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| 1 | CD74 is a survival receptor on colon epithelial cells显示文摘AIM: To investigate the expression and function of CD74 in normal murine colon epithelial cells (CEC) and colon carcinoma cells. METHODS: Expression of CD74 mRNA and protein were measured by reverse transcriptase-polymerase chain reaction (RT-PCR), Western blotting and fluorescence-activated cell sorter (FACS). The effect of migration inhibitory factor (MIF) on the survival of normal CEC from C57BL/6, NOD/SCID, and CD74 def icient mice both in vitro and in vivo, and on the CT26 carcinoma cell line was analyzed by (quantitative) qRT-PCR, RTPCR, Western blotting and FACS. RESULTS: CD74 was found to be expressed on normalCEC. Stimulation of CD74 by MIF induced a signaling cascade leading to up-regulation of Bcl-2 expression, resulting in a signif icant increased survival of CEC. CD74 was also expressed on the CT26 colon carcinoma cell line and its stimulation by MIF resulted in enhanced cell survival, up-regulation of Akt phosphorylation and Bcl-2 expression. | Nitsan Maharshak Sivan Cohen Frida Lantner Gili Hart Richard Bucala Idit Shachar | 2010 | World Journal of Gastroenterology2010，16，26： | 9 |
| 2 | Enteric bacterial proteases in inflammatory bowel diseasepathophysiology and clinical implications显示文摘Numerous reports have identified a dysbiosis in the intestinal microbiota in patients suffering from inflammatory bowel diseases(IBD),yet the mechanism(s)in which this complex microbial community initiates or perpetuates inflammation remains unclear.The purpose of this review is to present evidence for one such mechanism that implicates enteric microbial derived proteases in the pathogenesis of IBD.We highlight and discuss studies demonstrating that proteases and protease receptors are abundant in the digestive system.Additionally,we investigate studies demonstrating an association between increased luminal protease activity and activation of protease receptors,ultimately resulting in increased intestinal permeability and exacerbation of colitis in animal models as well as in human IBD.Proteases are essential for the normal functioning of bacteria and in some cases can serve as virulence factors for pathogenic bacteria.Although not classified as traditional virulence factors,proteases originating from commensal enteric bacteria also have a potential association with intestinal inflammation via increased enteric permeability.Reports of increased protease activity in stools from IBD patients support a possible mechanism for a dysbiotic enteric microbiota in IBD.A better understanding of these pathways and characterization of the enteric bacteria involved,their proteases,and protease receptors may pave the way for new therapeutic approaches for these diseases. | Ian M Carroll Nitsan Maharshak | 2013 | World Journal of Gastroenterology2013，19，43： | 6 |
| 3 | Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome显示文摘 | Yehuda Ringel Nitsan Maharshak | 2013 | AJP: Gastrointestinal and Liver Physiology2013，，8： | 4 |
| 4 | Increased fibrosis progression rates in hepatitis C patients carrying the prothrombin G20210A mutation显示文摘AIM: To examine whether hepatitis C virus (HCV)-infected patients who carry hypercoagulable mutationssuffer from increased rates of liver fi brosis. METHODS: We analyzed DNA samples of 168 HCV patients for three common hypercoagulable gene mutations: prothrombin 20210 (PT20210), factor V Leiden (FV Leiden) and methylene tetrahydrofolate reductase (MTHFR). The patients were consecutively recruited as part of the prospective 'Fibroscore Study' in France. The effect of the various mutations on the rate of fi-brosis was analyzed statistically and was correlated with epidemiological, clinical and biochemical data such as grade and stage of liver biopsies, patients' risk factors for liver cirrhosis, and timing of infection. RESULTS: Fifty two of the patients were categorized as 'fast fi brosers' and 116 as 'slow fi brosers'; 13% of the 'fast fi brosers' carried the PT20210 mutation as compared with 5.5% of the 'slow fi brosers', with an odds ratio of 4.76 (P = 0.033; 95% CI: 1.13-19.99) for 'fast' liver fibrosis. Carriage of MTHFR or FV Leiden mutations was not associated with enhanced liver fi brosis. CONCLUSION: Carriage of the PT20210 mutation is related to an increased rate of liver fi brosis in HCV patients. | Nitsan Maharshak Philippe Halfon Varda Deutsch Hava Peretz Shlomo Berliner Sigal Fishman Shira Zelber-Sagi Uri Rozovski Moshe Leshno Ran Oren | 2011 | World Journal of Gastroenterology2011，17，45： | 2 |
| 5 | Intestinal microbiotaand immune func-tion in the pathogenesis of irritable bowel syndrome显示文摘 | Ringel Y Maharshak N | 2013 | Am J PhysiolGastrointest Liver Physiol2013，305，8： | 1 |
| 6 | Maerophage migra- tion inhibitory factor induces B cell survival by aetivation of a CD74- CD44 receptor complex显示文摘 | Gore Yael Starlets Diana Maharshak Nitsan | 2008 | J Biol Chem2008，283，： | 1 |
| 7 | Correlated expression of high- sensitivity C-reactive protein in relation todisease activity in inflammatory bowel disease: lack of differences between Crohn's disease and ulcerative colitis显示文摘 | Zilbemlan L Maharshak N Arbel Y | 2006 | Digestion2006，73，4： | 1 |
| 8 | Macrophage migration inhibitory factor induces B cell survival by activation of a CD74-CD44 receptor complex显示文摘 | Gore Y Starlets D Maharshak N | 2008 | J Biol Chem2008，283，5： | 1 |
| 9 | Cutaneous manifestations of internal malignancies显示文摘 | Brenner S Tamir E Maharshak N | 2001 | Clin Dermatol2001，19，3： | 1 |
| 10 | Correlated expression of high sensitivity C -reactive protein in relation to disease activity in inflammatory bowel disease:lack of differences between Crohn's disease and ulcerative cliffs显示文摘 | Maharshak N Arbel Y | 2006 | Digestion2006，73，4： | 1 |
| 11 | Cutaneous manifestations of internal malignancies显示文摘 | Brenner S Tamir E Maharshak N | 2001 | Clin Dermatol2001，19，3： | 1 |
| 12 | Altered enteric microbiota ecolo- gy in interleukin 10-deficient mice during development and pro- gression of intestinal in{lammation显示文摘 | Maharshak N Christopher D | 2013 | Gut Microbes2013，4，4： | 1 |
| 13 | Diode laser treatment of retinopathy of prematurity: anatom- ical and refractive outcomes 显示文摘 | Axer-Siegel R Maharshak I Snir M | 2008 | Retina2008，28，6： | 1 |
| 14 | Cutaneous manifestations of internal malignancies 显示文摘 | Brenner S Tamir E Maharshak N | 2001 | Clin Dermatol2001，19，3： | 1 |
| 15 | Macrophage migration inhibitory factor induces B cell survival by activation of a CD74-CD44 receptor complex显示文摘 | Gore Y Starlets D Maharshak N | 2008 | J Biol Chem2008，283，5： | 1 |
| 16 | Cutaneous manifestations of internal malignancies显示文摘 | Brenner S Tamir E Maharshak N | 2001 | Clin Dermatol2001，19，3： | 1 |
| 17 | Correlated expression of high - sensitivity C - reactive protein in relation to disease activity in in- flammatory bowel disease: lack of differences between Crohn's disease and ulcerative colitis 显示文摘 | Zilberman L Maharshak N Arbel Y | 2006 | Digestion2006，73，4： | 1 |
| 18 | Pouch Inflammation Is Associated With a Decrease in Specific Bacterial Taxa显示文摘 | Leah Reshef Amir Kovacs Amos Ofer Lior Yahav Nitsan Maharshak Nirit Keren Fred M. Konikoff Hagit Tulchinsky Uri Gophna Iris Dotan | 2015 | Gastroenterology2015，，： | 1 |
| 19 | Airbag-induced bilateral corneal graft dehiscence显示文摘 | | 2005 | Cornea2005，24，1： | 1 |
| 20 | Carbon monoxide and heme oxygenase-1 prevent intestinal inflammation in mice by promoting bacterial clearance显示文摘 | Onyiah JC Sheikh SZ Maharshak N | 2013 | Gastroenterology2013，144，4： | 1 |
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