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| 1 | Effect of preoperative immunonutrition and other nutrition models on cellular immune parameters显示文摘AIM:To evaluate the effects of preoperative immunonutrition and other nutrition models on the cellular immunity parameters of patients with gastrointestinal tumors before surgical intervention.In addition,effects on postoperative complications were examined. METHODS:Patients with gastrointestinal tumors were randomized into 3 groups.The immunonutrition group received a combination of arginine,fatty acids and nucleotides.The second and third group received normal nutrition and standard enteral nutrition,respectively.Nutrition protocols were administered for 7 d prior to the operation.Nutritional parameters,in particular prealbumin levels and lymphocyte subpopulations(CD4+,CD8+,CD16+/56+,and CD69 cells)were evaluated before and after the nutrition protocols.Groups were compared in terms of postoperative complications and duration of hospital stay. RESULTS:Of the 42 patients who completed thestudy,16 received immunonutrition,13 received normal nutrition and 13 received standard enteral nutrition. prealbumin values were low in every group,but this parameter was improved after the nutritional protocol only in the immunonutrition group(13.64±8.83 vs 15.98±8.66,P=0.037).Groups were similar in terms of CD4+,CD16+/56,and CD69+prior to the nutritional protocol;whereas CD8+was higher in the standard nutrition group compared to the immunonutrition group.After nutritional protocols,none of the groups had an increase in their lymphocyte subpopulations.Also,groups did not differ in terms of postoperative complications and postoperative durations of hospital stay. CONCLUSION:Preoperative immunonutrition provided a significant increase in prealbumin levels,while it did not significantly alter T lymphocyte subpopulation counts,the rate of postoperative complications and the duration of hospital stay. | Yusuf Gunerhan Neset Koksal Umit Yasar Sahin Mehmet Ali Uzun Emel Ek■ioglu-Demiralp | 2009 | World Journal of Gastroenterology2009，15，4： | 21 |
| 2 | Treatment of retinopathy of prematurity: a review of conventional and promising new therapeutic options显示文摘Retinopathy of prematurity (ROP), a retinal vascular disease of premature infants, continues to be a major cause of preventable childhood blindness all over the world. The incidence of ROP varies among countries, being influenced by the quality of the level of neonatal intensive care. Here, we discuss the potential treatments that are now available or will soon or probably be available for ROP. Although ablation of the avascular retina with laser photocoagulation remains the current gold standard and well established therapy for ROP, some new therapeutic options including angiostatic therapies are being explored based on our knowledge of the pathophysiology of the ROP and complications and efficacy of laser treatment. However, prevention of the development of severe ROP and screening for ROP seem to be the best strategy in avoiding visual impairment caused by ROP in premature infants. New therapeutic interventions including vascular endothelial growth factor antibody administration, gene therapy and supplemental therapies should be supported with evidence-based data for the treatment of ROP. | Fatih Mehmet Mutlu Umit Serdar Sarici | 2013 | International Journal of Ophthalmology(English edition)2013，6，2： | 11 |
| 3 | Cerebral sinus thrombosis in patients with inflammatory bowel disease: A case report显示文摘Inflammatory bowel disease (IBD) is an idiopathic inflammatory disease of the gastrointestinal tract. The pathophysiology of IBD is probably the result of the complex interaction of genetic susceptibility and environmental influences. There is a well-known risk of thrombosis in patients with IBD. We present the case of a 53-year-old man with ulcerative colitis, who spontaneously developed intracranial sinus thrombosis that was treated with low molecular weight heparin. Literature was searched to assess the frequency and characteristics of cerebral sinus thrombosis in IBD and the role of certain etiopathological factors in such thrombotic patients. | Hasan Umit Talip Asil Yahya Celik Ahmet Tezel Gulbin Dokmeci Nermin Tuncbilek Ufuk Utku Ali Riza Soylu | 2005 | World Journal of Gastroenterology2005，11，34： | 6 |
| 4 | Incidence of toxoplasmosis in patients with cirrhosis显示文摘AIM:It is known that toxoplasmosis rarely leads to various liver pathologies,most common of which is granulomatose hepatitis in patients having normal immune systems. Patients who have cirrhosis of the liver are subject to a variety of cellular as well as humoral immunity disorders. Therefore, it may be considered that toxoplasmosis can cause more frequent and more severe diseases in patients with cirrhosis and is capable of changing the course of the disease.The aim of this study was to investigate the frequency of toxoplasmosis in patients with cirrhosis.METHODS:Serum samples were taken from 108 patients with cirrhosis under observation in the Hepatology Polyclinic of the Gastroenterology Clinic,and a control group made up of 50 healthy blood donors. IFAT and ELISA methods were used to investigate the IgG and IgM antibodies, which had developed from these sera.RESULTS:Toxoplasma IgG and IgM antibody positivity was found in 74 (68.5%) of the 108 cirrhotic patients and 24 (48%) of the 50 people in the control group. The difference between them was significant (P<0.05).CONCLUSION: In conclusion, it was found that the toxoplasma sero-prevalence in the cirrhotic patients in this study was higher. Cirrhotic patients are likely to form a toxoplasma risk group. More detailed studies are needed on this subject. | Sebnem Ustun Umit Aksoy Hande Dagci Galip Ersoz | 2004 | World Journal of Gastroenterology2004，10，3： | 6 |
| 5 | Effect of Different Surface Treatment Methods on the Friction and Wear Behavior of AISI 4140 Steel显示文摘In this study,the effects of various surface treatments on the friction and wear behavior of AISI 4140 steel have been evaluated.Sample surfaces of AISI 4140 steel were treated by quenching,carburizing,boronizing and plasma transferred arc (PTA) modification.The microstructural characteristics of surface treated steel samples were examined by optical microscopy and scanning electron microscopy (SEM).The mechanical properties of the samples including the surface roughness,microhardness,and abrasive and adhesive wear characteristics were also evaluated.Wear tests were applied by using a block-on-disc configuration under dry sliding conditions.The wear behavior and friction characteristics of the samples were determined as a function of sliding distance.Each sample group was compared with the other sample groups,and it was observed that the carburized samples demonstrated the lowest weight losses;however,PTA-treated samples demonstrated the lowest coefficient of friction in comparison to the other sample groups at the same sliding distance. | Mustafa Ulutan Osman N.Celik Hakan Gasan Umit Er | 2010 | Journal of Materials Science & Technology2010，26，3： | 5 |
| 6 | Rare pancreas tumor mimicking adenocarcinoma: Extramedullary plasmacytoma显示文摘Neoplastic proliferation of plasma cells is called plasma cell dyscrasias, and these neoplasms can present as a solitary neoplasm or multiple myeloma. Extramedullary plasmacytoma, in particular pancreatic plasmacytoma, is a rare manifestation of multiple myeloma. Although computerized tomography is useful for the diagnosis of extramedullary plasmacytoma, there are no specific radiologic markers that distinguish it from adenocarcinoma. Histological confirmation by biopsy is necessary for accurate diagnosis and management of the tumor. Endosonography is the most sensitive method for the diagnosis of pancreatic tumors, and the use of fine needle aspiration by endosonography is associated with a lower risk for malignant seeding and complications. Here, we report a case of pancreatic plasmacytoma in newly identified multiple myeloma as diagnosed by endosonography. Endosonography is a reliable and rapid method for the diagnosis of extramedullary plasmacytoma. Therefore, endosonographic fine needle aspiration should be the first choice for histological evaluation when pancreatic plasmacytoma is suspected. Ideally, the pathology would be performed at the same site as endosonographic biopsy. | Filiz Akyuz Davut Sahin Umit Akyuz Sezai Vatansever | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，3： | 4 |
| 7 | Keratinocyte 生长 factor-2 和自体同源的浆液加强处于在老鼠的角膜损坏的间充质的干细胞的再生效果显示文摘AIM:To investigate the healing process after severe corneal epithelial damage in rats treated with mesenchymal stem cells(MSCs)cultured with or without keratinocyte growth factor(KGF-2)and autologous serum(AS)on amniotic membrane(AM).Many patients are blind and devastated by severe ocular surface diseases due to limbal stem cell deficiency.Bone marrow-derived MSCs are potential sources for cellbased tissue engineering to repair or replace the corneal tissue,having the potential to differentiate to epithelial cells.METHODS:The study included 5 groups each including 10 female'Sprague Dawley'rats in addition to20 male rats used as bone marrow donors.Group I rats received AM+MSCs,Group II rats AM+MSCs cultured with KGF-2,Group III rats AM+MSCs cultured with KGF-2+AS,Group IV rats only AM and Group V rats,none.AS was derived from blood drawn from male rats and bone marrow was obtained from the femur and tibia bones of the same animals.Therapeutic effect was evaluated with clinical,histopathological and immunohistochemical assessment.MSC engraftment was demonstrated via detection of donor genotype(Y+)in the recipient tissue(X)with polymerase chain reaction.RESULTS:Corneal healing was significantly better in Groups I-III rats treated with MSC transplantation compared to Group IV and Group V rats with supportive treatment only.The best results were obtained in Group III rats with 90%transparency,70%lack of neovascularization,and 100%epithelium damage limited to less than 1/4 of cornea.CONCLUSION:We suggest that culture of MSCs with KGF-2 and AS on AM is effective in corneal repair in case of irreversible damage to limbal stem cells. | Ferda Alpaslan Pinarli Gülsen Okten Umit Beden Tunc Fisgin Mehmet Kefeli Nurten Kara Feride Duru Leman Tomak | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 4 |
| 8 | Slope stability evaluation and monitoring of a landslide: a case study from NE Turkey显示文摘Landslides are quite common natural hazards in the eastern Black Sea region of NE Turkey.Following the heavy rainfall in the K?prülü(Rize)village settlement area,located in this region where the slope debris overlies the agglomerates,a failure occurred.Due to the developed tension cracks and deformations on the ground,houses,tea gardens,and roads were damaged completely.To figure out the causes and mechanism of the sliding and to suggest the precautions,a detailed geotechnical study was carried out.Along the five survey lines,twelve boreholes were drilled with a total depth of 300 meters.Also,the geophysical surveys on ten profiles were conducted and the inclinometer measurements were taken in five boreholes.Undisturbed and disturbed samples were collected and laboratory experiments were performed.Inclinometer measurements indicated that the sliding started in the slope debris and then spread to the agglomeratic bedrock.The slope stability was examined using the limit equilibrium(LE)and finite element(FEM)analysis methods.The results of the slope stability analyses showed that the failure mode is talus slide with composite shape and outputs coincide with the inclinometer monitoring results.Based on the collected data,it is determined that there will be unavoidable engineering problems if no precautions are taken.Because of the negative reasons which make the application of supporting methods meaningless in the study area,it is considered that transferring the residences to a safer place without risk of natural hazards will be economical and reliable. | Ayberk KAYA Umit Murat MIDILLI | 2020 | Journal of Mountain Science2020，17，11： | 4 |
| 9 | Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats显示文摘AIM: To investigate whether antioxidants vitamin E and C can retard development of hepatic fibrosis in the bili- ary-obstructed rats. METHODS: Fifty Wistar albino rats were randomly as- signed to 5 groups (10 rats in each). Bile duct was liga- ted in 40 rats and they were treated as follows: group vitC, vitamin C 10 mg/kg sc daily; group vitE, vitamin E 15 mg/kg sc daily; group vitEC, both of the vitamins; bile duct-ligated (BDL, control) group, physiological saline sc. The fifth group was assigned to sham operation. At the end of fourth week, the rats were decapitated, and hepatic tissue biochemical collagen content and collagen surface area were measured. Hepatic tissue specimens were histopathologically evaluated according to Scheuer system. Serum hyaluronate levels were measured by ELISA method. RESULTS: Despite being higher than sham group, he- patic collagen level was significantly decreased in each of the vitC, vitE and vitEC groups (32.7 ± 1.2, 33.8 ± 2.9, 36.7 ± 0.5 μg collagen/mg protein, respectively) compared to BDL (48.3 ± 0.6 mg collagen/g protein) (P < 0.001 for each vitamin group). Each isolated vitamin C, isolated vitamin E and combined vitamin E/C supp-lementation prevented the increase in hepatic collagen surface density (7.0% ± 1.1%, 6.2% ± 1.7%, 12.3% ± 2.0%, respectively) compared to BDL (17.4% ± 5.6%) (P < 0.05 for each). The same beneficial effect of vitamin C, vitamin E and combined vitamin E/C treatment was also observed on the decrease of serum hyaluronate levels compared to BDL group (P < 0.001). The relative liver and spleen weights, serum transaminases, cholestatic enzymes, bilirubins and histopathological inflammation scores were not different between the antioxidant treat- ment groups and the control. However, fibrosis staging scores were obviously reduced only in the vitamin E/C combination group (vit EC: 2.4 ± 0.8 vs BDL: 3.1 ± 0.7; P < 0.05). CONCLUSION: Each antioxidant vitamin E, vitamin C and their combination retard hepatic fibrosis in biliary-obs- tructed rats. Oxidative stress may play a role in the patho- genesis of hepatic fibrosis in secondary biliary cirrhosis. | Ali Riza Soylu Nurettin Aydogdu Umit Nusret Basaran Semsi Altaner Orhan Tarcin Nursal Gedik Hasan Umit Ahmet Tezel Gulbin Dokmeci Huseyin Baloglu Mevlut Ture Kemal Kutlu Kadir Kaymak | 2006 | World Journal of Gastroenterology2006，12，42： | 4 |
| 10 | Prevalence of amebiasis in inflammatory bowel disease in Turkey显示文摘AIM: To explore the prevalence of amebiasis in inflammatory bowel disease (IBD) in Turkey.METHODS: In this study, amoeba prevalence in 160 cases of IBD, 130 of ulcerative colitis and 30 of Crohn′s disease were investigated in fresh faeces by means of wet mount+Lugol′s iodine staining, modified formol ethyl acetate and trichrome staining methods and to compare the diagnostic accuracy of wet mount+Lugol′s iodine staining,modified formol ethyl acetate and trichrome staining methods in the diagnosis of Entamoeba histolytica (E. histolytica)/Entamoeba dispar (E. dispar).RESULTS: E. histolytica/E. dispar cysts and trophozoites were found in 14 (8.75 %) of a total of 160 cases, 13 (10.0 %)of the 130 patients with ulcerative colitis and 1 (3.3 %) of the 30 patients with Crohn′s disease. As for the 105 patients in the control group who had not any gastrointestinal complaints, 2 (1.90 %) patients were found to have E.histolytica/E. dispar cysts in their faeces. Parasite prevalence in the patient group was determined to be significantly higher than that in the control group (Fischer′s Exact Test, P<0.05).When the three methods of determining parasites were compared with one another, the most effective one was found to be trichrome staining method (Kruskal-Wallis Test, P<0.01).CONCLUSION: Consequently, amoeba infections in IBD cases have a greater prevalence compared to the normal population. The trichrome staining method is more effective for the detection of E. histolytica/E. dispar than the wet mount+Lugol′s iodine staining, modified formol ethyl acetate methods. | Sebnem Ustun Hande Dagci Umit Aksoy Yuksel Guruz Galip Ersoz | 2003 | World Journal of Gastroenterology2003，9，8： | 3 |
| 11 | Cobalt,a reactive metal in releasing hydrogen from sodium borohydride by hydrolysis:A short review and a research perspective显示文摘Cobalt is commonly admitted as being a promising catalyst in accelerating NaBH4 hydrolysis,being as reactive as noble metals and much more cost-effective.This is the topic of the present paper.Herein,we survey(i) the NaBH4-devoted literature while especially focusing on the Co catalysts and(ii) our work on the same topic.Finally,we report(iii) reactivity results of newly developed Co-based catalysts.From both surveys,it mainly stands out that Co has been investigated as catalysts in various forms:namely,as chlorides,reduced nanoparticles(metal Co,Co boride,Co-B alloy),supported over supports and shaped.In doing so the reactivity can be easily varied achieving H2 generation rates from few to >1000 L(H2)/min·g(metal).Nevertheless,our work can be distinguished from the NaBH4 literature.Indeed,we are working on strategies that focus on making alternative Co-based catalysts.One of these strategies is illustrated here as we report new reactivity data of Co-based bimetallic supported catalysts.For example,we show that 20 wt% Co90Y10/γAl2O3-20 wt% Co95Hf5/γAl2O3 > 20 wt% Co99Zr1/γAl2O3 > 20 wt% Co/γAl2O3,the best catalysts showing HGRs of about 245 mL(H2)/min or 123 L(H2) /min·g(metals). | DEMIRCI Umit B AKDIM Ouardia HANNAUER Julien CHAMOUN Rita MIELE Philippe | 2010 | Science China Chemistry2010，53，9： | 3 |
| 12 | Post-procedure Elevated Amylase and Lipase Levels After Double-Balloon Enteroscopy: Relations with the Double-Balloon Technique显示文摘 | Cengiz Pata Umit Akyüz Yusuf Erzin Nilgun Mutlu Arzu Mercan Ahmet Dirican | 2010 | Digestive Diseases and Sciences2010，，7： | 3 |
| 13 | L-carnitine alleviates sciatic nerve crush injury in rats:functional and electron microscopy assessments显示文摘Several studies have demonstrated that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats with diabetes mellitus.It is hypothesized that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats.Rat sciatic nerve was crush injured by a forceps and exhibited degenerative changes.After intragastric administration of 50 and 100 mg/kg L-carnitine for 30 days,axon area,myelin sheath area,axon diameter,myelin sheath diameter,and numerical density of the myelinated axons of injured sciatic nerve were similar to normal,and the function of injured sciatic nerve also improved significantly.These findings suggest that L-carnitine exhibits neuroprotective effects on sciatic nerve crush injury in rats. | ümmü Zeynep Avsar Umit Avsar Ali Aydin Muhammed Yayla Berna Ozturkkaragoz Harun Un Murat Saritemur Tolga Mercantepe | 2014 | Neural Regeneration Research2014，9，10： | 3 |
| 14 | Relationship of cystatin C with coronary artery disease and its severity显示文摘 | Yusuf C. Doganer Umit Aydogan Aydogan Aydogdu Mustafa Aparci Halil Akbulut Polat Nerkiz Turker Turker Tuncer Cayci Cem Barcin Kenan Saglam | 2013 | Coronary Artery Disease2013，，2： | 2 |
| 15 | Sustainability of Touristic Potential of the Old Van City and Castle of Van in Terms of Cultural, Historical and Natural Values显示文摘 | Ayse Sirel Osman Umit Sirel | 2014 | Journal of Civil Engineering and Architecture2014，8，8： | 2 |
| 16 | A new treatment option for the resistant spasm of accommodation:clear lens extraction and multifocal intraocular lens implantation显示文摘Dear Editor,We write you to present a 20-year-old man with resistant spasm of accommodation without any organic cause treated with clear lens extraction(CLE)with phacoemulsification and multifocal intraocular lens(IOL)implantation.Spasm of accommodation is a rare condition | Ozgun Melike Gedar Totuk Umit Aykan | 2018 | International Journal of Ophthalmology(English edition)2018，11，1： | 2 |
| 17 | Mo loading effect over Mo/Si:Ti catalysts in the oxidative dehydrogenation of ethane显示文摘 | Rich B Watson Umit S Ozkan | 2002 | J Catal2002，208，： | 2 |
| 18 | Food impaction in older age:Think about an eosinophilic esophagitis显示文摘Eosinophilic esophagitis is an inflammatory condition of esophagus.It is generally seen in childhood and young population.Men are more commonly affected than women.However,it is not common in an advanced age.Eosinophilic esophagitis decreases the ability of the esophagus to stretch and accommodation against foods.Therefore,the major symptom in adults with eosinophilic esophagitis is difficulty in swallowing solid food(dysphagia).Specifically,the food gets stuck in the esophagus after it is swallowed.Less common symptoms include heartburn and chest pain.Because of this,it may be incorrectly diagnosed as a gastroesophageal reflux disease.Here,we reported a case presented with food impaction at advanced age.As a conclusion,eosinophilic esophagitis is a rare entity that must be remembered in advance aged patients presenting with food impaction. | Umit Akyüz Filiz Akyüz Kamil zdil Hasan Altun Ahmet Faruk Agan Aysegül Agan | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，2： | 2 |
| 19 | Hydrodeoxygenation of benzofuran over sulfided and reduced Ni-Mo/y-Al2O3 catalysts: effect of H2S 显示文摘 | Abdu Y Bunch Wang Xueqin Umit S Ozkan | 2007 | Journal of Molecular Catalysis A : Chemical2007，270，12： | 1 |
| 20 | Sliding-mode Control in Discrete-state and Hybrid Systems 显示文摘 | Murat Dogruel Umit Ozguner Sergey Drakunov | 1996 | IEEE Trans on Automatic Control1996，41，3： | 1 |
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