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| 1 | Diabetes-induced changes in cardiac voltage-gated ion channels显示文摘Diabetes mellitus affects the heart through various mechanisms such as microvascular defects,metabolic abnormalities,autonomic dysfunction and incompatible immune response.Furthermore,it can also cause functional and structural changes in the myocardium by a disease known as diabetic cardiomyopathy(DCM)in the absence of coronary artery disease.As DCM progresses it causes electrical remodeling of the heart,left ventricular dysfunction and heart failure.Electrophysiological changes in the diabetic heart contribute significantly to the incidence of arrhythmias and sudden cardiac death in diabetes mellitus patients.In recent studies,significant changes in repolarizing K+currents,Na+currents and L-type Ca^(2+)currents along with impaired Ca^(2+ )homeostasis and defective contractile function have been identified in the diabetic heart.In addition,insulin levels and other trophic factors change significantly to maintain the ionic channel expression in diabetic patients.There are many diagnostic tools and management options for DCM,but it is difficult to detect its development and to effectively prevent its progress.In this review,diabetes-associated alterations in voltage-sensitive cardiac ion channels are comprehensively assessed to understand their potential role in the pathophysiology and pathogenesis of DCM. | Nihal Ozturk Serkan Uslu Semir Ozdemir | 2021 | World Journal of Diabetes2021，12，1： | 6 |
| 2 | Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters. | V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 3 | Comparison of multichannel intraluminal impedance-pH monitoring and reflux scintigraphy in pediatric patients with suspected gastroesophageal reflux显示文摘AIM To evaluate the agreement of multichannel intraluminal impedance-p H monitoring(MII-p HM) and gastroesophageal reflux scintigraphy(GES) for the diagnosis of gastroesophageal reflux disease. METHODS Seventy-five consecutive patients with suspectedgastroesophageal reflux disease(GERD) underwent 24-h combined MII-p HM recording and one hour radionuclide scintigraphy during the course of the MIIpH M study. Catheters with 6 impedance channels and 1 p H sensor were placed transnasally. Impedance and p H data analysis were performed automatically and manually. For impedance monitoring, reflux was defined as a retrograde 50% drop in impedance, starting distally and propagating retrogradely to at least the next two more proximal measuring channels. Reflux index(RI, percentage of the entire record that esophageal p H is < 4.0) greater than 4.2% for p HM and number of refluxes more than 50 for 24 h for MII were accepted as positive test results. At scintigraphy, 240 frames of 15 seconds duration were acquired in the supine position. Gastroesophageal reflux was defined as at least one reflux episode in the esophagus. After scintigraphic evaluation, impedance-pH recordings and scintigraphic images were evaluated together and agreement between tests were evaluated with Cohen's kappa.RESULTS Sufficient data was obtained from 60(80%) patients(34 male, 56.7%) with a mean age of 8.7 ± 3.7 years(range: 2.5-17.3 years; median: 8.5 years). Chronic cough, nausea, regurgitation and vomiting were the most frequent symptoms. The mean time for recording of MII-pH M was 22.8 ± 2.4 h(range: 16-30 h; median: 22.7 h). At least one test was positive in 57(95%) patients. According to diagnostic criteria, GERD was diagnosed in 34(57.7%), 44(73.3%), 47(78.3%) and 51(85%) patients by means of p HM, MII, GES and MII-p HM, respectively. The observed percentage agreements/κ values for GES and p HM, GES and MII, GES and MII-p HM, and MII and p HM are 48.3%/-0.118; 61.7%/-0.042; 73.3%/0.116 and 60%/0.147, respectively. There was no or slight agreement between GES and p HM alone, MII alone or MII-p HM. p H monitoring alone missed 17 patients compared to combined MII-p HM. The addition of MII to pH monitoring increased the diagnosis rate by 50%.CONCLUSION No or slight agreement was found among p H monitoring, MII monitoring, MII-pH monitoring and GES for the diagnosis of gastroesophageal reflux disease. | Nuray Uslu Kizilkan Murat Fani Bozkurt Inci Nur Saltik Temizel Hülya Demir Aysel Yüce Biray Caner Hasan Ozen | 2016 | World Journal of Gastroenterology2016，22，43： | 2 |
| 4 | Open repair of Bankart lesions using suture anchors in hard workers显示文摘 | Cetik O Uslu M Ozsar B K | 2006 | Acta Orthop Belg2006，72，6： | 1 |
| 5 | Levels of soluble intercellular adhesion molecule-land total sialic acid in serum of patients with laryngeal cancer 显示文摘 | Akca YF Taysi S Uslu C | 2001 | Jpn J Clin Oncol2001，31，12： | 1 |
| 6 | Can serum CA125 levels predict the optimal primary cytoreduction in patients with advanced ovarian carcinoma?显示文摘 | Saygili U Guclu S Uslu T | 2002 | Gynecol Oncol2002，86，1： | 1 |
| 7 | Can serum CA-125 levels predict the optimal primary cytoreduction in patients with advanced ovarian carcinoma显示文摘 | Saygili U Gudu S Uslu T | 2002 | Gynecol Oncol2002，86，1： | 1 |
| 8 | Is There a Relationship Between Chronic Periodontitis and Erectile Dysfunction?显示文摘 | Fatih O?uz Abubekir Eltas Ali Beytur Ender Akdemir Mustafa ?zay Uslu Ali Güne? | 2012 | The Journal of Sexual Medicine2012，，3： | 1 |
| 9 | Arsenic trioxide-mediated cytotoxicity and apoptosis in proatate and ovarian carcinoma cell lines显示文摘 | Sanli U A Ezgin C | 2000 | Clin Cancer Res2000，6，12： | 1 |
| 10 | Effects of two different regimensof continuous hormone replacement therapy on endometrialhistopathology and postmenopausal uterine bleeding显示文摘 | Yildirin G Tugrul S Uslu H | 2006 | JAMA2006，273，5： | 1 |
| 11 | Bioaccumulation of copper (Ⅱ), lead(Ⅱ) and chromium(Ⅵ) by growing Aspergillusnig er显示文摘 | Dursun AY Uslu G Cuci Y | 2003 | Process Biochemistry2003，38，12： | 1 |
| 12 | Comparison of the ozonation and Fenton process performances for the treatment of antibiotic containing manure显示文摘 | Merih ?tker Uslu I??l Akmehmet Balc?o?lu | 2009 | Science of the Total Environment2009，，11： | 1 |
| 13 | Renal failure in obstructive jaudice 显示文摘 | Uslu A Cayci M Narta A | 2005 | Hepat ogastroent erology2005，52，61： | 1 |
| 14 | The evaluation of polycythemic newborns:efficacy of partial exchange transfusion显示文摘 | Uslu S Ozdemir H Bulbul A | 2011 | J Matern Fetal Neonatal Med2011，24，12： | 1 |
| 15 | The determinants of right ventricular function in patients with atrial septal defect显示文摘 | Gorgulu S Eren M Uslu N | 2006 | Int J Cardiol2006，111，： | 1 |
| 16 | The evaluation of the causes of subjective voice disturbances after thyroid surgery显示文摘 | Soylu L Ozbas S Uslu HY | 2007 | The American Journal of Surgery2007，194，： | 1 |
| 17 | Longitudinal left ventricular systolic function is impaired in patients with coronary slow flow显示文摘 | Nurkalem Z Gorgulu S Uslu N | | 0，，： | 1 |
| 18 | Effects of lipoprotein associated phospholipase A2 on arginase/nitric oxide pathway in hemodialysis patients显示文摘 | Tektas AK Uslu S Yalcin AU | 2012 | Ren Fail2012，34，6： | 1 |
| 19 | Serum cystatin C and urina ry enzymes as screening markers of renal dysfunction in diabetic patients显示文摘 | Uslu S Efe B Alatas O | | J Nephrol0，18，5： | 1 |
| 20 | Arsenic trioxide-mediated cytotoxicity and apoptosis in proatate and ovarian carcinoma cell lines显示文摘 | USLU R SANLI UA SEZGIN C | 2000 | Clin Cancer Res2000，6，12： | 1 |
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