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| 1 | From the Gla domain to a novel small-molecule detector of apoptosis显示文摘Apoptosis 在众多的医药混乱的病原学或致病起一个枢轴的作用,并且这样, apoptotic 房间指向可以实质地推进耐心的照顾。在我们为为 apoptosis 的新奇 low-molecular-weight 探针的探索,我们集中了于不平常的氨基酸纬 - carboxyglutamic 酸(Gla ) ,它在 clotting 因素的绑定起一个重要作用到否定地控告的 phospholipid 表面。基于 Gla 的 alkyl-malonic 酸主题,我们开发了并且现在介绍 ML-10 (2-(5-fluoro-pentyl )-2-methyl-malonic 酸, MW=206 Da ) , apoptosis 的小分子的察觉者的一个新奇家庭的原型的成员。ML-10 被发现在 apoptotic 房间执行选择举起和累积,当从可行或坏死的房间被排除时。有 caspase 激活, Annexin-V 绑定和 mitochondrial 膜潜力的混乱的 apoptotic 特点的 ML-10 举起相互关联。malonate 一半被发现为在 apoptosis 察觉的 ML-10 功能关键。ML-10 在早 apoptosis 对房间的特征的唯一的建筑群作出回应,包括膜潜力,房间膜和细胞质的永久使发酸,和膜正直的保藏的不可逆的损失。ML-10 因此是迄今为止知道的最紧缩的 apoptosis 探查。由于它的氟的符号原子, ML-10 对顺从与 18F 同位素标记收音机,向它为 apoptosis 的临床的正电子排放断层摄影术成像的潜在的未来使用。 | Avi Cohen Anat Shirvan Galit Levin Hagit Grimberg Ayelet Reshef Ilan Ziv | 2009 | Cell Research2009，19，5： | 12 |
| 2 | Incidence and management of colonoscopic perforations: 8 years' experience显示文摘瞄准:与诊断、治疗学的 colonoscopies 考察一个主要医药教学中心的经验并且估计相关结肠的穿孔的发生和管理。方法:所有 colonoscopies 在 1994 年 1 月之间表现了, 2001 年 12 月被学习。病人, colonoscopic 报告和过程相关的复杂并发症上的数据从部的计算机化的数据库被收集。有柱子的病人的医药记录程序的结肠的穿孔被考察。结果:120067 colonoscopies 的一个总数在学习的 8 年期间被执行。七个 colonoscopic 穿孔(4 女性, 3 男性) 被诊断(0.058%) 。五发生了在期间诊断并且二在治疗学的结肠镜检查期间。六在结肠镜检查以后被怀疑在期间或立即。除了都,一有弥漫的温柔的符号并且经历了立即的操作,主要修理在 4 个病人做。没有死亡被报导。结论:穿孔率在结肠镜检查期间是低的。不过,它是严肃的复杂并发症和它的早识别,治疗是必要的优化结果。在有早起作用的弥漫的腹膜炎的病人,干预使主要修理成为一种安全选择。 | Hagit Tulchinsky Osnat Madhala-Givon Nir Wasserberg Shiomo Lelcuk Yaron Niv | 2006 | World Journal of Gastroenterology2006，12，26： | 6 |
| 3 | An Interval >7 Weeks between Neoadjuvant Therapy and Surgery Improves Pathologic Complete Response and Disease–Free Survival in Patients with Locally Advanced Rectal Cancer显示文摘 | Hagit Tulchinsky Einat Shmueli Arie Figer Joseph M. Klausner Micha Rabau | 2008 | Annals of Surgical Oncology2008，，10： | 2 |
| 4 | Polysaccharideoligoamine based conjugates for gene delivery 显示文摘 | TONY AZZAM HAGIT ELIYAHU LIBI SHAPIRA | 2002 | J Med Chem2002，45，9： | 1 |
| 5 | Modification of flower color and fragrance by antisense suppression of the flavanone 3-hydroxylase gene显示文摘 | Amir Zuker Tzvi Tzfira Hagit Ben-Meir Marianna Ovadis Elena Shklarman Hanan Itzhaki Gert Forkmann Stefan Martens Inbal Neta-Sharir David Weiss Alexander Vainstein | 2002 | Molecular Breeding2002，，1： | 1 |
| 6 | A quantitative evaluation of the molecular binding affinity between a monoclonal antibody conjugated to a nanoparticle and an antigen by surface Plasmon resonance显示文摘 | Nir Debotton Hagit Zer Marcela Parnes | | 0，，02： | 1 |
| 7 | Modification of flower color and fragrance by antisense suppression of the flavanone 3-hydroxylase gene显示文摘 | Amir Zuker Tzvi Tzfira Hagit Ben-Meir Marianna Ovadis Elena Shklarman Hanan Itzhaki Gert Forkmann Stefan Martens Inbal Neta-Sharir David Weiss Alexander Vainstein | 2002 | Molecular Breeding2002，，1： | 1 |
| 8 | Discovering Semantic Features in the Literature : a foundation for building functional associations 显示文摘 | Monica Chagoyen Pedro Carmona - Saez Hagit Shatkay | 2006 | BMC2006，，7： | 1 |
| 9 | Photoinhibition – a historical perspective显示文摘 | Noam Adir Hagit Zer Susana Shochat Itzhak Ohad | 2003 | Photosynthesis Research2003，，： | 1 |
| 10 | Highly sensitive and rapid detection of antibody catalysis by luminescent bacteria显示文摘 | HAGIT S ANATOL E | 2000 | Bioorganic&Medicinal Chemistry Letters2000，，10： | 1 |
| 11 | Prevention of Dopamine-Induced Cell Death by Thiol Antioxidants: Possible Implications for Treatment of Parkinson’s Disease显示文摘 | Daniel Offen Ilan Ziv Hagit Sternin Eldad Melamed Ayala Hochman | 1996 | Experimental Neurology1996，，1： | 1 |
| 12 | Real-Time Pattern Matching Using Projection Kernels 显示文摘 | YACOV Hal-or HAGIT Hel-or | 2005 | IEEE Transactions on Pattern Analysis and Machine Intelligence2005，27，9： | 1 |
| 13 | The VP within Process Nominals: Evidence from Adverbs and the VP Anaphor Do-So显示文摘 | Jingqi Fu Thomas Roeper Hagit Borer | 2001 | Natural Language and Linguistic Theory2001，，3： | 1 |
| 14 | Modification of flower color and fragrance by antisense suppression of the flavanone 3-hydroxylase gene显示文摘 | Amir Zuker Tzvi Tzfira Hagit Ben-Meir Marianna Ovadis Elena Shklarman Hanan Itzhaki Gert Forkmann Stefan Martens Inbal Neta-Sharir David Weiss Alexander Vainstein | 2002 | Molecular Breeding2002，，1： | 1 |
| 15 | In vitro and in vivo evaluation of a paclitaxel conjugate with the divalent peptide E- that targets integrin αvβ3 显示文摘 | CLAUDIA R HAGIT M S MARTIN L B | 2009 | Int J Pharm2009，368，12： | 1 |
| 16 | Blockade of endogenous IL-18 ameliorates TNBS-induced colitis by decreasing local TNF-α. Production in mice显示文摘 | Tessa Ten Hove Anne Corbaz Hagit Amitai Shuki Aloni Ilana Belzer Pierre Graber Paul Drillenburg Sander J.H. Van Deventer Yolande Chvatchko Anje A. Te Velde | 2001 | Gastroenterology2001，，6： | 1 |
| 17 | Peptides targeting protein kina- ses : strategies and implications 显示文摘 | Oksana K B Hagit E F | 2006 | Physiology2006，21，： | 1 |
| 18 | ApoSense: a novel technology for functional molecular imaging of cell death in models of acute renal tubular necrosis显示文摘 | Maya Damianovich Ilan Ziv Samuel N. Heyman Seymour Rosen Ahuva Shina Dvora Kidron Tali Aloya Hagit Grimberg Galit Levin Ayelet Reshef Alfonso Bentolila Avi Cohen Anat Shirvan | 2006 | European Journal of Nuclear Medicine and Molecular Imaging2006，，3： | 1 |
| 19 | Restrictive Relatives in Modem Hebrew 显示文摘 | Borere Hagit | 1984 | Natural Language and Linguisitc Theory1984，，2： | 1 |
| 20 | Pouch Inflammation Is Associated With a Decrease in Specific Bacterial Taxa显示文摘 | Leah Reshef Amir Kovacs Amos Ofer Lior Yahav Nitsan Maharshak Nirit Keren Fred M. Konikoff Hagit Tulchinsky Uri Gophna Iris Dotan | 2015 | Gastroenterology2015，，： | 1 |
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