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| 1 | MicroRNAs as a potential prognostic factor in gastric cancer显示文摘AIM:To compare the microRNA (miR) profiles in the primary tumor of patients with recurrent and non-recurrent gastric cancer.METHODS:The study group included 45 patients who underwent curative gastrectomies from 1995 to 2005 without adjuvant or neoadjuvant therapy and for whom adequate tumor content was available.Total RNA was extracted from formalin-fixed paraffin-embedded tumor samples,preserving the small RNA fraction.Initial profiling using miR microarrays was performed to identify potential biomarkers of recurrence after resection.The expression of the differential miRs was later verified by quantitative real-time polymerase chain reaction (qRT-PCR).Findings were compared between patients who had a recurrence within 36 mo of surgery (bad-prognosis group,n=14,31%) and those who did not (good-prognosis group,n=31,69%).RESULTS:Three miRs,miR-451,miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P<0.0002,0.0027 and 0.0046 respectively).High expression of each miR was associated with poorer prognosis for both recurrence and survival.Using miR-451,the positive predictive value for non-recurrence was 100% (13/13).The expression of the differential miRs was verified by qRT-PCR,showing high correlation to the microarray data and similar separation into prognosis groups.CONCLUSION:This study identified three miRs,miR-451,miR-199a-3p and miR-195 to be predictive of recurrence of gastric cancer.Of these,miR-451 had the strongest prognostic impact. | Baruch Brenner Moshe B Hoshen Ofer Purim Miriam Ben David Karin Ashkenazi Gideon Marshak Yulia Kundel Ronen Brenner Sara Morgenstern Marisa Halpern Nitzan Rosenfeld Ayelet Chajut Yaron Niv Michal Kushnir | 2011 | World Journal of Gastroenterology2011，17，35： | 31 |
| 2 | From the Gla domain to a novel small-molecule detector of apoptosis显示文摘Apoptosis 在众多的医药混乱的病原学或致病起一个枢轴的作用,并且这样, apoptotic 房间指向可以实质地推进耐心的照顾。在我们为为 apoptosis 的新奇 low-molecular-weight 探针的探索,我们集中了于不平常的氨基酸纬 - carboxyglutamic 酸(Gla ) ,它在 clotting 因素的绑定起一个重要作用到否定地控告的 phospholipid 表面。基于 Gla 的 alkyl-malonic 酸主题,我们开发了并且现在介绍 ML-10 (2-(5-fluoro-pentyl )-2-methyl-malonic 酸, MW=206 Da ) , apoptosis 的小分子的察觉者的一个新奇家庭的原型的成员。ML-10 被发现在 apoptotic 房间执行选择举起和累积,当从可行或坏死的房间被排除时。有 caspase 激活, Annexin-V 绑定和 mitochondrial 膜潜力的混乱的 apoptotic 特点的 ML-10 举起相互关联。malonate 一半被发现为在 apoptosis 察觉的 ML-10 功能关键。ML-10 在早 apoptosis 对房间的特征的唯一的建筑群作出回应,包括膜潜力,房间膜和细胞质的永久使发酸,和膜正直的保藏的不可逆的损失。ML-10 因此是迄今为止知道的最紧缩的 apoptosis 探查。由于它的氟的符号原子, ML-10 对顺从与 18F 同位素标记收音机,向它为 apoptosis 的临床的正电子排放断层摄影术成像的潜在的未来使用。 | Avi Cohen Anat Shirvan Galit Levin Hagit Grimberg Ayelet Reshef Ilan Ziv | 2009 | Cell Research2009，19，5： | 12 |
| 3 | Recent advances in bone regeneration using adult stem cells显示文摘Bone is a highly vascularized tissue reliant on the close spatial and temporal association between bloodvessels and bone cells. Therefore, cells that participate in vasculogenesis and osteogenesis play a pivotal role in bone formation during prenatal and postnatal periods. Nevertheless, spontaneous healing of bone fracture is occasionally impaired due to insufficient blood and cellular supply to the site of injury. In these cases, bone regeneration process is interrupted, which might result in delayed union or even nonunion of the fracture. Nonunion fracture is difficult to treat and have a high financial impact. In the last decade, numerous technological advancements in bone tissue engineering and cell-therapy opened new horizon in the field of bone regeneration. This review starts with presentation of the biological processes involved in bone development, bone remodeling, fracture healing process and the microenvironment at bone healing sites. Then, we discuss the rationale for using adult stem cells and listed the characteristics of the available cells for bone regeneration. The mechanism of action and epigenetic regulations for osteogenic differentiation are also described. Finally, we review the literature for translational and clinical trials that investigated the use of adult stem cells(mesenchymal stem cells, endothelial progenitor cells and CD34+ blood progenitors) for bone regeneration. | Hadar Zigdon-Giladi Utai Rudich Gal Michaeli Geller Ayelet Evron | 2015 | World Journal of Stem Cells2015，7，3： | 9 |
| 4 | Effect of a specialized injury prevention program on static balance, dynamic balance and kicking accuracy of young soccer players显示文摘AIM To study the effect of balance intervention program using the 'FIFA 11+' program on static and dynamic balance and kicking accuracy of young soccer players.METHODS Twenty young soccer players were allocated to experimental(n = 10) or control(n = 10) groups. The experimental group performed the 'FIFA 11+' program three times a week for six weeks. The control group performed their normal warm-up routine. The primary outcomes were measured pre and post intervention, and assessed kicking accuracy, static balance and dynamic balance.RESULTS No differences were found in kicking accuracy following intervention, for both groups, however, static balance improved significantly among the experimental group with significant interaction with the control group, and with high effect size. In addition, the dynamic balance of the left leg of the experimental group, with medium effect size for interaction between groups.CONCLUSION The large effect size of balance improvement that was observed following six weeks of intervention sessions, implies that soccer trainers and coaches should consider the inclusion of 'FIFA 11+' as components of programs aimed at improving balance ability/control in young soccer players, as improvement in balance abilities may prevent injuries. | Ayelet Dunsky Ido Barzilay Orly Fox | 2017 | World Journal of Orthopedics2017，8，4： | 6 |
| 5 | Screening for Pancreatic Cancer in a High-Risk Cohort: An Eight-Year Experience显示文摘 | Wigdan Al-Sukhni Ayelet Borgida Heidi Rothenmund Spring Holter Kara Semotiuk Robert Grant Stephanie Wilson Malcolm Moore Steven Narod Kartik Jhaveri Masoom Haider Steven Gallinger | 2012 | Journal of Gastrointestinal Surgery2012，，4： | 3 |
| 6 | Convenient synthesis of δ-aminolevulinic acid显示文摘 | Abraham Nudelman | 1999 | Synthesis1999，，4： | 1 |
| 7 | The Origin of Human Mesenchymal Stromal Cells Dictates Their Reparative Properties显示文摘 | Nili Naftali‐Shani Ayelet Itzhaki‐Alfia Natalie Landa‐Rouben David Kain Radka Holbova Shimrit Adutler‐Lieber Natali Molotski Elad Asher Avishay Grupper Eran Millet Ariel Tessone Eyal Winkler Jens Kastrup Micha S. Feinberg Dov Zipori Meirav Pevsner‐Fischer | 2013 | Journal of the American Heart Association2013，，5： | 1 |
| 8 | A Taxometric Investigation of the Latent Structure of Worry 显示文摘 | Ayelet Meron Ruscio Borkovrc | 2001 | Jcmnal of Abnormal Psychology(2001)2001，，： | 1 |
| 9 | Ramipril administration to atherosclerotic mice reduce oxidized low-density lipoprotein uptake by their macrophage and blocks the progression of atherosclerosis显示文摘 | Marielle K Ayelet R Shlomo K Raymond C Michael A | 2002 | Atherosclerosis2002，161，1： | 1 |
| 10 | Ramipril administration to atherosclerotic mice reduces oxidized low-density lipoprotein uptake by their macrophages and blocks the progression of atherosclerosis显示文摘 | Hayek Tony Kaplan Marielle Raz Ayelet | 2002 | Atherosclerosi2002，161，1： | 1 |
| 11 | Oxidation-Specific Epitopes Are Danger-Associated Molecular Patterns Recognized by Pattern Recognition Receptors of Innate Immunity显示文摘 | Yury I. Miller Soo-Ho Choi Philipp Wiesner Longhou Fang Richard Harkewicz Karsten Hartvigsen Agnès Boullier Ayelet Gonen Cody J. Diehl Xuchu Que Erica Montano Peter X. Shaw Sotirios Tsimikas Christoph J. Binder Joseph L. Witztum | 2011 | Circulation Research2011，，2： | 1 |
| 12 | The Puzzle of Interlocking Power Hierarchies:Sharing the Pieces of Jurisdictional Authority显示文摘 | Ayelet Shachar | 2000 | Harvard Civil Rights-Civil Liberties Law Review2000，，35： | 1 |
| 13 | Perspective on Theories of Non - Fickian Transport in Heterogeneous Media 显示文摘 | SHLOMO P N AYELET B MONICA R | 2009 | Advances in Water Resources2009，，5： | 1 |
| 14 | GABA shunt deficiencies and accumulation of reactive oxygen intermediates: insight from Arabidopsis mutants显示文摘 | Aaron Fait Ayelet Yellin Hillel Fromm | 2004 | FEBS Letters2004，，2： | 1 |
| 15 | Patient Characteristics and Cell Source Determine the Number of Isolated Human Cardiac Progenitor Cells显示文摘 | Ayelet Itzhaki-Alfia Jonathan Leor Ehud Raanani Leonid Sternik Dan Spiegelstein Shiri Netser Radka Holbova Meirav Pevsner-Fischer Jacob Lavee Israel M. Barbash | 2009 | Circulation2009，，25： | 1 |
| 16 | Active anthocyanin degradation in Brunfelsia calycina (yesterday- today-tomorrow) flowers 显示文摘 | Hila Vaknin Ayelet Bar- Akiva Rinat Ovadia Ada Nissim Levi Izhak Forer David Weiss Michal Oren- Shamir | 2005 | Planta2005，，2005： | 1 |
| 17 | Picking winners: Olympic citizenship and the global race for talent显示文摘 | Ayelet Shachar | 2011 | Yale Law Journal2011，120，： | 1 |
| 18 | Assessment of response of brain metastases to radiotherapy by PET imaging of apoptosis with 18F-ML-10显示文摘 | Aaron Allen Miri Ben-Ami Ayelet Reshef Adam Steinmetz Yulia Kundel Edna Inbar Ruth Djaldetti Tal Davidson Eyal Fenig Ilan Ziv | 2012 | European Journal of Nuclear Medicine and Molecular Imaging2012，，9： | 1 |
| 19 | Patient Characteristics and Cell Source Determine the Number of Isolated Human Cardiac Progenitor Cells显示文摘 | Ayelet Itzhaki-Alfia Jonathan Leor Ehud Raanani Leonid Sternik Dan Spiegelstein Shiri Netser Radka Holbova Meirav Pevsner-Fischer Jacob Lavee Israel M. Barbash | 2009 | Circulation2009，，25： | 1 |
| 20 | The incremental value of 18F-FDG PET/CT in paediatric malignancies显示文摘 | Zvi Bar-Sever Zohar Keidar Ayelet Ben-Barak Rachel Bar-Shalom Sergey Postovsky Luda Guralnik Myriam W. Ben Arush Ora Israel | 2007 | European Journal of Nuclear Medicine and Molecular Imaging2007，，5： | 1 |
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