(NSAID ) 冒因素和耐心的特征的风险。方法:学习组由与高剂量止痛剂摄取进入紧急情况部门的 50 个病人组成(组我) 与自杀目的。三十个病人与或没有消化不良(组 II ) 的温和抱怨作为控制组被选择。学习组根据类型的使用和止痛剂的数字被成层。内视镜的调查结果根据 Lanza 分数(LS ) 被评估,表示根据基于尖锐腐蚀胃炎的组织病理学说的调查结果的一个得分系统的胃与十二指肠的损坏和活体检视的严厉。结果:胃与十二指肠的损坏是显著地在组更严重我与组 II 相比(P <
0.01 ) 。LS 在组 Ia 和 Ib 是类似的。然而, LS 在与另外的病人相比摄取了多重 NSAID (组 Ic ) 的病人是显著地更高的(P <
0.01 ) 。LS 被相关变老(P <
0.01 ) 并且摄取的药的全部的数量(P <
0.05 ) 在里面组我;但是它没与 Helicobacter pylori (H pylori ) 被相关暴露的感染或持续时间(P >
0.05 ) 。活体检视分数(BS ) 在组是更高的我比组 II (P <
0.01 ) ,并且在组 Ib 更高比组 Ia (P <
0.05 ) 。结论:组织病理学说的损坏在与摄取仅仅 acetaminophen 的那些相比摄取病人的 NSAID 之中是更严重的,在在这些组之间的内视镜的调查结果没有有效差量。在在这些组之间的 LS 没有有效差量。意义的这缺乏以高剂量的 acetaminophen 的胃的效果是显著的。 | Aliye Soylu Can Dolapcioglu Kemal Dolay Aydin Ciltas Nurgul Yasar Mustafa kalayci Halil Alis Nurten Sever | 2008 | World Journal of Gastroenterology2008，14，43： | 0 |
| 17 | Natural Walls of Anatolia: formation and development of Diş Kayalıkları as a structural landform (Sivas, Türkiye)显示文摘The Diş Kayalıkları is one of the largest and most striking examples of crests in the world and is located between Eskidere and Boğazören villages of the İmranlı district of the Sivas province in Turkey. The crests, which resemble castle walls when viewed from afar, have a real wall pattern due to the right-angled crack system of the bedrock when viewed closely. This study aims at investigating the geomorphological features of the Diş Kayalıkları and determining how the geological and geomorphological evolution of the Diş Kayalıkları took place and how the current formation mechanism continues. In the region, the mid-latitude continental climate prevails with cold humid winters and warm dry summers. The bedrock consists of Miocene bedded deposits of different resistance, folded by young tectonic movements. Diş Kayalıkları was formed by selective erosion of less resistant terrain around a pack of resistant rock on the steeper southern slope of an asymmetrical anticline. It has a length of 4750 m in the approximately northwest-southeast direction, a maximum height of 30 m, and a width varying between 5 and 8 m. In the present morphological appearance of the Diş Kayalıkları, it can be stated that the structure formed after the tectonic formation process was eroded under the control of the local climate and crest formation was realized. In the following process, the crest experienced a polycyclic process where different landforms were formed. There are smaller landforms such as karren, cave and rock window on Diş Kayalıkları, and macrofossil beds in some places. This highly attractive geomorphosite, unknown to wider public, should be investigated from various scientific aspects and should be brought to regional tourism by making the necessary infrastructure and promotion studies. | UZUN Ali AYLAR Faruk ZEYBEK Halil Ibrahim GÜRGÖZE Serkan BAHADIR Muhammet ALEMDAĞ Selçuk | 2023 | Journal of Mountain Science2023，20，7： | 0 |
| 18 | Modeling habitat suitability and utilization of the last surviving populations of fallow deer(Dama dama Linnaeus,1758)显示文摘DüzlerçamıWildlife Reserve Area(WRA)is the last natural habitat of fallow deer(Dama dama)in the world.Fallow deer is native to Turkey,however,its geographical range is currently confined to DüzlerçamıWRA,Antalya.To date,a detailed habitat investigation of fallow deer dis-tribution has not been conducted.This study is vital for the last surviving populations of fallow deer in Turkey.There-fore,we studied the habitat suitability and utilization of fal-low deer in the DüzlerçamıWRA.Vegetation and wildlife inventory was surveyed across a total of 304 sample areas between 2015 and 2017.Plant species were recorded accord-ing to the Braun-Blanquet method and wildlife surveys were based on footprints,feces,and other signs of fallow deer.Classification and regression tree techniques,as well as MAXENT,were used to model vegetation and fallow deer habitat.Topographic position index,terrain ruggedness index,roughness index,elevation,and bedrock formation were also calculated and included in the models.Based on our results,we drafted a habitat protection map for fallow deer.To ensure sustainability of habitats where populations of fallow deer are found in Turkey,we developed recommen-dations such as closuring human access of the 1st-degree Protection Area and reintroduction of the species to other potential habitats. | YasinÜnal ÖzdemirŞentürk Ali Kavgaci Halil Süel Serkan Gülsoy Idris Oğurlu | 2022 | Journal of Forestry Research2022，33，2： | 0 |
| 19 | Effect of Concentration on Polyacrylonitrile (PAN) Nanofibers显示文摘 | Umran Ozkoc Halil ibrahim icoglu Ali Kirecci | 2011 | 材料科学与工程(中英文版)2011，5，3： | 0 |
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