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| 1 | Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis显示文摘AIM: To investigate whether serum levels of two soluble forms of extracellular cytokeratin 18 (M30-antigen and M65-antigen) may differentiate nonalcoholic steatohepatitis (NASH) from simple steatosis in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: A total of 83 patients with suspected NAFLD and 49 healthy volunteers were investigated. Patients with suspected NAFLD were classified according to their liver histology into four groups: definitive NASH (n = 45), borderline NASH (n = 24), simple fatty liver (n = 9), and normal tissue (n = 5). Serum levels of caspase-3 generated cytokeratin-18 fragments (M30-antigen) and total cytokeratin-18 (M65-antigen) were determined by ELISA. RESULTS: Levels of M30-antigen and M65-antigen were significantly higher in patients with definitive NASH compared to the other groups. An abnormal value (> 121.60 IU/L) of M30-antigen yielded a 60.0% sensitivity and a 97.4% specificity for the diagnosis of NASH. Sensitivity and specificity of an abnormal M65-antigen level (> 243.82 IU/L) for the diagnosis of NASH were 68.9% and 81.6%, respectively. Among patients with NAFLD, M30-antigen and M65-antigen levels distinguished between advanced fibrosis and early-stage fibrosis with a sensitivity of 64.7% and 70.6%, and a specificity of 77.3% and 71.2%, respectively. CONCLUSION: Serum levels of M30-antigen and M65-antigen may be of clinical usefulness to identify patients with NASH. Further studies are mandatory to better assess the role of these apoptonecrotic biomarkers in NAFLD pathophysiology. | Yusuf Yilmaz Enver Dolar Engin Ulukaya Semra Akgoz Murat Keskin Murat Kiyici Sibel Aker Arzu Yilmaztepe Selim Gurel Macit Gulten Selim Giray Nak | 2007 | World Journal of Gastroenterology2007，13，6： | 19 |
| 2 | Liver histology according to the presence of metabolic syndrome in nonalcoholic fatty liver disease cases显示文摘AIM:To investigate the histologic features of the liver in nonalcoholic fatty liver disease (NAFLD) cases according to the presence of metabolic syndrome or its individual components. METHODS:We enrolled 81 patients (40 male,41 fe-male) who were diagnosed with fatty liver by ultraso-nographic scan and fulfi lled the inclusion criteria. First anamnesis,anthropometric,clinical,laboratory and imaging features of all participants were recorded and then liver biopsy was performed after gaining consent from patients. Diagnosis of metabolic syndrome was dependent on patients having 3 or more out of 5 risk criteria defined by the WHO. Biopsy specimens were assessed according to Brunt et al's classification. RESULTS:Sixty-nine of the 81 patients had nonalco-holic steatohepatitis (NASH),11 had simple fatty liver and 1 had cirrhosis according to histologic evaluation. Comparisons were made between two groups of NASH patients,those with and without metabolic syndrome. We did not detect statistically significant differences in liver histology between NASH patients with and wit-hout metabolic syndrome. CONCLUSION:NASH can progress without metabolic risk factors or the presence of metabolic syndrome. | Hüseyin Saadettin Uslusoy Selim Giray Nak Macit Gülten Zeynep Blylkll | 2009 | World Journal of Gastroenterology2009，15，9： | 12 |
| 3 | Evaluation of leukocyte esterase and nitrite strip tests to detect spontaneous bacterial peritonitis in cirrhotic patients显示文摘AIM: To investigate the diagnostic eff icacy of leukocyte esterase and nitrite reagent strips for bedside diagnosis of spontaneous bacterial peritonitis (SBP). METHODS: A total of 63 consecutive patients with cirrhotic ascites (38 male, 25 female) tested between April 2005 and July 2006 were included in the study. Bedside reagent strip testing was performed on ascitic ? uid and the results compared to manual cell counting and ascitic fluid culture. SBP was defined as having a polymorphonuclear ascites count of ≥ 250/mm3. RESULTS: Fifteen samples showed SBP. The sensitivity, specificity, positive and negative predictive values of the leukocyte esterase reagent strips were; 93%, 100%, 100%, and 98%, respectively. The sensitivity, specifi city, positive and negative predictive value of the nitrite reagent strips were 13%, 93%, 40%, and 77%, respectively. The combination of leukocyte esterase and nitrite reagents strips did not yield statistically signif icant effects on diagnostic accuracy. CONCLUSION: Leukocyte esterase reagent strips may provide a rapid, bedside diagnostic test for SBP. | Serkan Torun Enver Dolar Yusuf Yilmaz Murat Keskin Murat Kiyici Melda Sinirtas Emre Sarandol Selim Gurel Selim Giray Nak Macit Gulten | 2007 | World Journal of Gastroenterology2007，13，45： | 8 |
| 4 | Non-alcoholic steatohepatitis with normal aminotransferase values显示文摘AIM:To investigate the aspects of liver histology in patients with non-alcoholic steatohepatitis(NASH)who had normal aminotransferase levels. METHODS:Thirty-four patients diagnosed with liver steatosis by ultrasonographic examination participated in the study.We compared all nonalcoholic fatty liver disease and NASH cases,according to aminotransferase level,aspartate aminotransferase (AST)/alanine aminotransferase(ALT)ratio and presence of metabolic syndrome. RESULTS:Sixteen of 25 patients with high aminotransferase levels were diagnosed with NASH and nine with simple fatty liver according to liver histology. Among the nine patients with normal aminotransferase levels,seven had NASH and two had simple fatty liver. The patients with normal and high liver enzyme levels had almost the same prevalence of NASH and metabolic syndrome.Liver histology did not reveal any difference according to aminotransferase levels and AST/ALT ratio. CONCLUSION:Aminotransferase levels and AST/ALT ratio do not seem to be reliable predictors for NASH. Despite numerous non-invasive biomarkers,all patients with fatty liver should undergo liver biopsy. | Hüseyin Saadettin Uslusoy Selim Giray Nak Macit Gülten Zeynep B|y|kl| | 2009 | World Journal of Gastroenterology2009，15，15： | 7 |
| 5 | The significance of E266K polymorphism in the NOD1 gene on Helicobacter Pylori infection: an effective force on pathogenesis?显示文摘 | Banu Kara Hikmet Akkiz Figen Doran Suleyman Bayram Eren Erken Yuksel Gumurdullu Macit Sandikci | 2010 | Clinical and Experimental Medicine2010，，2： | 1 |
| 6 | Massive Lower Gastrointestinal Hemorrhage Secondary to Rectal Hemorrhoids in Elderly Patients Receiving Anticoagulant Therapy: Case Series显示文摘 | Burhan Ozdil Hikmet Akkiz Macit Sandikci Can Kece Arif Cosar | 2010 | Digestive Diseases and Sciences2010，，9： | 1 |
| 7 | The role of secondary cytoreductive surgery for recurrent ovarian cancer显示文摘 | Mete Gqngfr FVrat Ortac Macit Arvas | 2005 | Gynecologic Oncology2005，97，： | 1 |
| 8 | Growth performance of purebred Awassi, Morkaraman and Tushin lamb and their crosses under semi- intensive management in Turkey 显示文摘 | Macit M Karaoglu M Esenbuga N | 2001 | Small Ruminant Research2001，42，2： | 1 |
| 9 | The effects of phase change during the stand-by period in latent heat energy storage systems显示文摘 | Macit Toksoy Zafer Ilken | 1991 | Solar Energy1991，47，2： | 1 |
| 10 | Low-dose CT:practices and strategies of radiologists in university hospitals显示文摘 | Nevzat K Macit A | 2006 | Diagn Interv Radiol2006，12，1： | 1 |
| 11 | investigation of solid solution of ZrP207-Sr2P207 显示文摘 | Semih S Macit O Necmeddin Y | 2007 | Journal of Mater Science2007，42，15： | 1 |
| 12 | The protective effects of ozone therapy in a rat model of acetaminophen-induced liver injury显示文摘 | Husamettin Gul Bulent Uysal Erdinc Cakir Halil Yaman Enis Macit Ali Osman Yildirim Yusuf Emrah Eyi Umit Kaldirim Emin Oztas Emin Ozgur Akgul Tuncer Cayci Mehmet Ozler Turgut Topal Sukru Oter Ahmet Korkmaz Mehmet Toygar Suzi Demirbag | 2012 | Environmental Toxicology and Pharmacology2012，，1： | 1 |
| 13 | Characterization of nano- structured magnetite thin films produced by sol-gel pro- cessing显示文摘 | Ali Erderm Eken Macit Ozenbas | 2009 | Sol-Gel Sci Technol2009，50，3： | 1 |
| 14 | Effects of vitamin E supplementation on fattening perforce, non-carcass components and retail cut percentages, and meat quality traits of Awassi lambs显示文摘 | MACIT M AKSAKAL V EMSEN E | 2003 | Meat Sci2003，64，： | 1 |
| 15 | Growth performance and carcass characteristics of Awassi, Morkaraman and Tushin lambs grazed on pasture and supported with concentrate显示文摘 | MACIT I~i ESENBUGA N KARAOGLU M | 2002 | Small Rumin Res2002，44，3： | 1 |
| 16 | Effects of vitamin E supplementation on performance and meat quality traits of Morkaraman male lambs 显示文摘 | MACIT M AKSAKAL V EMSEN E | 2003 | Meat Sci2003，63，： | 1 |
| 17 | Growth performance of purebred Awassi, Morkaraman and Tushin lamb and their crosses under semi-intensive management in Turkey显示文摘 | MACIT M KARAOGLU M ESENBUGA N | 2001 | Small Ruminant Research2001，42，2： | 1 |
| 18 | Protective efficiacy of taurine against pulmonary edema progression:experimental study显示文摘 | Yucel O Kunak ZI Macit E | 2008 | J Cardiothorac Surg2008，3，： | 1 |
| 19 | The Effects of N-Acetylcysteine and Ozone Therapy on Oxidative Stress and Inflammation in Acetaminophen-Induced Nephrotoxicity Model显示文摘 | Fatma Ucar Mine Yavuz Taslipinar Bilal Firat Alp Ibrahim Aydin Fevzi Nuri Aydin Mehmet Agilli Mehmet Toygar Esin Ozkan Enis Macit Muzaffer Oztosun Tuncer Cayci Ayhan Ozcan | 2013 | Renal Failure2013，，5： | 1 |
| 20 | Growth performance and carcass chafacteristlcs of Awassi,Morkaraman and Tushin lambs grazed on pasture and supported with concentrate显示文摘 | Macit M Esenbuga N Karaglu M | 2002 | Small Ruminant Research2002，44，： | 1 |
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