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| 1 | Molecular identification of hepatitis B virus genotypes/subgenotypes:Revised classification hurdles and updated resolutions显示文摘The clinical course of infections with the hepatitis B virus(HBV)substantially varies between individuals,as a consequence of a complex interplay between viral,host,environmental and other factors.Due to the high genetic variability of HBV,the virus can be categorized into different HBV genotypes and subgenotypes,which considerably differ with respect to geographical distribution,transmission routes,disease progression,responses to antiviral therapy or vaccination,and clinical outcome measures such as cirrhosis or hepatocellular carcinoma.However,HBV(sub)genotyping has caused some controversies in the past due to misclassifications and incorrect interpretations of different genotyping methods.Thus,an accurate,holistic and dynamic classification system is essential.In this review article,we aimed at highlighting potential pitfalls in genetic and phylogenetic analyses of HBV and suggest novel terms for HBV classification.Analyzing fulllength genome sequences when classifying genotypes and subgenotypes is the foremost prerequisite of this classification system.Careful attention must be paid to all aspects of phylogenetic analysis,such as bootstrapping values and meeting the necessary thresholds for(sub)genotyping.Quasi-subgenotype refers to subgenotypes that were incorrectly suggested to be novel.As many of these strains were misclassified due to genetic differences resulting from recombination,we propose the term'recombino-subgenotype'.Moreover,immigration is an important confounding facet of global HBV distribution and substantially changes the geographic pattern of HBV(sub)genotypes.We therefore suggest the term'immigro-subgenotype'to distinguish exotic(sub)genotypes from native ones.We are strongly convinced that applying these two proposed terms in HBV classification will help harmonize this rapidly progressing field and allow for improved prophylaxis,diagnosis and treatment. | Mahmoud Reza Pourkarim Samad Amini-Bavil-Olyaee Fuat Kurbanov Marc Van Ranst Frank Tacke | 2014 | World Journal of Gastroenterology2014，20，23： | 20 |
| 2 | Hemostasis in liver transplantation:Pathophysiology,monitoring,and treatment显示文摘Recent findings in the pathophysiology and monitoring of hemostasis in patients with end stage liver disease have major impact on coagulation management during liver transplantation. There is increasing evidence, that the changes in both coagulation factors and platelet count regularly observed in patients with liver cirrhosis cannot be interpreted as a reliable indicator of diffuse bleeding risk. Instead, a differentiated view on hemostasis has led to the concept of a rebalanced coagulation system: While it is important to recognize that procoagulant factors are reduced in liver cirrhosis, it is also evident that synthesis of anticoagulant factors and fibrinolytic proteins produced in the liver is also diminished. Similarly, the decreased platelet count may be counterbalanced by increased platelet aggregability caused by highly active von Willebrand multimeres. The coagulation system is therefor stated to be rebalanced. While under normal 'unstressed' conditions diffuse bleeding is rarely observed, however both diffuse bleeding or thrombus formation may occur when compensation mechanisms are exhausted. While most patients presenting for liver transplantation have severe cirrhosis, liver function and thus production of pro- and anticoagulant factors can be preserved especially in cholestatic liver disease. During liver transplantation, profound changes in the hemostasis system can occur. Surgical bleeding can lead to diffuse bleeding as coagulation factors and platelets are already reduced. Ischemia and tissue trauma can lead to alterations of hemostasis comparable to trauma induced coagulopathy. A further common disturbance often starting with the reperfusion of the transplanted organ is hyperfibrinolysis which can eventually precipitate complete consumption of fibrinogen and an endogenous heparinization by glycocalyx shedding. Moreover, thrombotic events inliver transplantations are not uncommon and contribute to increased mortality. Besides conventional laboratory methods, bed-side monitoring of hemostasis(e.g., thrombelastography, thrombelastometry) is often used during liver transplantation to rapidly diagnose decreases in fibrinogen and platelet count as well as hyperfibrinolysis and to guide treatment with blood products, factor concentrates, and antifibrinolytics. There is also evidence which suggests when algorithms based on bed-side hemostasis monitoring are used a reduction of blood loss, blood product use, and eventual mortality are possible. Notably, the bed-side monitoring of anticoagulant pathways and the thrombotic risk is not possible at time and thus a cautious and restrictive use of blood products is recommended. | Matthias Hartmann Cynthia Szalai Fuat H Saner | 2016 | World Journal of Gastroenterology2016，22，4： | 11 |
| 3 | Clinicopathological features and outcomes of patients with gastric cancer:A single-center experience显示文摘AIM:To evaluate the location,histopathology,stages,and treatment of gastric cancer and to conduct survival analysis on prognostic factors.METHODS:Patients diagnosed with of stomach cancer in our clinic between 2000 and 2011,with follow-up or a treatment decision,were evaluated retrospectively.They were followed up by no treatment,adjuvant therapy,or metastatic therapy.We excluded from the study any patients whose laboratory records lacked the operating parameters.The type of surgery in patients diagnosed with gastric cancer was total gastrectomy,subtotal gastrectomy or palliative surgery.Patients with indications for adjuvant treatment were treated with adjuvant and/or radio-chemotherapy.Prognostic evaluation was made based on the parameters of the patient,tumor and treatment.RESULTS:In this study,outpatient clinic records of patients with gastric cancer diagnosis were analyzed retrospectively.A total of 796 patients were evaluated(552male,244 female).The median age was 58 years(22-90 years).The median follow-up period was 12 mo(1-276 mo),and median survival time was 12 mo(11.5-12.4 mo).Increased T stage and N stage resulted in a decrease in survival.Other prognostic factors related to the disease were positive surgical margins,lymphovascular invasion,perineural invasion,cardio-esophageal settlement,and the levels of tumor markers in metastatic disease.No prognostic significance of the patient's age,sex or tumor histopathology was detected.CONCLUSION:The prognostic factors identified in all groups and the proposed treatments according to stage should be applied,and innovations in the new targeted therapies should be followed. | Fatih Selcukbiricik Evin Buyukunal Deniz Tural Mustafa Ozguroglu Fuat Demirelli Suheyla Serdengecti | 2013 | World Journal of Gastroenterology2013，19，14： | 7 |
| 4 | Coagulation of a giant hemangioma in glans penis with holmium laser显示文摘在也引起一个可勃起的机能障碍(编辑) 那的龟头上与一个扩大的巨大的缝血管瘤介绍的一个 21 岁的人部分对 intracavernous 注射刺激测试作出回应。尽管在磁性的回声成像(MRI ) 的调查结果显示了一个腺的缝血管瘤,阴茎有颜色的 Doppler 超声揭示了一个入侵的 cavernausal 缝血管瘤到龟头。外科的切除根据腺损害的宽广延期被避免。钬激光凝结由于化妆联盟者担心被用于损害。然而,在钬激光申请不是出色的以后,化妆品是没有改进,在 intracavernous 注射刺激测试期望结果。在结论,钬激光申请不应该习惯于与阴茎海绵体有关的龟头的 heman-giomas,但是进一步的研究被需要在限制为龟头的小缝血管瘤揭示钬激光申请的效果。 | Emin Aydur Bulent Erol Lutfi Tahmaz Hasan Cem Irkilata Cenker Eken Ahmet Fuat Peker | 2008 | Asian Journal of Andrology2008，10，5： | 4 |
| 5 | 乙型肝炎病毒基因型C亚型和核心启动子、前C/核心区基因变异的关系显示文摘目的研究慢性乙型肝炎病毒(HBV)感染者中HBV基因型C亚型(HBV/C)的核心启动子、前C/核心区基因变异情况,分析HBV/C亚型的病毒学特征。方法用酶联免疫法(ELISA)筛选出79例HBV/C,再用聚合酶链反应-限制性酶长度多态性分析方法(PCR-RFLP)进行HBV/C亚型分析;同时针对HBV核心启动子、preC/核心区基因进行半巢式PCR及PCR产物直接测序。结果①79例HBV/C中,33例(41·8%)为HBV/C1亚型,46例(58·2%)为HBV/C2亚型。②HBV/C1亚型仅见于来自中国南方的患者(P<0·0001)。③A1898位点变异仅见于HBV/C1亚型(P=0·056),V1753位点变异在HBV/C1亚型中多见(P<0·05);HBV/C2以T1858(90%)、A1896(40%)位点变异多见(P<0·008)。T1762/A1764位点变异在HBV/C两种亚型中均常见。④肝细胞癌(HCC)患者中,V1753和T1762/A1764变异最常见(P<0·05)。结论HBV/C1和HBV/C2在中国有明显的地区差异;V1753合并T1762/A1764双变异与发展为HCC相关,尤其在HBV/C1患者。 | 袁静 龚作炯 Masashi Mizokami Yasuhito Tanaka Fuat Kurbanov Etsum Orito 徐六妹 蒋小玲 赖伟珍 陆坚 周伯平 | 2006 | 中华实验和临床病毒学杂志2006，20，4： | 3 |
| 6 | Effect of low molecular weight heparin (enoxaparin) on congenital cataract surgery显示文摘AIM: To assess the efficacy of intracameral enoxaparin (a low-molecular-weight heparin) infusion, in variable doses on postoperative inflammatory response in congenital cataract surgery.METHODS: It is a prospective, randomized controlled trial. Eighty eyes of 53 children with congenital cataract were enrolled in this study. Every eye had primary posterior capsulorrhexis and intraocular lens (IOL) implantation after lens aspiration. The eyes were divided into 4 equal groups. In group 1 balanced salt solution (BSS) without enoxaparin was used as an irrigation solution. Whereas in group 2, 3 and 4, 40mg, 20mg and 10mg enoxaparin in 500mL BSS was used respectively. The inflammatory response in the anterior chamber was compared among the groups with slit-lamp biomicroscopy.RESULTS: The mean follow-up period was (17.75±3.95) months in group 1, (18.00±5.15) months in group 2, (19.20±5.47) months in group 3 and (18.65±5.16) months in group 4. Mean number of inflammatory cells in the anterior chamber in group 1 was significantly higher than that of group 2, 3, 4 (P<0.001). There was fibrin formation in the anterior chambers of 3 eyes in group 1 and one eye in group 4. There was synechiae formation in 3 eyes of group 1 and one eye of group 4. There was no significant difference among the groups by means of fibrin or synechiae formation (P>0.05). There were IOL precipitates in 4 eyes of group 1 and 2 eyes of group 4. IOL precipitate formation was significantly higher in group 1 than that of group 2 and 3 in which there was no IOL precipitate (P=0.048). There was IOL subluxation in only one eye of group 1, 3 and 4 while no subluxation was observed in group 2 (P>0.05). There was no statistically significant difference detected about IOL subluxation occurance in all 4 groups (P>0.05). CONCLUSION: Complications of cataract surgery in congenital cataract patients associated with postoperative inflammatory response found to be decreased with the use of enoxaparin in intraocular infusion solutions. Furthermore according to our results the anti-inflammatory effect of enoxaparin was dose dependant. | Ihsan aa Alparslan Sahin Abdullah Kürsat Cingü Seyhmus Ari Fuat Alakus Yasin inar | 2012 | International Journal of Ophthalmology(English edition)2012，5，5： | 3 |
| 7 | New combination test for hepatitis C virus genotype and viral load determination using Amplicor GT HCV MONITOR test v2.0显示文摘AIM: To develop a new sensitive and inexpensive hepatitis C virus (HCV) combination test (HCV Guideline test) that enables the determination of HCV genotypes 1, 2 and 3,and simultaneous determination of HCV viral load using commercial Amplicor GT HCV MONITOR test v2.0 (microwell version).METHODS: The HCV Guideline test used the PCR product generated in commercial Amplicor GT HCV Monitor test v2.0 for viral load measurement using microwell plate version of Amplicor HCV Monitor and also captured on separate plates containing capture probes and competitive oligonucleotide probes specific for HCV genotypes 1, 2 and 3, The HCV genotype was subsequently determined using the biotin-labeled PCR product and five biotin-labeled HCV-specific probes.RESULTS: The sensitivity of the HCV Guideline test was 0.5 KIU/mL. Specificity of the HCV Guideline test was confirmed by direct sequencing of HCV core region and molecular evolutionary analyses based on a panel of 31 samples. The comparison of the HCV Guideline test and an in-house HCV core genotyping assay using 252 samples from chronic hepatitis C patients indicated concordant results for 97.2% of samples (59.5% genotype 1, 33.7% genotype 2, 6.0% genotype 3, and 0.8% mixed genotypes).Similarly, the HCV Guideline test showed concordance with a serological test, and the serological test failed to assign any serotype in 12.7% of the samples, indicating a better sensitivity of the HCV Guideline test.CONCLUSION: Clinically, both viral load and genotypes (1, 2 and 3) have been found to be major predictors of antiviral therapy outcome regarding chronic hepatitis C based on guidelines and they are, in normal circumstances,performed as separate stand-alone assays. The HCV Guideline test is a useful method for screening large cohorts in a routine clinical setting for determining the treatment regimen and for predicting the outcome of antiviral therapy of chronic hepatitis C. | Motokazu Mukaide Yasuhito Tanaka Hirokazu Kakuda Kei Fujiwara Fuat Kurbanov Eturo Orito Kentaro Yoshioka Kiyotaka Fujise Shoji Harada Takazumi Kozaki Kazuo Takemura Kazumasa Hikiji Masashi Mizokami | 2005 | World Journal of Gastroenterology2005，11，4： | 3 |
| 8 | Marketing in a postmodern world显示文摘 | A. Fuat Firat Nikhilesh Dholakia Alladi Venkatesh | 1995 | European Journal of Marketing1995，，1： | 2 |
| 9 | Specific mutations of basal core promoter are associated with chronic liver disease in hepatitis B virus subgenotype D1 prevalent in Turkey显示文摘 | Mustafa Sunbul Masaya Sugiyama Fuat Kurbanov Hakan Leblebicioglu Anis Khan Abeer Elkady Yasuhito Tanaka Masashi Mizokami | 2013 | Microbiol Immunol2013，，2： | 2 |
| 10 | Liver transplantation and neurological side effects显示文摘 | Fuat H. Saner Silvio Nadalin Arnold Radtke Georgios C. Sotiropoulos Gernot M. Kaiser Andreas Paul | 2009 | Metabolic Brain Disease2009，，1： | 2 |
| 11 | Chalcone 3-hydroxylation is not a general property of flavonoid 3 '-hydroxylase显示文摘 | KARIN S SILV/JA M FUAT T | 2009 | Plant Science2009，177，2： | 1 |
| 12 | Protective effects of recom2 binant human granulocyte colony stimulating factor in a rat model of necrotizing enterocolitis 显示文摘 | Canpolat Fuat Yurdakok Murat O zsoy | 2006 | Pediatric Surgery International2006，22，9： | 1 |
| 13 | Effects of various propolis concentrations on biochemical and hematological parameters of rainbow trout ( Oncorhynchus mykiss )显示文摘 | Zeliha Selamoglu Talas Mehmet Fuat Gulhan | 2009 | Ecotoxicology and Environmental Safety2009，，7： | 1 |
| 14 | R&D Policies, Endogenous Growth and Scale Effects显示文摘 | Fuat Sener | 2008 | Journal of Economic Dynamics & Control2008，32，12： | 1 |
| 15 | Layout optimization of trusses using simulated annealing显示文摘 | OGUZHAN H FUAT E | 2002 | Advances in Engineering Softwaer2002，33，： | 1 |
| 16 | Kinetics and thermodynamics of the adsorption of some dyestuffs and p-nitrophenol by chitosan and MCM-chitosan from aqueous solution 显示文摘 | Lhan U Fuat G | 2004 | Journal of Colloid and Interface Science2004，274，2： | 1 |
| 17 | Hydrogels in sensing applications 显示文摘 | Daniel Buenger Fuat Topuz Juergen Groll | 2012 | Prog Polym Sci2012，37，12： | 1 |
| 18 | 99mTc-MIBI Emboli in the Lungs Detected on SPECT/CT: A Pitfall in Parathyroid Scan显示文摘 | Mustafa Aras Tanju Yusuf Erdil Tunc Ones Fuat Dede Halil Turgut Turoglu | 2014 | Clinical Nuclear Medicine2014，，： | 1 |
| 19 | Kinetics and thermodyoamics of the adsorption of some dyestuffs and p-nitrophenol by chitosan and MCM-chitosan from aqueous solution 显示文摘 | Ilhan Uzun Fuat GO zel | 2004 | Journal of Colloid and Intel'face Science2004，274，2： | 1 |
| 20 | Evaluation of anti-hepatitis E virus (HEV) immunoglobulin A in a serological screening for HEV infection显示文摘 | Abeer Elkady Yasuhito Tanaka Fuat Kurbanov Noboru Hirashima Masaya Sugiyama Anis Khan Hideaki Kato Akihiko Okumura Masashi Mizokami | 2007 | Journal of Gastroenterology2007，，11： | 1 |
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