|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Inhibiting effect of antisense oligonucleotides phosphorthioate on gene expression of TIMP-1 in rat liver fibrosis显示文摘AIM To observe the inhibition of antisenseoligonucleotides (asON) phosphorthioate to thetissue inhibitors metalloproteinase-1 (TIMP-1)gene and protein expression in the liver tissue ofimmunologically induced hepatic fibrosis rats.The possibility of reversing hepatic fibrosisthrough gene therapy was observed.METHODS Human serum albumin (HSA) wasused to attack rats, as hepatic fibrosis model, inwhich asONs were used to block the gene andprotein expressing TIMP-1. According to theanalysis of modulator, structure protein, codingseries of TIMP-1 genome, we designed fourdifferent asONs. These asONs were injected intothe hepatic fibrosis models through coccygealvein. The results was observed by RT-PCR formeasuring TIMP-1 mRNA expression,immunohistochemistry and in situ hybridizationfor collagen Ⅰ, Ⅲ, special staining of collagenfiber, and electron microscopic examination.RESULTS Hepatic fibrosis could last within 363days in our modified model. The expressinglevel of TIMP-1 was high during hepatic fibrosisprocess. It has been proved by theimmunohistochemical and the electronmicroscopic examination that the asONphosphorthioate of TIMP-1 could exactly expressin vivo. The effect of colchicine wasdemonstrated to inhibit the expressing level ofmRNA and the content of collagen Ⅰ, Ⅲ in theliver of experimental hepatic fibrosis rats.However, the electron microscopy research andthe pathologic grading of hepatic fibrosisshowed that there was no significant differencebetween the treatment group and the modelgroup (P>0.05).CONCLUSION The experimental rat model ofhepatic fibrosis is one of the preferable modelsto estimate the curative effect of anti-hepaticfibrosis drugs. The asON phosphorthioate ofTIMP-1 could block the gene and proteinexpression of TIMP-1 in the liver of experimentalhepatic fibrosis rats at the mRNA level. It ispossible to reverse hepatic fibrosis, and it isexpected to study a new drug of anti-hepaticfibrosis on the genetic level. Colchicine has verylimited therapeutic effect on hepatic fibrosis,furthermore, its toxicity and side effects areobvious. | Qing He Nie Yong Qian Cheng Yu Mei Xie Yong Xing Zhou Yi Zhan Cao The Center of Infectious Disease Diagnosis and Treatment of PLA,Tangdu Hospital,Forth Military Medical University,Xi’an 710038,Shaanxi Province,ChinaDr,Qing He Nie graduated from Qinghai Medical College as a doctor in 1983,got master degree at Beijing 302 Army Hospital in 1993,got doctor degree at the Third Military Medical University in 1998,engaged in postdoctoral research at the Fourth Military Medical University from 1998 to 2000,now an associate professor,specialized in clinical and experimental research of infectious diseases,had more than 90 papers published,coauthor of ten books,first author of one book. | 2001 | World Journal of Gastroenterology2001，7，3： | 73 |
| 2 | TGF-β signaling in vascular biology and dysfunction显示文摘转变生长因素(TGF )- 尾家庭成员是多功能的 cytokines 在细胞上得到他们的效果包括 endothelial 和墙壁的细胞,经由特定的类型我和类型 II serine/threonine kinase 受体和细胞内部的 Smad 抄写因素。为表明小径部件的 TGF- 尾家庭的猛烈老鼠模型在合适的蛋黄囊 angiogenesis 揭示了他们的批评重要性。在人的基因研究在这些发信号的部件连接了变化到象世袭出血性的毛细管扩张,主要肺的高血压和 Marfan 症候群那样的特定的心血管的症候群。在这评论,我们在我们 TGF- 尾受体在脉管的生物学和疾病发信号的角色的理解的现在的最近的进展,并且讨论这怎么可以被申请治疗。 | Marie-Jose Goumans Zhen Liu Peter ten Dijke | 2009 | Cell Research2009，19，1： | 28 |
| 3 | TGF-β family co-receptor function and signaling显示文摘转变生长因素 --(TGF-) 家庭成员,它包括 TGF-s, activins 和骨头形态基因的蛋白质,是多种的 cytokines 得到细胞类型特定的效果在一高度在许多不同纸巾的上下文依赖者举止。经由 single-transmembrane 类型的这些分泌蛋白质 ligands 信号我和类型 II serine/threonine kinase 受体和细胞内部的 SMAD 抄写因素。在发信号的解除管制在疾病的一个宽广数组被含有,并且含有对复杂罚款在细胞的发信号的回答调节的需要。TGF- 家庭受体发信号紧张,持续时间,特性和差异被调整或调停的一重要出现机制通过房间表面合作受体。这里,我们提供为 TGF- 家庭成员被识别了的合作受体的概述。当一些看起来对 TGF- 家庭成员特定时,其它与另外的小径被分享并且为信号集成提供可能的方法。这评论集中于 TGF- 家庭合作受体的新奇功能,它继续发现。 | Joachim Nickel Peter ten Dijke Thomas D. Mueller | 2018 | Acta Biochimica et Biophysica Sinica2018，50，1： | 26 |
| 4 | TREATMENT OF METALS, POLYMER FILMS, AND FABRICS WITHA ONE ATMOSPHERE UNIFORM GLOW DISCHARGE PLASMA(OAUGDP) FOR INCREASED SURFACE ENERGY AND DIRECTIONAL ETCHING显示文摘Direct exposure of samples to the active species of air generated by a One Atmosphere Uniform Glow Discharge Plasma (OAUGDP) has been used to etch and to increase the surface energy of metallic surfaces, photoresist, polymer films, and nonwoven fab- rics. The OAUGDP is a non-thermal plasma with the classical characteristics of a DC normal glow discharge that operates in air (and other gases) at atmospheric pres- sure. Neither a vacuum system nor batch processing is necessary. A wide range of applications to metals, photoresist, films, fabrics, and polymeric webs can be accom- modated by direct exposure of the workpiece to the plasma in parallel-plate reactors. This technolopy is simple, it produces effects that can be obtained in no other way at one atmosphere; it generates minimal pollutants or unwanted by-products; and it is suitable for individual sample or online treatment of metallic surfaces, wafers, films, and fabrics. Early exposures of solid materials to the OAUGDP required minutes to produce rela- tively small increases of surface energy. These durations appeared too long for com- mercial application to fast-moving webs. Recent improvements in OAUGDP gas com- position, power density, plasma quality, recireulating gas flow, and impedance match- ing of the power supply to the parallel plate plasma reactor have made it possible to raise the surface energy of a variety of polymeric webs (PP, PET PE etc.) to levels of 60 to 70 dynes/cm with one second of exposure. In air plasmas, the high surface ener- gies are not durable, and fall to 50 dynes/cm after periods of weeks to months. Here, we report the exposure of metallic surfaces, photoresist, polymeric films, and nonwo- ven fabrics made of PP and PET to an impedance matched parallel plate OAUGDP for durations ranging from one second to several tens of seconds. Data will be re- ported on the surface energy, wettability, wickability, and aging effect of polymeric films and fabrics as functions of time of exposure, and time after exposure; the rate and uniformity of photoresist etching; and the production of sub-micron structures by OAUGDP etching at one atmosphere. | J. Reece Roth and Z. Y Chen (Plasma Sciences Laboratory, Department of Electrical and Computer Engineering, University of Tennessee, Knoxville, TN 37996-2100, USA) Peter P.- Y Tsai (Textiles and Nonwovens Development Center (TANDEC), University of Tenness | 2001 | Acta Metallurgica Sinica(English Letters)2001，14，6： | 18 |
| 5 | Design and dynamic simulation of hydraulic system of a new automatic transmission显示文摘A new hydraulic system of a novel automatic transmission (AT) was designed. The dimension and structure of valves and cylinders were designed by theoretical calculation. The dynamic simulation model of hydraulic system of AT was established by ITI-SimulationX. Simulation results and theoretical design results were compared to confirm the simulation model. Based on the confirmed simulation model, the simulation results of pressure and flow of the hydraulic system were analyzed. The dynamic simulation method is very helpful for designing and analyzing the performance of hydraulic system and further optimization design. The theoretical design method and dynamic simulation model are feasible for the real industrial applications. The research results can be used in hydraulic system design and optimization. | 王书翰 徐向阳 刘艳芳 戴振坤 TEN BERGE P 曲巍 | 2009 | Journal of Central South University2009，16，4： | 15 |
| 6 | Chemical composition of Galla chinensis extract and the effect of its main component(s) on the prevention of enamel demineralization in vitro显示文摘To determine the chemical composition of Galla chinensis extract(GCE) by several analysis techniques and to compare the efficacy of GCE and its main component(s) in inhibition of enamel demineralization,for the development of future anticaries agents,main organic composition of GCE was qualitatively determined by liquid chromatography-time of flight-mass spectrometry(LC-TOF-MS) and quantified by high-performance liquid chromatography-diode array detector(HPLC-DAD).Inorganic ions were tested by inductively coupled plasma-atomic emission spectroscopy and F was especially measured by ion chromatography.Then,bovine enamel blocks were randomly divided into four treatment groups and were subjected to a pH-cycling regime for 12 times.Each cycle included 5-min applications with one of four treatments:4 g?L 21 GCE solution,4 g?L 21 gallic acid(GA) solution,1 g?L 21 NaF solution(positive control),deionized water(DDW,negative control),and then 60-min application in pH 5.0 acidic buffer and 5-min application in neutral buffer.Acidic buffers were retained for calcium analysis.The main organic composition of GCE were GA and its isomer,and,to a lesser extent,small molecule gallotannins.The content of GA in GCE was 71.3%60.2%(w/w).Inorganic ions were present in various amounts,of which Ca was(13662.82) mg?g 21,and Zn was(6.860.1) mg?g 21.No F was detected in GCE.In pH cycling,GA showed an effect similar to GCE in inhibiting enamel demineralization(P.0.05).GA was found to be the main effective,demineralization inhibiting component of GCE and could be a promising agent for the development of anticaries agents. | Xue-Lian Huang Ming-Dong Liu Ji-Yao Li Xue-Dong Zhou Jacob M ten Cate | 2012 | International Journal of Oral Science2012，4，3： | 11 |
| 7 | UBE20 negatively regulates TRAF6-mediated NF-kB activation by inhibiting TRAF6 polyubiquitination显示文摘 | Xiaofei Zhang Juan Zhang Long Zhang Hans van Dam Peter ten Dijke | 2013 | Cell Research2013，23，3： | 8 |
| 8 | Percutaneous closure of secundum type atrial septal defects:More than 5-year follow-up显示文摘AIM: To investigate long-term efficacy of two different devices more than five years after percutaneous atrial septal defect(ASD) closure in adults.METHODS: All patients who underwent percutaneous closure of an ASD in the St. Antonius Hospital, Nieuwegein, The Netherlands, between February 1998 and December 2006 were included. Percutaneous closure took place under general anaesthesia and transesophageal echocardiographic moni toring. Transthoracic echocardiography(TTE) was performed 24 h post-procedure to visualize the device position and to look for residual shunting using color Doppler. All complications were registered. All patients were invited for an outpatient visit and contrast TTE more than 5-years after closure. Efficacy was based on the presence of a residual right-to-left shunt(RLS), graded as minimal, moderate or severe. The presence of a residual left-to-right shunt(LRS) was diagnosed using color Doppler, and was not graded. Descriptive statistics were used for patients' characteristics. Univariate analysis was used to identify predictors for residual shunting.RESULTS: In total, 104 patients(mean age 45.5 ± 17.1 years) underwent percutaneous ASD closure using an Amplatzer device(ASO) in 76 patients and a Cardioseal/Starflex device(CS/SF) in 28 patients. The mean follow-up was 6.4 ± 3.4 years. Device migration occurred in 4 patients of whom two cases occurred during the index hospitalization(1 ASO, 1 CS/SF). The other 2 cases of device migration occurred during the first 6 mo of follow-up(2 CS/SF). The recurrent thrombo-embolic event rate was similar in both groups: 0.4% per follow-up year. More than 12 mo post-ASD closure and latest follow-up, new-onset supraventricular tachyarrhythmia's occurred in 3.9% and 0% for the ASO and CS/SF group, respectively. The RLS rate at latest follow-up was 17.4%(minimal 10.9%, moderate 2.2%, severe 4.3%) and 45.5%(minimal 27.3%, moderate 18.2%, severe 0%) for the ASO- and CS/SF groups, respectively. There was no residual LRS in both groups.CONCLUSION: Percutaneous ASD closure has good long-term safety and efficacy profiles. The residual RLS rate seems to be high more than 5 years after closure, especially in the CS/SF. Residual LRS was not observed. | Roel JR Snijder Maarten J Suttorp Jurrien M Ten Berg Martijn C Post | 2015 | World Journal of Cardiology2015，7，3： | 6 |
| 9 | Endoscopic Tri-Modal Imaging Is More Effective Than Standard Endoscopy in Identifying Early-Stage Neoplasia in Barrett’s Esophagus显示文摘 | Wouter L. Curvers Lorenza Alvarez Herrero Michael B. Wallace Louis–Michel Wong Kee Song Krish Ragunath Herbert C. Wolfsen Ganapathy A. Prasad Kenneth K. Wang Venkataraman Subramanian Bas L.A.M. Weusten Fiebo J. Ten Kate Jacques J.G.H.M. Bergman | 2010 | Gastroenterology2010，，4： | 6 |
| 10 | Aspirin responsive platelet thrombophilia in essential thrombocythemia and polycythemia vera显示文摘Essential thrombocythemia(ET) and polycythemia vera(PV) frequently present with erythromelalgia and acrocyanotic complications, migraine-like microvascular cerebral and ocular transient ischemic attacks(MIAs) and/or acute coronary disease. The spectrum of MIAs in ET range from poorly localized symptoms of transient unsteadiness, dysarthria and scintillating scotoma to focal symptoms of transient monocular blindness, transient mono- or hemiparesis or both. The attacks all have a sudden onset, occur sequentially rather than simultaneously, last for a few seconds to several minutes and are usually associated with a dull, pulsatile or migraine-like headache. Increased hematocrit and blood viscosity in PV patients aggravate the microvascular ischemic syndrome of thrombocythemia to major arterial and venous thrombotic complications. Phlebotomy to correct hematocrit to normal in PV significantly reduces major arterial and venous thrombotic complications, but fails to prevent the platelet-mediated erythromelalgia and MIAs. Complete long-term relief of the erythromelalgic microvascular disturbances, MIAs and major thrombosis in ET and PV patients can be obtained with low dose aspirin and platelet reduction to normal, but not with anticoagulation. Skin punch biopsies from the erythromelalgic area show fibromuscular intimal proliferation of arterioles complicated by occlusive plateletrich thrombi leading to acrocyanotic ischemia. Symptomatic ET patients with erythromelalgic microvascular disturbances have shortened platelet survival, increased platelet activation markers β-thromboglobulin(β-TG), platelet factor 4(PF4) and thrombomoduline(TM), increased urinary thromboxane B2(TXB2) excretion, and no activation of the coagulation markers thrombin fragments F1+2 and fibrin degradation products. Inhibition of platelet cyclooxygenase(COX1) by aspirin is followed by the disappearance and no recurrence of microvascular disturbances, increase in platelet number, correction of the shortened platelet survival times to normal, and reduction of increased plasma levels of β-TG, PF4, TM and urinary TXB2 excretion to normal. These results indicate that platelet-mediated fibromuscular intimal proliferation and platelet-rich thrombi in the peripheral, cerebral and coronary end-arterial microvasculature are responsible for the erythromelalgic ischemic complica-tions, MIAs and splanchnic vein thrombosis. Baseline platelet P-selectin levels and arachidonic acid induced COX1 mediated platelet activation showed a highly significant increase of platelet P-selectin expression(not seen in ADP and collagen stimulated platelets), which was significantly higher in JAK2V617 F mutated compared to JAK2 wild type ET. | Jan Jacques Michiels Fibo WJ Ten Kate Peter J Koudstaal Perry JJ Van Genderen | 2013 | World Journal of Hematology2013，2，2： | 4 |
| 11 | Role of glycosylation in TGF-β signaling and epithelial-to-mesenchymal transition in cancer显示文摘Glycosylation is a common posttranslational modification on membrane-associated and secreted proteins that is of pivotal importance for regulating cell functions.Aberrant glycosylation can lead to uncontrolled cell proliferation,cell-matrix interactions,migration and differentiation,and has been shown to be involved in cancer and other diseases.The epithelial-to-mesenchymal transition is a key step in the metastatic process by which cancer cells gain the ability to invade tissues and extravasate into the bloodstream.This cellular transformation process,which is associated by morphological change,loss of epithelial traits and gain of mesenchymal markers,is triggered by the secreted cytokine transforming growth factor-β(TGF-β).TGF-βbioactivity is carefully regulated,and its effects on cells are mediated by its receptors on the cell surface.In this review,we first provide a brief overview of major types of glycans,namely,N-glycans,O-glycans,glycosphingolipids and glycosaminoglycans that are involved in cancer progression.Thereafter,we summarize studies on how the glycosylation of TGF-βsignaling components regulates TGF-βsecretion,bioavailability and TGF-βreceptor function.Then,we review glycosylation changes associated with TGF-β-induced epithelial-to-mesenchymal transition in cancer.Identifying and understanding the mechanisms by which glycosylation affects TGF-βsignaling and downstream biological responses will facilitate the identification of glycans as biomarkers and enable novel therapeutic approaches. | Jing Zhang Peter ten Dijke Manfred Wuhrer Tao Zhang | 2021 | Protein & Cell2021，12，2： | 4 |
| 12 | Stability of Low Crested and Submerged Breakwaters with Single Layer Armouring显示文摘 | Markus Muttray Erik ten Oever Bas Reedijk | 2012 | Journal of Shipping and Ocean Engineering2012，2，3： | 4 |
| 13 | Targeting TGFβ signal transduction for cancer therapy显示文摘Transforming growth factor-β(TGFβ) family members are structurally and functionally related cytokines that have diverse effects on the regulation of cell fate during embryonic development and in the maintenance of adult tissue homeostasis.Dysregulation of TGFβ family signaling can lead to a plethora of developmental disorders and diseases,including cancer,immune dysfunction,and fbrosis.In this review,we focus on TGFβ,a well-characterized family member that has a dichotomous role in cancer progression,acting in early stages as a tumor suppressor and in late stages as a tumor promoter.The functions of TGFβ are not limited to the regulation of proliferation,differentiation,apoptosis,epithelial-mesenchymal transition,and metastasis of cancer cells.Recent reports have related TGFβ to effects on cells that are present in the tumor microenvironment through the stimulation of extracellular matrix deposition,promotion of angiogenesis,and suppression of the ant-tumor immune reaction.The pro-oncogenic roles of TGFβ have attracted considerable attention because their intervention provides a therapeutic approach for cancer patients.However,the critical function of TGFβin maintaining tissue homeostasis makes targeting TGFβa challenge.Here,we review the pleiotropic functions of TGFβin cancer initiation and progression,summarize the recent clinical advancements regarding TGFβ signaling interventions for cancer treatment,and discuss the remaining challenges and opportunities related to targeting this pathway.We provide a perspective on synergistic therapies that combine anti-TGFβ therapy with cytotoxic chemotherapy,targeted therapy,radiotherapy,or immunotherapy. | Sijia Liu Jiang Ren Peter ten Dijke | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 4 |
| 14 | 复杂性区域疼痛综合征和纤维肌痛病人的身体变化及感官敏感度显示文摘复杂性区域性疼痛综合征(CRPS)和纤维肌痛都是病因不明的慢性疼痛性疾病。除了诊断标准中的症状外,病人还可主诉视力以及其他感觉或身体机能的变化。目前尚不清楚这些症状是否与年龄增长、持续的慢性疼痛或慢性疼痛的常见共患病(如抑郁或焦虑)有关。本文作者进行了一项在线调查,纳入CRPS(n=390)、纤维肌痛(n=425)以及同时患有CRPS和纤维肌痛(n=88)的病人,评估他们的躯体症状、身体变化以及感官敏感度的频率和类型的改变,并与其他慢性疼痛病人对照组(n=331)和无疼痛对照组(n=441)相比较。该调查评估了躯体症状(病人健康问卷,Patient health questionnaire-15,PHQ-15)、身体变化、疼痛/不适/困扰的诱发因素和疼痛的加剧因素。将年龄、性别、抑郁症量表(patient health questionnaire-9,PHQ-9)、广泛性焦虑障碍量表(generalized anxiety disorder,GAD-7)、疼痛持续时间、每天疼痛时间和与疼痛相关的诊断数量作为协变量分析其协方差。在控制协变量后,CRPS和/或纤维肌痛病人的躯体症状、身体变化包括运动及生理反应的变化、疼痛、不适、困扰的诱发因素和疼痛加剧因素均多于其他慢性疼痛及无疼痛对照组的病人。纤维肌痛与视力、听力、泌尿/肠道功能及饮食的改变相关。CRPS与头发、皮肤和指甲的改变相关,且与感染和愈合相关。同时患有CRPS和纤维肌痛的病人表现出这两种疾病的特征,除此之外,基本无其他症状。本研究的发现提示:尽管其具体的机制可能不同,但CRPS和纤维肌痛有共同的病理生理学基础。 | Ten Brink AF Peters L Kompouli PI 商澜镨(译) 李水清(校) | 2021 | 中国疼痛医学杂志2021，27，3： | 3 |
| 15 | Altered central pain processing after pancreatic surgery for chronic pancreatitis显示文摘 | S. A. Bouwense U. Ahmed Ali R. P. ten Broek Y. Issa C. H. van Eijck O. H. Wilder‐Smith H. van Goor | 2013 | Br J Surg2013，，13： | 3 |
| 16 | Cognitive performance in patients with COPD显示文摘 | Jeroen J.W Liesker Dirkje S Postma Rypko J Beukema Nick H.T ten Hacken Thys van der Molen Roland A Riemersma Ed H van Zomeren Huib A.M Kerstjens | 2003 | Respiratory Medicine2003，，4： | 3 |
| 17 | New insights into TGF-β–Smad signalling显示文摘 | Peter ten Dijke Caroline S Hill | 2004 | Trends in Biochemical Sciences2004，，5： | 3 |
| 18 | Arterial chemoembolization for hepatocellular carcinoma显示文摘ArterialchemoembolizationforhepatocelularcarcinomaFANJian,TENGaoJing,HEShiCheng,GUOJinHe,YANGDongPeiandWENGGuoYingSubje... | FAN Jian TEN Gao-Jing HE Shi-Cheng GUO Jin-He YANG Dong-Pei WENG Guo-Ying | 1998 | World Journal of Gastroenterology1998，4，1： | 3 |
| 19 | Reproducibility of the histological diagnosis of celiac disease显示文摘 | Amani Mubarak Peter Nikkels Roderick Houwen Fiebo Ten Kate | 2011 | Scandinavian Journal of Gastroenterology2011，，： | 2 |
| 20 | Autophagy, apoptosis and organelle features during cell exposure to cadmiumč显示文摘Cadmium(Cd)induces several effects in different tissues,but our knowledge of the toxic effects on organelles is insuffi cient.To observe the progression of Cd effects on organelle structure and function,HuH-7 cells(human hepatic carcinoma cell line)were exposed to CdCl2 in increasing concentrations(1μM–20μM)and exposure times(2 h–24 h).During Cd treatment,the cells exhibited a progressive decrease in viability that was both time-and dose-dependent.Cd treated cells displayed progressive morphological changes that included cytoplasm retraction and nuclear condensation preceding a total loss of cell adhesion.Treatment with 10μM for 12 h led to irreversible damages.Before these drastic and irreparable damages,treated cells(5μM for 12 h)presented a progressive loss of mitochondrial function and cytoplasm acidifi cation as well as dysfunction and disorganization of microfi laments and endoplasmic reticulum.These damages led to the induction of apoptotic events and an increase in autophagic bodies in the cytoplasm.These results revealed that Cd affects multiple intra-cellular targets that induce alterations in the mitochondria,cytoskeleton,endoplasmic reticulum and acidic compartments,ultimately culminating in cell death via apoptotic and autophagic pathways. | CRISTIANE DOS SANTOS VERGILIO EDÉSIO JOSÉTENÓRIO DE MELO | 2013 | BIOCELL2013，37，2： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员