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| 1 | Viral and host causes of fatty liver in chronic hepatitis B显示文摘AIM: To investigate the viral and host causes of fatty liver in chronic hepatitis B patients and the role of fat deposits in liver damage.METHODS: A total of 164 patients (113 males and 51 females, average age 35±11.3 years, and range 10-62 years) with previously untreated chronic hepatitis B were included in the study. The patients were divided into two groups depending on the result of liver biopsy: group without steatosis (100 patients with <5% hepatosteatosis) and group with steatosis (64 patients with >5% hepatosteatosis). The groups were compared in terms of gender, body mass index (BMI), liver enzymes (ALT, AST, ALP, GGT), cholesterol, triglyceride, HBeAg, viral load, and histological findings. In the group with steatosis, the patients were subdivided depending on the degree of steatosis into mild group (45 patients with 5-24% steatosis), and severe group (19 patients with >25% steatosis). RESULTS: In the group of chronic hepatitis B with steatosis, the mean age, BMI, cholesterol, and triglyceride levels were significantly higher than those in the group without steatosis (P<0.05). Steatosis was found in 53 (46.9%) of male patients and 11 (22%) of female patients (P<0.05). No significant difference was found in the positivity of ALT, AST, ALP, GGT, HBeAg, viral load, histological activity index (HAI) and stage between the two groups (P>0.05). In the group with severe steatosis, the BMI was significantly higher than that in the group with mild steatosis (P<0.05). No significant difference was found in the other parameters between the groups (P>0.05). CONCLUSION: Steatosis in chronic hepatitis B appears to be a result of metabolic factors of the host rather than the effect of viruses. Steatosis is unrelated to the HAI and degree of fibrosis, which are considered as the histological indicators of liver damage. | Emin Altiparmak Seyfettin K(o|¨)klü Mesut Yalinkilic Osman Yüksel Bahattin Cicek Ertugrul Kayacetin Tülin Sahin | 2005 | World Journal of Gastroenterology2005，11，20： | 52 |
| 2 | Role of surgery in colorectal cancer liver metastases显示文摘Colorectal carcinoma(CRC)is the third most common cancer,and approximately 35%-55%of patients with CRC will develop hepatic metastases during the course of their disease.Surgical resection represents the only chance of long-term survival.The goal of surgery should be to resect all metastases with negative histological margins while preserving sufficient functional hepatic parenchyma.Although resection remains the only chance of long-term survival,management strategies should be tailored for each case.For patients with extensive metastatic disease who would otherwise be unresectable,the combination of advances in medical therapy,such as systemic chemotherapy(CTX),and the improvement in surgical techniques for metastatic disease,have enhanced prognosis with prolongation of the median survival rate and cure.The use of portal vein embolization and preoperative CTX may also increase the number of patients suitable for surgical treatment.Despite current treatment options,many patients still experience a recurrence after hepatic resection.More active systemic CTX agents are beingused increasingly as adjuvant therapy either before or after surgery.Local tumor ablative therapies,such as microwave coagulation therapy and radiofrequency ablation therapy,should be considered as an adjunct to hepatic resection,in which resection cannot deal with all of the tumor lesions.Formulation of an individualized plan,which combines surgery with systemic CTX,is a necessary task of the multidisciplinary team.The aim of this paper is to discuss different approaches for patients that are treated due to CRC liver metastasis. | ?zgür Akgül Erdin? ?etinkaya ?iyar Ers?z Mesut Tez | 2014 | World Journal of Gastroenterology2014，20，20： | 40 |
| 3 | Red cell distribution width to platelet ratio: New and promising prognostic marker in acute pancreatitis显示文摘AIM: To evaluate the accuracy of red cell distribution width(RDW) to platelet ratio(RPR) to predict in-hospital mortality in acute pancreatitis(AP).METHODS: Between January 2010 and June 2012, 102 patients with AP were recruited to the study. In this retrospective cohort study, for all subjects, demographic data on hospital admission, AP etiology, comorbid diseases, organ failure assessment, laboratory parameters and length of hospital stay were examined. Additionally, we used a non-invasive prediction method in addition to the RPR to evaluate the disease severity. Multivariate logistic regression analyses were used to evaluate the impact of RPR on hospital admission to predict mortality.RESULTS:The male-female ratio(59/43)was 1.37with a median age of 56.5 years(17-89 years).In both univariate and multivariate analyses,RDW and RPR were presented as independent and significant variables on admission to predict mortality.The RPR obtained on hospital admission was persistently higher amongnon-survivors than among survivors(P<0.0001).The median RPR was 0.000087 in the non-survivor group and 0.000058 in the survivor group.RPR with a cutoff value of 0.000067 presented an area under the curve of 0.783(95%CI:0.688-0.878)in receiver operating characteristic curves and could predict the mortality of approximately 80%of the patients. | Erdin etinkaya Kazim Senol Baris Saylam Mesut Tez | 2014 | World Journal of Gastroenterology2014，20，39： | 38 |
| 4 | Gastric carcinogenesis显示文摘Gastric cancer is the second most common cancer worldwide and the second most common cause of cancer-related deaths. Despite complete resection of gastric cancer and lymph node dissection, as well as improvements in chemotherapy and radiotherapy, there are still 700 000 gastric cancer-related deaths per year worldwide and more than 80% of patients with advanced gastric cancer die of the disease or recurrent disease within 1 year after diagnosis. None of the treatment modalities we have been applying today can influence the overall survival rates:at present, the overall 5-year relative survival rate for gastric cancer is about 28%. Cellular metaplasia due to chronic inflammation, injury and repair are the most documented processes for neoplasia. It appears that chronic inflammation stimulates tumor development and plays a critical role in initiating, sustaining and advancing tumor growth. It is also evident that not all inflammation is tumorigenic. Additional mutations can be acquired, and this leads to the cancer cell gaining a further growth advantage and acquiring a more malignant phenotype. Intestinalization of gastric units, which is called 'intestinal metaplasia'; phenotypic antralization of fundic units, which is called 'spasmolytic polypeptide-expressing metaplasia'; and the development directly from the stem/progenitor cellzone are three pathways that have been described for gastric carcinogenesis. Also, an important factor for the development of gastrointestinal cancers is peritumoral stroma. However, the initiating cellular event in gastric metaplasia is still controversial. Understanding gastric carcinogenesis and its precursor lesions has been under intense investigation, and our paper attempts to highlight recent progress in this field of cancer research. | Ismail Gomceli Baris Demiriz Mesut Tez | 2012 | World Journal of Gastroenterology2012，18，37： | 25 |
| 5 | Histopathological comparison of topical therapy modalities for acute radiation proctitis in an experimental rat model显示文摘瞄准:与福尔马林相比评估为尖锐放射直肠炎的治疗可得到的流行热门治疗学的形式。方法:120 只老鼠的一个总数被使用。四个组(n = 30 ) 为每下列应用治疗形式与一个组一起被分析:控制, mesalazine,福尔马林, betamethasone,和 misoprostol。17.5 Gy 的单个部分被送到每只老鼠。在组老鼠被给 saline 的控制的老鼠,和在另外的三个组的老鼠在照耀以后开始第一天直到无痛苦的死亡的日子的一天收到了适当灌肠剂两次。在 d 上 5, 10,和 15,从每个组的十只老鼠是 euthanized,不知道处理赋值的一个病理学家用一个得分系统检验了直肠。结果:为表面上皮,腺(地窟) 和直肠的薄板 propria 基质的组织病理学说的分数在 d 上到达了他们的最大的水平 10。控制和福尔马林组有最高并且有的 mesalazine 最低,分别地在 d 上 10。在第 15 d 上, mesalazine, betamethasone,和 misoprostol 有 betamethasone 的最低分数。结论:Mesalazine, betamethasone,和 misoprostol 是最好的热门代理人因为放射直肠炎和福尔马林有煽动性的效果并且不应该被使用。 | Cagatay Korkut Oktar Asoglu Murat Aksoy Yersu Kapran Hatice Bilge Nese Kiremit-Korkut Mesut Parlak | 2006 | World Journal of Gastroenterology2006，12，30： | 18 |
| 6 | 计及分布式电源无功特性的弱环配电网复仿射潮流算法显示文摘为解决前推回代复仿射潮流算法在弱环及多分布式电源(DG)接口类型配电网中的适用性问题,在详细分析前推回代复仿射潮流计算特点的基础上,引入基于道路矩阵的回路分析法来解决该适应性问题。随后,针对仿射算术无法在区间不确定性条件下准确描述DG无功控制特性的不足,采用无功灵敏度矩阵与电压灵敏度矩阵两步修正的方式,提出了可计及DG无功控制特性的复仿射潮流改进算法。最后,基于IEEE 33节点系统、PG&E 69节点系统以及实际113节点系统扩展的含多DG接口类型的不同规模配电网验证了所提算法的有效性与准确性。 | 陈鹏伟 肖湘宁 Mesut BARAN | 2019 | 电力系统自动化2019，43，7： | 13 |
| 7 | Prognostic efficacy of inflammation-based markers in patients with curative colorectal cancer resection显示文摘AIM To evaluate the prognostic significance of neutrophilto-lymphocyte ratio(NLR), platelet-to-lymphocyte ratio(PLR), lymphocyte-to-monocyte ratio(LMR), and prognostic nutritional index(PNI) and other clinicopathological factors in patients undergoing curative resection of colon cancer.METHODS183 patients with histologically proven colorectal cancer who had undergone potentially curative resection between 2010 and 2016 at Ankara Numune Training and Research Hospital were retrospectively analyzed and clinicopathological characteristics included age, sex, tumor type, grade, size and localization, the number of metastatic and total number of lymph nodes removed, vascular and perineural invasion of the tumor, TNM stages, tumor marker levels(CEA, CA19-9, AFP, CA-125, CA15-3), complete blood counts, albumin levels, overall survival(months), NLR, PLR, LMR and PNI ratios were retrospectively reviewed and analyzed from the electronic database. The primary outcome measure was overall survival.RESULTS Regarding overall survival, on univariate analysis the following variables were significantly associated with poor outcome following resection: T-stage(P = 0.037), lymph node invasion(P = 0.037), cancer stage(P = 0.034), CEA(P = 0.042), CA19-9(P = 0.004), and PNI(P = 0.001). To evaluate the independent prognostic value, multivariate Cox proportional hazard analysis to control for other prognostic factors was used. Using cancer-specific death as an end point for NLR, PLR, LMR, PNI and CA19-9 the optimal cut off values were calculated by ROC analysis. Regarding overall survival, on multivariate analysis high CA19-9(HR = 1.001, 95%CI: 1.00-1.002, P = 0.012) and low PNI(HR = 0.938, 95%CI: 0.891-0.987, P = 0.014) were the only variables independently associated with shortened overall survival. Patients with a PNI < 35 had a median OS of 52.25 mo. In contrast, patients with an PNI > 35 had a median OS of 66 mo. Patients with a CA 19-9 < 17 had a median OS of 66 mo and in patients with a CA19-9 > 17 had a median OS of 53.76 mo.CONCLUSION This study shows that decrease in the PNI and increase in CA 19-9 is associated with poor survival in patients with resectable colon cancer. | özgür Akgül Erdinc Cetinkaya Metin Yalaza Sabri özden Mesut Tez | 2017 | World Journal of Gastrointestinal Oncology2017，9，7： | 11 |
| 8 | Importance of imaging and recent developments in diagnosis of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is one of the most common causes of chronic liver disease and is a major public health problem worldwide.It is a spectrum that includes simple steatosis,nonalcoholic steatohepatitis(NASH),fibrosis and cirrhosis.Recently,NAFLD prevalence in children and adolescents has increased too.The increasing prevalence has resulted in NASH-related chronic liver disease.Therefore,early diagnosis and treatment is quite important.Although liver biopsy is still the gold standard for diagnosis and staging of NAFLD,particularly for the diagnosis of NASH,imaging methods such as ultrasonography,computed tomography,magnetic resonance imaging with chemical shift imaging and especially magnetic resonance spectroscopy and elastography have been increasingly approved as noninvasive alternative methods.The aim of this review is to analyze the diagnostic accuracy and limitations of the imaging methods and recent developments in the diagnosis of NAFLD. | Mustafa Koplay Mesut Sivri Hasan Erdogan Alaaddin Nayman | 2015 | World Journal of Hepatology2015，7，5： | 7 |
| 9 | Congenital H-type anovestibuler fistula显示文摘The congenital H-type fistula between the anorectum and genital tract besides a normal anus is a rare entity in the spectrum of anorectal anomalies. We described a girl with an anovestibuler H-type fistula and left vulvar abscess. A 40-day-old girl presented symptoms after her parents noted the presence of stool at the vestibulum. On the physical examination, anus was in normal location and size, and had normal sphincter tone. A vestibuler opening was seen in the midline just below of the hymen. A fistulous communication was found between the vestibuler opening and the anus, just above the dentate line. There was a vulvar abscess which had a left lateral vulvar drainage opening 15 mm left lateral to the perineum. After the management of local inflammation and abscess, the patient was operated for primary repair of the fistula. A protective colostomy wasn′t performed prior the operation. A profuse diarrhea started after 5 hours of postoperation. After the diarrhea, a recurrent fistula was occurred on the second postoperative day. A divided sigmoid colostomy was performed. 2 months later, and anterior sagital anorectoplasty was reconstructed and colostomy was closed 1 month later. Various surgical techniques with or without protective colostomy have been described for double termination repair. But there is no consensus regarding surgical management of double termination. | Mesut Yazlcl Barlas Etensel Harun Gürsoy Sezen zklsaclk | 2003 | World Journal of Gastroenterology2003，9，4： | 4 |
| 10 | Inhibitory effects of regorafenib, a multiple tyrosine kinase inhibitor, on corneal neovascularization显示文摘AIM:To evaluate the inhibitory effects of regorafenib(BAY 73-4506),a multikinase inhibitor,on corneal neovascularization(NV).METHODS:Thirty adult male Sprague-Dawley rats weighing 250-300 g,were used.Corneal NV was induced by NaOH in the left eyes of each rat.Following the establishment of alkali burn,the animals were randomized into five groups according to topical treatment.Group 1(n=6)received 0.9%NaCl,Group 2(n=6)received dimethyl sulfoxide,Group 3(n=6)received regorafenib 1 mg/mL,Group 4(n=6)received bevacizumab 5 mg/mL and Group 5(n=6)received 0.1%dexamethasone phosphate.On the 7d,the corneal surface covered with neovascular vessels was measured on photographs as the percentage of the cornea's total area using computer-imaging analysis.The corneas obtained from rats were semiquantitatively evaluated for caspase-3 and vascular endothelial growth factor by immunostaining.RESULTS:A statistically significant difference in the percent area of corneal NV was found among the groups(P<0.001).Although the Group 5 had the smallest percent area of corneal NV,there was no difference among Groups 3,4 and 5(P>0.005).There was a statistically significant difference among the groups in apoptotic cell density(P=0.002).The staining intensity of vascular endothelial growth factor in the epithelial and endothelial layers of cornea was significantly different among the groups(P<0.05).The staining intensity of epithelial and endothelial vascular endothelial growth factor was significantly weaker in Groups 3,4 and 5 thanin Groups 1 and 2.CONCLUSION:Topical administration of regorafenib 1mg/mL is partly effective for preventing alkali-induced corneal NV in rats. | Halil Ibrahim Onder Mesut Erdurmus Yasin Yücel Bucak Hüseyin Simavli Murat Oktay Ahmet Sahap Kukner | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 4 |
| 11 | High adiponectin levels fail to protect against the risk of hypertension and,in women,against coronary disease:involvement in autoimmunity?显示文摘AIM:To investigate whether serum adiponectin protects against cardiometabolic risk in a population sample with prevailing metabolic syndrome.METHODS:Middle-aged adults representative of a general population with baseline circulating adiponectin measurements(n=1224)were analyzed prospectively at a mean of 3.8 years’follow-up,using continuous values or sex-specific tertiles.Total adiponectin was assayed by an ELISA kit.Type-2 diabetes was identified by criteria of the American Diabetes Association.Hypertension was defined as a blood pressure≥140 mmHg and/or≥90 mmHg and/or use of antihypertensive medication.Outcomes were predicted using Cox proportional hazards regression analysis in models that were controlled for potential confounders.RESULTS:In models of multiple linear regression,sex hormone-binding globulin,fasting insulin(inverse)and,in men,age were significant independent covariates of serum adiponectin which further tended in women to be positively associated with serum creatinine.Cox regression analyses for incident coronary heart disease(CHD),adjusted for sex,age,non-HDL cholesterol,waist circumference and C-reactive protein,revealed significant inverse association with adiponectin tertiles in men but not women(HR=0.66;95%CI:0.32-1.38 for highest tertile).Cox regression for type-2 diabetes in a similar model(wherein glucose replaced non-HDL cholesterol),adiponectin tertiles appeared to protect in each gender.HR for incident hypertension roughly displayed unity in each of the adiponectin tertiles(P-trend=0.67).CONCLUSION:High adiponectin levels failed to protect against the development of hypertension and,in women,against CHD,presumably paralleling impairment in renal function as well.Involvement of adiponectin in autoimmune complex with loss of antioxidative-antiatherogenic properties may be underlying. | Altan Onat Mesut Aydln Günay Can Bayram Kroglu Ahmet Karagz Servet Altay | 2013 | World Journal of Diabetes2013，4，5： | 3 |
| 12 | 跨文化视域下中国与土耳其茶文化比较研究显示文摘中国茶文化与社会生活、传统礼仪、儒释道都有不同程度的结合,是中国传统文化的象征。土耳其茶文化起源于古丝绸之路的中国,经过发展与改良,形成了自己独特的红茶文化。本文拟从中土茶文化的符号象征意义,茶俗异同,茶与文学艺术的结合进行中土茶文化的对比,探究中土茶文化内在的联系与各自的特色,建议通过茶文化交流进行有效的跨文化沟通,增进中土两国民心相通。 | 陈锦娟 Mesut Keskin | 2018 | 世界农业2018，，12： | 3 |
| 13 | Differences in individual susceptibility affect the development of trigeminal neuralgia显示文摘Trigeminal neuralgia is a syndrome due to dysfunctional hyperactivity of the trigeminal nerve,and is characterized by a sudden,usually unilateral,recurrent lancinating pain arising from one or more divisions of the nerve.The most accepted pathogenetic mechanism for trigeminal neuralgia is compression of the nerve at its dorsal root entry zone or in its distal course.In this paper,we report four cases with trigeminal neuralgia due to an unknown mechanism after an intracranial intervention.The onset of trigeminal neuralgia after surgical interventions that are unrelated to the trigeminal nerve suggests that in patients with greater individual susceptibility,nerve contact with the vascular structure due to postoperative pressure and changes in cerebrospinal fluid flow may cause the onset of pain. | Yusuf Kurtulus Duransoy Mesut Mete Emrah Akay Mehmet Seluki | 2013 | Neural Regeneration Research2013，8，14： | 3 |
| 14 | Is adiponectin level a predictor of nonalcoholic fatty liver disease in nondiabetic male patients?显示文摘AIM: To study the levels of adiponectin in nondiabetic patients with nonalcoholic fatty liver disease (NAFLD) in comparison with control group.METHODS: Thirty-five patients who had elevated serum aminotransferase levels with bright liver and 34 healthy volunteers without liver disease were evaluated. Age,gender and body mass index (BMI) were recorded. Fasting plasma glucose, insulin, adiponectin, proinsulin and lipid profile were measured. A standard oral glucose tolerance test (OGTT) with insulin response was performed and the index of insulin resistance was calculated according to the homeostasis model assessment (HOMA) method.RESULTS: According to the OGTT results, none of the participants had diabetes. Serum adiponectin levels were statistically significantly lower in patients with NAFLD than in control group (8.14±3.4 μg/mL vs12.4±9.4 μg/mL,respectively, P<0.01). A statistically significant correlation was found between adiponectin and BMI (r: -0.33, P<0.01),HOMA (r: -0.26, P<0.05), proinsulin (r: -0.32, P<0.01),AST (r: -0.25, P<0.05), ALT (r: -0.26, P<0.05) or GGT (r: -0.22, P<0.05). In multiple regression analysis models,adiponectin levels were the only predictor of NAFLD in males, whereas in female group it was the BMI.CONCLUSION: Low adiponectin level might be a predictor of NAFLD especially in male nondiabetics. | Haluk Sargin Mehmet Sargin Hülya Gozu Asuman Orcun Gülcan Baloglu Murat Ozisik Mesut Seker Oya Uygur-Bayramicli | 2005 | World Journal of Gastroenterology2005，11，37： | 3 |
| 15 | Contact lens impact on quality of life in keratoconus patients: rigid gas permeable versus soft siliconehydrogel keratoconus lenses显示文摘AIM: To determine the impact of rigid gas permeable(RGP) and silicone-hydrogel keratoconus lenses on the quality of life(Qo L) in keratoconus(KCN) patients using the self-reported results from the Contact Lens Impact on Quality of Life(CLIQ) Questionnaire.·METHODS: From January 2013 to April 2013, 27 consecutive KCN patients who wore RGP contact lenses(conflexair100 UV KE Zeiss-Whlk) or soft silicone-hydrogel contact lenses(SHCLs) for KCN(Kera Soft ICBausch&Lomb or Hydrocone Toris K-Swiss lens)completed the CLIQ questionnaire.·RESULTS: The mean age of 27 patients was 29.6±8.0y.Fifteen patients were RGP user. The groups were comparable with respect to the mean patient age, sex,and mean K values(P =0.1, P =0.8 and P =0.1, respectively).The mean CLIQperson measure was 42.8 ±5.5 in RGP group and 39.6 ±5.5 in SHCLs for KCN group(P =0.06).CLIQperson measure was positively correlated with steep K value(r =0.301, P =0.04). When eyes were stratified by visual acuity with contact lenses, the mean CLIQperson measure was 42. 01 ± 5. 6 in eyes with a visual acuity of20/20-20/25(n =44) and 38.4 ±5.26 in eyes with a visual acuity of 20/32 or less(n =10; P =0.097).·CONCLUSION: RGP lenses and SHCLs for KCN have similar impact on Qo L. | Elvin Hatice Yildiz Mesut Erdurmus Emine Savran Elibol Banu Acar Ece Turan Vural | 2015 | International Journal of Ophthalmology(English edition)2015，8，5： | 3 |
| 16 | Impact of laparoscopic surgery on bladder and sexual function after total mesorectal excision for rectal cancer显示文摘 | Oktar Asoglu Tugba Matlim Hasan Karanlik Murat Atar Mahmut Muslumanoglu Yersu Kapran Abdullah Igci Vahit Ozmen Mustafa Kecer Mesut Parlak | 2009 | Surgical Endoscopy2009，，2： | 2 |
| 17 | Gastric neuroendocrine neoplasms: A review显示文摘Gastric neuroendocrine neoplasms(g-NENs)or neuroendocrine tumors are generally slow-growing tumors with increasing incidence.They arise from enterochromaffin like cells and are divided into four types according to clinical characteristic features.Type 1 and 2 are gastrin dependent,whereas type 3 and 4 are sporadic.The reason for hypergastrinemia is atrophic gastritis in type 1,and gastrin releasing tumor(gastrinoma)in type 2 g-NEN.The diagnosis of g-NENs needs histopathological investigation taken by upper gastrointestinal endoscopy.g-NENs are positively stained with chomogranin A and synaptophysin.Grading is made with mitotic index and ki-67 proliferation index on histopathological analysis.It is crucial to discriminate between types of g-NENs,because the management,treatment and prognosis differ significantly between subtypes.Treatment options for g-NENs include endoscopic resection,surgical resection with or without antrectomy,medical treatment with somatostatin analogues,netazepide or chemotherapy regimens.Follow-up without excision is another option in appropriate cases.The prognosis of type 1 and 2 g-NENs are good,whereas the prognosis of type 3 and 4 g-NENs are close to the prognosis of gastric adenocancer. | Huseyin Koseoglu Tolga Duzenli Mesut Sezikli | 2021 | World Journal of Clinical Cases2021，9，27： | 2 |
| 18 | Can biliary-cyst communication be predicted before surgery for hepatic hydatid disease: does size matter?显示文摘 | Mehmet Kilic Omer Yoldas Mahmut Koc Mehmet Keskek Nazile Karakose Tamer Ertan Erdal Gocmen Mesut Tez | 2008 | The American Journal of Surgery2008，，5： | 2 |
| 19 | Comparison of Two Different Treatment Protocols in Helicobacter pylori Eradication显示文摘 | Isilay Nadir Ozlem Yonem Yasemin Ozin Zeki Mesut Yalin Kilic Orhan Sezgin | 2011 | Southern Medical Journal2011，，2： | 2 |
| 20 | Syringaldehyde exerts neuroprotective effect on cerebral ischemia injury in rats through anti-oxidative and anti-apoptotic properties显示文摘There are few studies on the neuroprotective effects of syringaldehyde in a rat model of cerebral ischemia. The study aimed to elucidate the mechanisms underlying the neuroprotective effects of syringaldehyde on ischemic brain cells. Rat models of cerebral ischemia were intraperitoneally administered syringaldehyde. At 6 and 24 hours after syringaldehyde administration, cell damage in the brain of cerebral ischemia rats was obviously reduced, superoxide dismutase activity and nuclear respiratory factor 1 expression in the brain tissue were markedly increased, malondiadehyde level was obviously decreased, apoptosis-related cysteine peptidase caspase-3 and-9 immunoreactivity was obviously decreased, and neurological function was markedly improved. These findings suggest that syringaldehyde exerts neuroprotective effects on cerebral ischemia injury through anti-oxidation and anti-apoptosis. | Aras Adem Bozkurt Guven Mustafa Akman Tar?k Ozkan Adile Sen Halil Murat K?l?coglu Mesut Kalkan Y?ld?ray Silan Coskun Cosar Murat | 2014 | Neural Regeneration Research2014，9，21： | 2 |
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